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Protein

Probable cyclic di-GMP phosphodiesterase PdeC

Gene

pdeC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation (PubMed:19460094).By similarity1 Publication

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.By similarity

GO - Molecular functioni

  • cyclic-guanylate-specific phosphodiesterase activity Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Ligandc-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:EG11938-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic di-GMP phosphodiesterase PdeCCurated (EC:3.1.4.52By similarity)
Gene namesi
Name:pdeC1 Publication
Synonyms:yjcC
Ordered Locus Names:b4061, JW4022
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11938 yjcC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697191 – 528Probable cyclic di-GMP phosphodiesterase PdeCAdd BLAST528

Proteomic databases

PaxDbiP32701
PRIDEiP32701

Expressioni

Inductioni

Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260840, 7 interactors
DIPiDIP-12548N
IntActiP32701, 6 interactors
STRINGi316407.85676813

Structurei

3D structure databases

ProteinModelPortaliP32701
SMRiP32701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 520EALPROSITE-ProRule annotationAdd BLAST253

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108M8H Bacteria
COG4943 LUCA
HOGENOMiHOG000117610
InParanoidiP32701
OMAiRLIAHFY

Family and domain databases

CDDicd01948 EAL, 1 hit
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR024744 CSS-motif_dom
IPR001633 EAL_dom
IPR035919 EAL_sf
PfamiView protein in Pfam
PF12792 CSS-motif, 1 hit
PF00563 EAL, 1 hit
SMARTiView protein in SMART
SM00052 EAL, 1 hit
SUPFAMiSSF141868 SSF141868, 1 hit
PROSITEiView protein in PROSITE
PS50883 EAL, 1 hit

Sequencei

Sequence statusi: Complete.

P32701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRARHQLL ALPGIIFLVL FPIILSLWIA FLWAKSEVNN QLRTFAQLAL
60 70 80 90 100
DKSELVIRQA DLVSDAAERY QGQVCTPAHQ KRMLNIIRGY LYINELIYAR
110 120 130 140 150
DNHFLCSSLI APVNGYTIAP ADYKREPNVS IYYYRDTPFF SGYKMTYMQR
160 170 180 190 200
GNYVAVINPL FWSEVMSDDP TLQWGVYDTV TKTFFSLSKE ASAATFSPLI
210 220 230 240 250
HLKDLTVQRN GYLYATVYST KRPIAAIVAT SYQRLITHFY NHLIFALPAG
260 270 280 290 300
ILGSLVLLLL WLRIRQNYLS PKRKLQRALE KHQLCLYYQP IIDIKTEKCI
310 320 330 340 350
GAEALLRWPG EQGQIMNPAE FIPLAEKEGM IEQITDYVID NVFRDLGDYL
360 370 380 390 400
ATHADRYVSI NLSASDFHTS RLIARINQKT EQYAVRPQQI KFEVTEHAFL
410 420 430 440 450
DVDKMTPIIL AFRQAGYEVA IDDFGIGYSN LHNLKSLNVD ILKIDKSFVE
460 470 480 490 500
TLTTHKTSHL IAEHIIELAH SLGLKTIAEG VETEEQVNWL RKRGVRYCQG
510 520
WFFAKAMPPQ VFMQWMEQLP ARELTRGQ
Length:528
Mass (Da):60,801
Last modified:November 1, 1997 - v2
Checksum:iF6E4819954912F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA Translation: AAC43155.1
U00096 Genomic DNA Translation: AAC77031.1
AP009048 Genomic DNA Translation: BAE78063.1
PIRiD65214
RefSeqiNP_418485.1, NC_000913.3
WP_000019548.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77031; AAC77031; b4061
BAE78063; BAE78063; BAE78063
GeneIDi948568
KEGGiecj:JW4022
eco:b4061
PATRICifig|511145.12.peg.4182

Similar proteinsi

Entry informationi

Entry nameiPDEC_ECOLI
AccessioniPrimary (citable) accession number: P32701
Secondary accession number(s): P76789, Q2M6P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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