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Entry version 162 (18 Sep 2019)
Sequence version 1 (01 Oct 1993)
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Protein

DNA-directed RNA polymerase III subunit RPC6

Gene

RPC34

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in recruitment of Pol III to the preinitiation complex. Involved in the configuration of an initiation-competent form of RNA polymerase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33322-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC6
Short name:
RNA polymerase III subunit C6
Alternative name(s):
C34
DNA-directed RNA polymerase III 36 kDa polypeptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPC34
Ordered Locus Names:YNR003C
ORF Names:N2031
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YNR003C

Saccharomyces Genome Database

More...
SGDi
S000005286 RPC34

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi89E → A: Cold-sensitive. Abolishes interaction with BRF1/TDS4. 1 Publication1
Mutagenesisi102 – 103RE → VA: Cold-sensitive. No effect on interaction with BRF1/TDS4. 1 Publication2
Mutagenesisi135 – 138KSVK → ASVA: Temperature-sensitive; cold-sensitive. Abolishes interaction with BRF1/TDS4. Stabilizes Pol III open complex formation. 4
Mutagenesisi135K → A: Cold-sensitive. Abolishes interaction with BRF1/TDS4. 1 Publication1
Mutagenesisi171 – 173DIE → AIA: Cold-sensitive. Abolishes interaction with BRF1/TDS4. 1 Publication3
Mutagenesisi171D → H: Cold-sensitive. Abolishes interaction with BRF1/TDS4. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739771 – 317DNA-directed RNA polymerase III subunit RPC6Add BLAST317

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32910

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32910

PRoteomics IDEntifications database

More...
PRIDEi
P32910

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

Interacts with BRF1/TDS4.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35829, 472 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2660 DNA-directed RNA polymerase III complex

Database of interacting proteins

More...
DIPi
DIP-202N

Protein interaction database and analysis system

More...
IntActi
P32910, 23 interactors

Molecular INTeraction database

More...
MINTi
P32910

STRING: functional protein association networks

More...
STRINGi
4932.YNR003C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32910

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186563

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32910

KEGG Orthology (KO)

More...
KOi
K03025

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELKFQAV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007832 RNA_pol_Rpc34
IPR016049 RNA_pol_Rpc34-like
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12780 PTHR12780, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05158 RNA_pol_Rpc34, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028763 RNA_pol_Rpc34, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMIENGLQ LSDNAKTLHS QMMSKGIGAL FTQQELQKQM GIGSLTDLMS
60 70 80 90 100
IVQELLDKNL IKLVKQNDEL KFQGVLESEA QKKATMSAEE ALVYSYIEAS
110 120 130 140 150
GREGIWSKTI KARTNLHQHV VLKCLKSLES QRYVKSVKSV KFPTRKIYML
160 170 180 190 200
YSLQPSVDIT GGPWFTDGEL DIEFINSLLT IVWRFISENT FPNGFKNFEN
210 220 230 240 250
GPKKNVFYAP NVKNYSTTQE ILEFITAAQV ANVELTPSNI RSLCEVLVYD
260 270 280 290 300
DKLEKVTHDC YRVTLESILQ MNQGEGEPEA GNKALEDEEE FSIFNYFKMF
310
PASKHDKEVV YFDEWTI
Length:317
Mass (Da):36,135
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDE5CD6FD08BDA7F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63746 Genomic DNA Translation: CAA45278.1
X77395 Genomic DNA Translation: CAA54572.1
Z71618 Genomic DNA Translation: CAA96279.1
BK006947 Genomic DNA Translation: DAA10545.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45107

NCBI Reference Sequences

More...
RefSeqi
NP_014400.1, NM_001183180.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNR003C_mRNA; YNR003C; YNR003C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855737

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNR003C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63746 Genomic DNA Translation: CAA45278.1
X77395 Genomic DNA Translation: CAA54572.1
Z71618 Genomic DNA Translation: CAA96279.1
BK006947 Genomic DNA Translation: DAA10545.1
PIRiA45107
RefSeqiNP_014400.1, NM_001183180.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FJ8electron microscopy3.90P1-317[»]
5FJ9electron microscopy4.60P1-317[»]
5FJAelectron microscopy4.65P1-317[»]
6CNBelectron microscopy4.10P1-317[»]
6CNCelectron microscopy4.10P1-317[»]
6CNDelectron microscopy4.80P1-317[»]
6CNFelectron microscopy4.50P1-317[»]
6EU0electron microscopy4.00P1-317[»]
6EU1electron microscopy3.40P1-317[»]
6EU2electron microscopy3.40P1-317[»]
6EU3electron microscopy3.30P1-317[»]
6F40electron microscopy3.70P1-317[»]
6F41electron microscopy4.30P1-317[»]
6F42electron microscopy5.50P1-317[»]
6F44electron microscopy4.20P1-317[»]
SMRiP32910
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi35829, 472 interactors
ComplexPortaliCPX-2660 DNA-directed RNA polymerase III complex
DIPiDIP-202N
IntActiP32910, 23 interactors
MINTiP32910
STRINGi4932.YNR003C

Proteomic databases

MaxQBiP32910
PaxDbiP32910
PRIDEiP32910

Genome annotation databases

EnsemblFungiiYNR003C_mRNA; YNR003C; YNR003C
GeneIDi855737
KEGGisce:YNR003C

Organism-specific databases

EuPathDBiFungiDB:YNR003C
SGDiS000005286 RPC34

Phylogenomic databases

HOGENOMiHOG000186563
InParanoidiP32910
KOiK03025
OMAiELKFQAV

Enzyme and pathway databases

BioCyciYEAST:G3O-33322-MONOMER
ReactomeiR-SCE-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32910

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR007832 RNA_pol_Rpc34
IPR016049 RNA_pol_Rpc34-like
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12780 PTHR12780, 1 hit
PfamiView protein in Pfam
PF05158 RNA_pol_Rpc34, 1 hit
PIRSFiPIRSF028763 RNA_pol_Rpc34, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC6_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32910
Secondary accession number(s): D6W1H9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 18, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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