TNFSF8

Protein namesⁱ	Recommended name: Tumor necrosis factor ligand superfamily member 8 Alternative name(s): CD30 ligand Short name: CD30-L CD_antigen: CD153
Gene namesⁱ	Name:TNFSF8 Synonyms:CD30L, CD30LG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106952.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11938 TNFSF8
MIMⁱ	603875 gene
neXtProtⁱ	NX_P32971

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 37	CytoplasmicSequence analysisAdd BLAST	37
Transmembraneⁱ	38 – 62	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	25
Topological domainⁱ	63 – 234	ExtracellularSequence analysisAdd BLAST	172

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	944
Open Targets More...OpenTargetsⁱ	ENSG00000106952
PharmGKBⁱ	PA36628

Polymorphism and mutation databases

BioMutaⁱ	TNFSF8
DMDMⁱ	416777

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185499	1 – 234	Tumor necrosis factor ligand superfamily member 8Add BLAST		234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	109	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	151 ↔ 177	Sequence analysis
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	189	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	201	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P32971
PeptideAtlas More...PeptideAtlasⁱ	P32971
PRIDEⁱ	P32971
ProteomicsDBⁱ	54895

PTM databases

iPTMnetⁱ	P32971
PhosphoSitePlusⁱ	P32971

Miscellaneous databases

PMAP-CutDBⁱ	P32971

PMAP-CutDBⁱ

P32971

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106952 Expressed in 128 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TNFSF8
ExpressionAtlasⁱ	P32971 baseline and differential
Genevisibleⁱ	P32971 HS

Interactionⁱ

Subunit structureⁱ

Homotrimer.Curated

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 8391931
tumor necrosis factor receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107382, 41 interactors
Database of interacting proteins More...DIPⁱ	DIP-2929N
IntActⁱ	P32971, 2 interactors
STRINGⁱ	9606.ENSP00000223795

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32971
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tumor necrosis factor family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHE9 Eukaryota ENOG4111CQK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011719
HOGENOMⁱ	HOG000136320
HOVERGENⁱ	HBG055267
InParanoidⁱ	P32971
KEGG Orthology (KO) More...KOⁱ	K05471
OMAⁱ	WAYLQVS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HNM
PhylomeDBⁱ	P32971
TreeFamⁱ	TF335780

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR021185 TNF_CD30_ligand_type IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PIRSFⁱ	PIRSF019548 TNF_CD30_ligand_type, 1 hit
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P32971-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL 
        60         70         80         90        100
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA 
       110        120        130        140        150
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ 
       160        170        180        190        200
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV 
       210        220        230 
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD

Length:234

Mass (Da):26,017

Last modified:October 1, 1993 - v1

Checksum:ⁱC653615682305B1B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X228	A0A087X228_HUMAN		Tumor necrosis factor ligand superf... Tumor necrosis factor ligand superfamily member 8	TNFSF8	164	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09753 mRNA Translation: AAA74594.1 AF006384 , AF006381, AF006382, AF006383 Genomic DNA Translation: AAB97877.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6810.1
PIRⁱ	A40710
NCBI Reference Sequences More...RefSeqⁱ	NP_001235.1, NM_001244.3
UniGeneⁱ	Hs.494901 Hs.654445

Genome annotation databases

Ensemblⁱ	ENST00000223795; ENSP00000223795; ENSG00000106952
GeneIDⁱ	944
KEGGⁱ	hsa:944

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32971	Tumor necrosis factor (Ligand) superfamily, member 8		HUMAN		234	UniRef100_P32971
TNF superfamily member 8		PANTR		234
Uncharacterized protein		PANPA		234

Protein	Similar proteins		Species	Score	Length	Source
P32971	Tumor necrosis factor (Ligand) superfamily, member 8		HUMAN		234	UniRef90_P32971
TNF superfamily member 8		PANTR		234
Uncharacterized protein		PANPA		234
Uncharacterized protein		AOTNA		240
Tumor necrosis factor ligand 3A		CALJA		234
+16

Protein	Similar proteins		Species	Score	Length	Source
P32971	Tumor necrosis factor (Ligand) superfamily, member 8		HUMAN		234	UniRef50_P32971
TNF superfamily member 8		PANTR		234
Uncharacterized protein		PANPA		234
Uncharacterized protein		AOTNA		240
Uncharacterized protein		CERAT		234
+86

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09753 mRNA Translation: AAA74594.1 AF006384 , AF006381, AF006382, AF006383 Genomic DNA Translation: AAB97877.1
CCDSⁱ	CCDS6810.1
PIRⁱ	A40710
RefSeqⁱ	NP_001235.1, NM_001244.3
UniGeneⁱ	Hs.494901 Hs.654445

3D structure databases

ProteinModelPortalⁱ	P32971
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107382, 41 interactors
DIPⁱ	DIP-2929N
IntActⁱ	P32971, 2 interactors
STRINGⁱ	9606.ENSP00000223795

PTM databases

iPTMnetⁱ	P32971
PhosphoSitePlusⁱ	P32971

Polymorphism and mutation databases

BioMutaⁱ	TNFSF8
DMDMⁱ	416777

Proteomic databases

PaxDbⁱ	P32971
PeptideAtlasⁱ	P32971
PRIDEⁱ	P32971
ProteomicsDBⁱ	54895

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000223795; ENSP00000223795; ENSG00000106952
GeneIDⁱ	944
KEGGⁱ	hsa:944

Organism-specific databases

CTDⁱ	944
DisGeNETⁱ	944
EuPathDBⁱ	HostDB:ENSG00000106952.7
GeneCardsⁱ	TNFSF8
HGNCⁱ	HGNC:11938 TNFSF8
MIMⁱ	603875 gene
neXtProtⁱ	NX_P32971
OpenTargetsⁱ	ENSG00000106952
PharmGKBⁱ	PA36628
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHE9 Eukaryota ENOG4111CQK LUCA
GeneTreeⁱ	ENSGT00390000011719
HOGENOMⁱ	HOG000136320
HOVERGENⁱ	HBG055267
InParanoidⁱ	P32971
KOⁱ	K05471
OMAⁱ	WAYLQVS
OrthoDBⁱ	EOG091G0HNM
PhylomeDBⁱ	P32971
TreeFamⁱ	TF335780

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors

Reactomeⁱ

R-HSA-5669034 TNFs bind their physiological receptors

Miscellaneous databases

GenomeRNAiⁱ	944
PMAP-CutDBⁱ	P32971
Protein Ontology More...PROⁱ	PR:P32971
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106952 Expressed in 128 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TNFSF8
ExpressionAtlasⁱ	P32971 baseline and differential
Genevisibleⁱ	P32971 HS

Family and domain databases

CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR021185 TNF_CD30_ligand_type IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PIRSFⁱ	PIRSF019548 TNF_CD30_ligand_type, 1 hit
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNFL8_HUMAN
Accessionⁱ	P32971Primary (citable) accession number: P32971 Secondary accession number(s): O43404
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1993
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Supporting data

UniProtKB - P32971 (TNFL8_HUMAN)

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Tumor necrosis factor ligand superfamily member 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ