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Protein

Cholinesterase

Gene

BCHE

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity).By similarity

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERimacmu-BCHE BCHE
MEROPSiS09.980

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
Pseudocholinesterase
Gene namesi
Name:BCHE
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000070286‹1 – ›141CholinesteraseAdd BLAST›141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei131PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Present in most cells except erythrocytes.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000004989

Structurei

3D structure databases

ProteinModelPortaliP32751
SMRiP32751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 50Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
HOGENOMiHOG000091866
HOVERGENiHBG106132
InParanoidiP32751

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P32751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NIDQSFPGFH GSEMWNPNTD LSEDCLYLNV WIPAPKPKNA TVLIWIYGGG
60 70 80 90 100
FQTGTSSLHV YDGKFLARVE RVIVVSMNYR VGALGFLALP GNPEAPGNMG
110 120 130 140
LFDQQLALQW VQKNIAAFGG NPKSVTLFGE SAGAASVSLH L
Length:141
Mass (Da):15,224
Last modified:October 1, 1993 - v1
Checksum:iA3C1135E1650D636
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62777 Genomic DNA Translation: AAA36836.1
PIRiG39768
UniGeneiMmu.29085

Similar proteinsi

Entry informationi

Entry nameiCHLE_MACMU
AccessioniPrimary (citable) accession number: P32751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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