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Entry version 198 (10 Feb 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Fimbrin

Gene

SAC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.

Miscellaneous

Present with 3510 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi29 – 401By similarityAdd BLAST12
Calcium bindingi64 – 752By similarityAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fimbrin
Alternative name(s):
ABP67
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAC6
Ordered Locus Names:YDR129C
ORF Names:YD9302.04C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002536, SAC6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR129C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000737571 – 642FimbrinAdd BLAST642

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32599

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32599

PRoteomics IDEntifications database

More...
PRIDEi
P32599

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P32599

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32599

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32185, 301 interactors

Database of interacting proteins

More...
DIPi
DIP-718N

Protein interaction database and analysis system

More...
IntActi
P32599, 21 interactors

Molecular INTeraction database

More...
MINTi
P32599

STRING: functional protein association networks

More...
STRINGi
4932.YDR129C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32599, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32599

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 50EF-hand 1Add BLAST35
Domaini51 – 86EF-hand 2Add BLAST36
Domaini139 – 259Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST121
Domaini287 – 390Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST104
Domaini411 – 521Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST111
Domaini534 – 642Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 394Actin-binding 1Add BLAST270
Regioni395 – 642Actin-binding 2Add BLAST248

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0046, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015284_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32599

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVRWAND

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR011992, EF-hand-dom_pair
IPR039959, Fimbrin/Plastin

The PANTHER Classification System

More...
PANTHERi
PTHR19961, PTHR19961, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 2 hits
PS50021, CH, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32599-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIVKLQRKF PILTQEDLFS TIEKFRAIDL DDKGWVEKQQ ALEAVSKDGD
60 70 80 90 100
ATYDEARETL KHVGVDASGR VELDDYVGLV AKLRESKTGA APQTTFNVAP
110 120 130 140 150
NSTPIVSTAA TGLQHKGKGT QAKIIVAGSQ TGTTHTINEE ERREFTKHIN
160 170 180 190 200
SVLAGDQDIG DLLPFPTDTF QLFDECRDGL VLSKLINDSV PDTIDTRVLN
210 220 230 240 250
WPKKGKELNN FQASENANIV INSAKAIGCV VVNVHSEDII EGREHLILGL
260 270 280 290 300
IWQIIRRGLL SKIDIKLHPE LYRLLEDDET LEQFLRLPPE QILLRWFNYH
310 320 330 340 350
LKQANWNRRV TNFSKDVSDG ENYTILLNQL DPALCSKAPL QTTDLMERAE
360 370 380 390 400
QVLQNAEKLD CRKYLTPSSL VAGNPKLNLA FVAHLFNTHP GLEPIQEEEK
410 420 430 440 450
PEIEEFDAEG EREARVFTLW LNSLDVDPPV ISLFDDLKDG LILLQAYEKV
460 470 480 490 500
MPGAVDFKHV NKRPASGAEI SRFKALENTN YAVDLGRAKG FSLVGIEGSD
510 520 530 540 550
IVDGNKLLTL GLVWQLMRRN ISITMKTLSS SGRDMSDSQI LKWAQDQVTK
560 570 580 590 600
GGKNSTIRSF KDQALSNAHF LLDVLNGIAP GYVDYDLVTP GNTEEERYAN
610 620 630 640
ARLAISIARK LGALIWLVPE DINEVRARLI ITFIASLMTL NK
Length:642
Mass (Da):71,773
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AF17D056173A690
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63867 Genomic DNA Translation: CAA45346.1
Z48179 Genomic DNA Translation: CAA88210.1
BK006938 Genomic DNA Translation: DAA11975.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29320

NCBI Reference Sequences

More...
RefSeqi
NP_010414.3, NM_001180437.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR129C_mRNA; YDR129C; YDR129C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR129C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63867 Genomic DNA Translation: CAA45346.1
Z48179 Genomic DNA Translation: CAA88210.1
BK006938 Genomic DNA Translation: DAA11975.1
PIRiS29320
RefSeqiNP_010414.3, NM_001180437.3

3D structure databases

SMRiP32599
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32185, 301 interactors
DIPiDIP-718N
IntActiP32599, 21 interactors
MINTiP32599
STRINGi4932.YDR129C

PTM databases

iPTMnetiP32599

Proteomic databases

MaxQBiP32599
PaxDbiP32599
PRIDEiP32599
TopDownProteomicsiP32599

Genome annotation databases

EnsemblFungiiYDR129C_mRNA; YDR129C; YDR129C
GeneIDi851707
KEGGisce:YDR129C

Organism-specific databases

SGDiS000002536, SAC6
VEuPathDBiFungiDB:YDR129C

Phylogenomic databases

eggNOGiKOG0046, Eukaryota
GeneTreeiENSGT00950000183097
HOGENOMiCLU_015284_3_0_1
InParanoidiP32599
OMAiMVRWAND

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32599
RNActiP32599, protein

Family and domain databases

CDDicd00014, CH, 3 hits
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR011992, EF-hand-dom_pair
IPR039959, Fimbrin/Plastin
PANTHERiPTHR19961, PTHR19961, 1 hit
PfamiView protein in Pfam
PF00307, CH, 4 hits
SMARTiView protein in SMART
SM00033, CH, 4 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 2 hits
PS50021, CH, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIMB_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32599
Secondary accession number(s): D6VSB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 10, 2021
This is version 198 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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