Pentatricopeptide repeat-containing protein PET309, mitochondrial

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mRNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The Pet309 pentatricopeptide repeat motifs mediate efficient binding to the mitochondrial COX1 transcript in yeast."
    Zamudio-Ochoa A., Camacho-Villasana Y., Garcia-Guerrero A.E., Perez-Martinez X.
    RNA Biol 11:953-967(2014) [PubMed] [Europe PMC] [Abstract]
• translation regulator activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae."
    Manthey G.M., McEwen J.E.
    EMBO J. 14:4031-4043(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• tRNA binding Source: UniProtKB

GO - Biological processⁱ

• mitochondrial cytochrome c oxidase assembly Source: SGDInferred from mutant phenotypeⁱ
  • Ref.1

    "The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae."
    Manthey G.M., McEwen J.E.
    EMBO J. 14:4031-4043(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• positive regulation of mitochondrial translational initiation Source: SGDInferred from mutant phenotypeⁱ
  • "The pentatricopeptide repeats present in Pet309 are necessary for translation but not for stability of the mitochondrial COX1 mRNA in yeast."
    Tavares-Carreon F., Camacho-Villasana Y., Zamudio-Ochoa A., Shingu-Vazquez M., Torres-Larios A., Perez-Martinez X.
    J Biol Chem 283:1472-1479(2008) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae."
    Manthey G.M., McEwen J.E.
    EMBO J. 14:4031-4043(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• tRNA 3'-end processing Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKRCAPAVLR NYNYKKGIWS TGVPDHIRKL LRDKSTSPLC SQDERNLVSY 
        60         70         80         90        100
FMARGSVPLK SVGSGLTKKA TTSITSNSAT TTFERQYLIK YLYRHQAYGN 
       110        120        130        140        150
VIKIAQKFLY TTIGSQRLLK QDASLPELKK FLLSLLILQR GIQLDQAISD 
       160        170        180        190        200
IIQRFLLTQK TMVIDLINSI FSRMVIMNMH EEAVYKWVKW MKLVNGHCEF 
       210        220        230        240        250
TNYMENKIVL RNFLSFMRQS NVRPDYLSYL KAIQLTQGPA IASQFATTLL 
       260        270        280        290        300
FLLTYIRKFS SAEAVWNYKC EHNLPIVSSD LTCILKTYCH MQKFNLVSST 
       310        320        330        340        350
YWKYPDAQHD QNQFDYLLVA HSRLHNWDAL QQQFNALFGI GKLPSIQHYG 
       360        370        380        390        400
ILMYTMARIG ELDSVNKLYT QLLRRGMIPT YAVLQSLLYA HYKVGDFAAC 
       410        420        430        440        450
FSHFELFKKY DITPSTATHT IMLKVYRGLN DLDGAFRILK RLSEDPSVEI 
       460        470        480        490        500
TEGHFALLIQ MCCKTTNHLI AQELFNLMTE HYNIQHTGKS ISALMDVYIE 
       510        520        530        540        550
SNRPTEAIAL FEKHSKNLSW RDGLISVYNK AIKAYIGLRN ANKCEELFDK 
       560        570        580        590        600
ITTSKLAVNS EFYKMMIKFL VTLNEDCETA LSIIDQLIKH SVIKVDATHF 
       610        620        630        640        650
EIIMEAYDKE GYRDGIINLY KTMSQNKVPA NSKILYYILK AVAKKSLQNN 
       660        670        680        690        700
EEIKETINMV EDIMENAANG TLDVTYNKLH PSVMAWPMRM IVKHDSPQRA 
       710        720        730        740        750
LELYNRYNEL FFKKHDWISN NNKFVMMRSL LVLLAQIEQW KDFETLFAKY 
       760        770        780        790        800
MDRIENIENL PSSTTPNIKL RSIFSGLFPY KVSQLIAMNK IDELPLLWKK 
       810        820        830        840        850
LREKGFILDN ISWNSAVEAL FKDPRTLSYG MKIVDDTLIH GYNLIHKFRL 
       860        870        880        890        900
LTKLSEDKTQ SSDKSWPTLK MKEKEPNKFQ PRLYLKSDTY NSIMRQLDTY 
       910        920        930        940        950
LDGIDDLKTL EDQVRDFISN YKYFMKDYLL MPRSKINKWE QIEMRHLSYF 
       960 
KELRKSKRVL PVSKF                                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XII
   Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names