UniProtKB - P32844 (SEC6_YEAST)
Protein
Exocyst complex component SEC6
Gene
SEC6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Miscellaneous
Present with 1080 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- SNARE binding Source: SGD
GO - Biological processi
- exocyst localization Source: SGD
- exocytosis Source: SGD
- Golgi to plasma membrane transport Source: SGD
- negative regulation of SNARE complex assembly Source: SGD
- protein transport Source: UniProtKB-KW
- vesicle tethering involved in exocytosis Source: SGD
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component SEC6 |
Gene namesi | Name:SEC6 Ordered Locus Names:YIL068C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001330, SEC6 |
VEuPathDBi | FungiDB:YIL068C |
Subcellular locationi
Other locations
Other locations
- cellular bud neck Source: SGD
- cellular bud tip Source: SGD
- exocyst Source: SGD
- mating projection tip Source: SGD
- prospore membrane Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000118931 | 2 – 805 | Exocyst complex component SEC6Add BLAST | 804 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | P32844 |
PaxDbi | P32844 |
PRIDEi | P32844 |
PTM databases
iPTMneti | P32844 |
Interactioni
Subunit structurei
The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.
Binary interactionsi
Hide detailsP32844
With | #Exp. | IntAct |
---|---|---|
EXO70 [P19658] | 3 | EBI-16874,EBI-6717 |
SEC10 [Q06245] | 2 | EBI-16874,EBI-16504 |
SEC5 [P89102] | 3 | EBI-16874,EBI-16865 |
SEC8 [P32855] | 3 | EBI-16874,EBI-16896 |
GO - Molecular functioni
- SNARE binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34924, 122 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-5649N |
IntActi | P32844, 20 interactors |
MINTi | P32844 |
STRINGi | 4932.YIL068C |
Miscellaneous databases
RNActi | P32844, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P32844 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32844 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SEC6 family.Curated
Phylogenomic databases
eggNOGi | KOG2286, Eukaryota |
GeneTreei | ENSGT01010000222400 |
HOGENOMi | CLU_011776_2_0_1 |
InParanoidi | P32844 |
OMAi | WFFNDLN |
Family and domain databases
Gene3Di | 1.10.357.70, 1 hit |
InterProi | View protein in InterPro IPR010326, EXOC3/Sec6 IPR042532, EXOC3/Sec6_C |
PANTHERi | PTHR21292, PTHR21292, 1 hit |
Pfami | View protein in Pfam PF06046, Sec6, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P32844-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDPLQQVC DLIKGDLSLE RVRDIKEQLL KEKSVVEYQL NKESDKYYGE
60 70 80 90 100
VEESLKLLNL SKNSVTSIKQ QINEVNKLGN DNRFAINRYD ILFRATKLYE
110 120 130 140 150
TVNTTSSIYD RIYNFVALME HIERLLVAEL AEDALETGCP HLLEIHFLLT
160 170 180 190 200
SARDFQEQVV VMAKEATEDA QRTVMKLFSR LSGIISKFDK LLDGLTYDIV
210 220 230 240 250
EMARAEQISL AIRLFKIYDL EEREDLRIEA IRNIIKKKEI EIEKSSIKKL
260 270 280 290 300
PNSKNTARLQ DETPKVIEYP TNKGLYQEIM SGTISTRTAP RGYKHFLING
310 320 330 340 350
INNSISEMFG EMREKYVGDQ KFDVLDNMDW IFNELIIVKE HIANCCPPHW
360 370 380 390 400
NIFEVYFDQY YKELHSLITD LVESEPETII ILDILAFDKT FQDTLKQDFG
410 420 430 440 450
FTKSEVKSVI GDKEKETLFK DYLNLIVVKM TEWIGNLEKA EFDVFLERST
460 470 480 490 500
PPHSDSDGLL FLDGTKTCFQ MFTQQVEVAA GTNQAKILVG VVERFSDLLT
510 520 530 540 550
KRQKNWISKI SEEIKKQINY NHKYDIDPES ITPEDECPGG LVEYLIAVSN
560 570 580 590 600
DQMKAADYAV AISSKYGKLV SKVYEKQITN HLEGTLDGFA EVAQCSSLGL
610 620 630 640 650
ITLMFDDLRK PYQEIFSKTW YMGSQAQQIA DTLDEYLLDI KPQMNSVLFV
660 670 680 690 700
NFIDNVIGET IIKFLTALSF EHSFKNKNNK FLEAMKRDFE IFYQLFVKVL
710 720 730 740 750
DGNESKDTLI TQNFTVMEFF MDLSCEPIDS ILDIWQKYLE VYWDSRIDLL
760 770 780 790 800
VGILKCRKDV SSSERKKIVQ QATEMLHEYR RNMEANGVDR EPTLMRRFVL
EFEKQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 91 | MSSDP…NRYDI → MKLINWVMIIDLQLIVMIY (PubMed:1523887).CuratedAdd BLAST | 91 | |
Sequence conflicti | 501 | K → E in CAA46004 (PubMed:1523887).Curated | 1 | |
Sequence conflicti | 627 – 628 | QQ → HE in CAA46004 (PubMed:1523887).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64738 Genomic DNA Translation: CAA46004.1 Z38060 Genomic DNA Translation: CAA86155.1 BK006942 Genomic DNA Translation: DAA08482.1 |
PIRi | S48411 |
RefSeqi | NP_012196.1, NM_001179418.1 |
Genome annotation databases
EnsemblFungii | YIL068C_mRNA; YIL068C; YIL068C |
GeneIDi | 854742 |
KEGGi | sce:YIL068C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64738 Genomic DNA Translation: CAA46004.1 Z38060 Genomic DNA Translation: CAA86155.1 BK006942 Genomic DNA Translation: DAA08482.1 |
PIRi | S48411 |
RefSeqi | NP_012196.1, NM_001179418.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FJI | X-ray | 2.40 | 1/2 | 411-805 | [»] | |
5YFP | electron microscopy | 4.40 | C | 1-805 | [»] | |
6VKL | electron microscopy | 4.40 | C | 1-805 | [»] | |
SMRi | P32844 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34924, 122 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-5649N |
IntActi | P32844, 20 interactors |
MINTi | P32844 |
STRINGi | 4932.YIL068C |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | P32844 |
Proteomic databases
MaxQBi | P32844 |
PaxDbi | P32844 |
PRIDEi | P32844 |
Genome annotation databases
EnsemblFungii | YIL068C_mRNA; YIL068C; YIL068C |
GeneIDi | 854742 |
KEGGi | sce:YIL068C |
Organism-specific databases
SGDi | S000001330, SEC6 |
VEuPathDBi | FungiDB:YIL068C |
Phylogenomic databases
eggNOGi | KOG2286, Eukaryota |
GeneTreei | ENSGT01010000222400 |
HOGENOMi | CLU_011776_2_0_1 |
InParanoidi | P32844 |
OMAi | WFFNDLN |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Miscellaneous databases
EvolutionaryTracei | P32844 |
PROi | PR:P32844 |
RNActi | P32844, protein |
Family and domain databases
Gene3Di | 1.10.357.70, 1 hit |
InterProi | View protein in InterPro IPR010326, EXOC3/Sec6 IPR042532, EXOC3/Sec6_C |
PANTHERi | PTHR21292, PTHR21292, 1 hit |
Pfami | View protein in Pfam PF06046, Sec6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEC6_YEAST | |
Accessioni | P32844Primary (citable) accession number: P32844 Secondary accession number(s): D6VVL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families