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UniProtKB - P32971 (TNFL8_HUMAN)
Protein
Tumor necrosis factor ligand superfamily member 8
Gene
TNFSF8
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: ProtInc
- tumor necrosis factor receptor binding Source: InterPro
GO - Biological processi
- CD8-positive, alpha-beta T cell differentiation Source: GO_Central
- cell-cell signaling Source: ProtInc
- defense response to Gram-positive bacterium Source: Ensembl
- immune response Source: InterPro
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of T cell proliferation Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | P32971 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P32971 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor ligand superfamily member 8Alternative name(s): CD30 ligand Short name: CD30-L CD_antigen: CD153 |
Gene namesi | Name:TNFSF8 Synonyms:CD30L, CD30LG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11938, TNFSF8 |
MIMi | 603875, gene |
neXtProti | NX_P32971 |
VEuPathDBi | HostDB:ENSG00000106952 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | CytoplasmicSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 62 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 25 | |
Topological domaini | 63 – 234 | ExtracellularSequence analysisAdd BLAST | 172 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 944 |
OpenTargetsi | ENSG00000106952 |
PharmGKBi | PA36628 |
Miscellaneous databases
Pharosi | P32971, Tbio |
Genetic variation databases
BioMutai | TNFSF8 |
DMDMi | 416777 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185499 | 1 – 234 | Tumor necrosis factor ligand superfamily member 8Add BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 151 ↔ 177 | Sequence analysis | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P32971 |
PaxDbi | P32971 |
PeptideAtlasi | P32971 |
PRIDEi | P32971 |
ProteomicsDBi | 54895 |
PTM databases
GlyGeni | P32971, 5 sites |
iPTMneti | P32971 |
PhosphoSitePlusi | P32971 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106952, Expressed in leukocyte and 144 other tissues |
ExpressionAtlasi | P32971, baseline and differential |
Genevisiblei | P32971, HS |
Organism-specific databases
HPAi | ENSG00000106952, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Homotrimer.
CuratedBinary interactionsi
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: ProtInc
- tumor necrosis factor receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 107382, 139 interactors |
DIPi | DIP-2929N |
IntActi | P32971, 38 interactors |
STRINGi | 9606.ENSP00000223795 |
Miscellaneous databases
RNActi | P32971, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tumor necrosis factor family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S54A, Eukaryota |
GeneTreei | ENSGT00390000011719 |
HOGENOMi | CLU_102229_0_0_1 |
InParanoidi | P32971 |
OMAi | FLVQCSN |
OrthoDBi | 1469711at2759 |
PhylomeDBi | P32971 |
TreeFami | TF335780 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR021185, TNF_CD30_ligand_type IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PIRSFi | PIRSF019548, TNF_CD30_ligand_type, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P32971-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL
60 70 80 90 100
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA
110 120 130 140 150
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ
160 170 180 190 200
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV
210 220 230
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X228 | A0A087X228_HUMAN | Tumor necrosis factor ligand superf... | TNFSF8 | 164 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09753 mRNA Translation: AAA74594.1 AF006384 , AF006381, AF006382, AF006383 Genomic DNA Translation: AAB97877.1 |
CCDSi | CCDS6810.1 |
PIRi | A40710 |
RefSeqi | NP_001235.1, NM_001244.3 |
Genome annotation databases
Ensembli | ENST00000223795; ENSP00000223795; ENSG00000106952 |
GeneIDi | 944 |
KEGGi | hsa:944 |
MANE-Selecti | ENST00000223795.3; ENSP00000223795.2; NM_001244.4; NP_001235.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09753 mRNA Translation: AAA74594.1 AF006384 , AF006381, AF006382, AF006383 Genomic DNA Translation: AAB97877.1 |
CCDSi | CCDS6810.1 |
PIRi | A40710 |
RefSeqi | NP_001235.1, NM_001244.3 |
3D structure databases
SMRi | P32971 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107382, 139 interactors |
DIPi | DIP-2929N |
IntActi | P32971, 38 interactors |
STRINGi | 9606.ENSP00000223795 |
PTM databases
GlyGeni | P32971, 5 sites |
iPTMneti | P32971 |
PhosphoSitePlusi | P32971 |
Genetic variation databases
BioMutai | TNFSF8 |
DMDMi | 416777 |
Proteomic databases
MassIVEi | P32971 |
PaxDbi | P32971 |
PeptideAtlasi | P32971 |
PRIDEi | P32971 |
ProteomicsDBi | 54895 |
Protocols and materials databases
Antibodypediai | 15592, 469 antibodies from 30 providers |
DNASUi | 944 |
Genome annotation databases
Ensembli | ENST00000223795; ENSP00000223795; ENSG00000106952 |
GeneIDi | 944 |
KEGGi | hsa:944 |
MANE-Selecti | ENST00000223795.3; ENSP00000223795.2; NM_001244.4; NP_001235.1 |
Organism-specific databases
CTDi | 944 |
DisGeNETi | 944 |
GeneCardsi | TNFSF8 |
HGNCi | HGNC:11938, TNFSF8 |
HPAi | ENSG00000106952, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 603875, gene |
neXtProti | NX_P32971 |
OpenTargetsi | ENSG00000106952 |
PharmGKBi | PA36628 |
VEuPathDBi | HostDB:ENSG00000106952 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S54A, Eukaryota |
GeneTreei | ENSGT00390000011719 |
HOGENOMi | CLU_102229_0_0_1 |
InParanoidi | P32971 |
OMAi | FLVQCSN |
OrthoDBi | 1469711at2759 |
PhylomeDBi | P32971 |
TreeFami | TF335780 |
Enzyme and pathway databases
PathwayCommonsi | P32971 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P32971 |
Miscellaneous databases
BioGRID-ORCSi | 944, 2 hits in 1036 CRISPR screens |
ChiTaRSi | TNFSF8, human |
GenomeRNAii | 944 |
Pharosi | P32971, Tbio |
PROi | PR:P32971 |
RNActi | P32971, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106952, Expressed in leukocyte and 144 other tissues |
ExpressionAtlasi | P32971, baseline and differential |
Genevisiblei | P32971, HS |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR021185, TNF_CD30_ligand_type IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PIRSFi | PIRSF019548, TNF_CD30_ligand_type, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TNFL8_HUMAN | |
Accessioni | P32971Primary (citable) accession number: P32971 Secondary accession number(s): O43404 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families