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Protein

Putative nucleoside permease NupX

Gene

nupX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YEIJ-MONOMER
MetaCyc:YEIJ-MONOMER

Protein family/group databases

TCDBi2.A.41.2.10 the concentrative nucleoside transporter (cnt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nucleoside permease NupXCurated
Gene namesi
Name:nupXImported
Synonyms:yeiJ
Ordered Locus Names:b2161, JW2148
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12029 nupX

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2PeriplasmicCurated2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 31CytoplasmicCurated8
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 95PeriplasmicCuratedAdd BLAST43
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Topological domaini119 – 172CytoplasmicCuratedAdd BLAST54
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 196PeriplasmicCurated3
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 246CytoplasmicCuratedAdd BLAST29
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 352PeriplasmicCuratedAdd BLAST85
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 394CytoplasmicCuratedAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416Periplasmic1 Publication1

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704571 – 416Putative nucleoside permease NupXAdd BLAST416

Proteomic databases

PaxDbiP33021
PRIDEiP33021

Interactioni

Protein-protein interaction databases

BioGridi4260459, 7 interactors
DIPiDIP-11922N
IntActiP33021, 1 interactor
STRINGi316385.ECDH10B_2318

Structurei

3D structure databases

ProteinModelPortaliP33021
SMRiP33021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D9N Bacteria
COG1972 LUCA
HOGENOMiHOG000267656
InParanoidiP33021
KOiK16325
OMAiVFMMGVE
PhylomeDBiP33021

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PfamiView protein in Pfam
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

Sequencei

Sequence statusi: Complete.

P33021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMRSVLGM VVLLTIAFLL SVNKKKISLR TVGAALVLQV VIGGIMLWLP
60 70 80 90 100
PGRWVAEKVA FGVHKVMAYS DAGSAFIFGS LVGPKMDTLF DGAGFIFGFR
110 120 130 140 150
VLPAIIFVTA LVSILYYIGV MGILIRILGG IFQKALNISK IESFVAVTTI
160 170 180 190 200
FLGQNEIPAI VKPFIDRLNR NELFTAICSG MASIAGSTMI GYAALGVPVE
210 220 230 240 250
YLLAASLMAI PGGILFARLL SPATESSQVS FNNLSFTETP PKSIIEAAAT
260 270 280 290 300
GAMTGLKIAA GVATVVMAFV AIIALINGII GGVGGWFGFE HASLESILGY
310 320 330 340 350
LLAPLAWVMG VDWSDANLAG SLIGQKLAIN EFVAYLNFSP YLQTAGTLDA
360 370 380 390 400
KTVAIISFAL CGFANFGSIG VVVGAFSAVA PHRAPEIAQL GLRALAAATL
410
SNLMSATIAG FFIGLA
Length:416
Mass (Da):43,410
Last modified:February 1, 1994 - v1
Checksum:iFB8E9C284A028B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60513.1
U00096 Genomic DNA Translation: AAC75222.1
AP009048 Genomic DNA Translation: BAE76638.1
PIRiH64984
RefSeqiNP_416666.1, NC_000913.3
WP_000382966.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75222; AAC75222; b2161
BAE76638; BAE76638; BAE76638
GeneIDi946655
KEGGiecj:JW2148
eco:b2161
PATRICifig|1411691.4.peg.78

Similar proteinsi

Entry informationi

Entry nameiNUPX_ECOLI
AccessioniPrimary (citable) accession number: P33021
Secondary accession number(s): Q2MAR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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