UniProtKB - P32519 (ELF1_HUMAN)
ETS-related transcription factor Elf-1
ELF1
Functioni
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 208 – 290 | ETSPROSITE-ProRule annotationAdd BLAST | 83 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- negative regulation of T cell receptor signaling pathway Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of cytokine production Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P32519 |
Reactomei | R-HSA-8939245, RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling |
SignaLinki | P32519 |
SIGNORi | P32519 |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-1Alternative name(s): E74-like factor 1 |
Gene namesi | Name:ELF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3316, ELF1 |
MIMi | 189973, gene |
neXtProti | NX_P32519 |
VEuPathDBi | HostDB:ENSG00000120690 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1997 |
OpenTargetsi | ENSG00000120690 |
PharmGKBi | PA27744 |
Miscellaneous databases
Pharosi | P32519, Tbio |
Genetic variation databases
BioMutai | ELF1 |
DMDMi | 212288097 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204085 | 1 – 619 | ETS-related transcription factor Elf-1Add BLAST | 619 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 163 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 168 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphoserineCombined sources | 1 | |
Modified residuei | 190 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P32519 |
jPOSTi | P32519 |
MassIVEi | P32519 |
MaxQBi | P32519 |
PaxDbi | P32519 |
PeptideAtlasi | P32519 |
PRIDEi | P32519 |
ProteomicsDBi | 19727 54879 [P32519-1] |
PTM databases
GlyGeni | P32519, 19 sites, 2 O-linked glycans (19 sites) |
iPTMneti | P32519 |
MetOSitei | P32519 |
PhosphoSitePlusi | P32519 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000120690, Expressed in secondary oocyte and 238 other tissues |
ExpressionAtlasi | P32519, baseline and differential |
Genevisiblei | P32519, HS |
Organism-specific databases
HPAi | ENSG00000120690, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes.
Interacts with RUNX1.
2 PublicationsBinary interactionsi
P32519
With | #Exp. | IntAct |
---|---|---|
HOXC13 [P31276] | 3 | EBI-765526,EBI-2293590 |
NFYC - isoform 1 [Q13952-2] | 3 | EBI-765526,EBI-11956831 |
SP1 [P08047] | 2 | EBI-765526,EBI-298336 |
Protein-protein interaction databases
BioGRIDi | 108312, 17 interactors |
DIPi | DIP-185N |
ELMi | P32519 |
IntActi | P32519, 17 interactors |
MINTi | P32519 |
STRINGi | 9606.ENSP00000239882 |
Miscellaneous databases
RNActi | P32519, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 199 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 300 – 366 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 564 – 592 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 303 – 339 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 564 – 584 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000157039 |
InParanoidi | P32519 |
OMAi | HNYSGLT |
PhylomeDBi | P32519 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE
110 120 130 140 150
AAEALLNMDS PGPMLDEKRI NNNIFSSPED DMVVAPVTHV SVTLDGIPEV
160 170 180 190 200
METQQVQEKY ADSPGASSPE QPKRKKGRKT KPPRPDSPAT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN
310 320 330 340 350
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS
360 370 380 390 400
KAAKPKDPVE VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA
410 420 430 440 450
ARTSTMQDET LNSSVQSIRT IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT
460 470 480 490 500
VIASTDPSAG TGSQKFILQA IPSSQPMTVL KENVMLQSQK AGSPPSIVLG
510 520 530 540 550
PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR SSQLVAHPPG
560 570 580 590 600
TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN
610
GFTSQVAMKQ NELLEPNSF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RRL5 | A0A0U1RRL5_HUMAN | ETS-related transcription factor El... | ELF1 | 615 | Annotation score: | ||
Q5T9E7 | Q5T9E7_HUMAN | ETS-related transcription factor El... | ELF1 | 24 | Annotation score: | ||
A0A0D9SG85 | A0A0D9SG85_HUMAN | ETS-related transcription factor El... | ELF1 | 124 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048942 | 58 | N → S1 PublicationCorresponds to variant dbSNP:rs7799Ensembl. | 1 | |
Natural variantiVAR_048943 | 343 | T → S1 PublicationCorresponds to variant dbSNP:rs1056820Ensembl. | 1 | |
Natural variantiVAR_048944 | 403 | T → I. Corresponds to variant dbSNP:rs7323148Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045682 | 122 – 145 | Missing in isoform 2. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M82882 mRNA No translation available. AK304289 mRNA Translation: BAG65147.1 AL157877 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08640.1 BC030507 mRNA Translation: AAH30507.1 |
CCDSi | CCDS45043.1 [P32519-2] CCDS9374.1 [P32519-1] |
PIRi | A43361 |
RefSeqi | NP_001138825.1, NM_001145353.1 [P32519-2] NP_758961.1, NM_172373.3 [P32519-1] XP_005266333.1, XM_005266276.1 XP_005266334.1, XM_005266277.3 XP_011533252.1, XM_011534950.1 XP_016875898.1, XM_017020409.1 XP_016875899.1, XM_017020410.1 XP_016875900.1, XM_017020411.1 XP_016875901.1, XM_017020412.1 XP_016875902.1, XM_017020413.1 |
Genome annotation databases
Ensembli | ENST00000239882; ENSP00000239882; ENSG00000120690 ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2] |
GeneIDi | 1997 |
KEGGi | hsa:1997 |
MANE-Selecti | ENST00000239882.7; ENSP00000239882.3; NM_172373.4; NP_758961.1 |
UCSCi | uc001uxs.4, human [P32519-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M82882 mRNA No translation available. AK304289 mRNA Translation: BAG65147.1 AL157877 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08640.1 BC030507 mRNA Translation: AAH30507.1 |
CCDSi | CCDS45043.1 [P32519-2] CCDS9374.1 [P32519-1] |
PIRi | A43361 |
RefSeqi | NP_001138825.1, NM_001145353.1 [P32519-2] NP_758961.1, NM_172373.3 [P32519-1] XP_005266333.1, XM_005266276.1 XP_005266334.1, XM_005266277.3 XP_011533252.1, XM_011534950.1 XP_016875898.1, XM_017020409.1 XP_016875899.1, XM_017020410.1 XP_016875900.1, XM_017020411.1 XP_016875901.1, XM_017020412.1 XP_016875902.1, XM_017020413.1 |
3D structure databases
SMRi | P32519 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108312, 17 interactors |
DIPi | DIP-185N |
ELMi | P32519 |
IntActi | P32519, 17 interactors |
MINTi | P32519 |
STRINGi | 9606.ENSP00000239882 |
PTM databases
GlyGeni | P32519, 19 sites, 2 O-linked glycans (19 sites) |
iPTMneti | P32519 |
MetOSitei | P32519 |
PhosphoSitePlusi | P32519 |
Genetic variation databases
BioMutai | ELF1 |
DMDMi | 212288097 |
Proteomic databases
EPDi | P32519 |
jPOSTi | P32519 |
MassIVEi | P32519 |
MaxQBi | P32519 |
PaxDbi | P32519 |
PeptideAtlasi | P32519 |
PRIDEi | P32519 |
ProteomicsDBi | 19727 54879 [P32519-1] |
Protocols and materials databases
ABCDi | P32519, 55 sequenced antibodies |
Antibodypediai | 906, 373 antibodies from 39 providers |
DNASUi | 1997 |
Genome annotation databases
Ensembli | ENST00000239882; ENSP00000239882; ENSG00000120690 ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2] |
GeneIDi | 1997 |
KEGGi | hsa:1997 |
MANE-Selecti | ENST00000239882.7; ENSP00000239882.3; NM_172373.4; NP_758961.1 |
UCSCi | uc001uxs.4, human [P32519-1] |
Organism-specific databases
CTDi | 1997 |
DisGeNETi | 1997 |
GeneCardsi | ELF1 |
HGNCi | HGNC:3316, ELF1 |
HPAi | ENSG00000120690, Tissue enhanced (bone) |
MIMi | 189973, gene |
neXtProti | NX_P32519 |
OpenTargetsi | ENSG00000120690 |
PharmGKBi | PA27744 |
VEuPathDBi | HostDB:ENSG00000120690 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000157039 |
InParanoidi | P32519 |
OMAi | HNYSGLT |
PhylomeDBi | P32519 |
TreeFami | TF318679 |
Enzyme and pathway databases
PathwayCommonsi | P32519 |
Reactomei | R-HSA-8939245, RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling |
SignaLinki | P32519 |
SIGNORi | P32519 |
Miscellaneous databases
BioGRID-ORCSi | 1997, 22 hits in 1072 CRISPR screens |
ChiTaRSi | ELF1, human |
GenomeRNAii | 1997 |
Pharosi | P32519, Tbio |
PROi | PR:P32519 |
RNActi | P32519, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120690, Expressed in secondary oocyte and 238 other tissues |
ExpressionAtlasi | P32519, baseline and differential |
Genevisiblei | P32519, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF1_HUMAN | |
Accessioni | P32519Primary (citable) accession number: P32519 Secondary accession number(s): B4E2I5 Q9UDE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 23, 2022 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families