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Protein

V-type proton ATPase subunit D

Gene

VMA8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.

Miscellaneous

Present with 8500 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • proton transmembrane transport Source: GOC
  • vacuolar acidification Source: SGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30169-MONOMER
ReactomeiR-SCE-1222556 ROS, RNS production in phagocytes
R-SCE-6798695 Neutrophil degranulation
R-SCE-77387 Insulin receptor recycling
R-SCE-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit D
Short name:
V-ATPase subunit D
Alternative name(s):
Vacuolar proton pump subunit D
Gene namesi
Name:VMA8
Ordered Locus Names:YEL051W
ORF Names:SYGP-ORF11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL051W
SGDiS000000777 VMA8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442441 – 256V-type proton ATPase subunit DAdd BLAST256

Proteomic databases

MaxQBiP32610
PaxDbiP32610
PRIDEiP32610

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e). Interacts with RAV1 and RAV2 components of the RAVE complex, which are essential for the stability and assembly of V-ATPase.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi36678, 412 interactors
ComplexPortaliCPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant
CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
DIPiDIP-2959N
IntActiP32610, 48 interactors
MINTiP32610
STRINGi4932.YEL051W

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32610
SMRiP32610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010770
HOGENOMiHOG000230791
InParanoidiP32610
KOiK02149
OMAiSKNIMGV
OrthoDBiEOG092C4UH1

Family and domain databases

InterProiView protein in InterPro
IPR002699 V_ATPase_D
PANTHERiPTHR11671 PTHR11671, 1 hit
PfamiView protein in Pfam
PF01813 ATP-synt_D, 1 hit
TIGRFAMsiTIGR00309 V_ATPase_subD, 1 hit

Sequencei

Sequence statusi: Complete.

P32610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGNREQVFP TRMTLGLMKT KLKGANQGYS LLKRKSEALT KRFRDITKRI
60 70 80 90 100
DDAKQKMGRV MQTAAFSLAE VSYATGENIG YQVQESVSTA RFKVRARQEN
110 120 130 140 150
VSGVYLSQFE SYIDPEINDF RLTGLGRGGQ QVQRAKEIYS RAVETLVELA
160 170 180 190 200
SLQTAFIILD EVIKVTNRRV NAIEHVIIPR TENTIAYINS ELDELDREEF
210 220 230 240 250
YRLKKVQEKK QNETAKLDAE MKLKRDRAEQ DASEVAADEE PQGETLVADQ

EDDVIF
Length:256
Mass (Da):29,194
Last modified:October 1, 1993 - v1
Checksum:iFDE93E1FAF0AEC5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18779 Genomic DNA Translation: AAB64991.1
BK006939 Genomic DNA Translation: DAA07603.1
PIRiS30826
RefSeqiNP_010863.1, NM_001178866.1

Genome annotation databases

EnsemblFungiiYEL051W; YEL051W; YEL051W
GeneIDi856659
KEGGisce:YEL051W

Similar proteinsi

Entry informationi

Entry nameiVATD_YEAST
AccessioniPrimary (citable) accession number: P32610
Secondary accession number(s): D3DLJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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