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UniProtKB - P32701 (PDEC_ECOLI)
Protein
Probable cyclic di-GMP phosphodiesterase PdeC
Gene
pdeC
Organism
Escherichia coli (strain K12)
Status
Functioni
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity).
Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation (PubMed:19460094).
By similarity1 PublicationCatalytic activityi
- EC:3.1.4.52By similarity
GO - Molecular functioni
- cyclic-guanylate-specific phosphodiesterase activity Source: EcoCyc
Keywordsi
Molecular function | Hydrolase |
Ligand | c-di-GMP |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11938-MONOMER |
BRENDAi | 3.1.4.52, 2026 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pdeC1 Publication Synonyms:yjcC Ordered Locus Names:b4061, JW4022 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169719 | 1 – 528 | Probable cyclic di-GMP phosphodiesterase PdeCAdd BLAST | 528 |
Proteomic databases
PaxDbi | P32701 |
PRIDEi | P32701 |
Expressioni
Inductioni
Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260840, 7 interactors |
DIPi | DIP-12548N |
IntActi | P32701, 6 interactors |
STRINGi | 511145.b4061 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 268 – 520 | EALPROSITE-ProRule annotationAdd BLAST | 253 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4943, Bacteria |
HOGENOMi | CLU_000445_131_1_6 |
InParanoidi | P32701 |
OMAi | RLIAHFY |
PhylomeDBi | P32701 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
i Sequence
Sequence statusi: Complete.
P32701-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHRARHQLL ALPGIIFLVL FPIILSLWIA FLWAKSEVNN QLRTFAQLAL
60 70 80 90 100
DKSELVIRQA DLVSDAAERY QGQVCTPAHQ KRMLNIIRGY LYINELIYAR
110 120 130 140 150
DNHFLCSSLI APVNGYTIAP ADYKREPNVS IYYYRDTPFF SGYKMTYMQR
160 170 180 190 200
GNYVAVINPL FWSEVMSDDP TLQWGVYDTV TKTFFSLSKE ASAATFSPLI
210 220 230 240 250
HLKDLTVQRN GYLYATVYST KRPIAAIVAT SYQRLITHFY NHLIFALPAG
260 270 280 290 300
ILGSLVLLLL WLRIRQNYLS PKRKLQRALE KHQLCLYYQP IIDIKTEKCI
310 320 330 340 350
GAEALLRWPG EQGQIMNPAE FIPLAEKEGM IEQITDYVID NVFRDLGDYL
360 370 380 390 400
ATHADRYVSI NLSASDFHTS RLIARINQKT EQYAVRPQQI KFEVTEHAFL
410 420 430 440 450
DVDKMTPIIL AFRQAGYEVA IDDFGIGYSN LHNLKSLNVD ILKIDKSFVE
460 470 480 490 500
TLTTHKTSHL IAEHIIELAH SLGLKTIAEG VETEEQVNWL RKRGVRYCQG
510 520
WFFAKAMPPQ VFMQWMEQLP ARELTRGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00006 Genomic DNA Translation: AAC43155.1 U00096 Genomic DNA Translation: AAC77031.1 AP009048 Genomic DNA Translation: BAE78063.1 |
PIRi | D65214 |
RefSeqi | NP_418485.1, NC_000913.3 WP_000019548.1, NZ_SSZK01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC77031; AAC77031; b4061 BAE78063; BAE78063; BAE78063 |
GeneIDi | 948568 |
KEGGi | ecj:JW4022 eco:b4061 |
PATRICi | fig|511145.12.peg.4182 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00006 Genomic DNA Translation: AAC43155.1 U00096 Genomic DNA Translation: AAC77031.1 AP009048 Genomic DNA Translation: BAE78063.1 |
PIRi | D65214 |
RefSeqi | NP_418485.1, NC_000913.3 WP_000019548.1, NZ_SSZK01000016.1 |
3D structure databases
AlphaFoldDBi | P32701 |
SMRi | P32701 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260840, 7 interactors |
DIPi | DIP-12548N |
IntActi | P32701, 6 interactors |
STRINGi | 511145.b4061 |
Proteomic databases
PaxDbi | P32701 |
PRIDEi | P32701 |
Genome annotation databases
EnsemblBacteriai | AAC77031; AAC77031; b4061 BAE78063; BAE78063; BAE78063 |
GeneIDi | 948568 |
KEGGi | ecj:JW4022 eco:b4061 |
PATRICi | fig|511145.12.peg.4182 |
Organism-specific databases
EchoBASEi | EB1882 |
Phylogenomic databases
eggNOGi | COG4943, Bacteria |
HOGENOMi | CLU_000445_131_1_6 |
InParanoidi | P32701 |
OMAi | RLIAHFY |
PhylomeDBi | P32701 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11938-MONOMER |
BRENDAi | 3.1.4.52, 2026 |
Miscellaneous databases
PROi | PR:P32701 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDEC_ECOLI | |
Accessioni | P32701Primary (citable) accession number: P32701 Secondary accession number(s): P76789, Q2M6P3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |