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Protein

Desmoglein-3

Gene

DSG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Miscellaneous

Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-3
Alternative name(s):
130 kDa pemphigus vulgaris antigen
Short name:
PVA
Cadherin family member 6
Gene namesi
Name:DSG3
Synonyms:CDHF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000134757.4
HGNCiHGNC:3050 DSG3
MIMi169615 gene
neXtProtiNX_P32926

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 615ExtracellularSequence analysisAdd BLAST566
Transmembranei616 – 640HelicalSequence analysisAdd BLAST25
Topological domaini641 – 999CytoplasmicSequence analysisAdd BLAST359

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1830
OpenTargetsiENSG00000134757
PharmGKBiPA27503

Protein family/group databases

Allergomei8248 Hom s DSG3

Polymorphism and mutation databases

BioMutaiDSG3
DMDMi239938621

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000385124 – 49Sequence analysisAdd BLAST26
ChainiPRO_000000385250 – 999Desmoglein-3Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi545N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

EPDiP32926
MaxQBiP32926
PaxDbiP32926
PeptideAtlasiP32926
PRIDEiP32926
ProteomicsDBi54887

PTM databases

iPTMnetiP32926
PhosphoSitePlusiP32926
SwissPalmiP32926

Miscellaneous databases

PMAP-CutDBiP32926

Expressioni

Tissue specificityi

Epidermis, tongue, tonsil, esophagus and carcinomas.

Gene expression databases

BgeeiENSG00000134757 Expressed in 90 organ(s), highest expression level in mouth mucosa
CleanExiHS_DSG3
GenevisibleiP32926 HS

Organism-specific databases

HPAiCAB069880
HPA046864
HPA056863

Interactioni

Protein-protein interaction databases

BioGridi108164, 5 interactors
ELMiP32926
STRINGi9606.ENSP00000257189

Structurei

Secondary structure

1999
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32926
SMRiP32926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 158Cadherin 1PROSITE-ProRule annotationAdd BLAST109
Domaini159 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini386 – 499Cadherin 4PROSITE-ProRule annotationAdd BLAST114
Repeati910 – 935Desmoglein repeat 1Add BLAST26
Repeati936 – 966Desmoglein repeat 2Add BLAST31

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiP32926
KOiK07598
OMAiQKAFACA
OrthoDBiEOG091G01K6
PhylomeDBiP32926
TreeFamiTF331809

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32926-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE
60 70 80 90 100
WVKFAKPCRE GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF
110 120 130 140 150
VVDKNTGDIN ITAIVDREET PSFLITCRAL NAQGLDVEKP LILTVKILDI
160 170 180 190 200
NDNPPVFSQQ IFMGEIEENS ASNSLVMILN ATDADEPNHL NSKIAFKIVS
210 220 230 240 250
QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA DKDGEGLSTQ
260 270 280 290 300
CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK
360 370 380 390 400
NKAEFHQSVI SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK
410 420 430 440 450
LVDYILGTYQ AIDEDTNKAA SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM
460 470 480 490 500
NRDSTFIVNK TITAEVLAID EYTGKTSTGT VYVRVPDFND NCPTAVLEKD
510 520 530 540 550
AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS ITTLNATSAL
560 570 580 590 600
LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP
610 620 630 640 650
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG
660 670 680 690 700
VTGGFIPVPD GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS
710 720 730 740 750
EVCTNTYARG TAVEGTSGME MTTKLGAATE SGGAAGFATG TVSGAASGFG
760 770 780 790 800
AATGVGICSS GQSGTMRTRH STGGTNKDYA DGAISMNFLD SYFSQKAFAC
810 820 830 840 850
AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD LDDSFLDSLG
860 870 880 890 900
PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT
910 920 930 940 950
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG
960 970 980 990
FDPLLTQNVI VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI
Length:999
Mass (Da):107,533
Last modified:June 16, 2009 - v2
Checksum:i7553CC917E8719BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110N → D in BAF83056 (PubMed:14702039).Curated1
Sequence conflicti298T → A in BAF83056 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055578509V → M. Corresponds to variant dbSNP:rs16961975Ensembl.1
Natural variantiVAR_059178912T → A2 PublicationsCorresponds to variant dbSNP:rs1380866Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76482 mRNA Translation: AAA60230.1
AK290367 mRNA Translation: BAF83056.1
AC021549 mRNA No translation available.
CCDSiCCDS11898.1
PIRiA41088 IJHUG3
RefSeqiNP_001935.2, NM_001944.2
UniGeneiHs.1925

Genome annotation databases

EnsembliENST00000257189; ENSP00000257189; ENSG00000134757
GeneIDi1830
KEGGihsa:1830
UCSCiuc002kws.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76482 mRNA Translation: AAA60230.1
AK290367 mRNA Translation: BAF83056.1
AC021549 mRNA No translation available.
CCDSiCCDS11898.1
PIRiA41088 IJHUG3
RefSeqiNP_001935.2, NM_001944.2
UniGeneiHs.1925

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EQXX-ray3.05A50-598[»]
ProteinModelPortaliP32926
SMRiP32926
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108164, 5 interactors
ELMiP32926
STRINGi9606.ENSP00000257189

Protein family/group databases

Allergomei8248 Hom s DSG3

PTM databases

iPTMnetiP32926
PhosphoSitePlusiP32926
SwissPalmiP32926

Polymorphism and mutation databases

BioMutaiDSG3
DMDMi239938621

Proteomic databases

EPDiP32926
MaxQBiP32926
PaxDbiP32926
PeptideAtlasiP32926
PRIDEiP32926
ProteomicsDBi54887

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257189; ENSP00000257189; ENSG00000134757
GeneIDi1830
KEGGihsa:1830
UCSCiuc002kws.4 human

Organism-specific databases

CTDi1830
DisGeNETi1830
EuPathDBiHostDB:ENSG00000134757.4
GeneCardsiDSG3
H-InvDBiHIX0027375
HGNCiHGNC:3050 DSG3
HPAiCAB069880
HPA046864
HPA056863
MIMi169615 gene
neXtProtiNX_P32926
OpenTargetsiENSG00000134757
PharmGKBiPA27503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiP32926
KOiK07598
OMAiQKAFACA
OrthoDBiEOG091G01K6
PhylomeDBiP32926
TreeFamiTF331809

Enzyme and pathway databases

ReactomeiR-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiDSG3 human
GeneWikiiDesmoglein_3
GenomeRNAii1830
PMAP-CutDBiP32926
PROiPR:P32926
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134757 Expressed in 90 organ(s), highest expression level in mouth mucosa
CleanExiHS_DSG3
GenevisibleiP32926 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDSG3_HUMAN
AccessioniPrimary (citable) accession number: P32926
Secondary accession number(s): A8K2V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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