Origin recognition complex subunit 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast."
    Donovan S., Harwood J., Drury L.S., Diffley J.F.
    Proc Natl Acad Sci U S A 94:5611-5616(1997) [PubMed] [Europe PMC] [Abstract]
  • "Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs."
    Tanaka T., Knapp D., Nasmyth K.
    Cell 90:649-660(1997) [PubMed] [Europe PMC] [Abstract]
• DNA replication origin binding Source: SGDInferred from direct assayⁱ
  • "Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro."
    Kawasaki Y., Kim H.D., Kojima A., Seki T., Sugino A.
    Genes Cells 11:745-756(2006) [PubMed] [Europe PMC] [Abstract]
  • "Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs."
    Tanaka T., Knapp D., Nasmyth K.
    Cell 90:649-660(1997) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• chromatin silencing at telomere Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae."
    Rehman M.A., Fourel G., Mathews A., Ramdin D., Espinosa M., Gilson E., Yankulov K.
    Genetics 174:1801-1810(2006) [PubMed] [Europe PMC] [Abstract]
• DNA replication initiation Source: SGDInferred from mutant phenotypeⁱ
  • "Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae."
    Gibson D.G., Bell S.P., Aparicio O.M.
    Genes Cells 11:557-573(2006) [PubMed] [Europe PMC] [Abstract]
  • "The origin recognition complex in silencing, cell cycle progression, and DNA replication."
    Loo S., Fox C.A., Rine J., Kobayashi R., Stillman B., Bell S.P.
    Mol. Biol. Cell 6:741-756(1995) [PubMed] [Europe PMC] [Abstract]
• histone H3-K4 methylation Source: SGDInferred from mutant phenotypeⁱ
  • "Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae."
    Kan J., Zou L., Zhang J., Wu R., Wang Z., Liang C.
    J Biol Chem 283:33803-33807(2008) [PubMed] [Europe PMC] [Abstract]
• pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGDInferred from direct assayⁱ
  • "Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro."
    Kawasaki Y., Kim H.D., Kojima A., Seki T., Sugino A.
    Genes Cells 11:745-756(2006) [PubMed] [Europe PMC] [Abstract]
• silent mating-type cassette heterochromatin assembly Source: SGDInferred from direct assayⁱ
  • "Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin."
    Palacios DeBeer M.A., Muller U., Fox C.A.
    Genes Dev 17:1817-1822(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLNGEDFVEH NDILSSPAKS RNVTPKRVDP HGERQLRRIH SSKKNLLERI 
        60         70         80         90        100
SLVGNERKNT SPDPALKPKT PSKAPRKRGR PRKIQEELTD RIKKDEKDTI 
       110        120        130        140        150
SSKKKRKLDK DTSGNVNEES KTSNNKQVME KTGIKEKRER EKIQVATTTY 
       160        170        180        190        200
EDNVTPQTDD NFVSNSPEPP EPATPSKKSL TTNHDFTSPL KQIIMNNLKE 
       210        220        230        240        250
YKDSTSPGKL TLSRNFTPTP VPKNKKLYQT SETKSASSFL DTFEGYFDQR 
       260        270        280        290        300
KIVRTNAKSR HTMSMAPDVT REEFSLVSNF FNENFQKRPR QKLFEIQKKM 
       310        320        330        340        350
FPQYWFELTQ GFSLLFYGVG SKRNFLEEFA IDYLSPKIAY SQLAYENELQ 
       360        370        380        390        400
QNKPVNSIPC LILNGYNPSC NYRDVFKEIT DLLVPAELTR SETKYWGNHV 
       410        420        430        440        450
ILQIQKMIDF YKNQPLDIKL ILVVHNLDGP SIRKNTFQTM LSFLSVIRQI 
       460        470        480        490        500
AIVASTDHIY APLLWDNMKA QNYNFVFHDI SNFEPSTVES TFQDVMKMGK 
       510        520        530        540        550
SDTSSGAEGA KYVLQSLTVN SKKMYKLLIE TQMQNMGNLS ANTGPKRGTQ 
       560        570        580        590        600
RTGVELKLFN HLCAADFIAS NEIALRSMLR EFIEHKMANI TKNNSGMEII 
       610        620
WVPYTYAELE KLLKTVLNTL                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome II
   Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families