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Protein

Cell division control protein 13

Gene

CDC13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG1-3] strand lengthening via interaction with EST1. Promotes [C1-3A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.3 Publications

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi500 – 686OBAdd BLAST187

GO - Molecular functioni

  • G-rich strand telomeric DNA binding Source: GO_Central
  • identical protein binding Source: IntAct
  • single-stranded telomeric DNA binding Source: SGD
  • telomerase inhibitor activity Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of telomerase activity Source: SGD
  • regulation of telomere maintenance via telomerase Source: SGD
  • ribonucleoprotein complex localization Source: SGD
  • telomere capping Source: SGD
  • telomere maintenance Source: SGD
  • telomere maintenance via telomerase Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-29601-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 13
Gene namesi
Name:CDC13
Ordered Locus Names:YDL220C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL220C
SGDiS000002379 CDC13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi50K → Q: Increase in length of X' and Y' telomeres. Disrupts interaction with POL1 but not FUN12. 1 Publication1
Mutagenesisi72I → T: Disrupts interaction with POL1 and FUN12. 1 Publication1
Mutagenesisi124C → R: Disrupts interaction with POL1 but not FUN12. 1 Publication1
Mutagenesisi149L → S: Disrupts interaction with POL1 but not FUN12. 1 Publication1
Mutagenesisi228S → P: Disrupts interaction with POL1 but not FUN12. 1 Publication1
Mutagenesisi243G → R: Disrupts interaction with POL1 and FUN12. 1 Publication1
Mutagenesisi392L → P: Disrupts interaction with POL1 but not FUN12. 1 Publication1
Mutagenesisi523I → V: Increase in length of X' and Y' telomeres. Disrupts interaction with POL1 but not FUN12. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894411 – 924Cell division control protein 13Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei306PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Modified residuei333PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32797
PaxDbiP32797
PRIDEiP32797

PTM databases

iPTMnetiP32797

Interactioni

Subunit structurei

Interacts with POL1, EST1, FUN12, STM1, STN1 and TEN1.7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi31825, 783 interactors
ComplexPortaliCPX-15 CST complex
DIPiDIP-1229N
IntActiP32797, 28 interactors
MINTiP32797
STRINGi4932.YDL220C

Structurei

Secondary structure

1924
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 25Combined sources5
Beta strandi32 – 46Combined sources15
Beta strandi48 – 56Combined sources9
Beta strandi62 – 64Combined sources3
Beta strandi70 – 75Combined sources6
Helixi79 – 95Combined sources17
Beta strandi113 – 115Combined sources3
Helixi118 – 120Combined sources3
Beta strandi125 – 135Combined sources11
Beta strandi138 – 148Combined sources11
Helixi151 – 160Combined sources10
Helixi178 – 195Combined sources18
Beta strandi197 – 200Combined sources4
Helixi203 – 205Combined sources3
Helixi211 – 221Combined sources11
Helixi348 – 352Combined sources5
Beta strandi359 – 372Combined sources14
Helixi377 – 380Combined sources4
Beta strandi381 – 383Combined sources3
Beta strandi385 – 390Combined sources6
Beta strandi394 – 396Combined sources3
Turni403 – 405Combined sources3
Beta strandi406 – 412Combined sources7
Helixi415 – 422Combined sources8
Helixi424 – 426Combined sources3
Helixi429 – 436Combined sources8
Turni437 – 439Combined sources3
Beta strandi444 – 453Combined sources10
Beta strandi463 – 472Combined sources10
Turni510 – 512Combined sources3
Beta strandi521 – 525Combined sources5
Beta strandi531 – 533Combined sources3
Beta strandi539 – 544Combined sources6
Beta strandi565 – 567Combined sources3
Turni571 – 573Combined sources3
Beta strandi575 – 580Combined sources6
Helixi581 – 592Combined sources12
Beta strandi595 – 597Combined sources3
Helixi599 – 602Combined sources4
Beta strandi617 – 624Combined sources8
Beta strandi626 – 629Combined sources4
Beta strandi631 – 634Combined sources4
Beta strandi642 – 644Combined sources3
Helixi645 – 648Combined sources4
Helixi653 – 668Combined sources16
Helixi670 – 675Combined sources6
Helixi677 – 680Combined sources4

3D structure databases

ProteinModelPortaliP32797
SMRiP32797
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32797

Family & Domainsi

Phylogenomic databases

InParanoidiP32797
KOiK11115
OMAiERICELF
OrthoDBiEOG092C0UX4

Family and domain databases

InterProiView protein in InterPro
IPR031749 Cdc13_N
IPR012340 NA-bd_OB-fold
IPR028389 POT1
IPR011564 Telomer_end-bd_POT1/Cdc13
PANTHERiPTHR14513 PTHR14513, 1 hit
PfamiView protein in Pfam
PF16853 CDC13_N, 1 hit
PF02765 POT1, 1 hit
SMARTiView protein in SMART
SM00976 Telo_bind, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequencei

Sequence statusi: Complete.

P32797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLEEPECP PHKNRIFVSS SKDFEGYPSK AIVPVQFVAL LTSIHLTETK
60 70 80 90 100
CLLGFSNFER RGDQSQEDQY LIKLKFKDRG SERLARITIS LLCQYFDIEL
110 120 130 140 150
PDLDSDSGAS PTVILRDIHL ERLCFSSCKA LYVSKHGNYT LFLEDIKPLD
160 170 180 190 200
LVSVISTIST KSTNSSKHSS SELISECDLN NSLVDIFNNL IEMNRDEKNR
210 220 230 240 250
FKFVKLIHYD IELKKFVQDQ QKVLSQKSKA AAINPFFVPN RLGIPYIESQ
260 270 280 290 300
NEFNSQLMTL NVDEPTTDIS NMGEEMHDSA DPIEDSDSST TSSTGKYFSS
310 320 330 340 350
KSYIQSQTPE RKTSVPNNWH DDDSGSKRKR KLSFHSPNAS SIRKAISYEQ
360 370 380 390 400
LSLASVGSVE RLEGKIVGMN PPQFASINEF KYCTLKLYFT QLLPNVPDKV
410 420 430 440 450
LVPGVNCIEI VIPTRERICE LFGVLNCQSD KISDILLLEK PDRISVEVER
460 470 480 490 500
ILWDNDKTAS PGMAVWSLKN ISTDTQAQAQ VQVPAQSSAS IDPSRTRMSK
510 520 530 540 550
MARKDPTIEF CQLGLDTFET KYITMFGMLV SCSFDKPAFI SFVFSDFTKN
560 570 580 590 600
DIVQNYLYDR YLIDYENKLE LNEGFKAIMY KNQFETFDSK LRKIFNNGLR
610 620 630 640 650
DLQNGRDENL SQYGIVCKMN IKVKMYNGKL NAIVRECEPV PHSQISSIAS
660 670 680 690 700
PSQCEHLRLF YQRAFKRIGE SAISRYFEEY RRFFPIHRNG SHLAKLRFDE
710 720 730 740 750
VKHEPKKSPT TPALAEHIPD LNADVSSFDV KFTDISSLLD SSARLPRPQQ
760 770 780 790 800
THKSNTLYSC EGRIIAIEYH ASDLCFHITN ELPLLQTRGL APERVLQLHI
810 820 830 840 850
ITSKNFAYFF NRSSAYLQRQ PLEEKYTQLA QFLGHSFKFN ITSSLTLFPD
860 870 880 890 900
TTVALQIWCP IECTFRELQQ QLAHPKVAAA PDSGSLDCAI NATVNPLRLL
910 920
AAQNGVTVKK EEDNDDDAGA VPTS
Length:924
Mass (Da):104,904
Last modified:July 11, 2002 - v2
Checksum:i9FE0AD08520A6F8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40L → A in AAA99990 (PubMed:7565765).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76550 Genomic DNA Translation: AAA99990.1
Z74269 Genomic DNA Translation: CAA98800.1
BK006938 Genomic DNA Translation: DAA11644.1
PIRiS67783 S27421
RefSeqiNP_010061.1, NM_001180280.1

Genome annotation databases

EnsemblFungiiYDL220C; YDL220C; YDL220C
GeneIDi851306
KEGGisce:YDL220C

Similar proteinsi

Entry informationi

Entry nameiCDC13_YEAST
AccessioniPrimary (citable) accession number: P32797
Secondary accession number(s): D6VRD4, Q07650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 11, 2002
Last modified: July 18, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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