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Entry version 179 (07 Oct 2020)
Sequence version 2 (21 Jun 2005)
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Protein

Ca(2+)/calmodulin-responsive adenylate cyclase

Gene

rut

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a membrane-bound, calmodulin-sensitive adenylyl cyclase. Inactivation of this cyclase leads to a learning and memory defect.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by calcium/calmodulin and G protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi280Magnesium 1PROSITE-ProRule annotation1
Metal bindingi280Magnesium 2PROSITE-ProRule annotation1
Metal bindingi281Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi324Magnesium 1PROSITE-ProRule annotation1
Metal bindingi324Magnesium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Lyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-170660, Adenylate cyclase activating pathway
R-DME-170670, Adenylate cyclase inhibitory pathway
R-DME-418597, G alpha (z) signalling events
R-DME-5610787, Hedgehog 'off' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ca(2+)/calmodulin-responsive adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Protein rutabaga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rut
ORF Names:CG9533
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003301, rut

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 60HelicalSequence analysisAdd BLAST19
Transmembranei65 – 84HelicalSequence analysisAdd BLAST20
Transmembranei101 – 115HelicalSequence analysisAdd BLAST15
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei152 – 174HelicalSequence analysisAdd BLAST23
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 705CytoplasmicSequence analysisAdd BLAST499
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21
Transmembranei730 – 750HelicalSequence analysisAdd BLAST21
Transmembranei770 – 791HelicalSequence analysisAdd BLAST22
Topological domaini792 – 813ExtracellularSequence analysisAdd BLAST22
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21
Transmembranei842 – 867HelicalSequence analysisAdd BLAST26
Transmembranei868 – 888HelicalSequence analysisAdd BLAST21
Topological domaini889 – 2248CytoplasmicSequence analysisAdd BLAST1360

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1026G → R: Abolishes catalytic activity. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001957161 – 2248Ca(2+)/calmodulin-responsive adenylate cyclaseAdd BLAST2248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32870

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mushroom bodies of the fly brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003301, Expressed in head and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P32870, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P32870, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58765, 16 interactors

Protein interaction database and analysis system

More...
IntActi
P32870, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073809

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32870

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini275 – 402Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST128
Domaini963 – 1107Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST145

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi515 – 530Gly-richAdd BLAST16
Compositional biasi569 – 602Gly-richAdd BLAST34
Compositional biasi1278 – 1297Gln-richAdd BLAST20
Compositional biasi1767 – 1810Gly/Ser-richAdd BLAST44
Compositional biasi2025 – 2040Asp/Glu-rich (acidic)Add BLAST16
Compositional biasi2200 – 2241Gln-richAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3619, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32870

KEGG Orthology (KO)

More...
KOi
K08041

Database of Orthologous Groups

More...
OrthoDBi
594476at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P32870

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR032628, AC_N
IPR009398, Adcy_conserved_dom
IPR029787, Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16214, AC_N, 1 hit
PF06327, DUF1053, 1 hit
PF00211, Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073, SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 2 hits
PS50125, GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P32870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHAVKATRG RPLNTLRFEN DELECLYQRY TLKLQRFSVL GVVALVFVLC
60 70 80 90 100
GVMAALSLTF NNAATFHNIF NAIVCGLFAV VLVLLQCSVI KDHHLPTLCY
110 120 130 140 150
GILLFTASIC VVSMPTLGSV FPVDTKEVMA EGVWQIVFVV FLAYAMMPLQ
160 170 180 190 200
IWEAVAFGIA LPSVHISLTV YKIFTDALRY LEYNQLIANI VIFIGVNVAG
210 220 230 240 250
LVVNIMMERA QRRTFLDTRN CIASRLEIQD ENEKLERLLL SVLPQHVAMQ
260 270 280 290 300
MKNDILSPVA GQFHRIYIQK HENVSILFAD IVGFTVLSSQ CSAQELVRLL
310 320 330 340 350
NELFGRFDQL AHDNHCLRIK ILGDCYYCVS GLPEPRKDHA KCAVEMGLDM
360 370 380 390 400
IDAIATVVEA TDVILNMRVG IHTGRVLCGV LGLRKWQFDV WSNDVTLANH
410 420 430 440 450
MESGGEPGRV HVTRATLDSL SGEYEVEAGH GDERSSYLRD HGVDTFFIVP
460 470 480 490 500
PPHRRKPLML NTLGVRSAIG SRRKLSFRNV SNVVMQLLHT IKFSEPVPFS
510 520 530 540 550
NIATGSFPSA ASALGGGVSV GGGGGGGGGG VARGSTCEAN SGNVQVSEKG
560 570 580 590 600
SRKVIRLQKI LHATPPPHGM GYGSVVGSGG GVDSGISGGG GCVSGGIAGG
610 620 630 640 650
GGVQVTVGTN PNSTASTISR IHRHNHKNNK SQSKVADKFK RPFRKRHSVA
660 670 680 690 700
AHHQPTNRVN RFLSQAINAR SVDCDKSEHV DRLTLRFRQS DMEREYHKDF
710 720 730 740 750
DLGFTTAMGC SLLLLILGAA LQVTALPRTL ILLLLFLFAF IWVSAILMLL
760 770 780 790 800
LAVRLKWIIW DISESFSLRM AITIFTVILI YSVGQVNVFT CVSDHPCSGN
810 820 830 840 850
GTTSFQNDSH RKCSLPQYVS LSAAFAFLSV SVFLRLPIIF KSLLVLGMGT
860 870 880 890 900
IYGLFIELSH QNIFECYDNR VNASIPLHLI SLARIAIFMI AILVHGRLVE
910 920 930 940 950
GTARLDFLWQ LQASQEKKEM DVLQESNKRI LHNLLPAHVA AHFLDAQFRN
960 970 980 990 1000
NMELYHQSYA KVGVIFASVP NFNEFYTEMD GSDQGLECLR LLNEIIADFD
1010 1020 1030 1040 1050
ELLKEDRFRG IDKIKTVGST YMAVVGLIPE YKIQPNDPNS VRRHMTALIE
1060 1070 1080 1090 1100
YVKAMRHSLQ EINSHSYNNF MLRVGINIGP VVAGVIGARK PQYDIWGNTV
1110 1120 1130 1140 1150
NVASRMDSTG VPGYSQVTQE VVDSLVGSHF EFRCRGTIKV KGKGDMVTYF
1160 1170 1180 1190 1200
LCDSGNKSLN GEVRNAMSLP QSLHAPDYYM KVSQFPENRV NTDTYSKKEN
1210 1220 1230 1240 1250
GHLYAGNGVE EQQLLLQHQH KQHDPLPLPA PPPPVHHHLH QQQQQRLNSK
1260 1270 1280 1290 1300
LQKQPIFMAN GGLPNIRENG NGHNGEHQQQ QQQQQQHQQQ QQQQQQHGGF
1310 1320 1330 1340 1350
MVATTTPPAA VAVPLQPQHH QLQFQHPHQH PLPSAVSVPV QHQILLHHQL
1360 1370 1380 1390 1400
QLQHQPVPSV MLREFNIIEN PTSGGRHQQM EQLPPHHGSL DLSGMGMGVG
1410 1420 1430 1440 1450
AGVLGSDCFM MPRRDRERTY VPPLNQHGHH PPHHLHSNLN LNQSQHPPSF
1460 1470 1480 1490 1500
TSLGYGQCRE SEPLLHASSV APVAKIMPMQ HAPKYEPPRY TSPHTMLSQQ
1510 1520 1530 1540 1550
HQQQQQQQHQ HQQPQSQSAQ DQQTHPAQDP HPLQRQYAMY SQQPQLPPKP
1560 1570 1580 1590 1600
VLRTYMKPLP KLPTDLEESR DMSSTDDLSS RPHSPSMSSS DESYSKTTEG
1610 1620 1630 1640 1650
EGEGDEDSPR MVNGGHLHHR NGYHLPAGGL VNPLQWLYPC DIQVDPTSPV
1660 1670 1680 1690 1700
VDMAHLHDFE LSSTTESQGH HTNSNTTSNT QHKGDSCNSF DFQKAAVGTA
1710 1720 1730 1740 1750
AGAAIATKSP FERELQRLLN ESSRARCLAT ATTTAGAIST TDQTASNGSR
1760 1770 1780 1790 1800
ELSYSLSNGK LSSANGHGVG GSGSGSGSGS GSGSAVGNGS GGSGSSNGNL
1810 1820 1830 1840 1850
SGGSGSNSNS GNNNSSHHKT EQQQNMDHEH LAGGKLLGSN SFMIAKHPVG
1860 1870 1880 1890 1900
LEAIKEITRN KNPSESSQMQ TSDTESCEIL HENRNQMHVL AMLEMHTAKE
1910 1920 1930 1940 1950
LNGSHAHHGQ HHQQPQRTHR QRPRSKELQY SHESLDGLDG AVQSQSQQRH
1960 1970 1980 1990 2000
QRYHHHHHHQ QRQQQQQRYN HVQEQEERDD TEDNLADEEF EDDEVGRDVR
2010 2020 2030 2040 2050
QKRLQKSELN HKRSEVATEA GNHHDDEVEE EDDDDDEEED HRNGGREAAP
2060 2070 2080 2090 2100
LTNGSMRGLE ANVINDELKY GATHLNHQSM DSNPLESQSE WSDDDCREEA
2110 2120 2130 2140 2150
TGGAESTGYI TDEPGLENIS LLNEAGLTDA EGALSDVNSL YNAPDVDDTS
2160 2170 2180 2190 2200
VSSRASSRLL SLDSLSGLYD CDLDSKHELA IVNASHKISS KFGQPLSPAQ
2210 2220 2230 2240
QQHQQQQQQQ QQQQQQHHQQ QLQQNPQHTQ AQSHLAPVQF QSAEELRE
Length:2,248
Mass (Da):248,824
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7E6B4656A2D073C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NF51M9NF51_DROME
Adenylate cyclase
rut AC, Ac12F, Dmel\CG9533, EP1603, RUT
2,055Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEL4M9PEL4_DROME
Adenylate cyclase
rut AC, Ac12F, Dmel\CG9533, EP1603, RUT
1,391Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PH52M9PH52_DROME
Adenylate cyclase
rut AC, Ac12F, Dmel\CG9533, EP1603, RUT
1,507Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHL3M9PHL3_DROME
Adenylate cyclase
rut AC, Ac12F, Dmel\CG9533, EP1603, RUT
2,146Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJN1M9PJN1_DROME
Adenylate cyclase
rut AC, Ac12F, Dmel\CG9533, EP1603, RUT
2,171Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64A → V in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti596G → S in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1286 – 1287QH → HQ in AAA28844 (PubMed:1739965).Curated2
Sequence conflicti1291Q → QH in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1406S → G in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1507Q → H in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1511 – 1514HQQP → QPQS in AAA28844 (PubMed:1739965).Curated4
Sequence conflicti1682H → Q in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1696A → T in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1771 – 1772Missing in AAA28844 (PubMed:1739965).Curated2
Sequence conflicti1801S → G in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1912H → HH in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti1950H → N in AAA28844 (PubMed:1739965).Curated1
Sequence conflicti2218H → Q in AAA28844 (PubMed:1739965).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M81887 mRNA Translation: AAA28844.1
AE014298 Genomic DNA Translation: AAF48388.1

Protein sequence database of the Protein Information Resource

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PIRi
C42088
D42088

NCBI Reference Sequences

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RefSeqi
NP_511156.2, NM_078601.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0073992; FBpp0073809; FBgn0003301

Database of genes from NCBI RefSeq genomes

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GeneIDi
32406

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG9533

UCSC genome browser

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UCSCi
CG9533-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81887 mRNA Translation: AAA28844.1
AE014298 Genomic DNA Translation: AAF48388.1
PIRiC42088
D42088
RefSeqiNP_511156.2, NM_078601.4

3D structure databases

SMRiP32870
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58765, 16 interactors
IntActiP32870, 6 interactors
STRINGi7227.FBpp0073809

Proteomic databases

PaxDbiP32870

Genome annotation databases

EnsemblMetazoaiFBtr0073992; FBpp0073809; FBgn0003301
GeneIDi32406
KEGGidme:Dmel_CG9533
UCSCiCG9533-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32406
FlyBaseiFBgn0003301, rut

Phylogenomic databases

eggNOGiKOG3619, Eukaryota
InParanoidiP32870
KOiK08041
OrthoDBi594476at2759
PhylomeDBiP32870

Enzyme and pathway databases

ReactomeiR-DME-170660, Adenylate cyclase activating pathway
R-DME-170670, Adenylate cyclase inhibitory pathway
R-DME-418597, G alpha (z) signalling events
R-DME-5610787, Hedgehog 'off' state

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32406, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
rut, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32406

Protein Ontology

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PROi
PR:P32870

Gene expression databases

BgeeiFBgn0003301, Expressed in head and 33 other tissues
ExpressionAtlasiP32870, baseline and differential
GenevisibleiP32870, DM

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR032628, AC_N
IPR009398, Adcy_conserved_dom
IPR029787, Nucleotide_cyclase
PfamiView protein in Pfam
PF16214, AC_N, 1 hit
PF06327, DUF1053, 1 hit
PF00211, Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044, CYCc, 2 hits
SUPFAMiSSF55073, SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 2 hits
PS50125, GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYA1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32870
Secondary accession number(s): Q9TWA7, Q9VY17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 21, 2005
Last modified: October 7, 2020
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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