UniProtKB - P32871 (PK3CA_BOVIN)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
PIK3CA
Functioni
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:1322797, PubMed:14729945).
Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity).
In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:15178440, PubMed:14729945).
Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
By similarity3 PublicationsCatalytic activityi
- EC:2.7.11.12 PublicationsThis reaction proceeds in the forward2 Publications direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H+1 Publication2 PublicationsEC:2.7.1.1371 Publication2 PublicationsThis reaction proceeds in the forward3 Publications direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H+By similarityEC:2.7.1.153By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
: phosphatidylinositol phosphate biosynthesis Pathwayi
This protein is involved in the pathway phosphatidylinositol phosphate biosynthesis, which is part of Phospholipid metabolism.3 PublicationsView all proteins of this organism that are known to be involved in the pathway phosphatidylinositol phosphate biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase activity Source: BHF-UCL
- 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- insulin receptor substrate binding Source: Ensembl
- phosphatidylinositol-3,4-bisphosphate 5-kinase activity Source: UniProtKB-EC
- phosphatidylinositol 3-kinase activity Source: BHF-UCL
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: UniProtKB-EC
- phosphatidylinositol kinase activity Source: GO_Central
- protein kinase activator activity Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- actin cytoskeleton organization Source: Ensembl
- adipose tissue development Source: Ensembl
- angiogenesis Source: UniProtKB-KW
- cardiac muscle cell contraction Source: Ensembl
- cell migration Source: GO_Central
- cellular response to glucose stimulus Source: Ensembl
- cellular response to hydrostatic pressure Source: Ensembl
- energy homeostasis Source: Ensembl
- glucose metabolic process Source: Ensembl
- hypomethylation of CpG island Source: Ensembl
- liver development Source: Ensembl
- negative regulation of actin filament depolymerization Source: Ensembl
- negative regulation of anoikis Source: Ensembl
- negative regulation of fibroblast apoptotic process Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- phagocytosis Source: UniProtKB-KW
- phosphatidylinositol 3-kinase signaling Source: GO_Central
- phosphatidylinositol-3-phosphate biosynthetic process Source: BHF-UCL
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: BHF-UCL
- positive regulation of lamellipodium assembly Source: BHF-UCL
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- protein kinase B signaling Source: Ensembl
- regulation of cellular respiration Source: Ensembl
- regulation of genetic imprinting Source: Ensembl
- regulation of multicellular organism growth Source: Ensembl
- relaxation of cardiac muscle Source: Ensembl
- response to muscle stretch Source: Ensembl
- vascular endothelial growth factor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Angiogenesis, Phagocytosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 908 |
Reactomei | R-BTA-109704, PI3K Cascade R-BTA-112399, IRS-mediated signalling R-BTA-1250342, PI3K events in ERBB4 signaling R-BTA-1257604, PIP3 activates AKT signaling R-BTA-1433557, Signaling by SCF-KIT R-BTA-1660499, Synthesis of PIPs at the plasma membrane R-BTA-1963642, PI3K events in ERBB2 signaling R-BTA-198203, PI3K/AKT activation R-BTA-201556, Signaling by ALK R-BTA-202424, Downstream TCR signaling R-BTA-2029485, Role of phospholipids in phagocytosis R-BTA-2424491, DAP12 signaling R-BTA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-BTA-389357, CD28 dependent PI3K/Akt signaling R-BTA-4420097, VEGFA-VEGFR2 Pathway R-BTA-5654689, PI-3K cascade:FGFR1 R-BTA-5654695, PI-3K cascade:FGFR2 R-BTA-5654710, PI-3K cascade:FGFR3 R-BTA-5654720, PI-3K cascade:FGFR4 R-BTA-5673001, RAF/MAP kinase cascade R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-BTA-9607240, FLT3 Signaling |
SABIO-RKi | P32871 |
UniPathwayi | UPA00220 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC:2.7.1.1371 Publication2 Publications, EC:2.7.1.153By similarity)Short name: PI3-kinase subunit alpha Short name: PI3K-alpha Short name: PI3Kalpha Short name: PtdIns-3-kinase subunit alpha Alternative name(s): Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha Short name: PtdIns-3-kinase subunit p110-alpha Short name: p110alpha Phosphoinositide-3-kinase catalytic alpha polypeptide Serine/threonine protein kinase PIK3CA (EC:2.7.11.12 Publications) |
Gene namesi | Name:PIK3CA |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000009232 |
VGNCi | VGNC:32889, PIK3CA |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- intercalated disc Source: Ensembl
- lamellipodium Source: Ensembl
- membrane Source: GO_Central
- perinuclear region of cytoplasm Source: BHF-UCL
- phosphatidylinositol 3-kinase complex Source: BHF-UCL
- phosphatidylinositol 3-kinase complex, class IA Source: GO_Central
- phosphatidylinositol 3-kinase complex, class IB Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088784 | 1 – 1068 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformAdd BLAST | 1068 |
Proteomic databases
PaxDbi | P32871 |
PRIDEi | P32871 |
PTM databases
iPTMneti | P32871 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000009232, Expressed in mammary gland and 101 other tissues |
Interactioni
Subunit structurei
Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).
Interacts with IRS1 in nuclear extracts.
Interacts with RUFY3.
Interacts with RASD2.
Interacts with APPL1.
Interacts with HRAS and KRAS. Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2.
Interacts with FAM83B; activates the PI3K/AKT signaling cascade.
By similarityBinary interactionsi
GO - Molecular functioni
- insulin receptor substrate binding Source: Ensembl
Protein-protein interaction databases
CORUMi | P32871 |
DIPi | DIP-39319N |
IntActi | P32871, 4 interactors |
STRINGi | 9913.ENSBTAP00000012168 |
Chemistry databases
BindingDBi | P32871 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P32871 |
SMRi | P32871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32871 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 105 | PI3K-ABDPROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 187 – 289 | PI3K-RBDPROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 330 – 487 | C2 PI3K-typePROSITE-ProRule annotationAdd BLAST | 158 | |
Domaini | 517 – 694 | PIK helicalPROSITE-ProRule annotationAdd BLAST | 178 | |
Domaini | 765 – 1051 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 287 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 771 – 777 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 912 – 920 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 931 – 957 | Activation loopPROSITE-ProRule annotationAdd BLAST | 27 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0904, Eukaryota |
GeneTreei | ENSGT00940000155531 |
HOGENOMi | CLU_002191_1_1_1 |
InParanoidi | P32871 |
OMAi | EHANWTV |
OrthoDBi | 204282at2759 |
TreeFami | TF102031 |
Family and domain databases
CDDi | cd05175, PI3Kc_IA_alpha, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR002420, PI3K-type_C2_dom IPR003113, PI3K_ABD IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR037704, PI3Kalpha_dom IPR015433, PI_Kinase IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00792, PI3K_C2, 1 hit PF02192, PI3K_p85B, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit |
SMARTi | View protein in SMART SM00142, PI3K_C2, 1 hit SM00143, PI3K_p85B, 1 hit SM00144, PI3K_rbd, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51544, PI3K_ABD, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF
60 70 80 90 100
KEARKYPLHQ LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK
110 120 130 140 150
VIEPVGNREE KILNREIGFA IGMPVCEFDM VKDPEVQDFR RNILNVCKEA
160 170 180 190 200
VDLRDLNSPH SRAMYVYPPN VESSPELPKH IYNKLDKGQI IVVIWVIVSP
210 220 230 240 250
NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK LCVLEYQGKY
260 270 280 290 300
ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPMD
310 320 330 340 350
CFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD
360 370 380 390 400
IDKIYVRTGI YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA
410 420 430 440 450
RLCLSICSVK GRKGAKEEHC PLAWGNINLF DYTDTLVSGK MALNLWPVPH
460 470 480 490 500
GLEDLLNPIG VTGSNPNKET PCLELEFDWF SSVVKFPDMS VIEEHANWSV
510 520 530 540 550
SREAGFSYSH AGLSNRLARD NELRENDKEQ LRAICTRDPL SEITEQEKDF
560 570 580 590 600
LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME
610 620 630 640 650
LLDCNYPDPM VRGFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV
660 670 680 690 700
RFLLKKALTN QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK
710 720 730 740 750
HLNRQVEAME KLINLTDILK QEKKDETQKV QMKFLVEQMR RPDFMDALQG
760 770 780 790 800
FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW LNWENPDIMS ELLFQNNEII
810 820 830 840 850
FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS IGDCVGLIEV
860 870 880 890 900
VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS
910 920 930 940 950
CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE
960 970 980 990 1000
RVPFVLTQDF LIVISKGAQE CTKTREFERF QEMCYKAYLA IRQHANLFIN
1010 1020 1030 1040 1050
LFSMMLGSGM PELQSFDDIA YIRKTLALDK TEQEALEYFM KQMNDAHHGG
1060
WTTKMDWIFH TIKQHALN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93252 mRNA Translation: AAA30698.1 |
PIRi | A43322 |
RefSeqi | NP_776999.1, NM_174574.1 |
Genome annotation databases
Ensembli | ENSBTAT00000012168; ENSBTAP00000012168; ENSBTAG00000009232 ENSBTAT00000072391; ENSBTAP00000068953; ENSBTAG00000009232 |
GeneIDi | 282306 |
KEGGi | bta:282306 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93252 mRNA Translation: AAA30698.1 |
PIRi | A43322 |
RefSeqi | NP_776999.1, NM_174574.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2V1Y | X-ray | 2.40 | A | 1-108 | [»] | |
AlphaFoldDBi | P32871 | |||||
SMRi | P32871 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P32871 |
DIPi | DIP-39319N |
IntActi | P32871, 4 interactors |
STRINGi | 9913.ENSBTAP00000012168 |
Chemistry databases
BindingDBi | P32871 |
ChEMBLi | CHEMBL2498 |
PTM databases
iPTMneti | P32871 |
Proteomic databases
PaxDbi | P32871 |
PRIDEi | P32871 |
Genome annotation databases
Ensembli | ENSBTAT00000012168; ENSBTAP00000012168; ENSBTAG00000009232 ENSBTAT00000072391; ENSBTAP00000068953; ENSBTAG00000009232 |
GeneIDi | 282306 |
KEGGi | bta:282306 |
Organism-specific databases
CTDi | 5290 |
VEuPathDBi | HostDB:ENSBTAG00000009232 |
VGNCi | VGNC:32889, PIK3CA |
Phylogenomic databases
eggNOGi | KOG0904, Eukaryota |
GeneTreei | ENSGT00940000155531 |
HOGENOMi | CLU_002191_1_1_1 |
InParanoidi | P32871 |
OMAi | EHANWTV |
OrthoDBi | 204282at2759 |
TreeFami | TF102031 |
Enzyme and pathway databases
UniPathwayi | UPA00220 |
BRENDAi | 2.7.1.137, 908 |
Reactomei | R-BTA-109704, PI3K Cascade R-BTA-112399, IRS-mediated signalling R-BTA-1250342, PI3K events in ERBB4 signaling R-BTA-1257604, PIP3 activates AKT signaling R-BTA-1433557, Signaling by SCF-KIT R-BTA-1660499, Synthesis of PIPs at the plasma membrane R-BTA-1963642, PI3K events in ERBB2 signaling R-BTA-198203, PI3K/AKT activation R-BTA-201556, Signaling by ALK R-BTA-202424, Downstream TCR signaling R-BTA-2029485, Role of phospholipids in phagocytosis R-BTA-2424491, DAP12 signaling R-BTA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-BTA-389357, CD28 dependent PI3K/Akt signaling R-BTA-4420097, VEGFA-VEGFR2 Pathway R-BTA-5654689, PI-3K cascade:FGFR1 R-BTA-5654695, PI-3K cascade:FGFR2 R-BTA-5654710, PI-3K cascade:FGFR3 R-BTA-5654720, PI-3K cascade:FGFR4 R-BTA-5673001, RAF/MAP kinase cascade R-BTA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-BTA-9607240, FLT3 Signaling |
SABIO-RKi | P32871 |
Miscellaneous databases
EvolutionaryTracei | P32871 |
PROi | PR:P32871 |
Gene expression databases
Bgeei | ENSBTAG00000009232, Expressed in mammary gland and 101 other tissues |
Family and domain databases
CDDi | cd05175, PI3Kc_IA_alpha, 1 hit |
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR002420, PI3K-type_C2_dom IPR003113, PI3K_ABD IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR037704, PI3Kalpha_dom IPR015433, PI_Kinase IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00792, PI3K_C2, 1 hit PF02192, PI3K_p85B, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit |
SMARTi | View protein in SMART SM00142, PI3K_C2, 1 hit SM00143, PI3K_p85B, 1 hit SM00144, PI3K_rbd, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51544, PI3K_ABD, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PK3CA_BOVIN | |
Accessioni | P32871Primary (citable) accession number: P32871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families