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UniProtKB - P32871 (PK3CA_BOVIN)

Entry version 179 (25 May 2022)
Sequence version 1 (01 Oct 1993)
Previous versions | rss
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Protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Gene

PIK3CA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:1322797, PubMed:14729945).

Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).

PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity).

In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:15178440, PubMed:14729945).

Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol phosphate biosynthesis

This protein is involved in the pathway phosphatidylinositol phosphate biosynthesis, which is part of Phospholipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol phosphate biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processAngiogenesis, Phagocytosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.137, 908

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-BTA-109704, PI3K Cascade
R-BTA-112399, IRS-mediated signalling
R-BTA-1250342, PI3K events in ERBB4 signaling
R-BTA-1257604, PIP3 activates AKT signaling
R-BTA-1433557, Signaling by SCF-KIT
R-BTA-1660499, Synthesis of PIPs at the plasma membrane
R-BTA-1963642, PI3K events in ERBB2 signaling
R-BTA-198203, PI3K/AKT activation
R-BTA-201556, Signaling by ALK
R-BTA-202424, Downstream TCR signaling
R-BTA-2029485, Role of phospholipids in phagocytosis
R-BTA-2424491, DAP12 signaling
R-BTA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-389357, CD28 dependent PI3K/Akt signaling
R-BTA-4420097, VEGFA-VEGFR2 Pathway
R-BTA-5654689, PI-3K cascade:FGFR1
R-BTA-5654695, PI-3K cascade:FGFR2
R-BTA-5654710, PI-3K cascade:FGFR3
R-BTA-5654720, PI-3K cascade:FGFR4
R-BTA-5673001, RAF/MAP kinase cascade
R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-9607240, FLT3 Signaling

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P32871

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00220

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC:2.7.1.1371 Publication2 Publications, EC:2.7.1.153By similarity)
Short name:
PI3-kinase subunit alpha
Short name:
PI3K-alpha
Short name:
PI3Kalpha
Short name:
PtdIns-3-kinase subunit alpha
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
Short name:
PtdIns-3-kinase subunit p110-alpha
Short name:
p110alpha
Phosphoinositide-3-kinase catalytic alpha polypeptide
Serine/threonine protein kinase PIK3CA (EC:2.7.11.12 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3CA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSBTAG00000009232

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:32889, PIK3CA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2498

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000887841 – 1068Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformAdd BLAST1068

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32871

PRoteomics IDEntifications database

More...PRIDEi		P32871

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32871

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSBTAG00000009232, Expressed in mammary gland and 101 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).

Interacts with IRS1 in nuclear extracts.

Interacts with RUFY3.

Interacts with RASD2.

Interacts with APPL1.

Interacts with HRAS and KRAS. Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2.

Interacts with FAM83B; activates the PI3K/AKT signaling cascade.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P32871

Database of interacting proteins

More...DIPi		DIP-39319N

Protein interaction database and analysis system

More...IntActi		P32871, 4 interactors

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000012168

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P32871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11068
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P32871

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P32871

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P32871

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 105PI3K-ABDPROSITE-ProRule annotationAdd BLAST90
Domaini187 – 289PI3K-RBDPROSITE-ProRule annotationAdd BLAST103
Domaini330 – 487C2 PI3K-typePROSITE-ProRule annotationAdd BLAST158
Domaini517 – 694PIK helicalPROSITE-ProRule annotationAdd BLAST178
Domaini765 – 1051PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST287

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni771 – 777G-loopPROSITE-ProRule annotation7
Regioni912 – 920Catalytic loopPROSITE-ProRule annotation9
Regioni931 – 957Activation loopPROSITE-ProRule annotationAdd BLAST27

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0904, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155531

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002191_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32871

Identification of Orthologs from Complete Genome Data

More...OMAi		EHANWTV

Database of Orthologous Groups

More...OrthoDBi		204282at2759

TreeFam database of animal gene trees

More...TreeFami		TF102031

Family and domain databases

Conserved Domains Database

More...CDDi		cd05175, PI3Kc_IA_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR003113, PI3K_ABD
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR037704, PI3Kalpha_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF 
        60         70         80         90        100
KEARKYPLHQ LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK 
       110        120        130        140        150
VIEPVGNREE KILNREIGFA IGMPVCEFDM VKDPEVQDFR RNILNVCKEA 
       160        170        180        190        200
VDLRDLNSPH SRAMYVYPPN VESSPELPKH IYNKLDKGQI IVVIWVIVSP 
       210        220        230        240        250
NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK LCVLEYQGKY 
       260        270        280        290        300
ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPMD 
       310        320        330        340        350
CFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD 
       360        370        380        390        400
IDKIYVRTGI YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA 
       410        420        430        440        450
RLCLSICSVK GRKGAKEEHC PLAWGNINLF DYTDTLVSGK MALNLWPVPH 
       460        470        480        490        500
GLEDLLNPIG VTGSNPNKET PCLELEFDWF SSVVKFPDMS VIEEHANWSV 
       510        520        530        540        550
SREAGFSYSH AGLSNRLARD NELRENDKEQ LRAICTRDPL SEITEQEKDF 
       560        570        580        590        600
LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME 
       610        620        630        640        650
LLDCNYPDPM VRGFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV 
       660        670        680        690        700
RFLLKKALTN QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK 
       710        720        730        740        750
HLNRQVEAME KLINLTDILK QEKKDETQKV QMKFLVEQMR RPDFMDALQG 
       760        770        780        790        800
FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW LNWENPDIMS ELLFQNNEII 
       810        820        830        840        850
FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS IGDCVGLIEV 
       860        870        880        890        900
VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS 
       910        920        930        940        950
CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE 
       960        970        980        990       1000
RVPFVLTQDF LIVISKGAQE CTKTREFERF QEMCYKAYLA IRQHANLFIN 
      1010       1020       1030       1040       1050
LFSMMLGSGM PELQSFDDIA YIRKTLALDK TEQEALEYFM KQMNDAHHGG 
      1060 
WTTKMDWIFH TIKQHALN
Length:1,068
Mass (Da):124,328
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC753DCC2F39FDDF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M93252 mRNA Translation: AAA30698.1

Protein sequence database of the Protein Information Resource

More...PIRi		A43322

NCBI Reference Sequences

More...RefSeqi		NP_776999.1, NM_174574.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSBTAT00000012168; ENSBTAP00000012168; ENSBTAG00000009232
ENSBTAT00000072391; ENSBTAP00000068953; ENSBTAG00000009232

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:282306

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93252 mRNA Translation: AAA30698.1
PIRiA43322
RefSeqiNP_776999.1, NM_174574.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V1YX-ray2.40A1-108[»]
AlphaFoldDBiP32871
SMRiP32871
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiP32871
DIPiDIP-39319N
IntActiP32871, 4 interactors
STRINGi9913.ENSBTAP00000012168

Chemistry databases

BindingDBiP32871
ChEMBLiCHEMBL2498

PTM databases

iPTMnetiP32871

Proteomic databases

PaxDbiP32871
PRIDEiP32871

Genome annotation databases

EnsembliENSBTAT00000012168; ENSBTAP00000012168; ENSBTAG00000009232
ENSBTAT00000072391; ENSBTAP00000068953; ENSBTAG00000009232
GeneIDi282306
KEGGibta:282306

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5290
VEuPathDBiHostDB:ENSBTAG00000009232
VGNCiVGNC:32889, PIK3CA

Phylogenomic databases

eggNOGiKOG0904, Eukaryota
GeneTreeiENSGT00940000155531
HOGENOMiCLU_002191_1_1_1
InParanoidiP32871
OMAiEHANWTV
OrthoDBi204282at2759
TreeFamiTF102031

Enzyme and pathway databases

UniPathwayiUPA00220
BRENDAi2.7.1.137, 908
ReactomeiR-BTA-109704, PI3K Cascade
R-BTA-112399, IRS-mediated signalling
R-BTA-1250342, PI3K events in ERBB4 signaling
R-BTA-1257604, PIP3 activates AKT signaling
R-BTA-1433557, Signaling by SCF-KIT
R-BTA-1660499, Synthesis of PIPs at the plasma membrane
R-BTA-1963642, PI3K events in ERBB2 signaling
R-BTA-198203, PI3K/AKT activation
R-BTA-201556, Signaling by ALK
R-BTA-202424, Downstream TCR signaling
R-BTA-2029485, Role of phospholipids in phagocytosis
R-BTA-2424491, DAP12 signaling
R-BTA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-389357, CD28 dependent PI3K/Akt signaling
R-BTA-4420097, VEGFA-VEGFR2 Pathway
R-BTA-5654689, PI-3K cascade:FGFR1
R-BTA-5654695, PI-3K cascade:FGFR2
R-BTA-5654710, PI-3K cascade:FGFR3
R-BTA-5654720, PI-3K cascade:FGFR4
R-BTA-5673001, RAF/MAP kinase cascade
R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-9607240, FLT3 Signaling
SABIO-RKiP32871

Miscellaneous databases

EvolutionaryTraceiP32871

Protein Ontology

More...PROi		PR:P32871

Gene expression databases

BgeeiENSBTAG00000009232, Expressed in mammary gland and 101 other tissues

Family and domain databases

CDDicd05175, PI3Kc_IA_alpha, 1 hit
Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR003113, PI3K_ABD
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR037704, PI3Kalpha_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK3CA_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32871
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 25, 2022
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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