Retrograde regulation protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• phosphoprotein binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p."
    Liu Z., Sekito T., Spirek M., Thornton J., Butow R.A.
    Mol Cell 12:401-411(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• maintenance of DNA trinucleotide repeats Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae."
    Bhattacharyya S., Rolfsmeier M.L., Dixon M.J., Wagoner K., Lahue R.S.
    Genetics 162:579-589(2002) [PubMed] [Europe PMC] [Abstract]
• mitochondria-nucleus signaling pathway Source: SGDInferred from mutant phenotypeⁱ
  • "Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast."
    Rothermel B.A., Shyjan A.W., Etheredge J.L., Butow R.A.
    J Biol Chem 270:29476-29482(1995) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus."
    Liao X., Butow R.A.
    Cell 72:61-71(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging Source: SGDInferred from mutant phenotypeⁱ
  • "Rtg2 protein links metabolism and genome stability in yeast longevity."
    Borghouts C., Benguria A., Wawryn J., Jazwinski S.M.
    Genetics 166:765-777(2004) [PubMed] [Europe PMC] [Abstract]
• nitrogen catabolite regulation of transcription from RNA polymerase II promoter Source: SGDInferred from mutant phenotypeⁱ
  • "A novel Rtg2p activity regulates nitrogen catabolism in yeast."
    Pierce M.M., Maddelein M.L., Roberts B.T., Wickner R.B.
    Proc Natl Acad Sci U S A 98:13213-13218(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: SGDInferred from direct assayⁱ
  • "Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast."
    Rothermel B.A., Shyjan A.W., Etheredge J.L., Butow R.A.
    J Biol Chem 270:29476-29482(1995) [PubMed] [Europe PMC] [Abstract]
• protein import into nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors."
    Komeili A., Wedaman K.P., O'Shea E.K., Powers T.
    J Cell Biol 151:863-878(2000) [PubMed] [Europe PMC] [Abstract]
• protein localization to nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p."
    Sekito T., Thornton J., Butow R.A.
    Mol Biol Cell 11:2103-2115(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: SGDInferred from mutant phenotypeⁱ
  • Ref.1

    "RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus."
    Liao X., Butow R.A.
    Cell 72:61-71(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• phosphoprotein binding Source: SGDInferred from direct assayⁱ
  • "Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p."
    Liu Z., Sekito T., Spirek M., Thornton J., Butow R.A.
    Mol Cell 12:401-411(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD 
        60         70         80         90        100
RVGLSLYEVQ YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV 
       110        120        130        140        150
RVIATEATRD AINADEFVNA VYGSTGWKVE ILGQEDETRV GIYGVVSSFN 
       160        170        180        190        200
TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS KPVSLPYGAG TLLRRMRTDD 
       210        220        230        240        250
NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR GGGLRGMGHL 
       260        270        280        290        300
LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS 
       310        320        330        340        350
DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ 
       360        370        380        390        400
DPLLIASRPY APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH 
       410        420        430        440        450
ASYPKELQPT AALHVATRGI IAGCHGLSHR ARALIGIALC SRWGGNIPES 
       460        470        480        490        500
EEKYSQELEQ VVLREGDKAE ALRIVWWTKY IGTIMYVICG VHPGGNIRDN 
       510        520        530        540        550
VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY EVVVRISKDD 
       560        570        580 
LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
3. Yeast chromosome VII
   Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names