VMA11

Functionⁱ

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.2 Publications

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	145	Essential for proton translocation		1

GO - Molecular functionⁱ

proton-transporting ATPase activity, rotational mechanism
Source: SGD
Traceable author statementⁱ
- 10224039
- 9442887

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro
vacuolar acidification
Source: SGD
Traceable author statementⁱ
- 10224039
- 9442887

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hydrogen ion transport, Ion transport, Transport

Biological process

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-34121-MONOMER

BioCycⁱ

YEAST:G3O-34121-MONOMER

Protein family/group databases

TCDBⁱ	3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase subunit c' Short name: V-ATPase subunit c' Alternative name(s): Proteolipid protein VMA11 Trifluoperazine resistance protein 3 V-ATPase 16 kDa proteolipid subunit 2 Vacuolar proton pump c' subunit
Gene namesⁱ	Name:VMA11 Synonyms:CLS9, TFP3 Ordered Locus Names:YPL234C ORF Names:P1064
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XVI

Organism-specific databases

EuPathDBⁱ	FungiDB:YPL234C
Saccharomyces Genome Database More...SGDⁱ	S000006155 VMA11

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 14	VacuolarSequence analysisAdd BLAST	14
Transmembraneⁱ	15 – 37	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	38 – 59	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 98	VacuolarSequence analysisAdd BLAST	18
Transmembraneⁱ	99 – 120	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	121 – 132	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	133 – 158	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	159 – 164	VacuolarSequence analysis	6

Keywords - Cellular componentⁱ

Membrane, Vacuole

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	145	E → D: Partial inactivation. 1 Publication		1
Mutagenesisⁱ	145	E → L or Q: Inactivation. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL1795084

ChEMBLⁱ

CHEMBL1795084

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071788	1 – 164	V-type proton ATPase subunit c'Add BLAST		164

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32842
PaxDbⁱ	P32842
PRIDEⁱ	P32842

Interactionⁱ

Subunit structureⁱ

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e). The proteolipid components c, c' and c'' are present as a hexameric ring that forms the proton-conducting pore.

Protein-protein interaction databases

BioGridⁱ	35928, 235 interactors
ComplexPortalⁱ	CPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
Database of interacting proteins More...DIPⁱ	DIP-5394N
IntActⁱ	P32842, 7 interactors
Molecular INTeraction database More...MINTⁱ	P32842
STRINGⁱ	4932.YPL234C

Chemistry databases

BindingDBⁱ

P32842

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 11	Combined sources	3
Helixⁱ	15 – 48	Combined sources	34
Turnⁱ	49 – 51	Combined sources	3
Helixⁱ	56 – 59	Combined sources	4
Helixⁱ	61 – 80	Combined sources	20
Beta strandⁱ	86 – 88	Combined sources	3
Helixⁱ	92 – 123	Combined sources	32
Helixⁱ	126 – 128	Combined sources	3
Helixⁱ	134 – 159	Combined sources	26

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TJ5	electron microscopy	3.90	D	17-163	[»]
	5VOX	electron microscopy	6.80	S	1-164	[»]
	5VOY	electron microscopy	7.90	S	1-164	[»]
	5VOZ	electron microscopy	7.60	S	1-164	[»]
	6C6L	electron microscopy	3.50	D	1-164	[»]
ProteinModelPortalⁱ	P32842
SMRⁱ	P32842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the V-ATPase proteolipid subunit family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000056520
KEGG Orthology (KO) More...KOⁱ	K02155
OMAⁱ	PDLIMKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5DS5

Family and domain databases

InterProⁱ	View protein in InterPro IPR002379 ATPase_proteolipid_c-like_dom IPR000245 ATPase_proteolipid_csu IPR011555 ATPase_proteolipid_su_C_euk IPR035921 F/V-ATP_Csub_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00137 ATP-synt_C, 2 hits
PRINTSⁱ	PR00122 VACATPASE
SUPFAMⁱ	SSF81333 SSF81333, 1 hit
TIGRFAMsⁱ	TIGR01100 V_ATP_synt_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P32842-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTQLASNIY APLYAPFFGF AGCAAAMVLS CLGAAIGTAK SGIGIAGIGT 
        60         70         80         90        100
FKPELIMKSL IPVVMSGILA IYGLVVAVLI AGNLSPTEDY TLFNGFMHLS 
       110        120        130        140        150
CGLCVGFACL SSGYAIGMVG DVGVRKYMHQ PRLFVGIVLI LIFSEVLGLY 
       160 
GMIVALILNT RGSE

Length:164

Mass (Da):17,037

Last modified:October 1, 1993 - v1

Checksum:ⁱC82D165064EEBBF7

GO

Sequence cautionⁱ

The sequence AAA35149 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	27 – 35	Missing in AAA35149 (PubMed:2192255).Curated		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10486 Genomic DNA Translation: BAA01367.1 M32736 Genomic DNA Translation: AAA35149.1 Frameshift. Z67751 Genomic DNA Translation: CAA91610.1 X94561 Genomic DNA Translation: CAA64253.1 Z73590 Genomic DNA Translation: CAA97951.1 AY558058 Genomic DNA Translation: AAS56384.1 BK006949 Genomic DNA Translation: DAA11202.1
PIRⁱ	A41712
NCBI Reference Sequences More...RefSeqⁱ	NP_015090.1, NM_001184048.1

Genome annotation databases

EnsemblFungiⁱ	YPL234C; YPL234C; YPL234C
GeneIDⁱ	855842
KEGGⁱ	sce:YPL234C

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P32842	V-type proton ATPase proteolipid subunit		YEASB		164
V-type proton ATPase proteolipid subunit		YEAS1		164
V-type proton ATPase proteolipid subunit		YEASK		164
V-type proton ATPase proteolipid subunit		YEAS8		164
V-type proton ATPase proteolipid subunit		YEASA		164
+27

Protein	Similar proteins		Species	Score	Length
P32842	V-type proton ATPase proteolipid subunit		YEASB		164
V-type proton ATPase proteolipid subunit		YEAS1		164
V-type proton ATPase proteolipid subunit		YEASK		164
V-type proton ATPase proteolipid subunit		YEAS8		164
V-type proton ATPase proteolipid subunit		YEASA		164
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D10486 Genomic DNA Translation: BAA01367.1 M32736 Genomic DNA Translation: AAA35149.1 Frameshift. Z67751 Genomic DNA Translation: CAA91610.1 X94561 Genomic DNA Translation: CAA64253.1 Z73590 Genomic DNA Translation: CAA97951.1 AY558058 Genomic DNA Translation: AAS56384.1 BK006949 Genomic DNA Translation: DAA11202.1
PIRⁱ	A41712
NCBI Reference Sequences More...RefSeqⁱ	NP_015090.1, NM_001184048.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TJ5	electron microscopy	3.90	D	17-163	[»]
	5VOX	electron microscopy	6.80	S	1-164	[»]
	5VOY	electron microscopy	7.90	S	1-164	[»]
	5VOZ	electron microscopy	7.60	S	1-164	[»]
	6C6L	electron microscopy	3.50	D	1-164	[»]
ProteinModelPortalⁱ	P32842
SMRⁱ	P32842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35928, 235 interactors
ComplexPortalⁱ	CPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
Database of interacting proteins More...DIPⁱ	DIP-5394N
IntActⁱ	P32842, 7 interactors
Molecular INTeraction database More...MINTⁱ	P32842
STRINGⁱ	4932.YPL234C

Chemistry databases

BindingDBⁱ	P32842
ChEMBLⁱ	CHEMBL1795084

Protein family/group databases

TCDBⁱ	3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32842
PaxDbⁱ	P32842
PRIDEⁱ	P32842

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YPL234C; YPL234C; YPL234C
GeneIDⁱ	855842
KEGGⁱ	sce:YPL234C

Organism-specific databases

EuPathDBⁱ	FungiDB:YPL234C
Saccharomyces Genome Database More...SGDⁱ	S000006155 VMA11

Phylogenomic databases

HOGENOMⁱ	HOG000056520
KEGG Orthology (KO) More...KOⁱ	K02155
OMAⁱ	PDLIMKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5DS5

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-34121-MONOMER

BioCycⁱ

YEAST:G3O-34121-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P32842

PROⁱ

PR:P32842

Family and domain databases

InterProⁱ	View protein in InterPro IPR002379 ATPase_proteolipid_c-like_dom IPR000245 ATPase_proteolipid_csu IPR011555 ATPase_proteolipid_su_C_euk IPR035921 F/V-ATP_Csub_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00137 ATP-synt_C, 2 hits
PRINTSⁱ	PR00122 VACATPASE
SUPFAMⁱ	SSF81333 SSF81333, 1 hit
TIGRFAMsⁱ	TIGR01100 V_ATP_synt_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VATL2_YEAST
Accessionⁱ	P32842Primary (citable) accession number: P32842 Secondary accession number(s): D6W3D6, P32365
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1993
	Last modified:	June 20, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - P32842 (VATL2_YEAST)

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V-type proton ATPase subunit c'

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Vacuole

Vacuole

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ