UniProtKB - P32926 (DSG3_HUMAN)
Protein
Desmoglein-3
Gene
DSG3
Organism
Homo sapiens (Human)
Status
Functioni
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Miscellaneous
Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.
GO - Molecular functioni
- calcium ion binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- cornification Source: Reactome
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- keratinization Source: Reactome
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P32926 |
Reactomei | R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Desmoglein-3Alternative name(s): 130 kDa pemphigus vulgaris antigen Short name: PVA Cadherin family member 6 |
Gene namesi | Name:DSG3 Synonyms:CDHF6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3050, DSG3 |
MIMi | 169615, gene |
neXtProti | NX_P32926 |
VEuPathDBi | HostDB:ENSG00000134757.4 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- desmosome By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- cornified envelope Source: Reactome
- plasma membrane Source: Reactome
Other locations
- cell-cell junction Source: GO_Central
- desmosome Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 50 – 615 | ExtracellularSequence analysisAdd BLAST | 566 | |
Transmembranei | 616 – 640 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 641 – 999 | CytoplasmicSequence analysisAdd BLAST | 359 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1830 |
OpenTargetsi | ENSG00000134757 |
PharmGKBi | PA27503 |
Miscellaneous databases
Pharosi | P32926, Tbio |
Protein family/group databases
Allergomei | 8248, Hom s DSG3 |
Genetic variation databases
BioMutai | DSG3 |
DMDMi | 239938621 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000003851 | 24 – 49 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000003852 | 50 – 999 | Desmoglein-3Add BLAST | 950 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 459 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 545 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, GlycoproteinProteomic databases
CPTACi | CPTAC-62 CPTAC-63 |
EPDi | P32926 |
jPOSTi | P32926 |
MassIVEi | P32926 |
MaxQBi | P32926 |
PaxDbi | P32926 |
PeptideAtlasi | P32926 |
PRIDEi | P32926 |
ProteomicsDBi | 54887 |
PTM databases
GlyGeni | P32926, 7 sites |
iPTMneti | P32926 |
PhosphoSitePlusi | P32926 |
SwissPalmi | P32926 |
Expressioni
Tissue specificityi
Epidermis, tongue, tonsil, esophagus and carcinomas.
Gene expression databases
Bgeei | ENSG00000134757, Expressed in mouth mucosa and 103 other tissues |
Genevisiblei | P32926, HS |
Organism-specific databases
HPAi | ENSG00000134757, Tissue enhanced (esophagus, lymphoid tissue, tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 108164, 5 interactors |
ELMi | P32926 |
IntActi | P32926, 2 interactors |
STRINGi | 9606.ENSP00000257189 |
Miscellaneous databases
RNActi | P32926, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P32926 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 158 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 159 – 268 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 269 – 383 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 386 – 499 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 114 | |
Repeati | 910 – 935 | Desmoglein repeat 1Add BLAST | 26 | |
Repeati | 936 – 966 | Desmoglein repeat 2Add BLAST | 31 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00950000182765 |
HOGENOMi | CLU_005284_0_0_1 |
InParanoidi | P32926 |
OMAi | WFEIETD |
OrthoDBi | 250139at2759 |
PhylomeDBi | P32926 |
TreeFami | TF331809 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf IPR009123, Desmoglein IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN PR01819, DESMOGLEIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 4 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P32926-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE
60 70 80 90 100
WVKFAKPCRE GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF
110 120 130 140 150
VVDKNTGDIN ITAIVDREET PSFLITCRAL NAQGLDVEKP LILTVKILDI
160 170 180 190 200
NDNPPVFSQQ IFMGEIEENS ASNSLVMILN ATDADEPNHL NSKIAFKIVS
210 220 230 240 250
QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA DKDGEGLSTQ
260 270 280 290 300
CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK
360 370 380 390 400
NKAEFHQSVI SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK
410 420 430 440 450
LVDYILGTYQ AIDEDTNKAA SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM
460 470 480 490 500
NRDSTFIVNK TITAEVLAID EYTGKTSTGT VYVRVPDFND NCPTAVLEKD
510 520 530 540 550
AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS ITTLNATSAL
560 570 580 590 600
LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP
610 620 630 640 650
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG
660 670 680 690 700
VTGGFIPVPD GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS
710 720 730 740 750
EVCTNTYARG TAVEGTSGME MTTKLGAATE SGGAAGFATG TVSGAASGFG
760 770 780 790 800
AATGVGICSS GQSGTMRTRH STGGTNKDYA DGAISMNFLD SYFSQKAFAC
810 820 830 840 850
AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD LDDSFLDSLG
860 870 880 890 900
PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT
910 920 930 940 950
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG
960 970 980 990
FDPLLTQNVI VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | N → D in BAF83056 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 298 | T → A in BAF83056 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055578 | 509 | V → M. Corresponds to variant dbSNP:rs16961975Ensembl. | 1 | |
Natural variantiVAR_059178 | 912 | T → A2 PublicationsCorresponds to variant dbSNP:rs1380866Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76482 mRNA Translation: AAA60230.1 AK290367 mRNA Translation: BAF83056.1 AC021549 mRNA No translation available. |
CCDSi | CCDS11898.1 |
PIRi | A41088, IJHUG3 |
RefSeqi | NP_001935.2, NM_001944.2 |
Genome annotation databases
Ensembli | ENST00000257189; ENSP00000257189; ENSG00000134757 |
GeneIDi | 1830 |
KEGGi | hsa:1830 |
UCSCi | uc002kws.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76482 mRNA Translation: AAA60230.1 AK290367 mRNA Translation: BAF83056.1 AC021549 mRNA No translation available. |
CCDSi | CCDS11898.1 |
PIRi | A41088, IJHUG3 |
RefSeqi | NP_001935.2, NM_001944.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EQX | X-ray | 3.05 | A | 50-598 | [»] | |
SMRi | P32926 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108164, 5 interactors |
ELMi | P32926 |
IntActi | P32926, 2 interactors |
STRINGi | 9606.ENSP00000257189 |
Protein family/group databases
Allergomei | 8248, Hom s DSG3 |
PTM databases
GlyGeni | P32926, 7 sites |
iPTMneti | P32926 |
PhosphoSitePlusi | P32926 |
SwissPalmi | P32926 |
Genetic variation databases
BioMutai | DSG3 |
DMDMi | 239938621 |
Proteomic databases
CPTACi | CPTAC-62 CPTAC-63 |
EPDi | P32926 |
jPOSTi | P32926 |
MassIVEi | P32926 |
MaxQBi | P32926 |
PaxDbi | P32926 |
PeptideAtlasi | P32926 |
PRIDEi | P32926 |
ProteomicsDBi | 54887 |
Protocols and materials databases
ABCDi | P32926, 8 sequenced antibodies |
Antibodypediai | 3464, 694 antibodies |
Genome annotation databases
Ensembli | ENST00000257189; ENSP00000257189; ENSG00000134757 |
GeneIDi | 1830 |
KEGGi | hsa:1830 |
UCSCi | uc002kws.4, human |
Organism-specific databases
CTDi | 1830 |
DisGeNETi | 1830 |
GeneCardsi | DSG3 |
HGNCi | HGNC:3050, DSG3 |
HPAi | ENSG00000134757, Tissue enhanced (esophagus, lymphoid tissue, tongue) |
MIMi | 169615, gene |
neXtProti | NX_P32926 |
OpenTargetsi | ENSG00000134757 |
PharmGKBi | PA27503 |
VEuPathDBi | HostDB:ENSG00000134757.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00950000182765 |
HOGENOMi | CLU_005284_0_0_1 |
InParanoidi | P32926 |
OMAi | WFEIETD |
OrthoDBi | 250139at2759 |
PhylomeDBi | P32926 |
TreeFami | TF331809 |
Enzyme and pathway databases
PathwayCommonsi | P32926 |
Reactomei | R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 1830, 5 hits in 865 CRISPR screens |
ChiTaRSi | DSG3, human |
GeneWikii | Desmoglein_3 |
GenomeRNAii | 1830 |
Pharosi | P32926, Tbio |
PROi | PR:P32926 |
RNActi | P32926, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134757, Expressed in mouth mucosa and 103 other tissues |
Genevisiblei | P32926, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf IPR009123, Desmoglein IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN PR01819, DESMOGLEIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 4 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSG3_HUMAN | |
Accessioni | P32926Primary (citable) accession number: P32926 Secondary accession number(s): A8K2V2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | June 16, 2009 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references