nusA

Functionⁱ

Participates in both transcription termination and antitermination.UniRule annotation

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: InterPro
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA-templated transcription, termination Source: UniProtKB-KW
transcription antitermination Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Transcription, Transcription antitermination, Transcription regulation, Transcription termination

Enzyme and pathway databases

BioCycⁱ	BSUB:BSU16600-MONOMER

BioCycⁱ

BSUB:BSU16600-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription termination/antitermination protein NusAUniRule annotation
Gene namesⁱ	Name:nusAUniRule annotation Ordered Locus Names:BSU16600
Organismⁱ	Bacillus subtilis (strain 168)
Taxonomic identifierⁱ	224308 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis
Proteomesⁱ	UP000001570 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00945

GO - Cellular componentⁱ

cytosol Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181960	1 – 371	Transcription termination/antitermination protein NusAAdd BLAST		371

Proteomic databases

PaxDbⁱ	P32727
PRIDEⁱ	P32727

Interactionⁱ

Subunit structureⁱ

Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.UniRule annotation

Protein-protein interaction databases

IntActⁱ	P32727, 1 interactor
Molecular INTeraction database More...MINTⁱ	P32727
STRINGⁱ	224308.Bsubs1_010100009146

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 13	Combined sources	10
Helixⁱ	20 – 36	Combined sources	17
Turnⁱ	40 – 42	Combined sources	3
Beta strandⁱ	46 – 50	Combined sources	5
Turnⁱ	51 – 54	Combined sources	4
Beta strandⁱ	55 – 67	Combined sources	13
Helixⁱ	77 – 81	Combined sources	5
Beta strandⁱ	92 – 96	Combined sources	5
Helixⁱ	102 – 123	Combined sources	22

3D structure databases

ProteinModelPortalⁱ	P32727
SMRⁱ	P32727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	135 – 199	S1 motifUniRule annotationAdd BLAST		65
Domainⁱ	301 – 367	KHUniRule annotationAdd BLAST		67

Sequence similaritiesⁱ

Belongs to the NusA family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CHV Bacteria COG0195 LUCA
HOGENOMⁱ	HOG000006395
InParanoidⁱ	P32727
KEGG Orthology (KO) More...KOⁱ	K02600
OMAⁱ	SRTTPKM
PhylomeDBⁱ	P32727

Family and domain databases

Gene3Dⁱ	3.30.1480.10, 1 hit 3.30.300.20, 2 hits
HAMAPⁱ	MF_00945_B NusA_B, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR015946 KH_dom-like_a/b IPR025249 KH_dom_NusA-like IPR009019 KH_sf_prok-type IPR012340 NA-bd_OB-fold IPR030842 NusA_bac IPR036555 NusA_N_sf IPR022967 S1_dom IPR003029 S1_domain IPR013735 TF_NusA_N IPR010213 Tscrpt_termination_fac_NusA
PANTHERⁱ	PTHR22648 PTHR22648, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13184 KH_5, 1 hit PF08529 NusA_N, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits SM00316 S1, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF54814 SSF54814, 2 hits SSF69705 SSF69705, 1 hit
TIGRFAMsⁱ	TIGR01953 NusA, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit PS50126 S1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P32727-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSELLDALT ILEKEKGISK EIIIEAIEAA LISAYKRNFN QAQNVRVDLN 
        60         70         80         90        100
RETGSIRVFA RKDVVDEVYD QRLEISIEEA QGIHPEYMVG DVVEIEVTPK 
       110        120        130        140        150
DFGRIAAQTA KQVVTQRVRE AERGVIYSEF IDREEDIMTG IVQRLDNKFI 
       160        170        180        190        200
YVSLGKIEAL LPVNEQMPNE SYKPHDRIKV YITKVEKTTK GPQIYVSRTH 
       210        220        230        240        250
PGLLKRLFEI EVPEIYDGTV ELKSVAREAG DRSKISVRTD DPDVDPVGSC 
       260        270        280        290        300
VGPKGQRVQA IVNELKGEKI DIVNWSSDPV EFVANALSPS KVLDVIVNEE 
       310        320        330        340        350
EKATTVIVPD YQLSLAIGKR GQNARLAAKL TGWKIDIKSE TDARELGIYP 
       360        370 
RELEEDDEPL FTEPETAESD E

Length:371

Mass (Da):41,725

Last modified:May 30, 2000 - v2

Checksum:ⁱ2FC7861E4C3094D3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	111 – 112	KQ → NE in CAA79231 (PubMed:8491709).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z18631 Genomic DNA Translation: CAA79231.1 AL009126 Genomic DNA Translation: CAB13533.1
PIRⁱ	C36905
NCBI Reference Sequences More...RefSeqⁱ	NP_389542.1, NC_000964.3 WP_003231912.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaⁱ	CAB13533; CAB13533; BSU16600
GeneIDⁱ	939628
KEGGⁱ	bsu:BSU16600
PATRICⁱ	fig\|224308.179.peg.1801

Protein	Similar proteins		Species	Score	Length
P32727	Transcription termination/antitermination protein NusA		BACIU		371
Transcription termination/antitermination protein NusA		Bacillus subtilis XF-1		371
Transcription termination/antitermination protein NusA		Bacillus sp. EGD-AK10		371
Transcription termination/antitermination protein NusA		Bacillus sp. FMQ74		371
Transcription termination/antitermination protein NusA		BACNB		371
+9

Protein	Similar proteins		Species	Score	Length
P32727	Transcription termination/antitermination protein NusA		BACIU		371
Transcription termination/antitermination protein NusA		Bacillus subtilis XF-1		371
Transcription termination/antitermination protein NusA		Bacillus sp. EGD-AK10		371
Transcription termination/antitermination protein NusA		Bacillus sp. FMQ74		371
Transcription termination/antitermination protein NusA		BACNB		371
+118

Protein	Similar proteins		Species	Score	Length
P32727	Transcription termination/antitermination protein NusA		BACIU		371
Transcription termination/antitermination protein NusA		Bacillus subtilis XF-1		371
Transcription termination/antitermination protein NusA		Bacillus sp. EGD-AK10		371
Transcription termination/antitermination protein NusA		Bacillus sp. FMQ74		371
Transcription termination/antitermination protein NusA		BACNB		371
+338

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z18631 Genomic DNA Translation: CAA79231.1 AL009126 Genomic DNA Translation: CAB13533.1
PIRⁱ	C36905
NCBI Reference Sequences More...RefSeqⁱ	NP_389542.1, NC_000964.3 WP_003231912.1, NZ_JNCM01000035.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MT4	NMR	-	A	1-124	[»]
ProteinModelPortalⁱ	P32727
SMRⁱ	P32727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P32727, 1 interactor
Molecular INTeraction database More...MINTⁱ	P32727
STRINGⁱ	224308.Bsubs1_010100009146

Proteomic databases

PaxDbⁱ	P32727
PRIDEⁱ	P32727

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAB13533; CAB13533; BSU16600
GeneIDⁱ	939628
KEGGⁱ	bsu:BSU16600
PATRICⁱ	fig\|224308.179.peg.1801

Phylogenomic databases

eggNOGⁱ	ENOG4105CHV Bacteria COG0195 LUCA
HOGENOMⁱ	HOG000006395
InParanoidⁱ	P32727
KEGG Orthology (KO) More...KOⁱ	K02600
OMAⁱ	SRTTPKM
PhylomeDBⁱ	P32727

Enzyme and pathway databases

BioCycⁱ	BSUB:BSU16600-MONOMER

BioCycⁱ

BSUB:BSU16600-MONOMER

Family and domain databases

Gene3Dⁱ	3.30.1480.10, 1 hit 3.30.300.20, 2 hits
HAMAPⁱ	MF_00945_B NusA_B, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR015946 KH_dom-like_a/b IPR025249 KH_dom_NusA-like IPR009019 KH_sf_prok-type IPR012340 NA-bd_OB-fold IPR030842 NusA_bac IPR036555 NusA_N_sf IPR022967 S1_dom IPR003029 S1_domain IPR013735 TF_NusA_N IPR010213 Tscrpt_termination_fac_NusA
PANTHERⁱ	PTHR22648 PTHR22648, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13184 KH_5, 1 hit PF08529 NusA_N, 1 hit PF00575 S1, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits SM00316 S1, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF54814 SSF54814, 2 hits SSF69705 SSF69705, 1 hit
TIGRFAMsⁱ	TIGR01953 NusA, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit PS50126 S1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUSA_BACSU
Accessionⁱ	P32727Primary (citable) accession number: P32727 Secondary accession number(s): O31756
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	May 30, 2000
	Last modified:	July 18, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Bacillus subtilis
Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniRef

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Supporting data

UniProtKB - P32727 (NUSA_BACSU)

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Transcription termination/antitermination protein NusA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ