Stx1a

Functionⁱ

Plays a role in hormone and neurotransmitter exocytosis (PubMed:17301173, PubMed:18167541, PubMed:20484665, PubMed:22411134, PubMed:7901002). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca²⁺-regulation of exocytosis acrosomal reaction in sperm.1 Publication4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	253 – 254	(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)1 Publication		2

GO - Molecular functionⁱ

ATP-dependent protein binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
calcium channel inhibitor activity Source: Ensembl
calcium-dependent protein binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
chloride channel inhibitor activity Source: Ensembl
ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
kinase binding Source: Ensembl
myosin binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
myosin head/neck binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
protein binding, bridging
Source: RGD
Inferred from physical interactionⁱ
- 16030255
protein domain specific binding
Source: RGD
Inferred from physical interactionⁱ
- 8999968
protein heterodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 16030255
protein N-terminus binding
Source: RGD
Inferred from direct assayⁱ
- 19255244
SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: MGI
Inferred from direct assayⁱ
- 7553862

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
modulation of excitatory postsynaptic potential
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 18703708
neurotransmitter transport
Source: RGD
Traceable author statementⁱ
- 11846792
positive regulation of calcium ion-dependent exocytosis
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of catecholamine secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 20484665
positive regulation of excitatory postsynaptic potential Source: Ensembl
positive regulation of exocytosis
Source: RGD
Inferred from direct assayⁱ
- 11331586
positive regulation of neurotransmitter secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 12183029
positive regulation of norepinephrine secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 18167541
protein localization to membrane
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 12093152
regulation of exocytosis
Source: RGD
Inferred from mutant phenotypeⁱ
- 16030255
regulation of synaptic vesicle priming Source: Ensembl
response to gravity
Source: RGD
Inferred from direct assayⁱ
- 15076716
SNARE complex assembly
Source: CAFA
Inferred from mutant phenotypeⁱ
- 12680753
- 9671503
synaptic vesicle docking
Source: UniProtKB
Inferred from expression patternⁱ
- 1321498
synaptic vesicle exocytosis
Source: SynGO
Inferred from direct assayⁱ
- 7901002
synaptic vesicle fusion to presynaptic active zone membrane
Source: SynGO
Inferred from genetic interactionⁱ
- 18703708
vesicle docking
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Exocytosis, Neurotransmitter transport, Transport

Biological process

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-RNO-181429 Serotonin Neurotransmitter Release Cycle R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle R-RNO-210500 Glutamate Neurotransmitter Release Cycle R-RNO-212676 Dopamine Neurotransmitter Release Cycle R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle R-RNO-449836 Other interleukin signaling R-RNO-5682910 LGI-ADAM interactions R-RNO-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle
R-RNO-449836 Other interleukin signaling
R-RNO-5682910 LGI-ADAM interactions
R-RNO-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntaxin-1A Alternative name(s): Neuron-specific antigen HPC-1 Synaptotagmin-associated 35 kDa protein Short name: P35A
Gene namesⁱ	Name:Stx1a Synonyms:Sap
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 12

Organism-specific databases

Rat genome database More...RGDⁱ	69430 Stx1a

RGDⁱ

69430 Stx1a

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Topological domainⁱ	1 – 265	CytoplasmicSequence analysisAdd BLAST		265
Transmembraneⁱ	266 – 288	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210189	1 – 288	Syntaxin-1AAdd BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	64	PhosphoserineCombined sources	1
Modified residueⁱ	95	PhosphoserineCombined sources	1
Modified residueⁱ	188	Phosphoserine; by DAPK11 Publication	1

Post-translational modificationⁱ

Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.1 Publication

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C), which hydrolyzes the 253-Lys-|-Ala-254 bond (PubMed:7737992). Cleavage inhibits neurotransmitter release (PubMed:7901002).2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P32851
PRIDEⁱ	P32851

PTM databases

iPTMnetⁱ	P32851
PhosphoSitePlusⁱ	P32851
SwissPalmⁱ	P32851

Miscellaneous databases

PMAP-CutDBⁱ	P32851

PMAP-CutDBⁱ

P32851

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in cerebral cortex, hippocampus, cerebellum, adrenal medulla and retina with weak expression detected in non-neuronal tissues.

Gene expression databases

Bgeeⁱ	ENSRNOG00000029165 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasⁱ	P32851 baseline and differential
Genevisibleⁱ	P32851 RN

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with KCNB1 (via C-terminus); the interaction increases in a calcium-dependent manner and induces a pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons (PubMed:17301173, PubMed:18167541, PubMed:20484665, PubMed:22411134). Interacts with OTOF, SYTL4, VAPA, SYBU and LGI3 (By similarity). Found in a complex with VAMP8 and SNAP23 (PubMed:9507000, PubMed:10336434). Interacts with SYT6 and SYT8; the interaction is Ca²⁺-dependent (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A (PubMed:11533035, PubMed:11832227, PubMed:12496247, PubMed:9759724). This complex binds to CPLX1 (PubMed:11832227). Binds STXBP6 (PubMed:12145319). Found in a ternary complex with STX1A and SNAP25 (PubMed:11533035). Interacts with PLCL1 (via C2 domain) (PubMed:23341457). Interacts with SLC6A4 (PubMed:11709063). Interacts with STXBP1 and DAPK1 (PubMed:10746715, PubMed:12730201). Interacts with PRRT2 (By similarity).By similarity15 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Apba1	O35430	3	EBI-539720,EBI-704760
Cadps	Q62717	3	EBI-539720,EBI-15804323
SNAP25	P60880-2	4	EBI-539720,EBI-12177361	From a different organism.
Snap25	P60879	7	EBI-539720,EBI-445270	From Mus musculus.
Snap25	P60881	29	EBI-539720,EBI-1027214
Snap25	P60881-2	6	EBI-539720,EBI-15685612
SNAP47	Q5SQN1	3	EBI-539720,EBI-10244848	From Homo sapiens.
Stxbp1	P61765	22	EBI-539720,EBI-1029097
Vamp2	P63045	8	EBI-539720,EBI-520880

GO - Molecular functionⁱ

ATP-dependent protein binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
calcium-dependent protein binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
kinase binding Source: Ensembl
myosin binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
myosin head/neck binding
Source: RGD
Inferred from physical interactionⁱ
- 16030255
protein binding, bridging
Source: RGD
Inferred from physical interactionⁱ
- 16030255
protein domain specific binding
Source: RGD
Inferred from physical interactionⁱ
- 8999968
protein heterodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 16030255
protein N-terminus binding
Source: RGD
Inferred from direct assayⁱ
- 19255244
SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: MGI
Inferred from direct assayⁱ
- 7553862

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	250448, 11 interactors
CORUMⁱ	P32851
Database of interacting proteins More...DIPⁱ	DIP-108N
IntActⁱ	P32851, 24 interactors
Molecular INTeraction database More...MINTⁱ	P32851
STRINGⁱ	10116.ENSRNOP00000040699

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	6 – 8	Combined sources	3
Helixⁱ	28 – 63	Combined sources	36
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	69 – 104	Combined sources	36
Turnⁱ	105 – 107	Combined sources	3
Helixⁱ	111 – 146	Combined sources	36
Helixⁱ	162 – 170	Combined sources	9
Helixⁱ	176 – 180	Combined sources	5
Beta strandⁱ	183 – 185	Combined sources	3
Helixⁱ	192 – 254	Combined sources	63
Helixⁱ	261 – 284	Combined sources	24

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00155
ProteinModelPortalⁱ	P32851
SMRⁱ	P32851
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P32851

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	192 – 254	t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 109	Sequence analysisAdd BLAST		42

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	13 – 19	Asp-rich (acidic)		7

Sequence similaritiesⁱ

Belongs to the syntaxin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119200
HOGENOMⁱ	HOG000286023
HOVERGENⁱ	HBG000497
InParanoidⁱ	P32851
KEGG Orthology (KO) More...KOⁱ	K04560
OMAⁱ	FEEIDHI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EUK
PhylomeDBⁱ	P32851
TreeFamⁱ	TF313763

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1A IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P32851-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN 
        60         70         80         90        100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI 
       110        120        130        140        150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ 
       160        170        180        190        200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS 
       210        220        230        240        250
EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD 
       260        270        280 
TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG

Length:288

Mass (Da):33,067

Last modified:October 1, 1993 - v1

Checksum:ⁱ8F929F489E323CAA

GO

Sequence cautionⁱ

The sequence BAA01231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10392 mRNA Translation: BAA01231.1 Different initiation. D12519 mRNA Translation: BAA02089.1 M95734 mRNA Translation: AAA42195.1
PIRⁱ	A38141
NCBI Reference Sequences More...RefSeqⁱ	NP_446240.2, NM_053788.2
UniGeneⁱ	Rn.9943

Genome annotation databases

Ensemblⁱ	ENSRNOT00000049601; ENSRNOP00000040699; ENSRNOG00000029165
GeneIDⁱ	116470
KEGGⁱ	rno:116470
UCSC genome browser More...UCSCⁱ	RGD:69430 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32851	Syntaxin 1A (Brain)		RAT		288	UniRef100_P32851

Protein	Similar proteins		Species	Score	Length	Source
P32851	Syntaxin-1A		BOVIN		288	UniRef90_P32851
Syntaxin-1A		MOUSE		288
Syntaxin-1A		PONAB		288
Syntaxin 1A (Brain)		RAT		288
Uncharacterized protein		Cebus capucinus imitator		288
+49

Protein	Similar proteins		Species	Score	Length	Source
P32851	Syntaxin-1A		MOUSE		288	UniRef50_P32851
Syntaxin-1A		BOVIN		288
Syntaxin-1A		PONAB		288
Syntaxin-1A		CAEBR		293
Syntaxin-1A homolog		CAEEL		291
+399

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10392 mRNA Translation: BAA01231.1 Different initiation. D12519 mRNA Translation: BAA02089.1 M95734 mRNA Translation: AAA42195.1
PIRⁱ	A38141
RefSeqⁱ	NP_446240.2, NM_053788.2
UniGeneⁱ	Rn.9943

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BR0	NMR	-	A	27-144	[»]
	1EZ3	X-ray	1.90	A/B/C	24-150	[»]
	1HVV	X-ray	2.40	A/B/C/D	190-264	[»]
	1JTH	X-ray	2.00	B/D	191-267	[»]
	1KIL	X-ray	2.30	B	191-250	[»]
	1N7S	X-ray	1.45	B	191-256	[»]
	1SFC	X-ray	2.40	B/F/J	180-262	[»]
	1URQ	X-ray	2.00	B	188-259	[»]
	2BU0	model	-	B	191-258	[»]
	2M8R	NMR	-	A	183-288	[»]
	2N1T	NMR	-	B	188-259	[»]
	3C98	X-ray	2.60	B	1-267	[»]
	3HD7	X-ray	3.40	B/F	183-288	[»]
	3IPD	X-ray	4.80	B/F	183-288	[»]
	3J96	electron microscopy	7.60	L	191-256	[»]
	3J97	electron microscopy	7.80	L	191-256	[»]
	3J98	electron microscopy	8.40	L	191-256	[»]
	3J99	electron microscopy	8.20	L	191-256	[»]
	3RK2	X-ray	2.20	B/F	191-253	[»]
	3RK3	X-ray	3.50	B	191-253	[»]
	3RL0	X-ray	3.80	B/F/J/N/R/V/Z/d	191-253	[»]
	4JEH	X-ray	2.50	B	25-266	[»]
	4JEU	X-ray	3.20	B	2-243	[»]
	5CCG	X-ray	3.50	B/H	191-256	[»]
	5CCH	X-ray	3.60	B	191-256	[»]
	5CCI	X-ray	4.10	B	191-256	[»]
	5KJ7	X-ray	3.50	B/H	191-256	[»]
	5KJ8	X-ray	4.10	B/H	191-256	[»]
	5W5C	X-ray	1.85	B	190-256	[»]
	5W5D	X-ray	2.50	B	190-256	[»]
	6MDM	electron microscopy	4.40	I	1-256	[»]
	6MDN	electron microscopy	4.40	I	1-256	[»]
DisProtⁱ	DP00155
ProteinModelPortalⁱ	P32851
SMRⁱ	P32851
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	250448, 11 interactors
CORUMⁱ	P32851
DIPⁱ	DIP-108N
IntActⁱ	P32851, 24 interactors
MINTⁱ	P32851
STRINGⁱ	10116.ENSRNOP00000040699

PTM databases

iPTMnetⁱ	P32851
PhosphoSitePlusⁱ	P32851
SwissPalmⁱ	P32851

Proteomic databases

PaxDbⁱ	P32851
PRIDEⁱ	P32851

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000049601; ENSRNOP00000040699; ENSRNOG00000029165
GeneIDⁱ	116470
KEGGⁱ	rno:116470
UCSCⁱ	RGD:69430 rat

Organism-specific databases

CTDⁱ	6804
RGDⁱ	69430 Stx1a

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
GeneTreeⁱ	ENSGT00760000119200
HOGENOMⁱ	HOG000286023
HOVERGENⁱ	HBG000497
InParanoidⁱ	P32851
KOⁱ	K04560
OMAⁱ	FEEIDHI
OrthoDBⁱ	EOG091G0EUK
PhylomeDBⁱ	P32851
TreeFamⁱ	TF313763

Enzyme and pathway databases

Reactomeⁱ	R-RNO-181429 Serotonin Neurotransmitter Release Cycle R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle R-RNO-210500 Glutamate Neurotransmitter Release Cycle R-RNO-212676 Dopamine Neurotransmitter Release Cycle R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle R-RNO-449836 Other interleukin signaling R-RNO-5682910 LGI-ADAM interactions R-RNO-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle
R-RNO-449836 Other interleukin signaling
R-RNO-5682910 LGI-ADAM interactions
R-RNO-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

EvolutionaryTraceⁱ	P32851
PMAP-CutDBⁱ	P32851
Protein Ontology More...PROⁱ	PR:P32851

Gene expression databases

Bgeeⁱ	ENSRNOG00000029165 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasⁱ	P32851 baseline and differential
Genevisibleⁱ	P32851 RN

Family and domain databases

CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1A IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STX1A_RAT
Accessionⁱ	P32851Primary (citable) accession number: P32851
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1993
	Last modified:	November 7, 2018
	This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Proteomes

Annotation systems

Supporting data

UniProtKB - P32851 (STX1A_RAT)

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Syntaxin-1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ