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Protein

E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

Gene

SLX5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci.10 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • SUMO binding Source: SGD
  • transferase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionRepressor, Transferase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29443-MONOMER
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 (EC:2.3.2.27)
Alternative name(s):
Hexose metabolism-related protein HEX3
RING-type E3 ubiquitin transferase SLX5Curated
Synthetic lethal of unknown function protein 5
Gene namesi
Name:SLX5
Synonyms:HEX3
Ordered Locus Names:YDL013W
ORF Names:D2875
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL013W
SGDiS000002171 SLX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839541 – 619E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32828
PaxDbiP32828
PRIDEiP32828
TopDownProteomicsiP32828

PTM databases

iPTMnetiP32828

Interactioni

Subunit structurei

Heterodimer. Interacts with SLX8 and SIR2.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SLX8P400722EBI-8276,EBI-22661

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32041, 883 interactors
ComplexPortaliCPX-3179 Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex
DIPiDIP-727N
IntActiP32828, 28 interactors
MINTiP32828
STRINGi4932.YDL013W

Structurei

3D structure databases

ProteinModelPortaliP32828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000001024
InParanoidiP32828
KOiK22645
OMAiFHCPYQT
OrthoDBiEOG092C1L6A

Family and domain databases

InterProiView protein in InterPro
IPR038886 E3_SLX5/Rfp1
PANTHERiPTHR28042 PTHR28042, 1 hit

Sequencei

Sequence statusi: Complete.

P32828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSDTNGRTK SNNSPSDNNP NETVILIDSD KEEDASIREA NLPVRLYPDR
60 70 80 90 100
RVGRRRDALN RFVRSDSRSR NSQRTHITAS SERPDFQANN DDITIIREVG
110 120 130 140 150
RFFGDDGPID PSAHYVDLDQ EPGSETLETP RTIQVDNTNG YLNDNGNNNE
160 170 180 190 200
SDDGLTIVEE RTTRPRVTLN LPGGERLEVT ATTTDIPIRR SFEFQEDLGA
210 220 230 240 250
SRRQLLRRSA TRARNLFVDR SDENDEDWTD DTHNLPEAIQ RARRESRMRM
260 270 280 290 300
SRRIAERQRR VQQQRVSSDE NISTSIRLQS IRERIQSYTP DIRSAFHRAE
310 320 330 340 350
SLHEFRSILQ NVAPITLQEC EEELMALFTE FRNQLLQNWA IDRVRNTQEE
360 370 380 390 400
ALRLHREALE RQERTAGRVF HRGTLRESIT NYLNFNGEDG FLSRLWSGPA
410 420 430 440 450
LSDADEERHT QNIIDMIQER EERERDVVMK NLMNKTRAQQ EEFEARAASL
460 470 480 490 500
PEGYSASFDT TPKMKLDITK NGKEETIIVT DDDLAKTLED IPVCCLCGAE
510 520 530 540 550
LGVGIPDDFT GISQKDRGVS FEGLVSKYKF HCPYQTLARP SMLDRDLSKR
560 570 580 590 600
TFIASCGHAF CGRCFARIDN AKKKSKMPKK KLAQLKGSAH PDNYGPKLCP
610
ADSCKKLIRS RGRLKEVYF
Length:619
Mass (Da):71,071
Last modified:October 1, 1993 - v1
Checksum:i75846FEA93A65AE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07745 Genomic DNA Translation: AAA34671.1
Z48432 Genomic DNA Translation: CAA88346.1
Z74061 Genomic DNA Translation: CAA98570.1
BK006938 Genomic DNA Translation: DAA11836.1
PIRiS30780
RefSeqiNP_010271.3, NM_001180072.3

Genome annotation databases

EnsemblFungiiYDL013W; YDL013W; YDL013W
GeneIDi851549
KEGGisce:YDL013W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07745 Genomic DNA Translation: AAA34671.1
Z48432 Genomic DNA Translation: CAA88346.1
Z74061 Genomic DNA Translation: CAA98570.1
BK006938 Genomic DNA Translation: DAA11836.1
PIRiS30780
RefSeqiNP_010271.3, NM_001180072.3

3D structure databases

ProteinModelPortaliP32828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32041, 883 interactors
ComplexPortaliCPX-3179 Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex
DIPiDIP-727N
IntActiP32828, 28 interactors
MINTiP32828
STRINGi4932.YDL013W

PTM databases

iPTMnetiP32828

Proteomic databases

MaxQBiP32828
PaxDbiP32828
PRIDEiP32828
TopDownProteomicsiP32828

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL013W; YDL013W; YDL013W
GeneIDi851549
KEGGisce:YDL013W

Organism-specific databases

EuPathDBiFungiDB:YDL013W
SGDiS000002171 SLX5

Phylogenomic databases

HOGENOMiHOG000001024
InParanoidiP32828
KOiK22645
OMAiFHCPYQT
OrthoDBiEOG092C1L6A

Enzyme and pathway databases

UniPathwayi
UPA00143

BioCyciYEAST:G3O-29443-MONOMER

Miscellaneous databases

PROiPR:P32828

Family and domain databases

InterProiView protein in InterPro
IPR038886 E3_SLX5/Rfp1
PANTHERiPTHR28042 PTHR28042, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLX5_YEAST
AccessioniPrimary (citable) accession number: P32828
Secondary accession number(s): D6VRX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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