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UniProtKB - P32833 (ORC2_YEAST)

Entry version 182 (25 May 2022)
Sequence version 2 (01 Feb 1994)
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Protein

Origin recognition complex subunit 2

Gene

ORC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.

1 Publication

Miscellaneous

Present with 1700 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-68616, Assembly of the ORC complex at the origin of replication
R-SCE-68949, Orc1 removal from chromatin
R-SCE-68962, Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Origin recognition complex subunit 2
Alternative name(s):
Origin recognition complex 71 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORC2
Synonyms:RRR1, SIR5
Ordered Locus Names:YBR060C
ORF Names:YBR0523
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000000264, ORC2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YBR060C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001270821 – 620Origin recognition complex subunit 2Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphothreonineCombined sources1
Modified residuei187PhosphothreonineCombined sources1
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P32833

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32833

PRoteomics IDEntifications database

More...PRIDEi		P32833

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P32833

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32833

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6.

Interacts with MCM10 and TAH11.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32764, 691 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-768, Nuclear origin recognition complex

Database of interacting proteins

More...DIPi		DIP-2285N

Protein interaction database and analysis system

More...IntActi		P32833, 17 interactors

Molecular INTeraction database

More...MINTi		P32833

STRING: functional protein association networks

More...STRINGi		4932.YBR060C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P32833, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1620
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P32833

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P32833

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 184DisorderedSequence analysisAdd BLAST184
Regioni204 – 225DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 45Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi80 – 116Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi130 – 146Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi147 – 167Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ORC2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2928, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022671_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32833

Identification of Orthologs from Complete Genome Data

More...OMAi		FIEHKMA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007220, ORC2

The PANTHER Classification System

More...PANTHERi		PTHR14052, PTHR14052, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04084, ORC2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNGEDFVEH NDILSSPAKS RNVTPKRVDP HGERQLRRIH SSKKNLLERI 
        60         70         80         90        100
SLVGNERKNT SPDPALKPKT PSKAPRKRGR PRKIQEELTD RIKKDEKDTI 
       110        120        130        140        150
SSKKKRKLDK DTSGNVNEES KTSNNKQVME KTGIKEKRER EKIQVATTTY 
       160        170        180        190        200
EDNVTPQTDD NFVSNSPEPP EPATPSKKSL TTNHDFTSPL KQIIMNNLKE 
       210        220        230        240        250
YKDSTSPGKL TLSRNFTPTP VPKNKKLYQT SETKSASSFL DTFEGYFDQR 
       260        270        280        290        300
KIVRTNAKSR HTMSMAPDVT REEFSLVSNF FNENFQKRPR QKLFEIQKKM 
       310        320        330        340        350
FPQYWFELTQ GFSLLFYGVG SKRNFLEEFA IDYLSPKIAY SQLAYENELQ 
       360        370        380        390        400
QNKPVNSIPC LILNGYNPSC NYRDVFKEIT DLLVPAELTR SETKYWGNHV 
       410        420        430        440        450
ILQIQKMIDF YKNQPLDIKL ILVVHNLDGP SIRKNTFQTM LSFLSVIRQI 
       460        470        480        490        500
AIVASTDHIY APLLWDNMKA QNYNFVFHDI SNFEPSTVES TFQDVMKMGK 
       510        520        530        540        550
SDTSSGAEGA KYVLQSLTVN SKKMYKLLIE TQMQNMGNLS ANTGPKRGTQ 
       560        570        580        590        600
RTGVELKLFN HLCAADFIAS NEIALRSMLR EFIEHKMANI TKNNSGMEII 
       610        620
WVPYTYAELE KLLKTVLNTL
Length:620
Mass (Da):71,238
Last modified:February 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i486E3E5CE353807F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L23924 Unassigned DNA Translation: AAA16325.1
Z21817 Genomic DNA Translation: CAA79883.1
Z35929 Genomic DNA Translation: CAA85003.1
BK006936 Genomic DNA Translation: DAA07180.1

Protein sequence database of the Protein Information Resource

More...PIRi		S38994

NCBI Reference Sequences

More...RefSeqi		NP_009616.1, NM_001178408.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YBR060C_mRNA; YBR060C; YBR060C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		852352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YBR060C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23924 Unassigned DNA Translation: AAA16325.1
Z21817 Genomic DNA Translation: CAA79883.1
Z35929 Genomic DNA Translation: CAA85003.1
BK006936 Genomic DNA Translation: DAA07180.1
PIRiS38994
RefSeqiNP_009616.1, NM_001178408.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V8Felectron microscopy3.90B1-620[»]
5ZR1electron microscopy3.00B1-620[»]
6RQCelectron microscopy4.40B1-620[»]
6WGCelectron microscopy4.30B1-620[»]
6WGGelectron microscopy8.10B1-620[»]
6WGIelectron microscopy10.00B1-620[»]
7MCAelectron microscopy3.60B1-620[»]
AlphaFoldDBiP32833
SMRiP32833
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32764, 691 interactors
ComplexPortaliCPX-768, Nuclear origin recognition complex
DIPiDIP-2285N
IntActiP32833, 17 interactors
MINTiP32833
STRINGi4932.YBR060C

PTM databases

iPTMnetiP32833

Proteomic databases

MaxQBiP32833
PaxDbiP32833
PRIDEiP32833
TopDownProteomicsiP32833

Genome annotation databases

EnsemblFungiiYBR060C_mRNA; YBR060C; YBR060C
GeneIDi852352
KEGGisce:YBR060C

Organism-specific databases

SGDiS000000264, ORC2
VEuPathDBiFungiDB:YBR060C

Phylogenomic databases

eggNOGiKOG2928, Eukaryota
GeneTreeiENSGT00390000015228
HOGENOMiCLU_022671_0_0_1
InParanoidiP32833
OMAiFIEHKMA

Enzyme and pathway databases

ReactomeiR-SCE-68616, Assembly of the ORC complex at the origin of replication
R-SCE-68949, Orc1 removal from chromatin
R-SCE-68962, Activation of the pre-replicative complex

Miscellaneous databases

Protein Ontology

More...PROi		PR:P32833
RNActiP32833, protein

Family and domain databases

InterProiView protein in InterPro
IPR007220, ORC2
PANTHERiPTHR14052, PTHR14052, 1 hit
PfamiView protein in Pfam
PF04084, ORC2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiORC2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32833
Secondary accession number(s): D6VQ60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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