We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P32801 (ELM1_YEAST)
Protein
Serine/threonine-protein kinase ELM1
Gene
ELM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Important role in G1 events required for bud emergence and septin organization. Coordinates cell growth and cell division at G2/M, essential for efficient cytokinesis and for regulation of SWE1.
2 PublicationsMiscellaneous
Present with 149 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 117 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 259 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 94 – 102 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: SGD
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: SGD
- protein serine kinase activity Source: RHEA
GO - Biological processi
- budding cell bud growth Source: SGD
- cell morphogenesis Source: SGD
- cellular response to glucose starvation Source: SGD
- intracellular signal transduction Source: GO_Central
- mitotic cytokinesis Source: SGD
- positive regulation of protein autophosphorylation Source: SGD
- protein autophosphorylation Source: SGD
- protein localization to septin ring Source: SGD
- protein phosphorylation Source: SGD
- pseudohyphal growth Source: SGD
- response to xenobiotic stimulus Source: SGD
- septin ring assembly Source: SGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 984 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ELM1 Ordered Locus Names:YKL048C ORF Names:YKL261 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001531, ELM1 |
VEuPathDBi | FungiDB:YKL048C |
Subcellular locationi
Cytoskeleton
- cellular bud neck septin ring Source: SGD
Other locations
- cellular bud neck Source: SGD
- cytoplasm Source: GO_Central
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 200 | T → G: Allows selective inhibition in vivo. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085951 | 1 – 640 | Serine/threonine-protein kinase ELM1Add BLAST | 640 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 516 | PhosphoserineCombined sources | 1 | |
Modified residuei | 519 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P32801 |
PaxDbi | P32801 |
PRIDEi | P32801 |
PTM databases
iPTMneti | P32801 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34085, 801 interactors |
DIPi | DIP-2731N |
IntActi | P32801, 8 interactors |
MINTi | P32801 |
STRINGi | 4932.YKL048C |
Miscellaneous databases
RNActi | P32801, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 420 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 333 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 47 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 520 – 547 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 562 – 587 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 47 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 566 – 587 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0585, Eukaryota |
HOGENOMi | CLU_019325_0_0_1 |
InParanoidi | P32801 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P32801-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPRQLIPTL IPEWAPLSQQ SCIREDELDS PPITPTSQTS SFGSSFSQQK
60 70 80 90 100
PTYSTIIGEN IHTILDEIRP YVKKITVSDQ DKKTINQYTL GVSAGSGQFG
110 120 130 140 150
YVRKAYSSTL GKVVAVKIIP KKPWNAQQYS VNQVMRQIQL WKSKGKITTN
160 170 180 190 200
MSGNEAMRLM NIEKCRWEIF AASRLRNNVH IVRLIECLDS PFSESIWIVT
210 220 230 240 250
NWCSLGELQW KRDDDEDILP QWKKIVISNC SVSTFAKKIL EDMTKGLEYL
260 270 280 290 300
HSQGCIHRDI KPSNILLDEE EKVAKLSDFG SCIFTPQSLP FSDANFEDCF
310 320 330 340 350
QRELNKIVGT PAFIAPELCH LGNSKRDFVT DGFKLDIWSL GVTLYCLLYN
360 370 380 390 400
ELPFFGENEF ETYHKIIEVS LSSKINGNTL NDLVIKRLLE KDVTLRISIQ
410 420 430 440 450
DLVKVLSRDQ PIDSRNHSQI SSSSVNPVRN EGPVRRFFGR LLTKKGKKKT
460 470 480 490 500
SGKGKDKVLV SATSKVTPSI HIDEEPDKEC FSTTVLRSSP DSSDYCSSLG
510 520 530 540 550
EEAIQVTDFL DTFCRSNESL PNLTVNNDKQ NSDMKTDRSE SSSHSSLKIP
560 570 580 590 600
TPIKAMIRLK SSPKENGNRT HINCSQDKPS SPLMDRTVGK RTVNNSGARK
610 620 630 640
LAHSSNILNF KAYINSEDSD IRETVEDVKT YLNFADNGQI
Sequence cautioni
The sequence AAA02892 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 390 | E → Y in AAA02892 (PubMed:8395007).Curated | 1 | |
Sequence conflicti | 484 – 485 | TV → SD in AAA02892 (PubMed:8395007).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81258 Unassigned DNA Translation: AAA02892.1 Frameshift. X71621 Genomic DNA No translation available. Z28048 Genomic DNA Translation: CAA81883.1 BK006944 Genomic DNA Translation: DAA09109.1 |
PIRi | S37869 |
RefSeqi | NP_012876.1, NM_001179614.1 |
Genome annotation databases
EnsemblFungii | YKL048C_mRNA; YKL048C; YKL048C |
GeneIDi | 853818 |
KEGGi | sce:YKL048C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81258 Unassigned DNA Translation: AAA02892.1 Frameshift. X71621 Genomic DNA No translation available. Z28048 Genomic DNA Translation: CAA81883.1 BK006944 Genomic DNA Translation: DAA09109.1 |
PIRi | S37869 |
RefSeqi | NP_012876.1, NM_001179614.1 |
3D structure databases
SMRi | P32801 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34085, 801 interactors |
DIPi | DIP-2731N |
IntActi | P32801, 8 interactors |
MINTi | P32801 |
STRINGi | 4932.YKL048C |
PTM databases
iPTMneti | P32801 |
Proteomic databases
MaxQBi | P32801 |
PaxDbi | P32801 |
PRIDEi | P32801 |
Genome annotation databases
EnsemblFungii | YKL048C_mRNA; YKL048C; YKL048C |
GeneIDi | 853818 |
KEGGi | sce:YKL048C |
Organism-specific databases
SGDi | S000001531, ELM1 |
VEuPathDBi | FungiDB:YKL048C |
Phylogenomic databases
eggNOGi | KOG0585, Eukaryota |
HOGENOMi | CLU_019325_0_0_1 |
InParanoidi | P32801 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 984 |
Miscellaneous databases
PROi | PR:P32801 |
RNActi | P32801, protein |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ELM1_YEAST | |
Accessioni | P32801Primary (citable) accession number: P32801 Secondary accession number(s): D6VXN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families