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Protein

ETS-related transcription factor Elf-1

Gene

ELF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
SIGNORiP32519

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-1
Alternative name(s):
E74-like factor 1
Gene namesi
Name:ELF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120690.14
HGNCiHGNC:3316 ELF1
MIMi189973 gene
neXtProtiNX_P32519

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1997
OpenTargetsiENSG00000120690
PharmGKBiPA27744

Polymorphism and mutation databases

BioMutaiELF1
DMDMi212288097

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040851 – 619ETS-related transcription factor Elf-1Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei190PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP32519
MaxQBiP32519
PaxDbiP32519
PeptideAtlasiP32519
PRIDEiP32519
ProteomicsDBi54879

PTM databases

iPTMnetiP32519
PhosphoSitePlusiP32519

Expressioni

Tissue specificityi

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.2 Publications

Gene expression databases

BgeeiENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_ELF1
ExpressionAtlasiP32519 baseline and differential
GenevisibleiP32519 HS

Organism-specific databases

HPAiCAB005172
HPA001755

Interactioni

Subunit structurei

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi108312, 9 interactors
DIPiDIP-185N
ELMiP32519
IntActiP32519, 14 interactors
MINTiP32519
STRINGi9606.ENSP00000239882

Structurei

3D structure databases

ProteinModelPortaliP32519
SMRiP32519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Asp6

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiP32519
KOiK09428
OMAiHLHTVTL
OrthoDBiEOG091G04RR
PhylomeDBiP32519
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P32519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE
110 120 130 140 150
AAEALLNMDS PGPMLDEKRI NNNIFSSPED DMVVAPVTHV SVTLDGIPEV
160 170 180 190 200
METQQVQEKY ADSPGASSPE QPKRKKGRKT KPPRPDSPAT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN
310 320 330 340 350
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS
360 370 380 390 400
KAAKPKDPVE VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA
410 420 430 440 450
ARTSTMQDET LNSSVQSIRT IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT
460 470 480 490 500
VIASTDPSAG TGSQKFILQA IPSSQPMTVL KENVMLQSQK AGSPPSIVLG
510 520 530 540 550
PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR SSQLVAHPPG
560 570 580 590 600
TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN
610
GFTSQVAMKQ NELLEPNSF
Length:619
Mass (Da):67,498
Last modified:July 22, 2008 - v2
Checksum:iFA0A51B3965616F3
GO
Isoform 2 (identifier: P32519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-145: Missing.

Note: No experimental confirmation available.
Show »
Length:595
Mass (Da):64,929
Checksum:iCAF5EFA51EFAE710
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRL5A0A0U1RRL5_HUMAN
ETS-related transcription factor El...
ELF1
615Annotation score:
Q5T9E7Q5T9E7_HUMAN
ETS-related transcription factor El...
ELF1
24Annotation score:
A0A0D9SG85A0A0D9SG85_HUMAN
ETS-related transcription factor El...
ELF1
124Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04894258N → S1 PublicationCorresponds to variant dbSNP:rs7799Ensembl.1
Natural variantiVAR_048943343T → S1 PublicationCorresponds to variant dbSNP:rs1056820Ensembl.1
Natural variantiVAR_048944403T → I. Corresponds to variant dbSNP:rs7323148Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045682122 – 145Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82882 mRNA No translation available.
AK304289 mRNA Translation: BAG65147.1
AL157877 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08640.1
BC030507 mRNA Translation: AAH30507.1
CCDSiCCDS45043.1 [P32519-2]
CCDS9374.1 [P32519-1]
PIRiA43361
RefSeqiNP_001138825.1, NM_001145353.1 [P32519-2]
NP_758961.1, NM_172373.3 [P32519-1]
XP_005266333.1, XM_005266276.1 [P32519-1]
XP_005266334.1, XM_005266277.3 [P32519-1]
XP_011533252.1, XM_011534950.1 [P32519-1]
XP_016875898.1, XM_017020409.1
XP_016875899.1, XM_017020410.1
XP_016875900.1, XM_017020411.1
XP_016875901.1, XM_017020412.1
XP_016875902.1, XM_017020413.1
UniGeneiHs.135646

Genome annotation databases

EnsembliENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]
GeneIDi1997
KEGGihsa:1997
UCSCiuc001uxs.4 human [P32519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82882 mRNA No translation available.
AK304289 mRNA Translation: BAG65147.1
AL157877 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08640.1
BC030507 mRNA Translation: AAH30507.1
CCDSiCCDS45043.1 [P32519-2]
CCDS9374.1 [P32519-1]
PIRiA43361
RefSeqiNP_001138825.1, NM_001145353.1 [P32519-2]
NP_758961.1, NM_172373.3 [P32519-1]
XP_005266333.1, XM_005266276.1 [P32519-1]
XP_005266334.1, XM_005266277.3 [P32519-1]
XP_011533252.1, XM_011534950.1 [P32519-1]
XP_016875898.1, XM_017020409.1
XP_016875899.1, XM_017020410.1
XP_016875900.1, XM_017020411.1
XP_016875901.1, XM_017020412.1
XP_016875902.1, XM_017020413.1
UniGeneiHs.135646

3D structure databases

ProteinModelPortaliP32519
SMRiP32519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108312, 9 interactors
DIPiDIP-185N
ELMiP32519
IntActiP32519, 14 interactors
MINTiP32519
STRINGi9606.ENSP00000239882

PTM databases

iPTMnetiP32519
PhosphoSitePlusiP32519

Polymorphism and mutation databases

BioMutaiELF1
DMDMi212288097

Proteomic databases

EPDiP32519
MaxQBiP32519
PaxDbiP32519
PeptideAtlasiP32519
PRIDEiP32519
ProteomicsDBi54879

Protocols and materials databases

DNASUi1997
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]
GeneIDi1997
KEGGihsa:1997
UCSCiuc001uxs.4 human [P32519-1]

Organism-specific databases

CTDi1997
DisGeNETi1997
EuPathDBiHostDB:ENSG00000120690.14
GeneCardsiELF1
HGNCiHGNC:3316 ELF1
HPAiCAB005172
HPA001755
MIMi189973 gene
neXtProtiNX_P32519
OpenTargetsiENSG00000120690
PharmGKBiPA27744
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiP32519
KOiK09428
OMAiHLHTVTL
OrthoDBiEOG091G04RR
PhylomeDBiP32519
TreeFamiTF318679

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
SIGNORiP32519

Miscellaneous databases

ChiTaRSiELF1 human
GenomeRNAii1997
PROiPR:P32519
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_ELF1
ExpressionAtlasiP32519 baseline and differential
GenevisibleiP32519 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELF1_HUMAN
AccessioniPrimary (citable) accession number: P32519
Secondary accession number(s): B4E2I5
, E9PDQ9, Q8N6F6, Q9UDE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 22, 2008
Last modified: October 10, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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