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Entry version 182 (16 Oct 2019)
Sequence version 2 (01 Feb 1995)
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Protein

Actin cytoskeleton-regulatory complex protein PAN1

Gene

PAN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.13 Publications

Caution

Was originally thought to be a subunit of PAB-dependent poly(A)-specific ribonuclease.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processEndocytosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31427-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-194840 Rho GTPase cycle
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SCE-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin cytoskeleton-regulatory complex protein PAN1
Alternative name(s):
Mitochondrial distribution of proteins protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAN1
Synonyms:DIM2, MDP3, MIP3
Ordered Locus Names:YIR006C
ORF Names:YIB6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YIR006C

Saccharomyces Genome Database

More...
SGDi
S000001445 PAN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582211 – 1480Actin cytoskeleton-regulatory complex protein PAN1Add BLAST1480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei241PhosphothreonineCombined sources1
Modified residuei570PhosphothreonineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei993PhosphothreonineCombined sources1
Modified residuei995PhosphothreonineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1250PhosphoserineCombined sources1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1321PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32521

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32521

PRoteomics IDEntifications database

More...
PRIDEi
P32521

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P32521

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32521

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers.

Component of the PAN1 actin cytoskeleton-regulatory complex composed of at least END3, PAN1, and SLA1.

Interacts directly with END3, and with ENT1, SCD5, SLA2, YAP1801 and YAP1802.

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34997, 648 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-426 PAN1 actin cytoskeleton-regulatory complex

Database of interacting proteins

More...
DIPi
DIP-1340N

Protein interaction database and analysis system

More...
IntActi
P32521, 22 interactors

Molecular INTeraction database

More...
MINTi
P32521

STRING: functional protein association networks

More...
STRINGi
4932.YIR006C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32521

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati142 – 1531-1Add BLAST12
Repeati164 – 1751-2Add BLAST12
Repeati188 – 1991-3Add BLAST12
Repeati215 – 2261-4Add BLAST12
Repeati235 – 2461-5Add BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini270 – 359EH 1PROSITE-ProRule annotationAdd BLAST90
Repeati328 – 3502-1Add BLAST23
Repeati392 – 4031-6Add BLAST12
Repeati409 – 4201-7Add BLAST12
Repeati422 – 4331-8Add BLAST12
Repeati446 – 4571-9Add BLAST12
Repeati467 – 4781-10Add BLAST12
Repeati498 – 5091-11Add BLAST12
Repeati510 – 5181-129
Repeati538 – 5481-13Add BLAST11
Repeati549 – 5561-148
Repeati564 – 5751-15Add BLAST12
Domaini600 – 689EH 2PROSITE-ProRule annotationAdd BLAST90
Repeati658 – 6802-2Add BLAST23
Repeati1084 – 10893-16
Repeati1090 – 10953-26
Repeati1096 – 11013-36
Repeati1102 – 11073-46
Repeati1108 – 11133-56
Repeati1114 – 11193-66
Repeati1120 – 11253-76
Repeati1315 – 13204-16
Repeati1321 – 13264-26
Repeati1327 – 13324-36
Repeati1340 – 13454-46
Repeati1346 – 13504-55
Repeati1355 – 13604-66
Repeati1361 – 13664-76
Repeati1372 – 13774-86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 57515 X 12 AA tandem repeats of [SPNAG]-[IL]-[QKNGT]-[PSA]-[QT]-[GQAPISTLYK]-T-G-[YFGML]-[YVMGAQL]-[QVLNPAG]-[ASQPN]Add BLAST434
Regioni328 – 6802 X 23 AA repeats of F-A-L-[AG]-M-H-L-[IV]-[NY]-[DG]-[VK]-L-[QN]-G-[DK]-[TP]-I-P-[YN]-[EV]-L-[DP]-SAdd BLAST353
Regioni1084 – 11257 X 6 AA tandem repeats of Q-[PS]-T-Q-P-VAdd BLAST42
Regioni1315 – 13778 X 6 AA repeats of [ATVSP]-P-[LVI]-P-[SPQILA]-[VAS]Add BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1131 – 1190Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 22Poly-Gln10
Compositional biasi29 – 34Poly-Gln6
Compositional biasi98 – 106Poly-Gln9
Compositional biasi1400 – 1406Poly-Pro7
Compositional biasi1452 – 1455Poly-Glu4
Compositional biasi1474 – 1480Poly-Pro7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAN1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32521

KEGG Orthology (KO)

More...
KOi
K20047

Identification of Orthologs from Complete Genome Data

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OMAi
PQRTGMQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052 EH, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013182 DUF1720
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08226 DUF1720, 3 hits
PF12763 EF-hand_4, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50031 EH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNPYQQQGM GYQQQQQQQQ QQPNGFYPQQ QQGQSSNQPQ GQPQPQQQMA
60 70 80 90 100
FNQPQATGIG GMPQSFGNSF SSMPQQPQTG YNNNGNNGSV YGNGNFGQQP
110 120 130 140 150
QQQQQQAKPQ HTGYVPNSSM PMMNTTGTMP PPNPAQQPQL QSIQPQGTGY
160 170 180 190 200
YQAANTANVH SVQPLQSQGT GYYVSTPNLI SSNQTQQPLQ AQGTGYYQSQ
210 220 230 240 250
PQQVPPPQQA QSLQPLKPQQ TGFYLQPQNQ APLEPLKPTA TGFVNSFANN
260 270 280 290 300
GLNNDIKIPA IRLSFITAQD QAKFETLFRS IVTNGSNTVS GANCRKILMR
310 320 330 340 350
SGLPPSQLAR IWTLCDTSKA GELLFPEFAL AMHLINDVLQ GDTIPYELDS
360 370 380 390 400
KTKNEVSSFI DAINLSIANQ DSSANDAPKT PFDEFITAGV QNLQPQPTGY
410 420 430 440 450
MPQTSFGIPL QSQITGGGVA SALNPQSTGF MAPTTFNMSM NTGTPGLNPQ
460 470 480 490 500
ITGGAPASMQ PNITGNALQP QTTGMMPQTT GMMPQTTGMM PQTSFGVNLG
510 520 530 540 550
PQLTGGALQS QYTGGYGSVM PQQSGPASMP NLSFNQQGLQ SQLTGLQPQP
560 570 580 590 600
TGFLPPSNFS ATMPLTAQKT GFGNNEIYTK SNFNNNLIDN SSQDKISTEE
610 620 630 640 650
KSLFYKIFET FDTQNKGLLD SPTAVEIFRK SGLNRADLEQ IWNLCDINNT
660 670 680 690 700
GQLNKQEFAL GMHLVYGKLN GKPIPNVLPS SLIPSSTKLL DNLKNQLKTE
710 720 730 740 750
PTTTKEKPSF GKIDALSYKN NDDDVLPNYR NRRKVYSAKN EEQSSFSSPS
760 770 780 790 800
AKSVNHSSST LQTDDISVDK TVEKKTAKPK YAGFSREINL KNIASLENEI
810 820 830 840 850
KNISNPENCY DSSIPSDLTS RFDAIIAKLP NLFNEISTID NEITNAKIQL
860 870 880 890 900
YRKKNPSSII GSGPNGEITE NDRKKAKSRA LLRARMSALT GKSTESEDSL
910 920 930 940 950
SMEDEQQSAE IKRIQQENGK NQEIIKDIRS SISDISASLK STMTGSNMIS
960 970 980 990 1000
NQEFERWEFG IGLEDGVREF LDDLKSNSNK SVTESSPFVP SSTPTPVDDR
1010 1020 1030 1040 1050
SSSPSYSQFK TAEERAAYLK EQAKKRMKEK LAKFDKNRRN VTQSSRSISS
1060 1070 1080 1090 1100
ENSREQPQQI AGSSNLVEPR ATPFQEEKYV EVAQPTQPVQ STQPVQPTQP
1110 1120 1130 1140 1150
VQPTQPVQPT QPVQPTQPVQ PTQPVQNVYN AKQESDDEDE DDEEKRLQEE
1160 1170 1180 1190 1200
LKRLKLKKKA DKEKRLAALR KQIEDAQNES DEEETNGKDN FGGHVNVPQA
1210 1220 1230 1240 1250
APVAPSAAFS QNSTNAPRSV HAAVTPAAGK NSTGLPSTTM GHNPYFKDAS
1260 1270 1280 1290 1300
ASSTSTFDAR AAEMQRRIQR GLDEDEDDGW SDEDESNNRV AVDNKVEEAK
1310 1320 1330 1340 1350
IGHPDHARAP PVTAAPLPSV TPVPPAVPVP QANTSNEKSS PIPIAPIPPS
1360 1370 1380 1390 1400
VTQEPPVPLA PPLPAVDGFQ EPPIPSAPAI ATAVQKSGSS TPALAGGVLP
1410 1420 1430 1440 1450
PPPPLPTQQA STSEPIIAHV DNYNGAEKGT GAYGSDSDDD VLSIPESVGT
1460 1470 1480
DEEEEGAQPV STAGIPSIPP AGIPPPPPLP
Length:1,480
Mass (Da):160,267
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3518495FF759553
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235P → T in AAA34841 (PubMed:1339314).Curated1
Sequence conflicti266 – 273ITAQDQAK → YYCPRSGKN in AAA34841 (PubMed:1339314).Curated8
Sequence conflicti474 – 487Missing AA sequence (PubMed:1339314).CuratedAdd BLAST14
Sequence conflicti653 – 657Missing in AAA34841 (PubMed:1339314).Curated5
Sequence conflicti1291A → R in AAA34841 (PubMed:1339314).Curated1
Sequence conflicti1396 – 1480GGVLP…PPPLP → EAFCLHPHLYQLNKLPLQNL LSLTLITTMVLKKARAHMDP ILMMTFYRFLNQLVQMKRKK GHNQFLLQVSHQFHLQVFLH PHPFHEDLICFL in AAA34841 (PubMed:1339314).CuratedAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z38062 Genomic DNA Translation: CAA86208.1
X79743 Genomic DNA Translation: CAB38097.1
M90688 Genomic DNA Translation: AAA34841.1
BK006942 Genomic DNA Translation: DAA08552.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48440

NCBI Reference Sequences

More...
RefSeqi
NP_012271.3, NM_001179528.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIR006C_mRNA; YIR006C; YIR006C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIR006C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38062 Genomic DNA Translation: CAA86208.1
X79743 Genomic DNA Translation: CAB38097.1
M90688 Genomic DNA Translation: AAA34841.1
BK006942 Genomic DNA Translation: DAA08552.1
PIRiS48440
RefSeqiNP_012271.3, NM_001179528.3

3D structure databases

SMRiP32521
ModBaseiSearch...

Protein-protein interaction databases

BioGridi34997, 648 interactors
ComplexPortaliCPX-426 PAN1 actin cytoskeleton-regulatory complex
DIPiDIP-1340N
IntActiP32521, 22 interactors
MINTiP32521
STRINGi4932.YIR006C

PTM databases

iPTMnetiP32521

Proteomic databases

MaxQBiP32521
PaxDbiP32521
PRIDEiP32521
TopDownProteomicsiP32521

Genome annotation databases

EnsemblFungiiYIR006C_mRNA; YIR006C; YIR006C
GeneIDi854822
KEGGisce:YIR006C

Organism-specific databases

EuPathDBiFungiDB:YIR006C
SGDiS000001445 PAN1

Phylogenomic databases

InParanoidiP32521
KOiK20047
OMAiPQRTGMQ

Enzyme and pathway databases

BioCyciYEAST:G3O-31427-MONOMER
ReactomeiR-SCE-194840 Rho GTPase cycle
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SCE-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32521

Family and domain databases

CDDicd00052 EH, 2 hits
InterProiView protein in InterPro
IPR013182 DUF1720
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF08226 DUF1720, 3 hits
PF12763 EF-hand_4, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00027 EH, 2 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50031 EH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAN1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32521
Secondary accession number(s): D6VVT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: October 16, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
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