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UniProtKB - P32926 (DSG3_HUMAN)

Entry version 182 (25 May 2022)
Sequence version 2 (16 Jun 2009)
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Protein

Desmoglein-3

Gene

DSG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Miscellaneous

Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P32926

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P32926

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Desmoglein-3Curated
Alternative name(s):
130 kDa pemphigus vulgaris antigen
Short name:
PVA
Cadherin family member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSG3Imported
Synonyms:CDHF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3050, DSG3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		169615, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P32926

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134757

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini50 – 615ExtracellularSequence analysisAdd BLAST566
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei616 – 640HelicalSequence analysisAdd BLAST25
Topological domaini641 – 999CytoplasmicSequence analysisAdd BLAST359

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Blistering, acantholytic, of oral and laryngeal mucosa (ABOLM)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by recurrent, suprabasal acantholytic blisters in the oral and laryngeal mucosa. Skin, conjunctival and genital mucosa, nail folds, and nails are unaffected. Normal structure is observed in the scalp epidermis and hair follicle.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_085271287 – 999Missing in ABOLM; unknown pathological significance; loss of expression in skin and mucosa. 1 PublicationAdd BLAST713

Organism-specific databases

DisGeNET

More...DisGeNETi		1830

MalaCards human disease database

More...MalaCardsi		DSG3
MIMi619226, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134757

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27503

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P32926, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		8248, Hom s DSG3

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DSG3

Domain mapping of disease mutations (DMDM)

More...DMDMi		239938621

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000385124 – 49Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000385250 – 999Desmoglein-3Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi545N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-62
CPTAC-63

Encyclopedia of Proteome Dynamics

More...EPDi		P32926

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P32926

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P32926

MaxQB - The MaxQuant DataBase

More...MaxQBi		P32926

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32926

PeptideAtlas

More...PeptideAtlasi		P32926

PRoteomics IDEntifications database

More...PRIDEi		P32926

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54887

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P32926, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32926

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P32926

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P32926

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Epidermis, tongue, tonsil, esophagus and carcinomas. Expressed in skin and mucosa (at protein level) (PubMed:30528827).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134757, Expressed in mouth mucosa and 104 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P32926, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134757, Tissue enhanced (esophagus, lymphoid tissue, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108164, 42 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P32926

Protein interaction database and analysis system

More...IntActi		P32926, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000257189

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P32926, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1999
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P32926

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P32926

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 158Cadherin 1PROSITE-ProRule annotationAdd BLAST109
Domaini159 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini386 – 499Cadherin 4PROSITE-ProRule annotationAdd BLAST114
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati910 – 935Desmoglein repeat 1Add BLAST26
Repeati936 – 966Desmoglein repeat 2Add BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01040000240514

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005284_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32926

Identification of Orthologs from Complete Genome Data

More...OMAi		KYVMGRN

Database of Orthologous Groups

More...OrthoDBi		250139at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P32926

TreeFam database of animal gene trees

More...TreeFami		TF331809

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR027397, Catenin-bd_sf
IPR009123, Desmoglein
IPR009122, Desmosomal_cadherin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN
PR01818, DESMOCADHERN
PR01819, DESMOGLEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 3 hits
PS50268, CADHERIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P32926-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE 
        60         70         80         90        100
WVKFAKPCRE GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF 
       110        120        130        140        150
VVDKNTGDIN ITAIVDREET PSFLITCRAL NAQGLDVEKP LILTVKILDI 
       160        170        180        190        200
NDNPPVFSQQ IFMGEIEENS ASNSLVMILN ATDADEPNHL NSKIAFKIVS 
       210        220        230        240        250
QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA DKDGEGLSTQ 
       260        270        280        290        300
CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 
       310        320        330        340        350
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK 
       360        370        380        390        400
NKAEFHQSVI SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK 
       410        420        430        440        450
LVDYILGTYQ AIDEDTNKAA SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM 
       460        470        480        490        500
NRDSTFIVNK TITAEVLAID EYTGKTSTGT VYVRVPDFND NCPTAVLEKD 
       510        520        530        540        550
AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS ITTLNATSAL 
       560        570        580        590        600
LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 
       610        620        630        640        650
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG 
       660        670        680        690        700
VTGGFIPVPD GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS 
       710        720        730        740        750
EVCTNTYARG TAVEGTSGME MTTKLGAATE SGGAAGFATG TVSGAASGFG 
       760        770        780        790        800
AATGVGICSS GQSGTMRTRH STGGTNKDYA DGAISMNFLD SYFSQKAFAC 
       810        820        830        840        850
AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD LDDSFLDSLG 
       860        870        880        890        900
PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 
       910        920        930        940        950
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG 
       960        970        980        990 
FDPLLTQNVI VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI
Length:999
Mass (Da):107,533
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7553CC917E8719BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110N → D in BAF83056 (PubMed:14702039).Curated1
Sequence conflicti298T → A in BAF83056 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_085271287 – 999Missing in ABOLM; unknown pathological significance; loss of expression in skin and mucosa. 1 PublicationAdd BLAST713
Natural variantiVAR_055578509V → M. Corresponds to variant dbSNP:rs16961975Ensembl.1
Natural variantiVAR_059178912T → A2 PublicationsCorresponds to variant dbSNP:rs1380866Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M76482 mRNA Translation: AAA60230.1
AK290367 mRNA Translation: BAF83056.1
AC021549 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11898.1

Protein sequence database of the Protein Information Resource

More...PIRi		A41088, IJHUG3

NCBI Reference Sequences

More...RefSeqi		NP_001935.2, NM_001944.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000257189.5; ENSP00000257189.4; ENSG00000134757.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1830

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000257189.5; ENSP00000257189.4; NM_001944.3; NP_001935.2

UCSC genome browser

More...UCSCi		uc002kws.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76482 mRNA Translation: AAA60230.1
AK290367 mRNA Translation: BAF83056.1
AC021549 mRNA No translation available.
CCDSiCCDS11898.1
PIRiA41088, IJHUG3
RefSeqiNP_001935.2, NM_001944.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

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Protein Data Bank Japan

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Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EQXX-ray3.05A50-598[»]
AlphaFoldDBiP32926
SMRiP32926
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108164, 42 interactors
ELMiP32926
IntActiP32926, 2 interactors
STRINGi9606.ENSP00000257189

Protein family/group databases

Allergomei8248, Hom s DSG3

PTM databases

GlyGeniP32926, 7 sites
iPTMnetiP32926
PhosphoSitePlusiP32926
SwissPalmiP32926

Genetic variation databases

BioMutaiDSG3
DMDMi239938621

Proteomic databases

CPTACiCPTAC-62
CPTAC-63
EPDiP32926
jPOSTiP32926
MassIVEiP32926
MaxQBiP32926
PaxDbiP32926
PeptideAtlasiP32926
PRIDEiP32926
ProteomicsDBi54887

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P32926, 8 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3464, 734 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		1830

Genome annotation databases

EnsembliENST00000257189.5; ENSP00000257189.4; ENSG00000134757.5
GeneIDi1830
KEGGihsa:1830
MANE-SelectiENST00000257189.5; ENSP00000257189.4; NM_001944.3; NP_001935.2
UCSCiuc002kws.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1830
DisGeNETi1830

GeneCards: human genes, protein and diseases

More...GeneCardsi		DSG3
HGNCiHGNC:3050, DSG3
HPAiENSG00000134757, Tissue enhanced (esophagus, lymphoid tissue, vagina)
MalaCardsiDSG3
MIMi169615, gene
619226, phenotype
neXtProtiNX_P32926
OpenTargetsiENSG00000134757
PharmGKBiPA27503
VEuPathDBiHostDB:ENSG00000134757

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT01040000240514
HOGENOMiCLU_005284_0_0_1
InParanoidiP32926
OMAiKYVMGRN
OrthoDBi250139at2759
PhylomeDBiP32926
TreeFamiTF331809

Enzyme and pathway databases

PathwayCommonsiP32926
ReactomeiR-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
SignaLinkiP32926

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1830, 9 hits in 1063 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DSG3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Desmoglein_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1830
PharosiP32926, Tbio

Protein Ontology

More...PROi		PR:P32926
RNActiP32926, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134757, Expressed in mouth mucosa and 104 other tissues
GenevisibleiP32926, HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR027397, Catenin-bd_sf
IPR009123, Desmoglein
IPR009122, Desmosomal_cadherin
PfamiView protein in Pfam
PF00028, Cadherin, 3 hits
PRINTSiPR00205, CADHERIN
PR01818, DESMOCADHERN
PR01819, DESMOGLEIN
SMARTiView protein in SMART
SM00112, CA, 4 hits
SUPFAMiSSF49313, SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 3 hits
PS50268, CADHERIN_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32926
Secondary accession number(s): A8K2V2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 16, 2009
Last modified: May 25, 2022
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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