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Protein

Rod outer segment membrane protein 1

Gene

Rom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Rod outer segment membrane protein 1
Short name:
ROSP1
Gene namesi
Name:Rom1
Synonyms:Rom-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97998 Rom1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 44HelicalSequence analysisAdd BLAST25
Topological domaini45 – 64LumenalSequence analysisAdd BLAST20
Transmembranei65 – 84HelicalSequence analysisAdd BLAST20
Topological domaini85 – 102CytoplasmicSequence analysisAdd BLAST18
Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
Topological domaini126 – 263LumenalSequence analysisAdd BLAST138
Transmembranei264 – 286HelicalSequence analysisAdd BLAST23
Topological domaini287 – 351CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681121 – 351Rod outer segment membrane protein 1Add BLAST351

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP32958
PRIDEiP32958

PTM databases

iPTMnetiP32958
PhosphoSitePlusiP32958

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiENSMUSG00000071648 Expressed in 164 organ(s), highest expression level in retina
CleanExiMM_ROM1
GenevisibleiP32958 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods.

Protein-protein interaction databases

BioGridi202954, 1 interactor
STRINGi10090.ENSMUSP00000093961

Structurei

3D structure databases

ProteinModelPortaliP32958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000016192
HOGENOMiHOG000026780
HOVERGENiHBG004964
InParanoidiP32958
KOiK17344
OMAiLWAQGCH
OrthoDBiEOG091G0956
PhylomeDBiP32958
TreeFamiTF331684

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000830 Peripherin/rom-1
IPR018498 Peripherin/rom-1_CS
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00218 PERIPHERNRDS
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00930 RDS_ROM1, 1 hit

Sequencei

Sequence statusi: Complete.

P32958-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVLPVVLP LQPRIRLAQG IWLLSWLLAL VGGLTLLCSG HLLVQLGHLG
60 70 80 90 100
TFLAPSCSFP ALPQTALAAG TVALGTGLGG AGASRASLDA AQYPPWRGVL
110 120 130 140 150
TPLLAVGTAA GGGLLTLALG LALALPVSLN QGLEEGLEAA LAHYKDTEVP
160 170 180 190 200
GRCQAKRLMD ELQLRYHCCG RHGYKDWFGV QWVSNRYLDP SDQDVVDRIQ
210 220 230 240 250
SNVEGLYLID GVPFSCCNPH SPRPCLQSQL SDPYAHPLFD PRQPNLNLWA
260 270 280 290 300
QGCHEVLLEH LQGLSGTLGS ILAVTLLLQI LVLLGLRYLQ TALEGLGGVI
310 320 330 340 350
DGEGEAQGYL FPGGLKDILK TAWLQGGLAH KPAPEEAPPD EEPPKEVLAE

A
Length:351
Mass (Da):37,265
Last modified:October 1, 1993 - v1
Checksum:i64CB47F552886394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96760 Genomic DNA Translation: AAA40063.1
BC014827 mRNA Translation: AAH14827.1
CCDSiCCDS29559.1
PIRiI68620
RefSeqiNP_033099.3, NM_009073.4
UniGeneiMm.426094

Genome annotation databases

EnsembliENSMUST00000096242; ENSMUSP00000093961; ENSMUSG00000071648
GeneIDi19881
KEGGimmu:19881
UCSCiuc008goc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96760 Genomic DNA Translation: AAA40063.1
BC014827 mRNA Translation: AAH14827.1
CCDSiCCDS29559.1
PIRiI68620
RefSeqiNP_033099.3, NM_009073.4
UniGeneiMm.426094

3D structure databases

ProteinModelPortaliP32958
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202954, 1 interactor
STRINGi10090.ENSMUSP00000093961

PTM databases

iPTMnetiP32958
PhosphoSitePlusiP32958

Proteomic databases

PaxDbiP32958
PRIDEiP32958

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096242; ENSMUSP00000093961; ENSMUSG00000071648
GeneIDi19881
KEGGimmu:19881
UCSCiuc008goc.2 mouse

Organism-specific databases

CTDi6094
MGIiMGI:97998 Rom1

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000016192
HOGENOMiHOG000026780
HOVERGENiHBG004964
InParanoidiP32958
KOiK17344
OMAiLWAQGCH
OrthoDBiEOG091G0956
PhylomeDBiP32958
TreeFamiTF331684

Miscellaneous databases

PROiPR:P32958
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071648 Expressed in 164 organ(s), highest expression level in retina
CleanExiMM_ROM1
GenevisibleiP32958 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000830 Peripherin/rom-1
IPR018498 Peripherin/rom-1_CS
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00218 PERIPHERNRDS
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00930 RDS_ROM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiROM1_MOUSE
AccessioniPrimary (citable) accession number: P32958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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