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Protein

Melanocortin receptor 5

Gene

MC5R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

GO - Molecular functioni

  • hormone binding Source: Ensembl
  • melanocortin receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiP33032

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 5
Short name:
MC5-R
Alternative name(s):
MC-2
Gene namesi
Name:MC5R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000176136.5
HGNCiHGNC:6933 MC5R
MIMi600042 gene
neXtProtiNX_P33032

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 61Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini62 – 73CytoplasmicSequence analysisAdd BLAST12
Transmembranei74 – 97Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini98 – 114ExtracellularSequence analysisAdd BLAST17
Transmembranei115 – 138Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini139 – 155CytoplasmicSequence analysisAdd BLAST17
Transmembranei156 – 179Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini180 – 186ExtracellularSequence analysis7
Transmembranei187 – 211Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini212 – 239CytoplasmicSequence analysisAdd BLAST28
Transmembranei240 – 265Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini266 – 273ExtracellularSequence analysis8
Transmembranei274 – 297Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini298 – 325CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235Q → K: 10% increase of binding to alpha-MSH. 1 Publication1
Mutagenesisi272R → C: 690% increase of binding to alpha-MSH. 1 Publication1

Organism-specific databases

DisGeNETi4161
OpenTargetsiENSG00000176136
PharmGKBiPA30677

Chemistry databases

ChEMBLiCHEMBL4608
GuidetoPHARMACOLOGYi286

Polymorphism and mutation databases

BioMutaiMC5R
DMDMi729996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697281 – 325Melanocortin receptor 5Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1
Lipidationi312S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP33032
PRIDEiP33032
ProteomicsDBi54896

PTM databases

iPTMnetiP33032
PhosphoSitePlusiP33032

Expressioni

Tissue specificityi

Expressed in the brain but not in the melanoma cells.

Gene expression databases

BgeeiENSG00000176136
CleanExiHS_MC5R
ExpressionAtlasiP33032 baseline and differential
GenevisibleiP33032 HS

Organism-specific databases

HPAiHPA042365

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MRAPQ8TCY52EBI-9538507,EBI-9538727

Protein-protein interaction databases

BioGridi110331, 1 interactor
DIPiDIP-48792N
IntActiP33032, 2 interactors
STRINGi9606.ENSP00000318077

Chemistry databases

BindingDBiP33032

Structurei

3D structure databases

ProteinModelPortaliP33032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiP33032
KOiK04203
OMAiVSLYIHM
OrthoDBiEOG091G0BVW
PhylomeDBiP33032
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001908 Melancort_rcpt
IPR000621 Melancort_rcpt_5
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF5 PTHR22750:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01063 MELNOCORTN5R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P33032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS
60 70 80 90 100
LLENILVIGA IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN
110 120 130 140 150
NKHLVIADAF VRHIDNVFDS MICISVVASM CSLLAIAVDR YVTIFYALRY
160 170 180 190 200
HHIMTARRSG AIIAGIWAFC TGCGIVFILY SESTYVILCL ISMFFAMLFL
210 220 230 240 250
LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV TMLLGVFTVC
260 270 280 290 300
WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ
310 320
EMRKTFKEII CCRGFRIACS FPRRD
Length:325
Mass (Da):36,601
Last modified:February 1, 1995 - v3
Checksum:i8BEC17E1BDA059BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149R → A in AAA59566 (PubMed:8179577).Curated1
Sequence conflicti221 – 234ALPGA…QRTSM → LCPGPALRGRGPAW (PubMed:8396929).CuratedAdd BLAST14
Sequence conflicti297F → Y in AAA59566 (PubMed:8179577).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013128209F → L2 PublicationsCorresponds to variant dbSNP:rs2236700Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25470 Genomic DNA Translation: CAA80962.1
L27080 Genomic DNA Translation: AAA59566.1
U08353 Genomic DNA Translation: AAB60376.1
AY268429 Genomic DNA Translation: AAP23196.1
EF444993 Genomic DNA Translation: ACA06012.1
CH471113 Genomic DNA Translation: EAX01504.1
BC069153 mRNA Translation: AAH69153.1
BC069545 mRNA Translation: AAH69545.1
BC095531 mRNA Translation: AAH95531.1
CCDSiCCDS11868.1
PIRiJC5592
JN0764
RefSeqiNP_005904.1, NM_005913.2
UniGeneiHs.248145

Genome annotation databases

EnsembliENST00000324750; ENSP00000318077; ENSG00000176136
ENST00000589410; ENSP00000468086; ENSG00000176136
GeneIDi4161
KEGGihsa:4161
UCSCiuc010xaf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMC5R_HUMAN
AccessioniPrimary (citable) accession number: P33032
Secondary accession number(s): B0YJ34, Q502V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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