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Protein

Syntaxin-2

Gene

STX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC
  • protein dimerization activity Source: UniProtKB
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

Protein family/group databases

MoonDBiP32856 Curated
MoonProtiP32856

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:STX2
Synonyms:EPIM, STX2A, STX2B, STX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111450.13
HGNCiHGNC:3403 STX2
MIMi132350 gene
neXtProtiNX_P32856

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2054
OpenTargetsiENSG00000111450
PharmGKBiPA27831

Polymorphism and mutation databases

BioMutaiSTX2
DMDMi292495060

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101961 – 288Syntaxin-2Add BLAST288

Proteomic databases

EPDiP32856
MaxQBiP32856
PaxDbiP32856
PeptideAtlasiP32856
PRIDEiP32856
ProteomicsDBi54883
54884 [P32856-2]
54885 [P32856-3]

PTM databases

iPTMnetiP32856
PhosphoSitePlusiP32856
SwissPalmiP32856

Expressioni

Gene expression databases

BgeeiENSG00000111450 Expressed in 211 organ(s), highest expression level in testis
CleanExiHS_STX2
ExpressionAtlasiP32856 baseline and differential
GenevisibleiP32856 HS

Organism-specific databases

HPAiCAB079007
HPA038189
HPA069176

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108368, 17 interactors
CORUMiP32856
IntActiP32856, 54 interactors
MINTiP32856
STRINGi9606.ENSP00000376178

Structurei

3D structure databases

ProteinModelPortaliP32856
SMRiP32856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 101Sequence analysisAdd BLAST67

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiP32856
KOiK08486
OMAiAVRYQKK
OrthoDBiEOG091G0EUK
PhylomeDBiP32856
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028671 STX2
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF36 PTHR19957:SF36, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: P32856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV
60 70 80 90 100
EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD
110 120 130 140 150
QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR
160 170 180 190 200
QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD
210 220 230 240 250
IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET
260 270 280
KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK
Length:288
Mass (Da):33,341
Last modified:March 23, 2010 - v3
Checksum:i5668E6BF891360B4
GO
Isoform 1 (identifier: P32856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS

Show »
Length:287
Mass (Da):33,337
Checksum:iB3A3B5F6813E0F32
GO
Isoform 2 (identifier: P32856-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

Show »
Length:277
Mass (Da):32,425
Checksum:iD2188E346FA7E2FA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNU7J3KNU7_HUMAN
Syntaxin-2
STX2
112Annotation score:

Sequence cautioni

The sequence BAA03436 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89R → A in BAA03436 (PubMed:8466509).Curated1
Sequence conflicti276A → V in BAA03436 (PubMed:8466509).Curated1
Sequence conflicti288K → I in BAA03436 (PubMed:8466509).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01485042S → T. Corresponds to variant dbSNP:rs17564Ensembl.1
Natural variantiVAR_05725954K → R. Corresponds to variant dbSNP:rs7301926Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006335263 – 288KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_006334264 – 288KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1. 2 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14582 mRNA Translation: BAA03436.1 Frameshift.
AC073912 Genomic DNA No translation available.
BC047496 mRNA Translation: AAH47496.1
CCDSiCCDS9269.1 [P32856-2]
CCDS9270.1 [P32856-1]
PIRiJN0466
RefSeqiNP_001971.2, NM_001980.3 [P32856-2]
NP_919337.1, NM_194356.2 [P32856-1]
UniGeneiHs.437585

Genome annotation databases

EnsembliENST00000261653; ENSP00000261653; ENSG00000111450 [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450 [P32856-1]
GeneIDi2054
KEGGihsa:2054
UCSCiuc001uio.6 human [P32856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14582 mRNA Translation: BAA03436.1 Frameshift.
AC073912 Genomic DNA No translation available.
BC047496 mRNA Translation: AAH47496.1
CCDSiCCDS9269.1 [P32856-2]
CCDS9270.1 [P32856-1]
PIRiJN0466
RefSeqiNP_001971.2, NM_001980.3 [P32856-2]
NP_919337.1, NM_194356.2 [P32856-1]
UniGeneiHs.437585

3D structure databases

ProteinModelPortaliP32856
SMRiP32856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108368, 17 interactors
CORUMiP32856
IntActiP32856, 54 interactors
MINTiP32856
STRINGi9606.ENSP00000376178

Protein family/group databases

MoonDBiP32856 Curated
MoonProtiP32856

PTM databases

iPTMnetiP32856
PhosphoSitePlusiP32856
SwissPalmiP32856

Polymorphism and mutation databases

BioMutaiSTX2
DMDMi292495060

Proteomic databases

EPDiP32856
MaxQBiP32856
PaxDbiP32856
PeptideAtlasiP32856
PRIDEiP32856
ProteomicsDBi54883
54884 [P32856-2]
54885 [P32856-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261653; ENSP00000261653; ENSG00000111450 [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450 [P32856-1]
GeneIDi2054
KEGGihsa:2054
UCSCiuc001uio.6 human [P32856-1]

Organism-specific databases

CTDi2054
DisGeNETi2054
EuPathDBiHostDB:ENSG00000111450.13
GeneCardsiSTX2
HGNCiHGNC:3403 STX2
HPAiCAB079007
HPA038189
HPA069176
MIMi132350 gene
neXtProtiNX_P32856
OpenTargetsiENSG00000111450
PharmGKBiPA27831
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiP32856
KOiK08486
OMAiAVRYQKK
OrthoDBiEOG091G0EUK
PhylomeDBiP32856
TreeFamiTF313763

Miscellaneous databases

ChiTaRSiSTX2 human
GeneWikiiSTX2
GenomeRNAii2054
PROiPR:P32856
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111450 Expressed in 211 organ(s), highest expression level in testis
CleanExiHS_STX2
ExpressionAtlasiP32856 baseline and differential
GenevisibleiP32856 HS

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR028671 STX2
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF36 PTHR19957:SF36, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX2_HUMAN
AccessioniPrimary (citable) accession number: P32856
Secondary accession number(s): Q86VW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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