UniProtKB - P32551 (QCR2_RAT)
Cytochrome b-c1 complex subunit 2, mitochondrial
Uqcrc2
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- protein-containing complex binding Source: RGD
GO - Biological processi
- oxidation-reduction process Source: UniProtKB-KW
- proteolysis Source: InterPro
- response to drug Source: RGD
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport |
Protein family/group databases
MEROPSi | M16.974 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 2, mitochondrialAlternative name(s): Complex III subunit 2 Core protein II Ubiquinol-cytochrome-c reductase complex core protein 2 |
Gene namesi | Name:Uqcrc2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359150, Uqcrc2 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial respiratory chain complex III Source: RGD
- mitochondrial respiratory chain complex IV Source: RGD
- mitochondrion Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 14 | MitochondrionBy similarityAdd BLAST | 14 | |
ChainiPRO_0000026793 | 15 – 452 | Cytochrome b-c1 complex subunit 2, mitochondrialAdd BLAST | 438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 65 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 198 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 249 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 367 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P32551 |
PaxDbi | P32551 |
PRIDEi | P32551 |
2D gel databases
World-2DPAGEi | 0004:P32551 |
PTM databases
CarbonylDBi | P32551 |
iPTMneti | P32551 |
PhosphoSitePlusi | P32551 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000036742, Expressed in heart and 21 other tissues |
Genevisiblei | P32551, RN |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (By similarity).
Interacts with RAB5IF (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 254272, 4 interactors |
CORUMi | P32551 |
IntActi | P32551, 6 interactors |
MINTi | P32551 |
STRINGi | 10116.ENSRNOP00000021514 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2583, Eukaryota |
GeneTreei | ENSGT00940000154915 |
HOGENOMi | CLU_009902_0_0_1 |
InParanoidi | P32551 |
OMAi | APKFALY |
OrthoDBi | 1000258at2759 |
PhylomeDBi | P32551 |
TreeFami | TF105033 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MKLLSRAGSF SRFYSLKVAP KLKTSAPGGV PLQPQELEFT KLPNGLVIAS
60 70 80 90 100
LENYAPLSRI GLFIKAGSRY ENYNYLGTSH LLRLASTLTT KGASSFKITR
110 120 130 140 150
GIEAVGGKLS VTATRENMAY TVEGIRDDIE ILMEFLLNVT TAPEFRRWEV
160 170 180 190 200
AALRSQLKID KAVAFQNPQT RIIENLHDVA YKNALANPLY CPDYRMGKIT
210 220 230 240 250
SEELHYFVQN HFTSARMALV GLGVSHSILK EVAEQFLNIR GGLGLAGAKA
260 270 280 290 300
KYRGGEIREQ NGDNLVHAAI VAESAAIGNA EANAFSVLQH LLGAGPHIKR
310 320 330 340 350
GNNTTSLLSQ SVAKGSQQPF DVSAFNASYS DSGLFGIYTV SQAAAAGDVI
360 370 380 390 400
NAAYNQVKAV AQGNLSSADV QAAKNKLKAG YLMSVETSEG FLSEIGSQAL
410 420 430 440 450
ATGSYMPPPT VLQQIDAVAD ADVVKAAKKF VSGKKSMTAS GNLGHTPFLD
EL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 445 | H → N (PubMed:2162168).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083610 mRNA Translation: AAH83610.1 |
PIRi | S29510 |
RefSeqi | NP_001006971.1, NM_001006970.1 |
Genome annotation databases
Ensembli | ENSRNOT00000021514; ENSRNOP00000021514; ENSRNOG00000036742 |
GeneIDi | 293448 |
KEGGi | rno:293448 |
UCSCi | RGD:1359150, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083610 mRNA Translation: AAH83610.1 |
PIRi | S29510 |
RefSeqi | NP_001006971.1, NM_001006970.1 |
3D structure databases
SMRi | P32551 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 254272, 4 interactors |
CORUMi | P32551 |
IntActi | P32551, 6 interactors |
MINTi | P32551 |
STRINGi | 10116.ENSRNOP00000021514 |
Protein family/group databases
MEROPSi | M16.974 |
PTM databases
CarbonylDBi | P32551 |
iPTMneti | P32551 |
PhosphoSitePlusi | P32551 |
2D gel databases
World-2DPAGEi | 0004:P32551 |
Proteomic databases
jPOSTi | P32551 |
PaxDbi | P32551 |
PRIDEi | P32551 |
Genome annotation databases
Ensembli | ENSRNOT00000021514; ENSRNOP00000021514; ENSRNOG00000036742 |
GeneIDi | 293448 |
KEGGi | rno:293448 |
UCSCi | RGD:1359150, rat |
Organism-specific databases
CTDi | 7385 |
RGDi | 1359150, Uqcrc2 |
Phylogenomic databases
eggNOGi | KOG2583, Eukaryota |
GeneTreei | ENSGT00940000154915 |
HOGENOMi | CLU_009902_0_0_1 |
InParanoidi | P32551 |
OMAi | APKFALY |
OrthoDBi | 1000258at2759 |
PhylomeDBi | P32551 |
TreeFami | TF105033 |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport |
Miscellaneous databases
PROi | PR:P32551 |
Gene expression databases
Bgeei | ENSRNOG00000036742, Expressed in heart and 21 other tissues |
Genevisiblei | P32551, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR2_RAT | |
Accessioni | P32551Primary (citable) accession number: P32551 Secondary accession number(s): Q5XIR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries