UniProtKB - P33033 (MC3R_MOUSE)
Protein
Melanocortin receptor 3
Gene
Mc3r
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (PubMed:19036988).1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- melanocortin receptor activity Source: MGI
- melanocyte-stimulating hormone receptor activity Source: MGI
- neuropeptide binding Source: MGI
- peptide hormone binding Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: MGI
- circadian regulation of gene expression Source: UniProtKB
- homoiothermy Source: MGI
- locomotor rhythm Source: UniProtKB
- regulation of blood pressure Source: MGI
- regulation of feeding behavior Source: UniProtKB
- regulation of heart rate Source: MGI
- regulation of metabolic process Source: GO_Central
- sodium ion homeostasis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Biological rhythms |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocortin receptor 3Short name: MC3-R |
Gene namesi | Name:Mc3r |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96929, Mc3r |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 64 – 75 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 76 – 100 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 101 – 118 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 119 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 141 – 160 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 161 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 186 | ExtracellularSequence analysis | 5 | |
Transmembranei | 187 – 210 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 211 – 245 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 246 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 269 – 277 | ExtracellularSequence analysis | 9 | |
Transmembranei | 278 – 301 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 302 – 323 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069719 | 1 – 323 | Melanocortin receptor 3Add BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 16 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 315 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P33033 |
PRIDEi | P33033 |
PTM databases
GlyGeni | P33033, 3 sites |
Expressioni
Tissue specificityi
Brain.
Gene expression databases
Bgeei | ENSMUSG00000038537, Expressed in Ammon's horn and 36 other tissues |
ExpressionAtlasi | P33033, baseline and differential |
Genevisiblei | P33033, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 201340, 1 interactor |
STRINGi | 10090.ENSMUSP00000047358 |
Chemistry databases
BindingDBi | P33033 |
Miscellaneous databases
RNActi | P33033, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P33033 |
OMAi | DQFIQHM |
OrthoDBi | 1037679at2759 |
PhylomeDBi | P33033 |
TreeFami | TF332646 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002122, Mcort_3_rcpt IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF4, PTHR22750:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01061, MELNOCORTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P33033-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNSM NLG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74983 Genomic DNA Translation: CAA52918.1 |
CCDSi | CCDS17127.1 |
PIRi | S43850 |
RefSeqi | NP_032587.1, NM_008561.3 |
Genome annotation databases
Ensembli | ENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537 |
GeneIDi | 17201 |
KEGGi | mmu:17201 |
UCSCi | uc008ocl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74983 Genomic DNA Translation: CAA52918.1 |
CCDSi | CCDS17127.1 |
PIRi | S43850 |
RefSeqi | NP_032587.1, NM_008561.3 |
3D structure databases
SMRi | P33033 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201340, 1 interactor |
STRINGi | 10090.ENSMUSP00000047358 |
Chemistry databases
BindingDBi | P33033 |
ChEMBLi | CHEMBL4774 |
GuidetoPHARMACOLOGYi | 284 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P33033, 3 sites |
Proteomic databases
PaxDbi | P33033 |
PRIDEi | P33033 |
Protocols and materials databases
Antibodypediai | 2935, 320 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537 |
GeneIDi | 17201 |
KEGGi | mmu:17201 |
UCSCi | uc008ocl.1, mouse |
Organism-specific databases
CTDi | 4159 |
MGIi | MGI:96929, Mc3r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P33033 |
OMAi | DQFIQHM |
OrthoDBi | 1037679at2759 |
PhylomeDBi | P33033 |
TreeFami | TF332646 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 17201, 0 hits in 17 CRISPR screens |
PROi | PR:P33033 |
RNActi | P33033, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038537, Expressed in Ammon's horn and 36 other tissues |
ExpressionAtlasi | P33033, baseline and differential |
Genevisiblei | P33033, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002122, Mcort_3_rcpt IPR001908, Melancort_rcpt IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF4, PTHR22750:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01061, MELNOCORTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MC3R_MOUSE | |
Accessioni | P33033Primary (citable) accession number: P33033 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries