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Protein

Tumor necrosis factor ligand superfamily member 8

Gene

Tnfsf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Molecular functioni

GO - Biological processi

  • CD8-positive, alpha-beta T cell differentiation Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • immune response Source: InterPro
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:Tnfsf8
Synonyms:Cd30l, Cd30lg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88328 Tnfsf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST24
Topological domaini68 – 239ExtracellularSequence analysisAdd BLAST172

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855001 – 239Tumor necrosis factor ligand superfamily member 8Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 182Sequence analysis
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32972
PRIDEiP32972

PTM databases

PhosphoSitePlusiP32972

Expressioni

Gene expression databases

BgeeiENSMUSG00000028362 Expressed in 56 organ(s), highest expression level in lymph node
ExpressionAtlasiP32972 baseline and differential
GenevisibleiP32972 MM

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030047

Structurei

3D structure databases

ProteinModelPortaliP32972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE9 Eukaryota
ENOG4111CQK LUCA
GeneTreeiENSGT00390000011719
HOGENOMiHOG000136320
HOVERGENiHBG055267
InParanoidiP32972
KOiK05471
OMAiWAYLQVS
OrthoDBiEOG091G0HNM
PhylomeDBiP32972
TreeFamiTF335780

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021185 TNF_CD30_ligand_type
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF019548 TNF_CD30_ligand_type, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT
60 70 80 90 100
ALVCLVVAVA IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS
110 120 130 140 150
KKSWAYLQVS KHLNNTKLSW NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL
160 170 180 190 200
QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT VCESGVQSKN IYQNLSQFLL
210 220 230
HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD
Length:239
Mass (Da):26,519
Last modified:October 1, 1993 - v1
Checksum:i29003157DD425159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09754 mRNA Translation: AAA74595.1
CCDSiCCDS18264.1
PIRiB40710
RefSeqiNP_033429.1, NM_009403.3
UniGeneiMm.4664

Genome annotation databases

EnsembliENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362
GeneIDi21949
KEGGimmu:21949
UCSCiuc008thd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTNFL8_MOUSE
AccessioniPrimary (citable) accession number: P32972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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