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Entry version 176 (07 Oct 2020)
Sequence version 1 (13 Aug 1987)
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Protein

Interferon alpha-8

Gene

IFNA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P32881

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-909733, Interferon alpha/beta signaling
R-HSA-912694, Regulation of IFNA signaling
R-HSA-933541, TRAF6 mediated IRF7 activation
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha-8
Short name:
IFN-alpha-8
Alternative name(s):
Interferon alpha-B
Short name:
LeIF B
Interferon alpha-B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNA8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000120242.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5429, IFNA8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147568, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P32881

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3445

Open Targets

More...
OpenTargetsi
ENSG00000120242

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29668
PA88

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P32881, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3856161

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFNA8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
417188

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001636524 – 189Interferon alpha-8Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P32881

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P32881

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32881

PeptideAtlas

More...
PeptideAtlasi
P32881

PRoteomics IDEntifications database

More...
PRIDEi
P32881

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54886

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120242, Expressed in cerebellar hemisphere and 3 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P32881, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120242, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109668, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-6017N

Protein interaction database and analysis system

More...
IntActi
P32881, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369553

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32881, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32881

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SQAC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_109427_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32881

KEGG Orthology (KO)

More...
KOi
K05414

Identification of Orthologs from Complete Genome Data

More...
OMAi
TETHLMY

Database of Orthologous Groups

More...
OrthoDBi
1358010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P32881

TreeFam database of animal gene trees

More...
TreeFami
TF336177

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00095, IFab, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR000471, Interferon_alpha/beta/delta

The PANTHER Classification System

More...
PANTHERi
PTHR11691, PTHR11691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00143, Interferon, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00266, INTERFERONAB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00076, IFabd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266, SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00252, INTERFERON_A_B_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P32881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL
110 120 130 140 150
DETLLDEFYI ELDQQLNDLE SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN LQKRLKSKE
Length:189
Mass (Da):21,989
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83128DA2B6DBB2C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8L → M in CAA23806 (PubMed:6164048).Curated1
Sequence conflicti8L → M in CAA23811 (PubMed:6163083).Curated1
Sequence conflicti121 – 124SCVM → VLCD in CAA23806 (PubMed:6164048).Curated4
Sequence conflicti121 – 124SCVM → VLCD in CAA23811 (PubMed:6163083).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021975137E → K. Corresponds to variant dbSNP:rs3739630Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X03125 Genomic DNA Translation: CAA26903.1
K01900 mRNA Translation: AAA52716.1
V00545 mRNA Translation: CAA23806.1
V00550 mRNA Translation: CAA23811.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58610.1
BC104828 mRNA Translation: AAI04829.1
BC104830 mRNA Translation: AAI04831.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6507.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93747, IVHUA4
B61413
D23753, IVHUI8

NCBI Reference Sequences

More...
RefSeqi
NP_002161.2, NM_002170.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380205; ENSP00000369553; ENSG00000120242

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3445

UCSC genome browser

More...
UCSCi
uc003zpc.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA Translation: CAA26903.1
K01900 mRNA Translation: AAA52716.1
V00545 mRNA Translation: CAA23806.1
V00550 mRNA Translation: CAA23811.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58610.1
BC104828 mRNA Translation: AAI04829.1
BC104830 mRNA Translation: AAI04831.1
CCDSiCCDS6507.1
PIRiA93747, IVHUA4
B61413
D23753, IVHUI8
RefSeqiNP_002161.2, NM_002170.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6JHDNMR-A24-189[»]
SMRiP32881
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109668, 11 interactors
DIPiDIP-6017N
IntActiP32881, 9 interactors
STRINGi9606.ENSP00000369553

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA8
DMDMi417188

Proteomic databases

jPOSTiP32881
MassIVEiP32881
PaxDbiP32881
PeptideAtlasiP32881
PRIDEiP32881
ProteomicsDBi54886

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P32881, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24879, 122 antibodies

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242
GeneIDi3445
KEGGihsa:3445
UCSCiuc003zpc.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3445
DisGeNETi3445
EuPathDBiHostDB:ENSG00000120242.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFNA8
HGNCiHGNC:5429, IFNA8
HPAiENSG00000120242, Tissue enhanced (brain)
MIMi147568, gene
neXtProtiNX_P32881
OpenTargetsiENSG00000120242
PharmGKBiPA29668
PA88

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SQAC, Eukaryota
GeneTreeiENSGT01000000214611
HOGENOMiCLU_109427_0_0_1
InParanoidiP32881
KOiK05414
OMAiTETHLMY
OrthoDBi1358010at2759
PhylomeDBiP32881
TreeFamiTF336177

Enzyme and pathway databases

PathwayCommonsiP32881
ReactomeiR-HSA-909733, Interferon alpha/beta signaling
R-HSA-912694, Regulation of IFNA signaling
R-HSA-933541, TRAF6 mediated IRF7 activation
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3445, 4 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IFNA8, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IFNA8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3445
PharosiP32881, Tbio

Protein Ontology

More...
PROi
PR:P32881
RNActiP32881, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120242, Expressed in cerebellar hemisphere and 3 other tissues
GenevisibleiP32881, HS

Family and domain databases

CDDicd00095, IFab, 1 hit
InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR000471, Interferon_alpha/beta/delta
PANTHERiPTHR11691, PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143, Interferon, 1 hit
PRINTSiPR00266, INTERFERONAB
SMARTiView protein in SMART
SM00076, IFabd, 1 hit
SUPFAMiSSF47266, SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252, INTERFERON_A_B_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFNA8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32881
Secondary accession number(s): P01565
, P09236, Q5VWV7, Q5VYQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 7, 2020
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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