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UniProtKB - P33032 (MC5R_HUMAN)
Protein
Melanocortin receptor 5
Gene
MC5R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- hormone binding Source: Ensembl
- melanocortin receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P33032 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P33032 |
SIGNORi | P33032 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocortin receptor 5Short name: MC5-R Alternative name(s): MC-2 |
Gene namesi | Name:MC5R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6933, MC5R |
MIMi | 600042, gene |
neXtProti | NX_P33032 |
VEuPathDBi | HostDB:ENSG00000176136 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 61 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 62 – 73 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 74 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 24 | |
Topological domaini | 98 – 114 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 115 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 139 – 155 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 156 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 180 – 186 | ExtracellularSequence analysis | 7 | |
Transmembranei | 187 – 211 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 212 – 239 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 240 – 265 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 266 – 273 | ExtracellularSequence analysis | 8 | |
Transmembranei | 274 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 298 – 325 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 235 | Q → K: 10% increase of binding to alpha-MSH. 1 Publication | 1 | |
Mutagenesisi | 272 | R → C: 690% increase of binding to alpha-MSH. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4161 |
OpenTargetsi | ENSG00000176136 |
PharmGKBi | PA30677 |
Miscellaneous databases
Pharosi | P33032, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4608 |
DrugBanki | DB11653, Bremelanotide |
DrugCentrali | P33032 |
GuidetoPHARMACOLOGYi | 286 |
Genetic variation databases
BioMutai | MC5R |
DMDMi | 729996 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069728 | 1 – 325 | Melanocortin receptor 5Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 20 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 311 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 312 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P33032 |
PeptideAtlasi | P33032 |
PRIDEi | P33032 |
PTM databases
GlyGeni | P33032, 4 sites |
iPTMneti | P33032 |
PhosphoSitePlusi | P33032 |
Expressioni
Tissue specificityi
Expressed in the brain but not in the melanoma cells.
Gene expression databases
Bgeei | ENSG00000176136, Expressed in neocortex and 42 other tissues |
ExpressionAtlasi | P33032, baseline and differential |
Genevisiblei | P33032, HS |
Organism-specific databases
HPAi | ENSG00000176136, Tissue enhanced (epididymis, lymphoid tissue) |
Interactioni
Binary interactionsi
P33032
With | #Exp. | IntAct |
---|---|---|
MRAP [Q8TCY5] | 2 | EBI-9538507,EBI-9538727 |
Protein-protein interaction databases
BioGRIDi | 110331, 1 interactor |
DIPi | DIP-48792N |
IntActi | P33032, 2 interactors |
STRINGi | 9606.ENSP00000318077 |
Chemistry databases
BindingDBi | P33032 |
Miscellaneous databases
RNActi | P33032, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234510 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P33032 |
OMAi | LYCSCFM |
OrthoDBi | 877700at2759 |
PhylomeDBi | P33032 |
TreeFami | TF332646 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001908, MC3-5R IPR000621, Melancort_rcpt_5 IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF5, PTHR22750:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01063, MELNOCORTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P33032-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS
60 70 80 90 100
LLENILVIGA IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN
110 120 130 140 150
NKHLVIADAF VRHIDNVFDS MICISVVASM CSLLAIAVDR YVTIFYALRY
160 170 180 190 200
HHIMTARRSG AIIAGIWAFC TGCGIVFILY SESTYVILCL ISMFFAMLFL
210 220 230 240 250
LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV TMLLGVFTVC
260 270 280 290 300
WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ
310 320
EMRKTFKEII CCRGFRIACS FPRRD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | R → A in AAA59566 (PubMed:8179577).Curated | 1 | |
Sequence conflicti | 221 – 234 | ALPGA…QRTSM → LCPGPALRGRGPAW (PubMed:8396929).CuratedAdd BLAST | 14 | |
Sequence conflicti | 297 | F → Y in AAA59566 (PubMed:8179577).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013128 | 209 | F → L2 PublicationsCorresponds to variant dbSNP:rs2236700Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z25470 Genomic DNA Translation: CAA80962.1 L27080 Genomic DNA Translation: AAA59566.1 U08353 Genomic DNA Translation: AAB60376.1 AY268429 Genomic DNA Translation: AAP23196.1 EF444993 Genomic DNA Translation: ACA06012.1 CH471113 Genomic DNA Translation: EAX01504.1 BC069153 mRNA Translation: AAH69153.1 BC069545 mRNA Translation: AAH69545.1 BC095531 mRNA Translation: AAH95531.1 |
CCDSi | CCDS11868.1 |
PIRi | JC5592 JN0764 |
RefSeqi | NP_005904.1, NM_005913.2 |
Genome annotation databases
Ensembli | ENST00000324750.5; ENSP00000318077.3; ENSG00000176136.6 ENST00000589410.2; ENSP00000468086.2; ENSG00000176136.6 |
GeneIDi | 4161 |
KEGGi | hsa:4161 |
MANE-Selecti | ENST00000589410.2; ENSP00000468086.2; NM_005913.3; NP_005904.1 |
UCSCi | uc010xaf.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Melanocortin receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z25470 Genomic DNA Translation: CAA80962.1 L27080 Genomic DNA Translation: AAA59566.1 U08353 Genomic DNA Translation: AAB60376.1 AY268429 Genomic DNA Translation: AAP23196.1 EF444993 Genomic DNA Translation: ACA06012.1 CH471113 Genomic DNA Translation: EAX01504.1 BC069153 mRNA Translation: AAH69153.1 BC069545 mRNA Translation: AAH69545.1 BC095531 mRNA Translation: AAH95531.1 |
CCDSi | CCDS11868.1 |
PIRi | JC5592 JN0764 |
RefSeqi | NP_005904.1, NM_005913.2 |
3D structure databases
AlphaFoldDBi | P33032 |
SMRi | P33032 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110331, 1 interactor |
DIPi | DIP-48792N |
IntActi | P33032, 2 interactors |
STRINGi | 9606.ENSP00000318077 |
Chemistry databases
BindingDBi | P33032 |
ChEMBLi | CHEMBL4608 |
DrugBanki | DB11653, Bremelanotide |
DrugCentrali | P33032 |
GuidetoPHARMACOLOGYi | 286 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P33032, 4 sites |
iPTMneti | P33032 |
PhosphoSitePlusi | P33032 |
Genetic variation databases
BioMutai | MC5R |
DMDMi | 729996 |
Proteomic databases
PaxDbi | P33032 |
PeptideAtlasi | P33032 |
PRIDEi | P33032 |
Protocols and materials databases
Antibodypediai | 7155, 428 antibodies from 37 providers |
DNASUi | 4161 |
Genome annotation databases
Ensembli | ENST00000324750.5; ENSP00000318077.3; ENSG00000176136.6 ENST00000589410.2; ENSP00000468086.2; ENSG00000176136.6 |
GeneIDi | 4161 |
KEGGi | hsa:4161 |
MANE-Selecti | ENST00000589410.2; ENSP00000468086.2; NM_005913.3; NP_005904.1 |
UCSCi | uc010xaf.3, human |
Organism-specific databases
CTDi | 4161 |
DisGeNETi | 4161 |
GeneCardsi | MC5R |
HGNCi | HGNC:6933, MC5R |
HPAi | ENSG00000176136, Tissue enhanced (epididymis, lymphoid tissue) |
MIMi | 600042, gene |
neXtProti | NX_P33032 |
OpenTargetsi | ENSG00000176136 |
PharmGKBi | PA30677 |
VEuPathDBi | HostDB:ENSG00000176136 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234510 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P33032 |
OMAi | LYCSCFM |
OrthoDBi | 877700at2759 |
PhylomeDBi | P33032 |
TreeFami | TF332646 |
Enzyme and pathway databases
PathwayCommonsi | P33032 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P33032 |
SIGNORi | P33032 |
Miscellaneous databases
BioGRID-ORCSi | 4161, 7 hits in 1057 CRISPR screens |
GeneWikii | Melanocortin_5_receptor |
GenomeRNAii | 4161 |
Pharosi | P33032, Tchem |
PROi | PR:P33032 |
RNActi | P33032, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176136, Expressed in neocortex and 42 other tissues |
ExpressionAtlasi | P33032, baseline and differential |
Genevisiblei | P33032, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001908, MC3-5R IPR000621, Melancort_rcpt_5 IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF5, PTHR22750:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01063, MELNOCORTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MC5R_HUMAN | |
Accessioni | P33032Primary (citable) accession number: P33032 Secondary accession number(s): B0YJ34, Q502V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families