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UniProtKB - P32844 (SEC6_YEAST)

Entry version 167 (10 Feb 2021)
Sequence version 2 (01 Feb 1995)
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Protein

Exocyst complex component SEC6

Gene

SEC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-264876, Insulin processing

Protein family/group databases

Transport Classification Database

More...TCDBi		1.F.2.1.1, the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component SEC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC6
Ordered Locus Names:YIL068C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000001330, SEC6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YIL068C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189312 – 805Exocyst complex component SEC6Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P32844

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32844

PRoteomics IDEntifications database

More...PRIDEi		P32844

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32844

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		34924, 122 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1890, Exocyst

Database of interacting proteins

More...DIPi		DIP-5649N

Protein interaction database and analysis system

More...IntActi		P32844, 20 interactors

Molecular INTeraction database

More...MINTi		P32844

STRING: functional protein association networks

More...STRINGi		4932.YIL068C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P32844, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1805
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P32844

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P32844

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2286, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011776_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32844

Identification of Orthologs from Complete Genome Data

More...OMAi		WFFNDLN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.357.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010326, EXOC3/Sec6
IPR042532, EXOC3/Sec6_C

The PANTHER Classification System

More...PANTHERi		PTHR21292, PTHR21292, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06046, Sec6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P32844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDPLQQVC DLIKGDLSLE RVRDIKEQLL KEKSVVEYQL NKESDKYYGE 
        60         70         80         90        100
VEESLKLLNL SKNSVTSIKQ QINEVNKLGN DNRFAINRYD ILFRATKLYE 
       110        120        130        140        150
TVNTTSSIYD RIYNFVALME HIERLLVAEL AEDALETGCP HLLEIHFLLT 
       160        170        180        190        200
SARDFQEQVV VMAKEATEDA QRTVMKLFSR LSGIISKFDK LLDGLTYDIV 
       210        220        230        240        250
EMARAEQISL AIRLFKIYDL EEREDLRIEA IRNIIKKKEI EIEKSSIKKL 
       260        270        280        290        300
PNSKNTARLQ DETPKVIEYP TNKGLYQEIM SGTISTRTAP RGYKHFLING 
       310        320        330        340        350
INNSISEMFG EMREKYVGDQ KFDVLDNMDW IFNELIIVKE HIANCCPPHW 
       360        370        380        390        400
NIFEVYFDQY YKELHSLITD LVESEPETII ILDILAFDKT FQDTLKQDFG 
       410        420        430        440        450
FTKSEVKSVI GDKEKETLFK DYLNLIVVKM TEWIGNLEKA EFDVFLERST 
       460        470        480        490        500
PPHSDSDGLL FLDGTKTCFQ MFTQQVEVAA GTNQAKILVG VVERFSDLLT 
       510        520        530        540        550
KRQKNWISKI SEEIKKQINY NHKYDIDPES ITPEDECPGG LVEYLIAVSN 
       560        570        580        590        600
DQMKAADYAV AISSKYGKLV SKVYEKQITN HLEGTLDGFA EVAQCSSLGL 
       610        620        630        640        650
ITLMFDDLRK PYQEIFSKTW YMGSQAQQIA DTLDEYLLDI KPQMNSVLFV 
       660        670        680        690        700
NFIDNVIGET IIKFLTALSF EHSFKNKNNK FLEAMKRDFE IFYQLFVKVL 
       710        720        730        740        750
DGNESKDTLI TQNFTVMEFF MDLSCEPIDS ILDIWQKYLE VYWDSRIDLL 
       760        770        780        790        800
VGILKCRKDV SSSERKKIVQ QATEMLHEYR RNMEANGVDR EPTLMRRFVL 

EFEKQ
Length:805
Mass (Da):93,428
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B09BBBE15389239
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 91MSSDP…NRYDI → MKLINWVMIIDLQLIVMIY (PubMed:1523887).CuratedAdd BLAST91
Sequence conflicti501K → E in CAA46004 (PubMed:1523887).Curated1
Sequence conflicti627 – 628QQ → HE in CAA46004 (PubMed:1523887).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X64738 Genomic DNA Translation: CAA46004.1
Z38060 Genomic DNA Translation: CAA86155.1
BK006942 Genomic DNA Translation: DAA08482.1

Protein sequence database of the Protein Information Resource

More...PIRi		S48411

NCBI Reference Sequences

More...RefSeqi		NP_012196.1, NM_001179418.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YIL068C_mRNA; YIL068C; YIL068C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		854742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YIL068C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64738 Genomic DNA Translation: CAA46004.1
Z38060 Genomic DNA Translation: CAA86155.1
BK006942 Genomic DNA Translation: DAA08482.1
PIRiS48411
RefSeqiNP_012196.1, NM_001179418.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FJIX-ray2.401/2411-805[»]
5YFPelectron microscopy4.40C1-805[»]
6VKLelectron microscopy4.40C1-805[»]
SMRiP32844
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi34924, 122 interactors
ComplexPortaliCPX-1890, Exocyst
DIPiDIP-5649N
IntActiP32844, 20 interactors
MINTiP32844
STRINGi4932.YIL068C

Protein family/group databases

TCDBi1.F.2.1.1, the octameric exocyst (exocyst) family

PTM databases

iPTMnetiP32844

Proteomic databases

MaxQBiP32844
PaxDbiP32844
PRIDEiP32844

Genome annotation databases

EnsemblFungiiYIL068C_mRNA; YIL068C; YIL068C
GeneIDi854742
KEGGisce:YIL068C

Organism-specific databases

SGDiS000001330, SEC6
VEuPathDBiFungiDB:YIL068C

Phylogenomic databases

eggNOGiKOG2286, Eukaryota
GeneTreeiENSGT01010000222400
HOGENOMiCLU_011776_2_0_1
InParanoidiP32844
OMAiWFFNDLN

Enzyme and pathway databases

ReactomeiR-SCE-264876, Insulin processing

Miscellaneous databases

EvolutionaryTraceiP32844

Protein Ontology

More...PROi		PR:P32844
RNActiP32844, protein

Family and domain databases

Gene3Di1.10.357.70, 1 hit
InterProiView protein in InterPro
IPR010326, EXOC3/Sec6
IPR042532, EXOC3/Sec6_C
PANTHERiPTHR21292, PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046, Sec6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC6_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32844
Secondary accession number(s): D6VVL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: February 10, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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