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Entry version 186 (17 Jun 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Pre-mRNA-splicing helicase BRR2

Gene

BRR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.4 Publications

Miscellaneous

Present with 1440 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi521 – 528ATPPROSITE-ProRule annotation8
Nucleotide bindingi1370 – 1377ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30332-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing helicase BRR2 (EC:3.6.4.13)
Alternative name(s):
Protein Snu246
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRR2
Synonyms:RSS1, SNU246
Ordered Locus Names:YER172C
ORF Names:SYGP-ORF66
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YER172C

Saccharomyces Genome Database

More...
SGDi
S000000974 BRR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi858G → R: Reduces spliceosomal pre-mRNA splicing. 1 Publication1
Mutagenesisi938W → Q: Strongly reduced unwinding of U4/U6 snRNA. 1 Publication1
Mutagenesisi1107R → A: Reduced ATP-dependent RNA helicase activity. 1 Publication1
Mutagenesisi1110R → N: Abolishes unwinding of U4/U6 snRNA. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001020861 – 2163Pre-mRNA-splicing helicase BRR2Add BLAST2163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei403PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32639

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P32639

PRoteomics IDEntifications database

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PRIDEi
P32639

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32639

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1. Interaction with PRP8 is important for recruitment to the U4/U6-U5 tri-snRNP complex. Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36925, 569 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1651 PRP19-associated complex
CPX-25 U4/U6.U5 tri-snRNP complex
CPX-29 U5 snRNP

Database of interacting proteins

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DIPi
DIP-850N

Protein interaction database and analysis system

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IntActi
P32639, 71 interactors

Molecular INTeraction database

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MINTi
P32639

STRING: functional protein association networks

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STRINGi
4932.YER172C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P32639 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P32639

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P32639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini508 – 692Helicase ATP-binding 1PROSITE-ProRule annotationAdd BLAST185
Domaini718 – 921Helicase C-terminalPROSITE-ProRule annotationAdd BLAST204
Domaini998 – 1308SEC63 1Add BLAST311
Domaini1357 – 1533Helicase ATP-binding 2PROSITE-ProRule annotationAdd BLAST177
Domaini1846 – 2160SEC63 2Add BLAST315

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi634 – 637DEIH box4
Motifi1474 – 1477DDAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1570 – 1575Poly-Ala6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two helicase domains. The N-terminal helicase domain has catalytic activity by itself, contrary to the C-terminal helicase domain that may have a regulatory role and enhance the activity of the first helicase domain.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000174511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000335_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P32639

KEGG Orthology (KO)

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KOi
K12854

Identification of Orthologs from Complete Genome Data

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OMAi
KKMENWW

Family and domain databases

Database of protein disorder

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DisProti
DP01330

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041094 Brr2_helicase_PWI
IPR035892 C2_domain_sf
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014756 Ig_E-set
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 2 hits
PF00271 Helicase_C, 1 hit
PF18149 Helicase_PWI, 1 hit
PF02889 Sec63, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487 DEXDc, 2 hits
SM00490 HELICc, 1 hit
SM00973 Sec63, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 2 hits
SSF52540 SSF52540, 3 hits
SSF81296 SSF81296, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 2 hits
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEHETKDKA KKIREIYRYD EMSNKVLKVD KRFMNTSQNP QRDAEISQPK
60 70 80 90 100
SMSGRISAKD MGQGLCNNIN KGLKENDVAV EKTGKSASLK KIQQHNTILN
110 120 130 140 150
SSSDFRLHYY PKDPSNVETY EQILQWVTEV LGNDIPHDLI IGTADIFIRQ
160 170 180 190 200
LKENEENEDG NIEERKEKIQ HELGINIDSL KFNELVKLMK NITDYETHPD
210 220 230 240 250
NSNKQAVAIL ADDEKSDEEE VTEMSNNANV LGGEINDNED DDEEYDYNDV
260 270 280 290 300
EVNSKKKNKR ALPNIENDII KLSDSKTSNI ESVPIYSIDE FFLQRKLRSE
310 320 330 340 350
LGYKDTSVIQ DLSEKILNDI ETLEHNPVAL EQKLVDLLKF ENISLAEFIL
360 370 380 390 400
KNRSTIFWGI RLAKSTENEI PNLIEKMVAK GLNDLVEQYK FRETTHSKRE
410 420 430 440 450
LDSGDDQPQS SEAKRTKFSN PAIPPVIDLE KIKFDESSKL MTVTKVSLPE
460 470 480 490 500
GSFKRVKPQY DEIHIPAPSK PVIDYELKEI TSLPDWCQEA FPSSETTSLN
510 520 530 540 550
PIQSKVFHAA FEGDSNMLIC APTGSGKTNI ALLTVLKALS HHYNPKTKKL
560 570 580 590 600
NLSAFKIVYI APLKALVQEQ VREFQRRLAF LGIKVAELTG DSRLSRKQID
610 620 630 640 650
ETQVLVSTPE KWDITTRNSN NLAIVELVRL LIIDEIHLLH DDRGPVLESI
660 670 680 690 700
VARTFWASKY GQEYPRIIGL SATLPNYEDV GRFLRVPKEG LFYFDSSFRP
710 720 730 740 750
CPLSQQFCGI KERNSLKKLK AMNDACYEKV LESINEGNQI IVFVHSRKET
760 770 780 790 800
SRTATWLKNK FAEENITHKL TKNDAGSKQI LKTEAANVLD PSLRKLIESG
810 820 830 840 850
IGTHHAGLTR SDRSLSEDLF ADGLLQVLVC TATLAWGVNL PAHTVIIKGT
860 870 880 890 900
DVYSPEKGSW EQLSPQDVLQ MLGRAGRPRY DTFGEGIIIT DQSNVQYYLS
910 920 930 940 950
VLNQQLPIES QFVSKLVDNL NAEVVAGNIK CRNDAVNWLA YTYLYVRMLA
960 970 980 990 1000
SPMLYKVPDI SSDGQLKKFR ESLVHSALCI LKEQELVLYD AENDVIEATD
1010 1020 1030 1040 1050
LGNIASSFYI NHASMDVYNR ELDEHTTQID LFRIFSMSEE FKYVSVRYEE
1060 1070 1080 1090 1100
KRELKQLLEK APIPIREDID DPLAKVNVLL QSYFSQLKFE GFALNSDIVF
1110 1120 1130 1140 1150
IHQNAGRLLR AMFEICLKRG WGHPTRMLLN LCKSATTKMW PTNCPLRQFK
1160 1170 1180 1190 1200
TCPVEVIKRL EASTVPWGDY LQLETPAEVG RAIRSEKYGK QVYDLLKRFP
1210 1220 1230 1240 1250
KMSVTCNAQP ITRSVMRFNI EIIADWIWDM NVHGSLEPFL LMLEDTDGDS
1260 1270 1280 1290 1300
ILYYDVLFIT PDIVGHEFTL SFTYELKQHN QNNLPPNFFL TLISENWWHS
1310 1320 1330 1340 1350
EFEIPVSFNG FKLPKKFPPP TPLLENISIS TSELGNDDFS EVFEFKTFNK
1360 1370 1380 1390 1400
IQSQVFESLY NSNDSVFVGS GKGTGKTAMA ELALLNHWRQ NKGRAVYINP
1410 1420 1430 1440 1450
SGEKIDFLLS DWNKRFSHLA GGKIINKLGN DPSLNLKLLA KSHVLLATPV
1460 1470 1480 1490 1500
QFELLSRRWR QRKNIQSLEL MIYDDAHEIS QGVYGAVYET LISRMIFIAT
1510 1520 1530 1540 1550
QLEKKIRFVC LSNCLANARD FGEWAGMTKS NIYNFSPSER IEPLEINIQS
1560 1570 1580 1590 1600
FKDVEHISFN FSMLQMAFEA SAAAAGNRNS SSVFLPSRKD CMEVASAFMK
1610 1620 1630 1640 1650
FSKAIEWDML NVEEEQIVPY IEKLTDGHLR APLKHGVGIL YKGMASNDER
1660 1670 1680 1690 1700
IVKRLYEYGA VSVLLISKDC SAFACKTDEV IILGTNLYDG AEHKYMPYTI
1710 1720 1730 1740 1750
NELLEMVGLA SGNDSMAGKV LILTSHNMKA YYKKFLIEPL PTESYLQYII
1760 1770 1780 1790 1800
HDTLNNEIAN SIIQSKQDCV DWFTYSYFYR RIHVNPSYYG VRDTSPHGIS
1810 1820 1830 1840 1850
VFLSNLVETC LNDLVESSFI EIDDTEAEVT AEVNGGDDEA TEIISTLSNG
1860 1870 1880 1890 1900
LIASHYGVSF FTIQSFVSSL SNTSTLKNML YVLSTAVEFE SVPLRKGDRA
1910 1920 1930 1940 1950
LLVKLSKRLP LRFPEHTSSG SVSFKVFLLL QAYFSRLELP VDFQNDLKDI
1960 1970 1980 1990 2000
LEKVVPLINV VVDILSANGY LNATTAMDLA QMLIQGVWDV DNPLRQIPHF
2010 2020 2030 2040 2050
NNKILEKCKE INVETVYDIM ALEDEERDEI LTLTDSQLAQ VAAFVNNYPN
2060 2070 2080 2090 2100
VELTYSLNNS DSLISGVKQK ITIQLTRDVE PENLQVTSEK YPFDKLESWW
2110 2120 2130 2140 2150
LVLGEVSKKE LYAIKKVTLN KETQQYELEF DTPTSGKHNL TIWCVCDSYL
2160
DADKELSFEI NVK
Length:2,163
Mass (Da):246,185
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFAF7E3B7168D944
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18922 Genomic DNA Translation: AAB64699.1
BK006939 Genomic DNA Translation: DAA07834.1

Protein sequence database of the Protein Information Resource

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PIRi
S50675

NCBI Reference Sequences

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RefSeqi
NP_011099.1, NM_001179062.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YER172C_mRNA; YER172C; YER172C

Database of genes from NCBI RefSeq genomes

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GeneIDi
856919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YER172C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18922 Genomic DNA Translation: AAB64699.1
BK006939 Genomic DNA Translation: DAA07834.1
PIRiS50675
RefSeqiNP_011099.1, NM_001179062.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HIBX-ray2.00A1851-2163[»]
3IM1X-ray1.65A1839-2163[»]
3IM2X-ray1.99A1839-2163[»]
3JCMelectron microscopy3.80N1-2163[»]
4BGDX-ray3.10A442-2163[»]
5DCAX-ray2.80A113-2163[»]
5GANelectron microscopy3.60B1-2163[»]
5GAOelectron microscopy3.60B1-2163[»]
5GAPelectron microscopy3.60B1-2163[»]
5GM6electron microscopy3.50B1-2163[»]
5LJ5electron microscopy3.80B1-2163[»]
5LQWelectron microscopy5.80C1-2163[»]
5M52X-ray3.40A/B1-2163[»]
5M5PX-ray4.20A/C271-2163[»]
5NRLelectron microscopy7.20B1-2163[»]
5ZWMelectron microscopy3.40D1-2163[»]
5ZWOelectron microscopy3.90D1-2163[»]
SMRiP32639
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36925, 569 interactors
ComplexPortaliCPX-1651 PRP19-associated complex
CPX-25 U4/U6.U5 tri-snRNP complex
CPX-29 U5 snRNP
DIPiDIP-850N
IntActiP32639, 71 interactors
MINTiP32639
STRINGi4932.YER172C

PTM databases

iPTMnetiP32639

Proteomic databases

MaxQBiP32639
PaxDbiP32639
PRIDEiP32639

Genome annotation databases

EnsemblFungiiYER172C_mRNA; YER172C; YER172C
GeneIDi856919
KEGGisce:YER172C

Organism-specific databases

EuPathDBiFungiDB:YER172C
SGDiS000000974 BRR2

Phylogenomic databases

GeneTreeiENSGT00940000174511
HOGENOMiCLU_000335_1_0_1
InParanoidiP32639
KOiK12854
OMAiKKMENWW

Enzyme and pathway databases

BioCyciYEAST:G3O-30332-MONOMER

Miscellaneous databases

EvolutionaryTraceiP32639

Protein Ontology

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PROi
PR:P32639
RNActiP32639 protein

Family and domain databases

DisProtiDP01330
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR041094 Brr2_helicase_PWI
IPR035892 C2_domain_sf
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014756 Ig_E-set
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 2 hits
PF00271 Helicase_C, 1 hit
PF18149 Helicase_PWI, 1 hit
PF02889 Sec63, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 2 hits
SM00490 HELICc, 1 hit
SM00973 Sec63, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits
SSF52540 SSF52540, 3 hits
SSF81296 SSF81296, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 2 hits
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRR2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32639
Secondary accession number(s): D3DM80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: June 17, 2020
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
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