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Entry version 179 (29 Sep 2021)
Sequence version 3 (01 Feb 1995)
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Protein

Mannan polymerase II complex ANP1 subunit

Gene

ANP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the organization of the secretory pathway. Required to maintain a functional Golgi apparatus.

The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-1,6-mannosyltransferase activity Source: UniProtKB

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT62, Glycosyltransferase Family 62

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannan polymerase II complex ANP1 subunit
Short name:
M-Pol II subunit ANP1
Alternative name(s):
Aminonitrophenyl propanediol resistance protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANP1
Synonyms:GEM3
Ordered Locus Names:YEL036C
ORF Names:SYGP-ORF28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000762, ANP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YEL036C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 27Helical; Signal-anchor for type II membrane proteinAdd BLAST12
Topological domaini28 – 500LumenalSequence analysisAdd BLAST473

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936681 – 500Mannan polymerase II complex ANP1 subunitAdd BLAST500

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32629

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32629

PRoteomics IDEntifications database

More...
PRIDEi
P32629

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the M-Pol II complex composed of ANP1, MNN9, MNN10, MNN11 and HOC1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36693, 668 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1839, alpha-1,6-mannosyltransferase complex, M-Pol II variant

Database of interacting proteins

More...
DIPi
DIP-845N

Protein interaction database and analysis system

More...
IntActi
P32629, 21 interactors

Molecular INTeraction database

More...
MINTi
P32629

STRING: functional protein association networks

More...
STRINGi
4932.YEL036C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32629, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32629

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni424 – 500DisorderedSequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi438 – 473Polar residuesSequence analysisAdd BLAST36
Compositional biasi475 – 500Basic and acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ANP1/MMN9/VAN1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDT, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017872_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32629

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPRFFNH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029044, Nucleotide-diphossugar_trans

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYNNRKLSF NPTTVSIAGT LLTVFFLTRL VLSFFSISLF QLVTFQGIFK
60 70 80 90 100
PYVPDFKNTP SVEFYDLRNY QGNKDGWQQG DRILFCVPLR DASEHLPMFF
110 120 130 140 150
NHLNTMTYPH NLIDLSFLVS DSSDNTMGVL LSNLQMAQSQ QDKSKRFGNI
160 170 180 190 200
EIYEKDFGQI IGQSFSDRHG FGAQGPRRKL MARARNWLGS VALKPYHSWV
210 220 230 240 250
YWRDVDVETI PTTIMEDLMH HDKDVIVPNV WRPLPDWLGN IQPYDLNSWK
260 270 280 290 300
ESEGGLQLAD SLDEDAVIVE GYPEYATWRP HLAYMRDPNG NPEDEMELDG
310 320 330 340 350
IGGVSILAKA KVFRTGSHFP AFSFEKHAET EAFGRLSRRM NYNVIGLPHY
360 370 380 390 400
VIWHIYEPSS DDLKHMAWMA EEEKRKLEEE RIREFYNKIW EIGFEDVRDQ
410 420 430 440 450
WNEERDSILK NIDSTLNNKV TVDWSEEGDG SELVDSKGDF VSPNNQQQQQ
460 470 480 490 500
QQQQQQQQQQ QQQQQQQLDG NPQGKPLDDN DKNKKKHPKE VPLDFDPDRN
Length:500
Mass (Da):58,182
Last modified:February 1, 1995 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i845B395CE548CD14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220 – 224HHDKD → QSGQGN in AAD13971 (PubMed:8411151).Curated5
Sequence conflicti220 – 224HHDKD → QSGQGN in AAA34426 (PubMed:8411151).Curated5
Sequence conflicti313F → L in AAD13971 (PubMed:8411151).Curated1
Sequence conflicti313F → L in AAA34426 (PubMed:8411151).Curated1
Sequence conflicti313F → L in AAB28440 (PubMed:8411151).Curated1
Sequence conflicti313F → L in AAA34937 (PubMed:8411151).Curated1
Sequence conflicti472 – 500PQGKP…DPDRN → RRGNLLMTTTRTRKNILKKF H in AAD13971 (PubMed:8411151).CuratedAdd BLAST29
Sequence conflicti472 – 500PQGKP…DPDRN → RRGNLLMTTTRTRKNILKKF H in AAA34426 (PubMed:8411151).CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S65964 Genomic DNA Translation: AAD13971.1
L22171 Genomic DNA Translation: AAA34426.1
S66114 mRNA Translation: AAB28440.1
L22173 Genomic DNA Translation: AAA34937.1
U18779 Genomic DNA Translation: AAB65006.1
BK006939 Genomic DNA Translation: DAA07617.1

Protein sequence database of the Protein Information Resource

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PIRi
S50508

NCBI Reference Sequences

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RefSeqi
NP_010878.1, NM_001178851.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YEL036C_mRNA; YEL036C; YEL036C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YEL036C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65964 Genomic DNA Translation: AAD13971.1
L22171 Genomic DNA Translation: AAA34426.1
S66114 mRNA Translation: AAB28440.1
L22173 Genomic DNA Translation: AAA34937.1
U18779 Genomic DNA Translation: AAB65006.1
BK006939 Genomic DNA Translation: DAA07617.1
PIRiS50508
RefSeqiNP_010878.1, NM_001178851.1

3D structure databases

SMRiP32629
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36693, 668 interactors
ComplexPortaliCPX-1839, alpha-1,6-mannosyltransferase complex, M-Pol II variant
DIPiDIP-845N
IntActiP32629, 21 interactors
MINTiP32629
STRINGi4932.YEL036C

Protein family/group databases

CAZyiGT62, Glycosyltransferase Family 62

Proteomic databases

MaxQBiP32629
PaxDbiP32629
PRIDEiP32629

Genome annotation databases

EnsemblFungiiYEL036C_mRNA; YEL036C; YEL036C
GeneIDi856675
KEGGisce:YEL036C

Organism-specific databases

SGDiS000000762, ANP1
VEuPathDBiFungiDB:YEL036C

Phylogenomic databases

eggNOGiENOG502QVDT, Eukaryota
GeneTreeiENSGT00940000176370
HOGENOMiCLU_017872_0_0_1
InParanoidiP32629
OMAiLPRFFNH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32629
RNActiP32629, protein

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044, Nucleotide-diphossugar_trans
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANP1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32629
Secondary accession number(s): D3DLL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: September 29, 2021
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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