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UniProtKB - P32970 (CD70_HUMAN)

Entry version 174 (02 Dec 2020)
Sequence version 2 (06 Jun 2002)
Previous versions | rss
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Protein

CD70 antigen

Gene

CD70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P32970

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5669034, TNFs bind their physiological receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		P32970

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD70
Synonyms:CD27L, CD27LG, TNFSF7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000125726.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:11937, CD70

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602840, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P32970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 193ExtracellularSequence analysisAdd BLAST155

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lymphoproliferative syndrome 3 (LPFS3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081988179 – 193Missing in LPFS3; loss of interaction with CD27. 1 PublicationAdd BLAST15
Natural variantiVAR_081989186 – 193Missing in LPFS3; loss of interaction with CD27. 1 Publication8

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		970

MalaCards human disease database

More...MalaCardsi		CD70
MIMi618261, phenotype

Open Targets

More...OpenTargetsi		ENSG00000125726

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		538958, Combined immunodeficiency due to CD70 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36627

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P32970, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3712913

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD70

Domain mapping of disease mutations (DMDM)

More...DMDMi		21431837

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854971 – 193CD70 antigenAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi133 ↔ 151Sequence analysis
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P32970

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P32970

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32970

PeptideAtlas

More...PeptideAtlasi		P32970

PRoteomics IDEntifications database

More...PRIDEi		P32970

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4807
54894 [P32970-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P32970, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32970

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P32970

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P32970

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125726, Expressed in prostate gland and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P32970, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P32970, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125726, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107408, 90 interactors

Protein interaction database and analysis system

More...IntActi		P32970, 81 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000245903

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P32970, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TEKD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_114585_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32970

Identification of Orthologs from Complete Genome Data

More...OMAi		FGVQWVH

Database of Orthologous Groups

More...OrthoDBi		1236901at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P32970

TreeFam database of animal gene trees

More...TreeFami		TF338269

Family and domain databases

Conserved Domains Database

More...CDDi		cd00184, TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042374, CD70
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR15152, PTHR15152, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00229, TNF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00207, TNF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49842, SSF49842, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P32970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL 
        60         70         80         90        100
ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR 
       110        120        130        140        150
DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG 
       160        170        180        190 
CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP
Length:193
Mass (Da):21,118
Last modified:June 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9265856E33BE4D50
GO
Isoform 2 (identifier: P32970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-193: CTIASQRLTP...TFFGVQWVRP → LFGFWNWGLK...TDEENRGVNR

Show »
Length:208
Mass (Da):23,438
Checksum:i191D07D576433B6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZW2M0QZW2_HUMAN
CD70 antigen
CD70
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154A → V in AAA36175 (PubMed:8387892).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081988179 – 193Missing in LPFS3; loss of interaction with CD27. 1 PublicationAdd BLAST15
Natural variantiVAR_081989186 – 193Missing in LPFS3; loss of interaction with CD27. 1 Publication8

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056416151 – 193CTIAS…QWVRP → LFGFWNWGLKVKCFLRHLIW TAHCFIPLTQLVFMQALQSW RNHHCSHFTDEENRGVNR in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L08096 mRNA Translation: AAA36175.1
S69339 mRNA Translation: AAB30121.1
BT007211 mRNA Translation: AAP35875.1
AK298467 mRNA Translation: BAG60680.1
EF064709 Genomic DNA Translation: ABK41892.1
AC008760 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69074.1
BC000725 mRNA Translation: AAH00725.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12170.1 [P32970-1]
CCDS82283.1 [P32970-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I56214, A40738

NCBI Reference Sequences

More...RefSeqi		NP_001243.1, NM_001252.4 [P32970-1]
NP_001317261.1, NM_001330332.1 [P32970-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000245903; ENSP00000245903; ENSG00000125726 [P32970-1]
ENST00000423145; ENSP00000395294; ENSG00000125726 [P32970-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:970

UCSC genome browser

More...UCSCi		uc002mfi.3, human [P32970-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08096 mRNA Translation: AAA36175.1
S69339 mRNA Translation: AAB30121.1
BT007211 mRNA Translation: AAP35875.1
AK298467 mRNA Translation: BAG60680.1
EF064709 Genomic DNA Translation: ABK41892.1
AC008760 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69074.1
BC000725 mRNA Translation: AAH00725.1
CCDSiCCDS12170.1 [P32970-1]
CCDS82283.1 [P32970-2]
PIRiI56214, A40738
RefSeqiNP_001243.1, NM_001252.4 [P32970-1]
NP_001317261.1, NM_001330332.1 [P32970-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi107408, 90 interactors
IntActiP32970, 81 interactors
STRINGi9606.ENSP00000245903

Chemistry databases

ChEMBLiCHEMBL3712913

PTM databases

GlyGeniP32970, 3 sites
iPTMnetiP32970
PhosphoSitePlusiP32970
SwissPalmiP32970

Polymorphism and mutation databases

BioMutaiCD70
DMDMi21431837

Proteomic databases

EPDiP32970
MassIVEiP32970
PaxDbiP32970
PeptideAtlasiP32970
PRIDEiP32970
ProteomicsDBi4807
54894 [P32970-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P32970, 39 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24212, 843 antibodies

The DNASU plasmid repository

More...DNASUi		970

Genome annotation databases

EnsembliENST00000245903; ENSP00000245903; ENSG00000125726 [P32970-1]
ENST00000423145; ENSP00000395294; ENSG00000125726 [P32970-2]
GeneIDi970
KEGGihsa:970
UCSCiuc002mfi.3, human [P32970-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		970
DisGeNETi970
EuPathDBiHostDB:ENSG00000125726.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD70
HGNCiHGNC:11937, CD70
HPAiENSG00000125726, Tissue enhanced (blood, lymphoid tissue)
MalaCardsiCD70
MIMi602840, gene
618261, phenotype
neXtProtiNX_P32970
OpenTargetsiENSG00000125726
Orphaneti538958, Combined immunodeficiency due to CD70 deficiency
PharmGKBiPA36627

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TEKD, Eukaryota
GeneTreeiENSGT00390000006744
HOGENOMiCLU_114585_0_0_1
InParanoidiP32970
OMAiFGVQWVH
OrthoDBi1236901at2759
PhylomeDBiP32970
TreeFamiTF338269

Enzyme and pathway databases

PathwayCommonsiP32970
ReactomeiR-HSA-5669034, TNFs bind their physiological receptors
SIGNORiP32970

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		970, 3 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD70, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		970
PharosiP32970, Tbio

Protein Ontology

More...PROi		PR:P32970
RNActiP32970, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125726, Expressed in prostate gland and 143 other tissues
ExpressionAtlasiP32970, baseline and differential
GenevisibleiP32970, HS

Family and domain databases

CDDicd00184, TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR042374, CD70
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom
PANTHERiPTHR15152, PTHR15152, 1 hit
PfamiView protein in Pfam
PF00229, TNF, 1 hit
SMARTiView protein in SMART
SM00207, TNF, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD70_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32970
Secondary accession number(s): B4DPR8, Q53XX4, Q96J57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 6, 2002
Last modified: December 2, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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