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Protein

60S ribosomal protein L9

Gene

RPL9

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • rRNA binding Source: InterPro
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L9
Alternative name(s):
Large ribosomal subunit protein uL61 Publication
Gene namesi
Name:RPL9
ORF Names:OK/SW-cl.103
AND
Name:RPL9P7
AND
Name:RPL9P8
AND
Name:RPL9P9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163682.15
HGNCiHGNC:10369 RPL9
MIMi603686 gene
neXtProtiNX_P32969

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6133
OpenTargetsiENSG00000163682
PharmGKBiPA34769

Polymorphism and mutation databases

BioMutaiRPL9
DMDMi417677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001310971 – 19260S ribosomal protein L9Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP32969
PaxDbiP32969
PeptideAtlasiP32969
PRIDEiP32969
ProteomicsDBi54893
TopDownProteomicsiP32969

2D gel databases

SWISS-2DPAGEiP32969

PTM databases

iPTMnetiP32969
PhosphoSitePlusiP32969
SwissPalmiP32969

Expressioni

Gene expression databases

BgeeiENSG00000163682 Expressed in 93 organ(s), highest expression level in ectocervix
CleanExiHS_RPL9
ExpressionAtlasiP32969 baseline and differential
GenevisibleiP32969 HS

Organism-specific databases

HPAiHPA003372

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi112053, 177 interactors
CORUMiP32969
IntActiP32969, 62 interactors
MINTiP32969
STRINGi9606.ENSP00000346022

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32969
SMRiP32969
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32969

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3255 Eukaryota
COG0097 LUCA
GeneTreeiENSGT00390000015224
HOGENOMiHOG000039905
HOVERGENiHBG000942
InParanoidiP32969
KOiK02940
OMAiVFQDGIY
OrthoDBiEOG091G0R6Z
PhylomeDBiP32969
TreeFamiTF300033

Family and domain databases

Gene3Di3.90.930.12, 2 hits
InterProiView protein in InterPro
IPR000702 Ribosomal_L6
IPR020040 Ribosomal_L6_a/b-dom
IPR036789 Ribosomal_L6_a/b-dom_sf
IPR002359 Ribosomal_L6_CS2
PANTHERiPTHR11655 PTHR11655, 1 hit
PfamiView protein in Pfam
PF00347 Ribosomal_L6, 2 hits
PIRSFiPIRSF002162 Ribosomal_L6, 1 hit
SUPFAMiSSF56053 SSF56053, 2 hits
PROSITEiView protein in PROSITE
PS00700 RIBOSOMAL_L6_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P32969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK
60 70 80 90 100
KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP
110 120 130 140 150
INVVIQENGS LVEIRNFLGE KYIRRVRMRP GVACSVSQAQ KDELILEGND
160 170 180 190
IELVSNSAAL IQQATTVKNK DIRKFLDGIY VSEKGTVQQA DE
Length:192
Mass (Da):21,863
Last modified:October 1, 1993 - v1
Checksum:i0249E6CA12F77934
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y5Y7A0A2R8Y5Y7_HUMAN
60S ribosomal protein L9
RPL9
220Annotation score:
D6RAN4D6RAN4_HUMAN
60S ribosomal protein L9
RPL9
181Annotation score:
H0Y9R4H0Y9R4_HUMAN
60S ribosomal protein L9
RPL9
90Annotation score:
H0Y9V9H0Y9V9_HUMAN
60S ribosomal protein L9
RPL9
113Annotation score:
E7ESE0E7ESE0_HUMAN
60S ribosomal protein L9
RPL9
166Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → E in AAB01040 (PubMed:8597601).Curated1
Sequence conflicti11D → E in AAB01041 (PubMed:8597601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14531 mRNA Translation: BAA03401.1
U09953 mRNA Translation: AAB01040.1
U09954 Genomic DNA Translation: AAB01041.1
U21138 mRNA Translation: AAA63752.1
AB062431 mRNA Translation: BAB93494.1
BC000483 mRNA Translation: AAH00483.1
BC004156 mRNA Translation: AAH04156.1
BC004206 mRNA Translation: AAH04206.1
BC007967 mRNA Translation: AAH07967.1
BC012149 mRNA Translation: AAH12149.1
BC031906 mRNA Translation: AAH31906.1
BC066318 mRNA Translation: AAH66318.1
BC070214 mRNA Translation: AAH70214.1
AB007169 Genomic DNA Translation: BAA25830.1
CCDSiCCDS3452.1
PIRiS65792
RefSeqiNP_000652.2, NM_000661.4
NP_001020092.1, NM_001024921.3
UniGeneiHs.412370
Hs.513083
Hs.730597

Genome annotation databases

EnsembliENST00000295955; ENSP00000346022; ENSG00000163682
ENST00000449470; ENSP00000400467; ENSG00000163682
ENST00000645496; ENSP00000494697; ENSG00000163682
GeneIDi6133
KEGGihsa:6133

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14531 mRNA Translation: BAA03401.1
U09953 mRNA Translation: AAB01040.1
U09954 Genomic DNA Translation: AAB01041.1
U21138 mRNA Translation: AAA63752.1
AB062431 mRNA Translation: BAB93494.1
BC000483 mRNA Translation: AAH00483.1
BC004156 mRNA Translation: AAH04156.1
BC004206 mRNA Translation: AAH04206.1
BC007967 mRNA Translation: AAH07967.1
BC012149 mRNA Translation: AAH12149.1
BC031906 mRNA Translation: AAH31906.1
BC066318 mRNA Translation: AAH66318.1
BC070214 mRNA Translation: AAH70214.1
AB007169 Genomic DNA Translation: BAA25830.1
CCDSiCCDS3452.1
PIRiS65792
RefSeqiNP_000652.2, NM_000661.4
NP_001020092.1, NM_001024921.3
UniGeneiHs.412370
Hs.513083
Hs.730597

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQLNMR-A1-87[»]
4UG0electron microscopy-LH1-192[»]
4V6Xelectron microscopy5.00CH1-192[»]
5AJ0electron microscopy3.50AH1-192[»]
5LKSelectron microscopy3.60LH1-192[»]
5T2Celectron microscopy3.60o1-192[»]
6EK0electron microscopy2.90LH1-192[»]
ProteinModelPortaliP32969
SMRiP32969
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112053, 177 interactors
CORUMiP32969
IntActiP32969, 62 interactors
MINTiP32969
STRINGi9606.ENSP00000346022

PTM databases

iPTMnetiP32969
PhosphoSitePlusiP32969
SwissPalmiP32969

Polymorphism and mutation databases

BioMutaiRPL9
DMDMi417677

2D gel databases

SWISS-2DPAGEiP32969

Proteomic databases

EPDiP32969
PaxDbiP32969
PeptideAtlasiP32969
PRIDEiP32969
ProteomicsDBi54893
TopDownProteomicsiP32969

Protocols and materials databases

DNASUi6133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295955; ENSP00000346022; ENSG00000163682
ENST00000449470; ENSP00000400467; ENSG00000163682
ENST00000645496; ENSP00000494697; ENSG00000163682
GeneIDi6133
KEGGihsa:6133

Organism-specific databases

CTDi6133
DisGeNETi6133
EuPathDBiHostDB:ENSG00000163682.15
GeneCardsiRPL9
RPL9P7
RPL9P8
RPL9P9
HGNCiHGNC:10369 RPL9
HPAiHPA003372
MIMi603686 gene
neXtProtiNX_P32969
OpenTargetsiENSG00000163682
PharmGKBiPA34769
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3255 Eukaryota
COG0097 LUCA
GeneTreeiENSGT00390000015224
HOGENOMiHOG000039905
HOVERGENiHBG000942
InParanoidiP32969
KOiK02940
OMAiVFQDGIY
OrthoDBiEOG091G0R6Z
PhylomeDBiP32969
TreeFamiTF300033

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL9 human
EvolutionaryTraceiP32969
GeneWikiiRPL9
GenomeRNAii6133
PROiPR:P32969
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163682 Expressed in 93 organ(s), highest expression level in ectocervix
CleanExiHS_RPL9
ExpressionAtlasiP32969 baseline and differential
GenevisibleiP32969 HS

Family and domain databases

Gene3Di3.90.930.12, 2 hits
InterProiView protein in InterPro
IPR000702 Ribosomal_L6
IPR020040 Ribosomal_L6_a/b-dom
IPR036789 Ribosomal_L6_a/b-dom_sf
IPR002359 Ribosomal_L6_CS2
PANTHERiPTHR11655 PTHR11655, 1 hit
PfamiView protein in Pfam
PF00347 Ribosomal_L6, 2 hits
PIRSFiPIRSF002162 Ribosomal_L6, 1 hit
SUPFAMiSSF56053 SSF56053, 2 hits
PROSITEiView protein in PROSITE
PS00700 RIBOSOMAL_L6_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL9_HUMAN
AccessioniPrimary (citable) accession number: P32969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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