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Entry version 164 (12 Aug 2020)
Sequence version 2 (01 Oct 1996)
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Protein

Zinc finger protein FZF1

Gene

FZF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor.

Miscellaneous

Present with 2120 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30723-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein FZF1
Alternative name(s):
Sulfite resistance protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FZF1
Synonyms:SUL1
Ordered Locus Names:YGL254W
ORF Names:NCR299
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGL254W

Saccharomyces Genome Database

More...
SGDi
S000003223, FZF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000468051 – 299Zinc finger protein FZF1Add BLAST299

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32805

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32805

PRoteomics IDEntifications database

More...
PRIDEi
P32805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33025, 101 interactors

Database of interacting proteins

More...
DIPi
DIP-1324N

Protein interaction database and analysis system

More...
IntActi
P32805, 8 interactors

Molecular INTeraction database

More...
MINTi
P32805

STRING: functional protein association networks

More...
STRINGi
4932.YGL254W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32805, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32805

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 107Nuclear localization signalSequence analysisAdd BLAST12

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 179C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri246 – 271C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_068955_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32805

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTHAFIP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG
60 70 80 90 100
KKFIRPCHLR VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL
110 120 130 140 150
ASRIDRKHEG VNANVKAELN GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD
160 170 180 190 200
DMQVLQCPYK SCQKVTSFND DLINHMLQHH IASKLVVPSG DPSLKESLPT
210 220 230 240 250
SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE SYWSDNRCKH
260 270 280 290
SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY
Length:299
Mass (Da):33,994
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4E7257F012B32FF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA47998 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180H → D in CAA54996 (PubMed:7992510).Curated1
Sequence conflicti235T → W (PubMed:8322518).Curated1
Sequence conflicti246N → Y in CAA54996 (PubMed:7992510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti110G → E in strain: Sgu52E and Sgu52F. 1
Natural varianti120N → D in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti228V → I in strain: MMW1-15h2, MMW1-2h2, Sgu52E and Sgu52F. 1
Natural varianti238D → N in strain: MMW1-15h2 and MMW1-2h2. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67787 Genomic DNA Translation: CAA47998.1 Sequence problems.
X78104 Genomic DNA Translation: CAA54996.1
AY949902 Genomic DNA Translation: AAY27304.1
AY949903 Genomic DNA Translation: AAY27305.1
AY949905 Genomic DNA Translation: AAY27307.1
AY949906 Genomic DNA Translation: AAY27308.1
AY949908 Genomic DNA Translation: AAY27310.1
AY949909 Genomic DNA Translation: AAY27311.1
AY949910 Genomic DNA Translation: AAY27312.1
AY949911 Genomic DNA Translation: AAY27313.1
AY949912 Genomic DNA Translation: AAY27314.1
AY949913 Genomic DNA Translation: AAY27315.1
AY949914 Genomic DNA Translation: AAY27316.1
AY949915 Genomic DNA Translation: AAY27317.1
AY949916 Genomic DNA Translation: AAY27318.1
AY949917 Genomic DNA Translation: AAY27319.1
AY949918 Genomic DNA Translation: AAY27320.1
AY949919 Genomic DNA Translation: AAY27321.1
X94357 Genomic DNA Translation: CAA64133.1
Z72776 Genomic DNA Translation: CAA96974.1
BK006941 Genomic DNA Translation: DAA07865.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61607

NCBI Reference Sequences

More...
RefSeqi
NP_011260.1, NM_001181120.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL254W_mRNA; YGL254W; YGL254W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL254W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67787 Genomic DNA Translation: CAA47998.1 Sequence problems.
X78104 Genomic DNA Translation: CAA54996.1
AY949902 Genomic DNA Translation: AAY27304.1
AY949903 Genomic DNA Translation: AAY27305.1
AY949905 Genomic DNA Translation: AAY27307.1
AY949906 Genomic DNA Translation: AAY27308.1
AY949908 Genomic DNA Translation: AAY27310.1
AY949909 Genomic DNA Translation: AAY27311.1
AY949910 Genomic DNA Translation: AAY27312.1
AY949911 Genomic DNA Translation: AAY27313.1
AY949912 Genomic DNA Translation: AAY27314.1
AY949913 Genomic DNA Translation: AAY27315.1
AY949914 Genomic DNA Translation: AAY27316.1
AY949915 Genomic DNA Translation: AAY27317.1
AY949916 Genomic DNA Translation: AAY27318.1
AY949917 Genomic DNA Translation: AAY27319.1
AY949918 Genomic DNA Translation: AAY27320.1
AY949919 Genomic DNA Translation: AAY27321.1
X94357 Genomic DNA Translation: CAA64133.1
Z72776 Genomic DNA Translation: CAA96974.1
BK006941 Genomic DNA Translation: DAA07865.1
PIRiS61607
RefSeqiNP_011260.1, NM_001181120.1

3D structure databases

SMRiP32805
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33025, 101 interactors
DIPiDIP-1324N
IntActiP32805, 8 interactors
MINTiP32805
STRINGi4932.YGL254W

Proteomic databases

MaxQBiP32805
PaxDbiP32805
PRIDEiP32805

Genome annotation databases

EnsemblFungiiYGL254W_mRNA; YGL254W; YGL254W
GeneIDi852638
KEGGisce:YGL254W

Organism-specific databases

EuPathDBiFungiDB:YGL254W
SGDiS000003223, FZF1

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
HOGENOMiCLU_068955_0_0_1
InParanoidiP32805
OMAiHTHAFIP

Enzyme and pathway databases

BioCyciYEAST:G3O-30723-MONOMER
ReactomeiR-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32805
RNActiP32805, protein

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFZF1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32805
Secondary accession number(s): D6VV81
, Q2VQB9, Q2VQC2, Q2VQC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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