UniProtKB - P32608 (RTG2_YEAST)
Protein
Retrograde regulation protein 2
Gene
RTG2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. In particular, required for the retrograde expression of the peroxisomal isoform of citrate synthase, CIT2.
Miscellaneous
Present with 3260 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- phosphoprotein binding Source: SGD
GO - Biological processi
- maintenance of DNA trinucleotide repeats Source: SGD
- mitochondria-nucleus signaling pathway Source: SGD
- negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging Source: SGD
- nitrogen catabolite regulation of transcription from RNA polymerase II promoter Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- protein import into nucleus Source: SGD
- protein localization to nucleus Source: SGD
- regulation of transcription by RNA polymerase II Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: Retrograde regulation protein 2 |
Gene namesi | Name:RTG2 Ordered Locus Names:YGL252C ORF Names:NRF588 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YGL252C |
SGDi | S000003221, RTG2 |
Subcellular locationi
Nucleus
- SLIK (SAGA-like) complex Source: SGD
Other locations
- cytoplasm Source: SGD
- transcriptionally active chromatin Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194312 | 1 – 588 | Retrograde regulation protein 2Add BLAST | 588 |
Proteomic databases
MaxQBi | P32608 |
PaxDbi | P32608 |
PRIDEi | P32608 |
PTM databases
iPTMneti | P32608 |
Interactioni
Binary interactionsi
P32608
With | #Exp. | IntAct |
---|---|---|
SPT7 [P35177] | 2 | EBI-16322,EBI-17958 |
GO - Molecular functioni
- phosphoprotein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 33027, 451 interactors |
ComplexPortali | CPX-675, SLIK (SAGA-like) complex |
DIPi | DIP-6826N |
IntActi | P32608, 20 interactors |
MINTi | P32608 |
STRINGi | 4932.YGL252C |
Miscellaneous databases
RNActi | P32608, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GppA/Ppx family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRXN, Eukaryota |
HOGENOMi | CLU_033165_0_0_1 |
InParanoidi | P32608 |
OMAi | STQITWM |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR003695, Ppx_GppA |
Pfami | View protein in Pfam PF02541, Ppx-GppA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
i Sequence
Sequence statusi: Complete.
P32608-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD
60 70 80 90 100
RVGLSLYEVQ YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV
110 120 130 140 150
RVIATEATRD AINADEFVNA VYGSTGWKVE ILGQEDETRV GIYGVVSSFN
160 170 180 190 200
TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS KPVSLPYGAG TLLRRMRTDD
210 220 230 240 250
NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR GGGLRGMGHL
260 270 280 290 300
LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS
310 320 330 340 350
DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ
360 370 380 390 400
DPLLIASRPY APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH
410 420 430 440 450
ASYPKELQPT AALHVATRGI IAGCHGLSHR ARALIGIALC SRWGGNIPES
460 470 480 490 500
EEKYSQELEQ VVLREGDKAE ALRIVWWTKY IGTIMYVICG VHPGGNIRDN
510 520 530 540 550
VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY EVVVRISKDD
560 570 580
LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97691 Genomic DNA Translation: AAA96809.1 X94357 Genomic DNA Translation: CAA64135.1 Z72774 Genomic DNA Translation: CAA96972.1 AY692809 Genomic DNA Translation: AAT92828.1 BK006941 Genomic DNA Translation: DAA07867.1 |
PIRi | S61609 |
RefSeqi | NP_011262.1, NM_001181118.1 |
Genome annotation databases
EnsemblFungii | YGL252C_mRNA; YGL252C; YGL252C |
GeneIDi | 852640 |
KEGGi | sce:YGL252C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97691 Genomic DNA Translation: AAA96809.1 X94357 Genomic DNA Translation: CAA64135.1 Z72774 Genomic DNA Translation: CAA96972.1 AY692809 Genomic DNA Translation: AAT92828.1 BK006941 Genomic DNA Translation: DAA07867.1 |
PIRi | S61609 |
RefSeqi | NP_011262.1, NM_001181118.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33027, 451 interactors |
ComplexPortali | CPX-675, SLIK (SAGA-like) complex |
DIPi | DIP-6826N |
IntActi | P32608, 20 interactors |
MINTi | P32608 |
STRINGi | 4932.YGL252C |
PTM databases
iPTMneti | P32608 |
Proteomic databases
MaxQBi | P32608 |
PaxDbi | P32608 |
PRIDEi | P32608 |
Genome annotation databases
EnsemblFungii | YGL252C_mRNA; YGL252C; YGL252C |
GeneIDi | 852640 |
KEGGi | sce:YGL252C |
Organism-specific databases
EuPathDBi | FungiDB:YGL252C |
SGDi | S000003221, RTG2 |
Phylogenomic databases
eggNOGi | ENOG502QRXN, Eukaryota |
HOGENOMi | CLU_033165_0_0_1 |
InParanoidi | P32608 |
OMAi | STQITWM |
Miscellaneous databases
PROi | PR:P32608 |
RNActi | P32608, protein |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR003695, Ppx_GppA |
Pfami | View protein in Pfam PF02541, Ppx-GppA, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTG2_YEAST | |
Accessioni | P32608Primary (citable) accession number: P32608 Secondary accession number(s): D6VV83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names