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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation5 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
Ordered Locus Names:UL38
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

  • host cell nucleus Source: UniProtKB-SubCell
  • viral capsid Source: CACAO

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004363791 – 465Triplex capsid protein 1Add BLAST465

Proteomic databases

PRIDEiP32888

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi971404, 3 interactors
DIPiDIP-2193N

Structurei

3D structure databases

SMRiP32888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG09000074

Family and domain databases

HAMAPiMF_04018 HSV_TRX1, 1 hit
InterProiView protein in InterPro
IPR004999 Herpes_1
PfamiView protein in Pfam
PF03327 Herpes_VP19C, 1 hit

Sequencei

Sequence statusi: Complete.

P32888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTNPLPATP SVWGGSTVEL PPTTRDTAGQ GLLRRVLRPP ISRRDGPGLP
60 70 80 90 100
RGSGPRRAAS TLWLLGLDGT DAPPGALTPN DDTEQALDKI LRGTMRGGAA
110 120 130 140 150
LIGSPRHHLT RQVILTDLCQ PNADRAGTLL LALRHPADLP HLAHQRAPPG
160 170 180 190 200
RQTERLGEAW GQLMEATALG SGRAESGCTR AGLVSFNFLV AACAASYDAR
210 220 230 240 250
DAADAVRAHV TANYRGTRVG ARLDRFSECL RAMVHTHVFP HEVMRFFGGL
260 270 280 290 300
VSWVTQDELA SVTAVCAGPQ EAAHTGHPGR PRSAVILPAC AFVDLDAELG
310 320 330 340 350
LGGPGAAFLY LVFTYRQRRD QELCCVYVIK SQLPPRGLEP ALERLFGRLR
360 370 380 390 400
ITNTIHGTED MTPPAPNRNP DFPLAGLAAN PQTPRCSAGQ VTNPQFADRL
410 420 430 440 450
YRWQPDLRGR PTARTCTYAA FAELGMMPED SPRCLHRTER FGAVSVPVVI
460
LEGVVWRPGE WRACA
Length:465
Mass (Da):50,263
Last modified:October 1, 1993 - v1
Checksum:i5F00147AE29B3092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32313.1
PIRiB30088 WMBEZ8
RefSeqiYP_009137113.1, NC_001806.2

Genome annotation databases

GeneIDi2703359
KEGGivg:2703359

Similar proteinsi

Entry informationi

Entry nameiTRX1_HHV11
AccessioniPrimary (citable) accession number: P32888
Secondary accession number(s): P10222
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 15, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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