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Entry version 148 (08 May 2019)
Sequence version 4 (12 Dec 2006)
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Protein

Flocculation protein FLO1

Gene

FLO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca2+-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mannose binding Source: SGD

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28884-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flocculation protein FLO1
Short name:
Flocculin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLO1
Synonyms:FLO2, FLO4, FLO8
Ordered Locus Names:YAR050W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YAR050W

Saccharomyces Genome Database

More...
SGDi
S000000084 FLO1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

For many industrial applications in which the yeast S.cerevisiae is used, e.g. beer, wine and alcohol production, appropriate flocculation behavior is one of the most important characteristics of a good production strain. The ability of yeast cells to flocculate is of considerable importance, as it provides an effective, environment-friendly, simple and cost-free way to separate yeast cells from the fermentation product at the end of fermentation.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002127325 – 1514Flocculation protein FLO1Add BLAST1490
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000212741515 – 1537Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1114N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1514GPI-anchor amidated glycineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively N- and O-glycosylated.Curated
The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32768

PRoteomics IDEntifications database

More...
PRIDEi
P32768

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31813, 61 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YAR050W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32768

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 249PA14PROSITE-ProRule annotationAdd BLAST176
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati278 – 3221-1Add BLAST45
Repeati323 – 3671-2Add BLAST45
Repeati368 – 4121-3Add BLAST45
Repeati413 – 4571-4Add BLAST45
Repeati458 – 5021-5Add BLAST45
Repeati503 – 5471-6Add BLAST45
Repeati548 – 5921-7Add BLAST45
Repeati593 – 6371-8Add BLAST45
Repeati638 – 6821-9Add BLAST45
Repeati683 – 7271-10Add BLAST45
Repeati728 – 7721-11Add BLAST45
Repeati773 – 8171-12Add BLAST45
Repeati818 – 8621-13Add BLAST45
Repeati863 – 9071-14Add BLAST45
Repeati908 – 9521-15Add BLAST45
Repeati953 – 9971-16Add BLAST45
Repeati998 – 10421-17Add BLAST45
Repeati1043 – 10871-18Add BLAST45
Repeati1118 – 11372-1Add BLAST20
Repeati1138 – 11572-2Add BLAST20
Repeati1226 – 12763-1Add BLAST51
Repeati1291 – 13413-2Add BLAST51
Repeati1342 – 13923-3Add BLAST51
Repeati1408 – 14164-19
Repeati1417 – 14254-29
Repeati1426 – 14344-39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni197 – 240Sugar recognitionAdd BLAST44
Regioni278 – 108718 X 45 AA approximate tandem repeats, Thr-richAdd BLAST810
Regioni1118 – 11572 X 20 AA approximate tandem repeats, Ser/Thr-richAdd BLAST40
Regioni1226 – 13923 X 51 AA approximate repeats, Ser/Thr-richAdd BLAST167
Regioni1408 – 14343 X 9 AA approximate tandem repeats, Thr-richAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The number of the intragenic tandem repeats varies between different S.cerevisiae strains. There is a linear correlation between protein size and the extend of adhesion: the more repeats, the stronger the adhesion properties and the greater the fraction of flocculating cells. The Ser/Thr-rich repeats are also important for proper cell wall targeting of the protein.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flocculin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32768

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEMANAF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001389 Flocculin
IPR037524 PA14/GLEYA
IPR011658 PA14_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00624 Flocculin, 18 hits
PF07691 PA14, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00758 PA14, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51820 PA14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P32768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMPHRYMFL AVFTLLALTS VASGATEACL PAGQRKSGMN INFYQYSLKD
60 70 80 90 100
SSTYSNAAYM AYGYASKTKL GSVGGQTDIS IDYNIPCVSS SGTFPCPQED
110 120 130 140 150
SYGNWGCKGM GACSNSQGIA YWSTDLFGFY TTPTNVTLEM TGYFLPPQTG
160 170 180 190 200
SYTFKFATVD DSAILSVGGA TAFNCCAQQQ PPITSTNFTI DGIKPWGGSL
210 220 230 240 250
PPNIEGTVYM YAGYYYPMKV VYSNAVSWGT LPISVTLPDG TTVSDDFEGY
260 270 280 290 300
VYSFDDDLSQ SNCTVPDPSN YAVSTTTTTT EPWTGTFTST STEMTTVTGT
310 320 330 340 350
NGVPTDETVI VIRTPTTAST IITTTEPWNS TFTSTSTELT TVTGTNGVRT
360 370 380 390 400
DETIIVIRTP TTATTAITTT EPWNSTFTST STELTTVTGT NGLPTDETII
410 420 430 440 450
VIRTPTTATT AMTTTQPWND TFTSTSTELT TVTGTNGLPT DETIIVIRTP
460 470 480 490 500
TTATTAMTTT QPWNDTFTST STELTTVTGT NGLPTDETII VIRTPTTATT
510 520 530 540 550
AMTTTQPWND TFTSTSTEIT TVTGTNGLPT DETIIVIRTP TTATTAMTTP
560 570 580 590 600
QPWNDTFTST STEMTTVTGT NGLPTDETII VIRTPTTATT AITTTEPWNS
610 620 630 640 650
TFTSTSTEMT TVTGTNGLPT DETIIVIRTP TTATTAITTT QPWNDTFTST
660 670 680 690 700
STEMTTVTGT NGLPTDETII VIRTPTTATT AMTTTQPWND TFTSTSTEIT
710 720 730 740 750
TVTGTTGLPT DETIIVIRTP TTATTAMTTT QPWNDTFTST STEMTTVTGT
760 770 780 790 800
NGVPTDETVI VIRTPTSEGL ISTTTEPWTG TFTSTSTEMT TVTGTNGQPT
810 820 830 840 850
DETVIVIRTP TSEGLVTTTT EPWTGTFTST STEMTTITGT NGVPTDETVI
860 870 880 890 900
VIRTPTSEGL ISTTTEPWTG TFTSTSTEMT TITGTNGQPT DETVIVIRTP
910 920 930 940 950
TSEGLISTTT EPWTGTFTST STEMTHVTGT NGVPTDETVI VIRTPTSEGL
960 970 980 990 1000
ISTTTEPWTG TFTSTSTEVT TITGTNGQPT DETVIVIRTP TSEGLISTTT
1010 1020 1030 1040 1050
EPWTGTFTST STEMTTVTGT NGQPTDETVI VIRTPTSEGL VTTTTEPWTG
1060 1070 1080 1090 1100
TFTSTSTEMS TVTGTNGLPT DETVIVVKTP TTAISSSLSS SSSGQITSSI
1110 1120 1130 1140 1150
TSSRPIITPF YPSNGTSVIS SSVISSSVTS SLFTSSPVIS SSVISSSTTT
1160 1170 1180 1190 1200
STSIFSESSK SSVIPTSSST SGSSESETSS AGSVSSSSFI SSESSKSPTY
1210 1220 1230 1240 1250
SSSSLPLVTS ATTSQETASS LPPATTTKTS EQTTLVTVTS CESHVCTESI
1260 1270 1280 1290 1300
SPAIVSTATV TVSGVTTEYT TWCPISTTET TKQTKGTTEQ TTETTKQTTV
1310 1320 1330 1340 1350
VTISSCESDV CSKTASPAIV STSTATINGV TTEYTTWCPI STTESRQQTT
1360 1370 1380 1390 1400
LVTVTSCESG VCSETASPAI VSTATATVND VVTVYPTWRP QTANEESVSS
1410 1420 1430 1440 1450
KMNSATGETT TNTLAAETTT NTVAAETITN TGAAETKTVV TSSLSRSNHA
1460 1470 1480 1490 1500
ETQTASATDV IGHSSSVVSV SETGNTKSLT SSGLSTMSQQ PRSTPASSMV
1510 1520 1530
GYSTASLEIS TYAGSANSLL AGSGLSVFIA SLLLAII
Length:1,537
Mass (Da):160,668
Last modified:December 12, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7D4213C46ED23EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330S → G in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti349R → P in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti375S → G in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti384L → M in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti416 – 422QPWNDTF → HHGTTLL in AAX47297 (PubMed:16086015).Curated7
Sequence conflicti429L → M in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti429L → M in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti436N → K in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti464N → D in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti469S → P in AAX47297 (PubMed:16086015).Curated1
Sequence conflicti474L → M in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti519I → M in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti550P → T in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti609M → L in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti637I → M in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti699I → M in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti706T → N in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti926H → T in CAA55024 (PubMed:7483845).Curated1
Sequence conflicti926H → T in AAX47294 (PubMed:16086015).Curated1
Sequence conflicti926H → T in AAX47295 (PubMed:16086015).Curated1
Sequence conflicti926H → T in AAX47297 (PubMed:16086015).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti303 – 797Missing in strain: S288c / KV295. Add BLAST495
Natural varianti317 – 946Missing in strain: S288c / KV333. Add BLAST630
Natural varianti317 – 901Missing in strain: S288c / KV291. Add BLAST585

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X78160 Genomic DNA Translation: CAA55024.1
AY949845 Genomic DNA Translation: AAX47294.1
AY949846 Genomic DNA Translation: AAX47295.1
AY949847 Genomic DNA Translation: AAX47296.1
AY949848 Genomic DNA Translation: AAX47297.1
EF670005 Genomic DNA Translation: ABS87371.1
L28920 Genomic DNA Translation: AAC09499.1 Sequence problems.
BK006935 Genomic DNA Translation: DAA07007.1

Protein sequence database of the Protein Information Resource

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PIRi
S53465

NCBI Reference Sequences

More...
RefSeqi
NP_009424.1, NM_001178230.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YAR050W_mRNA; YAR050W_mRNA; YAR050W

Database of genes from NCBI RefSeq genomes

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GeneIDi
851289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAR050W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78160 Genomic DNA Translation: CAA55024.1
AY949845 Genomic DNA Translation: AAX47294.1
AY949846 Genomic DNA Translation: AAX47295.1
AY949847 Genomic DNA Translation: AAX47296.1
AY949848 Genomic DNA Translation: AAX47297.1
EF670005 Genomic DNA Translation: ABS87371.1
L28920 Genomic DNA Translation: AAC09499.1 Sequence problems.
BK006935 Genomic DNA Translation: DAA07007.1
PIRiS53465
RefSeqiNP_009424.1, NM_001178230.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LHLX-ray1.43A23-271[»]
4LHNX-ray2.12A23-271[»]
SMRiP32768
ModBaseiSearch...

Protein-protein interaction databases

BioGridi31813, 61 interactors
STRINGi4932.YAR050W

Proteomic databases

PaxDbiP32768
PRIDEiP32768

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAR050W_mRNA; YAR050W_mRNA; YAR050W
GeneIDi851289
KEGGisce:YAR050W

Organism-specific databases

EuPathDBiFungiDB:YAR050W
SGDiS000000084 FLO1

Phylogenomic databases

GeneTreeiENSGT00940000176342
InParanoidiP32768
OMAiCEMANAF

Enzyme and pathway databases

BioCyciYEAST:G3O-28884-MONOMER

Miscellaneous databases

Protein Ontology

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PROi
PR:P32768

Family and domain databases

InterProiView protein in InterPro
IPR001389 Flocculin
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
PfamiView protein in Pfam
PF00624 Flocculin, 18 hits
PF07691 PA14, 1 hit
SMARTiView protein in SMART
SM00758 PA14, 1 hit
PROSITEiView protein in PROSITE
PS51820 PA14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLO1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32768
Secondary accession number(s): A7U4Y7
, D6VPN7, Q58HH7, Q58HH8, Q58HH9, Q58HI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 12, 2006
Last modified: May 8, 2019
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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