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UniProtKB - P33073 (SDHA_PEPAS)
Protein
L-serine dehydratase, alpha chain
Gene
sdhA
Organism
Peptoniphilus asaccharolyticus (Peptostreptococcus asaccharolyticus)
Status
Functioni
Catalytic activityi
- EC:4.3.1.17
Cofactori
[4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster.
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- L-serine ammonia-lyase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Biological process | Gluconeogenesis |
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: L-serine dehydratase, alpha chain (EC:4.3.1.17)Short name: SDH Alternative name(s): L-serine deaminase Short name: L-SD |
Gene namesi | Name:sdhA |
Organismi | Peptoniphilus asaccharolyticus (Peptostreptococcus asaccharolyticus) |
Taxonomic identifieri | 1258 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Tissierellia › Tissierellales › Peptoniphilaceae › Peptoniphilus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171915 | 1 – 292 | L-serine dehydratase, alpha chainAdd BLAST | 292 |
Interactioni
Subunit structurei
Heterooctamer of four alpha chains and four beta chains.
Family & Domainsi
Sequence similaritiesi
Belongs to the iron-sulfur dependent L-serine dehydratase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005130, Ser_deHydtase-like_asu IPR004642, Ser_deHydtase_asu |
Pfami | View protein in Pfam PF03313, SDH_alpha, 1 hit |
TIGRFAMsi | TIGR00718, sda_alpha, 1 hit |
i Sequence
Sequence statusi: Complete.
P33073-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNTAREIID VCNERGIKIY DLVLEEEIKN SHTTEEEIRK KLDAVIDVMH
60 70 80 90 100
ASATKNLTQS DVTEYKMIDG FAKRTYEYAN SGKSIVGDFL AKAMAMAFST
110 120 130 140 150
SEVNASMGKI VAAPTAGSSG IMPAMLVAAT EKYNFDRTTI QNGFLTSIGI
160 170 180 190 200
GQVITKYATF AGAEGGCQAE CGSASAMAAA ALVEMLGGTV EQALHAASIT
210 220 230 240 250
IINVLGLVCD PIAGLVQYPC TFRNASGVIN AFISADLALA GVESLVPFDE
260 270 280 290
VVIAMGEVGN SMIEALRETG LGGLAGSKTG QKIRRDFLKE GD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | Missing AA sequence (PubMed:2065681).Curated | 1 | |
Sequence conflicti | 12 | C → Q AA sequence (PubMed:2065681).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76260 Genomic DNA Translation: AAC45546.1 |
PIRi | S16224 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76260 Genomic DNA Translation: AAC45546.1 |
PIRi | S16224 |
3D structure databases
SMRi | P33073 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Family and domain databases
InterProi | View protein in InterPro IPR005130, Ser_deHydtase-like_asu IPR004642, Ser_deHydtase_asu |
Pfami | View protein in Pfam PF03313, SDH_alpha, 1 hit |
TIGRFAMsi | TIGR00718, sda_alpha, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDHA_PEPAS | |
Accessioni | P33073Primary (citable) accession number: P33073 Secondary accession number(s): O33922 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | July 15, 1999 | |
Last modified: | December 11, 2019 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families