Cell division control protein 13

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G-rich strand telomeric DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance."
    Mason M., Wanat J.J., Harper S., Schultz D.C., Speicher D.W., Johnson F.B., Skordalakes E.
    Structure 21:109-120(2013) [PubMed] [Europe PMC] [Abstract]
• single-stranded telomeric DNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA-binding interface of Cdc13p."
    Lin Y.C., Wu Lee Y.H., Lin J.J.
    Biochem. J. 403:289-295(2007) [PubMed] [Europe PMC] [Abstract]
  • "Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance."
    Nugent C.I., Hughes T.R., Lue N.F., Lundblad V.
    Science 274:249-252(1996) [PubMed] [Europe PMC] [Abstract]
  • "The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo."
    Lin J.J., Zakian V.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:13760-13765(1996) [PubMed] [Europe PMC] [Abstract]
• telomerase inhibitor activity Source: SGDInferred from direct assayⁱ
  • "Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p."
    Zappulla D.C., Roberts J.N., Goodrich K.J., Cech T.R., Wuttke D.S.
    Nucleic Acids Res. 37:354-367(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell cycle Source: UniProtKB-KW
• cell division Source: UniProtKB-KW
• negative regulation of telomerase activity Source: SGDInferred from direct assayⁱ
  • "Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p."
    Zappulla D.C., Roberts J.N., Goodrich K.J., Cech T.R., Wuttke D.S.
    Nucleic Acids Res. 37:354-367(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of telomere maintenance via telomerase Source: SGDInferred from direct assayⁱ
  • "Modulation of yeast telomerase activity by Cdc13 and Est1 in vitro."
    Chen Y.F., Lu C.Y., Lin Y.C., Yu T.Y., Chang C.P., Li J.R., Li H.W., Lin J.J.
    Sci Rep 6:34104-34104(2016) [PubMed] [Europe PMC] [Abstract]
• ribonucleoprotein complex localization Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase."
    Shen Z.J., Hsu P.H., Su Y.T., Yang C.W., Kao L., Tseng S.F., Tsai M.D., Teng S.C.
    Nat Commun 5:5312-5312(2014) [PubMed] [Europe PMC] [Abstract]
• telomere capping Source: SGDInferred from mutant phenotypeⁱ
  • Ref.1

    "Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint."
    Garvik B., Carson M., Hartwell L.
    Mol. Cell. Biol. 15:6128-6138(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• telomere maintenance Source: SGDInferred from mutant phenotypeⁱ
  • Ref.6

    "New function of CDC13 in positive telomere length regulation."
    Meier B., Driller L., Jaklin S., Feldmann H.M.
    Mol. Cell. Biol. 21:4233-4245(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH EST1.
• telomere maintenance via telomerase Source: SGDInferred from mutant phenotypeⁱ
  • "Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes."
    Lendvay T.S., Morris D.K., Sah J., Balasubramanian B., Lundblad V.
    Genetics 144:1399-1412(1996) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance."
    Mason M., Wanat J.J., Harper S., Schultz D.C., Speicher D.W., Johnson F.B., Skordalakes E.
    Structure 21:109-120(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDTLEEPECP PHKNRIFVSS SKDFEGYPSK AIVPVQFVAL LTSIHLTETK 
        60         70         80         90        100
CLLGFSNFER RGDQSQEDQY LIKLKFKDRG SERLARITIS LLCQYFDIEL 
       110        120        130        140        150
PDLDSDSGAS PTVILRDIHL ERLCFSSCKA LYVSKHGNYT LFLEDIKPLD 
       160        170        180        190        200
LVSVISTIST KSTNSSKHSS SELISECDLN NSLVDIFNNL IEMNRDEKNR 
       210        220        230        240        250
FKFVKLIHYD IELKKFVQDQ QKVLSQKSKA AAINPFFVPN RLGIPYIESQ 
       260        270        280        290        300
NEFNSQLMTL NVDEPTTDIS NMGEEMHDSA DPIEDSDSST TSSTGKYFSS 
       310        320        330        340        350
KSYIQSQTPE RKTSVPNNWH DDDSGSKRKR KLSFHSPNAS SIRKAISYEQ 
       360        370        380        390        400
LSLASVGSVE RLEGKIVGMN PPQFASINEF KYCTLKLYFT QLLPNVPDKV 
       410        420        430        440        450
LVPGVNCIEI VIPTRERICE LFGVLNCQSD KISDILLLEK PDRISVEVER 
       460        470        480        490        500
ILWDNDKTAS PGMAVWSLKN ISTDTQAQAQ VQVPAQSSAS IDPSRTRMSK 
       510        520        530        540        550
MARKDPTIEF CQLGLDTFET KYITMFGMLV SCSFDKPAFI SFVFSDFTKN 
       560        570        580        590        600
DIVQNYLYDR YLIDYENKLE LNEGFKAIMY KNQFETFDSK LRKIFNNGLR 
       610        620        630        640        650
DLQNGRDENL SQYGIVCKMN IKVKMYNGKL NAIVRECEPV PHSQISSIAS 
       660        670        680        690        700
PSQCEHLRLF YQRAFKRIGE SAISRYFEEY RRFFPIHRNG SHLAKLRFDE 
       710        720        730        740        750
VKHEPKKSPT TPALAEHIPD LNADVSSFDV KFTDISSLLD SSARLPRPQQ 
       760        770        780        790        800
THKSNTLYSC EGRIIAIEYH ASDLCFHITN ELPLLQTRGL APERVLQLHI 
       810        820        830        840        850
ITSKNFAYFF NRSSAYLQRQ PLEEKYTQLA QFLGHSFKFN ITSSLTLFPD 
       860        870        880        890        900
TTVALQIWCP IECTFRELQQ QLAHPKVAAA PDSGSLDCAI NATVNPLRLL 
       910        920 
AAQNGVTVKK EEDNDDDAGA VPTS                             

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
3. Yeast chromosome IV
   Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names