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Protein

Vacuolar morphogenesis protein 7

Gene

VAM7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.

Miscellaneous

Present with 2360 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-30689-MONOMER

Protein family/group databases

TCDBi1.F.1.1.2 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar morphogenesis protein 7
Gene namesi
Name:VAM7
Ordered Locus Names:YGL212W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL212W
SGDiS000003180 VAM7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657601 – 316Vacuolar morphogenesis protein 7Add BLAST316

Proteomic databases

MaxQBiP32912
PaxDbiP32912
PRIDEiP32912

PTM databases

iPTMnetiP32912

Interactioni

Subunit structurei

Possibly multimeric. Associates with VAM3.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33044, 704 interactors
ComplexPortaliCPX-1887 Vacuolar t-SNARE complex
DIPiDIP-1722N
IntActiP32912, 36 interactors
MINTiP32912
STRINGi4932.YGL212W

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32912
SMRiP32912
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32912

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 124PXPROSITE-ProRule annotationAdd BLAST124
Domaini250 – 312t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 186Sequence analysisAdd BLAST19

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP32912
KOiK08502
OMAiQMWRRYS
OrthoDBiEOG092C4Z3K

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P32912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANSVGKMS EKLRIKVDDV KINPKYVLYG VSTPNKRLYK RYSEFWKLKT
60 70 80 90 100
RLERDVGSTI PYDFPEKPGV LDRRWQRRYD DPEMIDERRI GLERFLNELY
110 120 130 140 150
NDRFDSRWRD TKIAQDFLQL SKPNVSQEKS QQHLETADEV GWDEMIRDIK
160 170 180 190 200
LDLDKESDGT PSVRGALRAR TKLHKLRERL EQDVQKKSLP STEVTRRAAL
210 220 230 240 250
LRSLLKECDD IGTANIAQDR GRLLGVATSD NSSTTEVQGR TNNDLQQGQM
260 270 280 290 300
QMVRDQEQEL VALHRIIQAQ RGLALEMNEE LQTQNELLTA LEDDVDNTGR
310
RLQIANKKAR HFNNSA
Length:316
Mass (Da):36,711
Last modified:October 1, 1993 - v1
Checksum:i2F992AEC0ACBC8FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11379 Genomic DNA Translation: BAA01977.1
U33754 Genomic DNA Translation: AAC49494.1
Z72734 Genomic DNA Translation: CAA96928.1
BK006941 Genomic DNA Translation: DAA07904.1
PIRiS31263
RefSeqiNP_011303.1, NM_001181077.1

Genome annotation databases

EnsemblFungiiYGL212W; YGL212W; YGL212W
GeneIDi852660
KEGGisce:YGL212W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11379 Genomic DNA Translation: BAA01977.1
U33754 Genomic DNA Translation: AAC49494.1
Z72734 Genomic DNA Translation: CAA96928.1
BK006941 Genomic DNA Translation: DAA07904.1
PIRiS31263
RefSeqiNP_011303.1, NM_001181077.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KMDNMR-A8-124[»]
ProteinModelPortaliP32912
SMRiP32912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33044, 704 interactors
ComplexPortaliCPX-1887 Vacuolar t-SNARE complex
DIPiDIP-1722N
IntActiP32912, 36 interactors
MINTiP32912
STRINGi4932.YGL212W

Protein family/group databases

TCDBi1.F.1.1.2 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiP32912

Proteomic databases

MaxQBiP32912
PaxDbiP32912
PRIDEiP32912

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL212W; YGL212W; YGL212W
GeneIDi852660
KEGGisce:YGL212W

Organism-specific databases

EuPathDBiFungiDB:YGL212W
SGDiS000003180 VAM7

Phylogenomic databases

InParanoidiP32912
KOiK08502
OMAiQMWRRYS
OrthoDBiEOG092C4Z3K

Enzyme and pathway databases

BioCyciYEAST:G3O-30689-MONOMER

Miscellaneous databases

EvolutionaryTraceiP32912
PROiPR:P32912

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAM7_YEAST
AccessioniPrimary (citable) accession number: P32912
Secondary accession number(s): D6VTU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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