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Protein

Interferon alpha-8

Gene

IFNA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-8
Short name:
IFN-alpha-8
Alternative name(s):
Interferon alpha-B
Short name:
LeIF B
Interferon alpha-B2
Gene namesi
Name:IFNA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120242.3
HGNCiHGNC:5429 IFNA8
MIMi147568 gene
neXtProtiNX_P32881

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3445
OpenTargetsiENSG00000120242
PharmGKBiPA29668
PA88

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA8
DMDMi417188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001636524 – 189Interferon alpha-8Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP32881
PeptideAtlasiP32881
PRIDEiP32881
ProteomicsDBi54886

Expressioni

Gene expression databases

BgeeiENSG00000120242 Expressed in 2 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_IFNA8
GenevisibleiP32881 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109668, 10 interactors
DIPiDIP-6017N
IntActiP32881, 1 interactor
STRINGi9606.ENSP00000369553

Structurei

3D structure databases

ProteinModelPortaliP32881
SMRiP32881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG050765
InParanoidiP32881
KOiK05414
OMAiTETHLMY
OrthoDBiEOG091G0MJ6
PhylomeDBiP32881
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL
110 120 130 140 150
DETLLDEFYI ELDQQLNDLE SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN LQKRLKSKE
Length:189
Mass (Da):21,989
Last modified:August 13, 1987 - v1
Checksum:i83128DA2B6DBB2C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → M in CAA23806 (PubMed:6164048).Curated1
Sequence conflicti8L → M in CAA23811 (PubMed:6163083).Curated1
Sequence conflicti121 – 124SCVM → VLCD in CAA23806 (PubMed:6164048).Curated4
Sequence conflicti121 – 124SCVM → VLCD in CAA23811 (PubMed:6163083).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021975137E → K. Corresponds to variant dbSNP:rs3739630Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA Translation: CAA26903.1
K01900 mRNA Translation: AAA52716.1
V00545 mRNA Translation: CAA23806.1
V00550 mRNA Translation: CAA23811.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58610.1
BC104828 mRNA Translation: AAI04829.1
BC104830 mRNA Translation: AAI04831.1
CCDSiCCDS6507.1
PIRiA93747 IVHUA4
B61413
D23753 IVHUI8
RefSeqiNP_002161.2, NM_002170.3
UniGeneiHs.73890

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242
GeneIDi3445
KEGGihsa:3445
UCSCiuc003zpc.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA Translation: CAA26903.1
K01900 mRNA Translation: AAA52716.1
V00545 mRNA Translation: CAA23806.1
V00550 mRNA Translation: CAA23811.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58610.1
BC104828 mRNA Translation: AAI04829.1
BC104830 mRNA Translation: AAI04831.1
CCDSiCCDS6507.1
PIRiA93747 IVHUA4
B61413
D23753 IVHUI8
RefSeqiNP_002161.2, NM_002170.3
UniGeneiHs.73890

3D structure databases

ProteinModelPortaliP32881
SMRiP32881
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109668, 10 interactors
DIPiDIP-6017N
IntActiP32881, 1 interactor
STRINGi9606.ENSP00000369553

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA8
DMDMi417188

Proteomic databases

PaxDbiP32881
PeptideAtlasiP32881
PRIDEiP32881
ProteomicsDBi54886

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242
GeneIDi3445
KEGGihsa:3445
UCSCiuc003zpc.1 human

Organism-specific databases

CTDi3445
DisGeNETi3445
EuPathDBiHostDB:ENSG00000120242.3
GeneCardsiIFNA8
HGNCiHGNC:5429 IFNA8
HPAiHPA047557
MIMi147568 gene
neXtProtiNX_P32881
OpenTargetsiENSG00000120242
PharmGKBiPA29668
PA88
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG050765
InParanoidiP32881
KOiK05414
OMAiTETHLMY
OrthoDBiEOG091G0MJ6
PhylomeDBiP32881
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA8
GenomeRNAii3445
PROiPR:P32881
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120242 Expressed in 2 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_IFNA8
GenevisibleiP32881 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA8_HUMAN
AccessioniPrimary (citable) accession number: P32881
Secondary accession number(s): P01565
, P09236, Q5VWV7, Q5VYQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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