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Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).2 Publications

GO - Molecular functioni

  • integrin binding Source: BHF-UCL
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell adhesion, Phagocytosis

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-5621575 CD209 (DC-SIGN) signaling
SIGNORiP32942

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CDw50
ICAM-R
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000076662.9
HGNCiHGNC:5346 ICAM3
MIMi146631 gene
neXtProtiNX_P32942

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 485ExtracellularSequence analysisAdd BLAST456
Transmembranei486 – 510HelicalSequence analysisAdd BLAST25
Topological domaini511 – 547CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3385
OpenTargetsiENSG00000076662
PharmGKBiPA29594

Chemistry databases

ChEMBLiCHEMBL3712862

Polymorphism and mutation databases

BioMutaiICAM3
DMDMi206729872

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001479430 – 547Intercellular adhesion molecule 3Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi53 ↔ 96PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi57 ↔ 100Combined sources1 Publication
Glycosylationi84N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi87N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi139 ↔ 190PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi241 ↔ 294PROSITE-ProRule annotation
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 375PROSITE-ProRule annotation
Glycosylationi363N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi423 ↔ 462PROSITE-ProRule annotation
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP32942
MaxQBiP32942
PaxDbiP32942
PeptideAtlasiP32942
PRIDEiP32942
ProteomicsDBi54892

PTM databases

GlyConnecti286
iPTMnetiP32942
PhosphoSitePlusiP32942
UniCarbKBiP32942

Expressioni

Tissue specificityi

Leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000076662 Expressed in 182 organ(s), highest expression level in blood
CleanExiHS_ICAM3
ExpressionAtlasiP32942 baseline and differential
GenevisibleiP32942 HS

Organism-specific databases

HPAiCAB002498
HPA049820

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109612, 9 interactors
IntActiP32942, 13 interactors
STRINGi9606.ENSP00000160262

Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32942
SMRiP32942
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32942

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 103Ig-like C2-type 1Add BLAST58
Domaini132 – 197Ig-like C2-type 2Add BLAST66
Domaini234 – 301Ig-like C2-type 3Add BLAST68
Domaini329 – 382Ig-like C2-type 4Add BLAST54
Domaini416 – 469Ig-like C2-type 5Add BLAST54

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiP32942
KOiK06486
OMAiYGPKIDR
OrthoDBiEOG091G022Y
PhylomeDBiP32942
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P32942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF
60 70 80 90 100
VNCSTDCPSS EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC
110 120 130 140 150
NGSQITGSSN ITVYRLPERV ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL
160 170 180 190 200
TVVLLRWEEE LSRQPAVEEP AEVTATVLAS RDDHGAPFSC RTELDMQPQG
210 220 230 240 250
LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD CTLDGLFPAS
260 270 280 290 300
EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG
310 320 330 340 350
ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP
360 370 380 390 400
AAAPGQPAQL QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP
410 420 430 440 450
KIDRATCPQH LKWKDKTRHV LQCQARGNPY PELRCLKEGS SREVPVGIPF
460 470 480 490 500
FVNVTHNGTY QCQASSSRGK YTLVVVMDIE AGSSHFVPVF VAVLLTLGVV
510 520 530 540
TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG EEPSRAE
Length:547
Mass (Da):59,541
Last modified:September 23, 2008 - v2
Checksum:i4B7BDC02F24F3031
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERN2K7ERN2_HUMAN
Intercellular adhesion molecule 3
ICAM3
470Annotation score:
K7EP52K7EP52_HUMAN
Intercellular adhesion molecule 3
ICAM3
301Annotation score:
K7ERF0K7ERF0_HUMAN
Intercellular adhesion molecule 3
ICAM3
192Annotation score:
K7EQC7K7EQC7_HUMAN
Intercellular adhesion molecule 3
ICAM3
132Annotation score:
K7ELH4K7ELH4_HUMAN
Intercellular adhesion molecule 3
ICAM3
40Annotation score:
K7ERJ4K7ERJ4_HUMAN
Intercellular adhesion molecule 3
ICAM3
23Annotation score:
K7EMH0K7EMH0_HUMAN
Intercellular adhesion molecule 3
ICAM3
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60S → F in AAB24331 (PubMed:1448173).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04654763I → V. Corresponds to variant dbSNP:rs17697947Ensembl.1
Natural variantiVAR_059394115R → G2 PublicationsCorresponds to variant dbSNP:rs7258015Ensembl.1
Natural variantiVAR_046548143D → G3 PublicationsCorresponds to variant dbSNP:rs2304237Ensembl.1
Natural variantiVAR_024498525S → T. Corresponds to variant dbSNP:rs2230399Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50015 mRNA Translation: AAB24331.2 Sequence problems.
X69711 mRNA Translation: CAA49369.1
X69819 mRNA Translation: CAA49473.1
DQ217937 Genomic DNA Translation: ABB01007.1
CH471106 Genomic DNA Translation: EAW84092.1
BC058903 mRNA Translation: AAH58903.1
CCDSiCCDS12235.1
PIRiS28904
RefSeqiNP_002153.2, NM_002162.4
UniGeneiHs.654563

Genome annotation databases

EnsembliENST00000160262; ENSP00000160262; ENSG00000076662
GeneIDi3385
KEGGihsa:3385
UCSCiuc002mob.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

ICAM-3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50015 mRNA Translation: AAB24331.2 Sequence problems.
X69711 mRNA Translation: CAA49369.1
X69819 mRNA Translation: CAA49473.1
DQ217937 Genomic DNA Translation: ABB01007.1
CH471106 Genomic DNA Translation: EAW84092.1
BC058903 mRNA Translation: AAH58903.1
CCDSiCCDS12235.1
PIRiS28904
RefSeqiNP_002153.2, NM_002162.4
UniGeneiHs.654563

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T0PX-ray1.66B30-114[»]
ProteinModelPortaliP32942
SMRiP32942
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109612, 9 interactors
IntActiP32942, 13 interactors
STRINGi9606.ENSP00000160262

Chemistry databases

ChEMBLiCHEMBL3712862

PTM databases

GlyConnecti286
iPTMnetiP32942
PhosphoSitePlusiP32942
UniCarbKBiP32942

Polymorphism and mutation databases

BioMutaiICAM3
DMDMi206729872

Proteomic databases

EPDiP32942
MaxQBiP32942
PaxDbiP32942
PeptideAtlasiP32942
PRIDEiP32942
ProteomicsDBi54892

Protocols and materials databases

DNASUi3385
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000160262; ENSP00000160262; ENSG00000076662
GeneIDi3385
KEGGihsa:3385
UCSCiuc002mob.3 human

Organism-specific databases

CTDi3385
DisGeNETi3385
EuPathDBiHostDB:ENSG00000076662.9
GeneCardsiICAM3
H-InvDBiHIX0014743
HGNCiHGNC:5346 ICAM3
HPAiCAB002498
HPA049820
MIMi146631 gene
neXtProtiNX_P32942
OpenTargetsiENSG00000076662
PharmGKBiPA29594
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiP32942
KOiK06486
OMAiYGPKIDR
OrthoDBiEOG091G022Y
PhylomeDBiP32942
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-5621575 CD209 (DC-SIGN) signaling
SIGNORiP32942

Miscellaneous databases

ChiTaRSiICAM3 human
EvolutionaryTraceiP32942
GeneWikiiICAM3
GenomeRNAii3385
PROiPR:P32942
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000076662 Expressed in 182 organ(s), highest expression level in blood
CleanExiHS_ICAM3
ExpressionAtlasiP32942 baseline and differential
GenevisibleiP32942 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICAM3_HUMAN
AccessioniPrimary (citable) accession number: P32942
Secondary accession number(s): Q6PD68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 23, 2008
Last modified: October 10, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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