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UniProtKB - P32565 (RPN2_YEAST)

Entry version 188 (23 Feb 2022)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

26S proteasome regulatory subunit RPN2

Gene

RPN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

1 Publication

Miscellaneous

Present with 4750 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SCE-382556, ABC-family proteins mediated transport
R-SCE-5668541, TNFR2 non-canonical NF-kB pathway
R-SCE-5687128, MAPK6/MAPK4 signaling
R-SCE-5689880, Ub-specific processing proteases
R-SCE-6798695, Neutrophil degranulation
R-SCE-68949, Orc1 removal from chromatin
R-SCE-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SCE-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SCE-75815, Ubiquitin-dependent degradation of Cyclin D
R-SCE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SCE-8948751, Regulation of PTEN stability and activity
R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome regulatory subunit RPN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPN2
Synonyms:SEN3
Ordered Locus Names:YIL075C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000001337, RPN2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YIL075C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001738082 – 94526S proteasome regulatory subunit RPN2Add BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei801PhosphothreonineCombined sources1
Modified residuei932PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-acetylated by NAT1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P32565

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P32565

PRoteomics IDEntifications database

More...PRIDEi		P32565

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P32565

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBR1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		34917, 144 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2262, 26S Proteasome complex

Database of interacting proteins

More...DIPi		DIP-4638N

Protein interaction database and analysis system

More...IntActi		P32565, 84 interactors

Molecular INTeraction database

More...MINTi		P32565

STRING: functional protein association networks

More...STRINGi		4932.YIL075C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P32565, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1945
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P32565

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati366 – 399PC 1Add BLAST34
Repeati403 – 440PC 2Add BLAST38
Repeati445 – 479PC 3Add BLAST35
Repeati480 – 514PC 4Add BLAST35
Repeati516 – 549PC 5Add BLAST34
Repeati550 – 585PC 6Add BLAST36
Repeati586 – 618PC 7Add BLAST33
Repeati620 – 654PC 8Add BLAST35
Repeati655 – 692PC 9Add BLAST38
Repeati698 – 734PC 10Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni810 – 851DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi818 – 851Basic and acidic residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2062, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002323_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P32565

Identification of Orthologs from Complete Genome Data

More...OMAi		CMDIVQE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016642, 26S_Psome_Rpn2
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR035266, PSMD1
IPR040623, RPN2_C

The PANTHER Classification System

More...PANTHERi		PTHR10943:SF2, PTHR10943:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01851, PC_rep, 2 hits
PF18004, RPN2_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015947, 26S_Psome_Rpn2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P32565-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTTAAPLL ALLRENQDSV KTYALESINN VVDQLWSEIS NELPDIEALY 
        60         70         80         90        100
DDDTFSDREM AALIASKVYY NLGEYESAVK YALAAKDRFD IDEKSQFVET 
       110        120        130        140        150
IVSKSIEMYV QEASKQYTKD EQFYTKDIID PKLTSIFERM IEKCLKASEL 
       160        170        180        190        200
KLALGIALEG YRLDIIESAL KSKLDQDSTS ENVKIINYLL TLAITTVTNS 
       210        220        230        240        250
KFRSSILRKS FDFLMNMPNC DYLTLNKVVV NLNDAGLALQ LFKKLKEEND 
       260        270        280        290        300
EGLSAQIAFD LVSSASQQLL EILVTELTAQ GYDPALLNIL SGLPTCDYYN 
       310        320        330        340        350
TFLLNNKNID IGLLNKSKSS LDGKFSLFHT AVSVANGFMH AGTTDNSFIK 
       360        370        380        390        400
ANLPWLGKAQ NWAKFTATAS LGVIHKGNLL EGKKVMAPYL PGSRASSRFI 
       410        420        430        440        450
KGGSLYGLGL IYAGFGRDTT DYLKNIIVEN SGTSGDEDVD VLLHGASLGI 
       460        470        480        490        500
GLAAMGSANI EVYEALKEVL YNDSATSGEA AALGMGLCML GTGKPEAIHD 
       510        520        530        540        550
MFTYSQETQH GNITRGLAVG LALINYGRQE LADDLITKML ASDESLLRYG 
       560        570        580        590        600
GAFTIALAYA GTGNNSAVKR LLHVAVSDSN DDVRRAAVIA LGFVLLRDYT 
       610        620        630        640        650
TVPRIVQLLS KSHNAHVRCG TAFALGIACA GKGLQSAIDV LDPLTKDPVD 
       660        670        680        690        700
FVRQAAMIAL SMILIQQTEK LNPQVADINK NFLSVITNKH QEGLAKFGAC 
       710        720        730        740        750
VAQGIMNAGG RNVTIQLENA DTGTLDTKSV VGLVMFSQFW YWFPLAHFLS 
       760        770        780        790        800
LSFTPTTVIG IRGSDQAIPK FQMNCYAKED AFSYPRMYEE ASGKEVEKVA 
       810        820        830        840        850
TAVLSTTARA KARAKKTKKE KGPNEEEKKK EHEEKEKERE TNKKGIKETK 
       860        870        880        890        900
ENDEEFYKNK YSSKPYKVDN MTRILPQQSR YISFIKDDRF VPVRKFKGNN 
       910        920        930        940 
GVVVLRDREP KEPVALIETV RQMKDVNAPL PTPFKVDDNV DFPSA
Length:945
Mass (Da):104,232
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i881E78EBC6BD934F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti333 – 334SV → RL in AAA87613 (PubMed:7565784).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L06321 Genomic DNA Translation: AAA87613.1
Z37997 Genomic DNA Translation: CAA86095.1
BK006942 Genomic DNA Translation: DAA08475.1

Protein sequence database of the Protein Information Resource

More...PIRi		S48369

NCBI Reference Sequences

More...RefSeqi		NP_012190.1, NM_001179425.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YIL075C_mRNA; YIL075C; YIL075C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		854735

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YIL075C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06321 Genomic DNA Translation: AAA87613.1
Z37997 Genomic DNA Translation: CAA86095.1
BK006942 Genomic DNA Translation: DAA08475.1
PIRiS48369
RefSeqiNP_012190.1, NM_001179425.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCOelectron microscopy4.80N1-945[»]
3JCPelectron microscopy4.60N1-945[»]
4ADYX-ray2.70A/B2-945[»]
4CR2electron microscopy7.70N1-945[»]
4CR3electron microscopy9.30N1-945[»]
4CR4electron microscopy8.80N1-945[»]
5A5Belectron microscopy9.50N1-945[»]
5MPBelectron microscopy7.80N1-945[»]
5MPCelectron microscopy7.70N1-945[»]
5MPDelectron microscopy4.10N1-945[»]
5MPEelectron microscopy4.50N1-945[»]
5WVIelectron microscopy6.30N1-945[»]
5WVKelectron microscopy4.20N1-945[»]
6FVTelectron microscopy4.10N4-925[»]
6FVUelectron microscopy4.50N4-925[»]
6FVVelectron microscopy5.40N4-925[»]
6FVWelectron microscopy4.50N4-925[»]
6FVXelectron microscopy4.90N4-925[»]
6FVYelectron microscopy6.10N4-925[»]
6J2Celectron microscopy7.00N1-945[»]
6J2Nelectron microscopy7.50N1-945[»]
6J2Qelectron microscopy3.80N1-945[»]
6J2Xelectron microscopy3.80N1-945[»]
6J30electron microscopy4.50N1-945[»]
SMRiP32565
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi34917, 144 interactors
ComplexPortaliCPX-2262, 26S Proteasome complex
DIPiDIP-4638N
IntActiP32565, 84 interactors
MINTiP32565
STRINGi4932.YIL075C

PTM databases

iPTMnetiP32565

Proteomic databases

MaxQBiP32565
PaxDbiP32565
PRIDEiP32565

Genome annotation databases

EnsemblFungiiYIL075C_mRNA; YIL075C; YIL075C
GeneIDi854735
KEGGisce:YIL075C

Organism-specific databases

SGDiS000001337, RPN2
VEuPathDBiFungiDB:YIL075C

Phylogenomic databases

eggNOGiKOG2062, Eukaryota
GeneTreeiENSGT00940000153386
HOGENOMiCLU_002323_0_0_1
InParanoidiP32565
OMAiCMDIVQE

Enzyme and pathway databases

ReactomeiR-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SCE-382556, ABC-family proteins mediated transport
R-SCE-5668541, TNFR2 non-canonical NF-kB pathway
R-SCE-5687128, MAPK6/MAPK4 signaling
R-SCE-5689880, Ub-specific processing proteases
R-SCE-6798695, Neutrophil degranulation
R-SCE-68949, Orc1 removal from chromatin
R-SCE-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SCE-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SCE-75815, Ubiquitin-dependent degradation of Cyclin D
R-SCE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SCE-8948751, Regulation of PTEN stability and activity
R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:P32565
RNActiP32565, protein

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016642, 26S_Psome_Rpn2
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR035266, PSMD1
IPR040623, RPN2_C
PANTHERiPTHR10943:SF2, PTHR10943:SF2, 1 hit
PfamiView protein in Pfam
PF01851, PC_rep, 2 hits
PF18004, RPN2_C, 1 hit
PIRSFiPIRSF015947, 26S_Psome_Rpn2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPN2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32565
Secondary accession number(s): D6VVK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 188 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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