UniProtKB - P32519 (ELF1_HUMAN)

BLAST

>sp|P32519|ELF1_HUMAN ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2
MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM
ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI
NNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKT
KPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKL
VDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIN
DEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVE
VAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRT
IQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVL
KENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPR
SSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSN
GFTSQVAMKQNELLEPNSF

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History
Entry version 173 (10 Oct 2018)
Sequence version 2 (22 Jul 2008)
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Protein

ETS-related transcription factor Elf-1

Gene

ELF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	208 – 290	ETSPROSITE-ProRule annotationAdd BLAST		83

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14970218
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8756667
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8756667

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: GO_Central
negative regulation of T cell receptor signaling pathway Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 19674970
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 14970218
- 19674970
regulation of B cell receptor signaling pathway Source: Reactome
regulation of cytokine-mediated signaling pathway Source: Reactome
regulation of cytokine production Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
SIGNORⁱ	P32519

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ETS-related transcription factor Elf-1 Alternative name(s): E74-like factor 1
Gene namesⁱ	Name:ELF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120690.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3316 ELF1
MIMⁱ	189973 gene
neXtProtⁱ	NX_P32519

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1997
Open Targets More...OpenTargetsⁱ	ENSG00000120690
PharmGKBⁱ	PA27744

Polymorphism and mutation databases

BioMutaⁱ	ELF1
DMDMⁱ	212288097

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204085	1 – 619	ETS-related transcription factor Elf-1Add BLAST		619

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	110	PhosphoserineCombined sources	1
Modified residueⁱ	163	PhosphoserineCombined sources	1
Modified residueⁱ	167	PhosphoserineCombined sources	1
Modified residueⁱ	168	PhosphoserineCombined sources	1
Modified residueⁱ	187	PhosphoserineCombined sources	1
Modified residueⁱ	190	PhosphothreonineCombined sources	1
Modified residueⁱ	432	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P32519
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32519
PaxDbⁱ	P32519
PeptideAtlas More...PeptideAtlasⁱ	P32519
PRIDEⁱ	P32519
ProteomicsDBⁱ	54879

PTM databases

iPTMnetⁱ	P32519
PhosphoSitePlusⁱ	P32519

Expressionⁱ

Tissue specificityⁱ

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_ELF1
ExpressionAtlasⁱ	P32519 baseline and differential
Genevisibleⁱ	P32519 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005172 HPA001755

HPAⁱ

CAB005172
HPA001755

Interactionⁱ

Subunit structureⁱ

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HOXC13	P31276	3	EBI-765526,EBI-2293590
SP1	P08047	2	EBI-765526,EBI-298336

Protein-protein interaction databases

BioGridⁱ	108312, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-185N
ELMⁱ	P32519
IntActⁱ	P32519, 14 interactors
Molecular INTeraction database More...MINTⁱ	P32519
STRINGⁱ	9606.ENSP00000239882

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32519
SMRⁱ	P32519
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	75 – 80	Poly-Asp		6

Sequence similaritiesⁱ

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3804 Eukaryota ENOG4111K4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118996
HOGENOMⁱ	HOG000049253
HOVERGENⁱ	HBG007183
InParanoidⁱ	P32519
KEGG Orthology (KO) More...KOⁱ	K09428
OMAⁱ	HLHTVTL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04RR
PhylomeDBⁱ	P32519
TreeFamⁱ	TF318679

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR022084 TF_Elf_N IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12310 Elf-1_N, 1 hit PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P32519-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG 
        60         70         80         90        100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE 
       110        120        130        140        150
AAEALLNMDS PGPMLDEKRI NNNIFSSPED DMVVAPVTHV SVTLDGIPEV 
       160        170        180        190        200
METQQVQEKY ADSPGASSPE QPKRKKGRKT KPPRPDSPAT TPNISVKKKN 
       210        220        230        240        250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW 
       260        270        280        290        300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN 
       310        320        330        340        350
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS 
       360        370        380        390        400
KAAKPKDPVE VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA 
       410        420        430        440        450
ARTSTMQDET LNSSVQSIRT IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT 
       460        470        480        490        500
VIASTDPSAG TGSQKFILQA IPSSQPMTVL KENVMLQSQK AGSPPSIVLG 
       510        520        530        540        550
PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR SSQLVAHPPG 
       560        570        580        590        600
TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN 
       610 
GFTSQVAMKQ NELLEPNSF

Length:619

Mass (Da):67,498

Last modified:July 22, 2008 - v2

Checksum:ⁱFA0A51B3965616F3

Isoform 2 (identifier: P32519-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
122-145: Missing.

« Hide

        10         20         30         40         50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG 
        60         70         80         90        100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE 
       110        120        130        140        150
AAEALLNMDS PGPMLDEKRI NGIPEVMETQ QVQEKYADSP GASSPEQPKR 
       160        170        180        190        200
KKGRKTKPPR PDSPATTPNI SVKKKNKDGK GNTIYLWEFL LALLQDKATC 
       210        220        230        240        250
PKYIKWTQRE KGIFKLVDSK AVSRLWGKHK NKPDMNYETM GRALRYYYQR 
       260        270        280        290        300
GILAKVEGQR LVYQFKEMPK DLIYINDEDP SSSIESSDPS LSSSATSNRN 
       310        320        330        340        350
QTSRSRVSSS PGVKGGATTV LKPGNSKAAK PKDPVEVAQP SEVLRTVQPT 
       360        370        380        390        400
QSPYPTQLFR TVHVVQPVQA VPEGEAARTS TMQDETLNSS VQSIRTIQAP 
       410        420        430        440        450
TQVPVVVSPR NQQLHTVTLQ TVPLTTVIAS TDPSAGTGSQ KFILQAIPSS 
       460        470        480        490        500
QPMTVLKENV MLQSQKAGSP PSIVLGPAQV QQVLTSNVQT ICNGTVSVAS 
       510        520        530        540        550
SPSFSATAPV VTFSPRSSQL VAHPPGTVIT SVIKTQETKT LTQEVEKKES 
       560        570        580        590 
EDHLKENTEK TEQQPQPYVM VVSSSNGFTS QVAMKQNELL EPNSF

Note: No experimental confirmation available.

Show »

Length:595

Mass (Da):64,929

Checksum:ⁱCAF5EFA51EFAE710

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RRL5	A0A0U1RRL5_HUMAN	ETS-related transcription factor El... ETS-related transcription factor Elf-1	ELF1	615	Annotation score:
Q5T9E7	Q5T9E7_HUMAN	ETS-related transcription factor El... ETS-related transcription factor Elf-1	ELF1	24	Annotation score:
A0A0D9SG85	A0A0D9SG85_HUMAN	ETS-related transcription factor El... ETS-related transcription factor Elf-1	ELF1	124	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048942	58	N → S1 PublicationCorresponds to variant dbSNP:rs7799Ensembl.	1
Natural variantⁱVAR_048943	343	T → S1 PublicationCorresponds to variant dbSNP:rs1056820Ensembl.	1
Natural variantⁱVAR_048944	403	T → I. Corresponds to variant dbSNP:rs7323148Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045682	122 – 145	Missing in isoform 2. 1 PublicationAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M82882 mRNA No translation available. AK304289 mRNA Translation: BAG65147.1 AL157877 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08640.1 BC030507 mRNA Translation: AAH30507.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45043.1 [P32519-2] CCDS9374.1 [P32519-1]
PIRⁱ	A43361
NCBI Reference Sequences More...RefSeqⁱ	NP_001138825.1, NM_001145353.1 [P32519-2] NP_758961.1, NM_172373.3 [P32519-1] XP_005266333.1, XM_005266276.1 [P32519-1] XP_005266334.1, XM_005266277.3 [P32519-1] XP_011533252.1, XM_011534950.1 [P32519-1] XP_016875898.1, XM_017020409.1 XP_016875899.1, XM_017020410.1 XP_016875900.1, XM_017020411.1 XP_016875901.1, XM_017020412.1 XP_016875902.1, XM_017020413.1
UniGeneⁱ	Hs.135646

Genome annotation databases

Ensemblⁱ	ENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1] ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]
GeneIDⁱ	1997
KEGGⁱ	hsa:1997
UCSC genome browser More...UCSCⁱ	uc001uxs.4 human [P32519-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32519	E74-like factor 1 (Ets domain transcription factor), isoform CRA_a		HUMAN		619	UniRef100_P32519
E74 like ETS transcription factor 1		GORGO		619
ETS-related transcription factor Elf-1 (Fragment)		HUMAN		615
Uncharacterized protein DKFZp686H0575		HUMAN		361
cDNA FLJ38147 fis, clone D9OST2003762, highly similar to ETS-RELATED TRANSCRIPTION FACTOR ELF-1		HUMAN		143
+1

Protein	Similar proteins		Species	Score	Length	Source
P32519	E74-like factor 1 (Ets domain transcription factor), isoform CRA_a		HUMAN		619	UniRef90_P32519
E74 like ETS transcription factor 1		GORGO		619
ETS-related transcription factor Elf-1 isoform X1		ERIEU		624
Uncharacterized protein		PAPAN		620
E74 like ETS transcription factor 1		HORSE		620
+136
P32519-2	E74-like factor 1 (Ets domain transcription factor)		PANTR		595	UniRef90_P32519-2
Uncharacterized protein		Cebus capucinus imitator		595
ETS-related transcription factor Elf-1 isoform X2		TARSY		595
ELF1 isoform 5		PONAB		595
ETS-related transcription factor Elf-1 isoform X2		LEPWE		595
+26

Protein	Similar proteins		Species	Score	Length	Source
P32519	ETS-related transcription factor Elf-1		BOVIN		614	UniRef50_P32519
ETS-related transcription factor Elf-1		MOUSE		612
E74-like factor 1 (Ets domain transcription factor), isoform CRA_a		HUMAN		619
E74 like ETS transcription factor 1		GORGO		619
ETS-related transcription factor Elf-1 isoform X1		ERIEU		624
+412

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M82882 mRNA No translation available. AK304289 mRNA Translation: BAG65147.1 AL157877 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08640.1 BC030507 mRNA Translation: AAH30507.1
CCDSⁱ	CCDS45043.1 [P32519-2] CCDS9374.1 [P32519-1]
PIRⁱ	A43361
RefSeqⁱ	NP_001138825.1, NM_001145353.1 [P32519-2] NP_758961.1, NM_172373.3 [P32519-1] XP_005266333.1, XM_005266276.1 [P32519-1] XP_005266334.1, XM_005266277.3 [P32519-1] XP_011533252.1, XM_011534950.1 [P32519-1] XP_016875898.1, XM_017020409.1 XP_016875899.1, XM_017020410.1 XP_016875900.1, XM_017020411.1 XP_016875901.1, XM_017020412.1 XP_016875902.1, XM_017020413.1
UniGeneⁱ	Hs.135646

3D structure databases

ProteinModelPortalⁱ	P32519
SMRⁱ	P32519
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108312, 9 interactors
DIPⁱ	DIP-185N
ELMⁱ	P32519
IntActⁱ	P32519, 14 interactors
MINTⁱ	P32519
STRINGⁱ	9606.ENSP00000239882

PTM databases

iPTMnetⁱ	P32519
PhosphoSitePlusⁱ	P32519

Polymorphism and mutation databases

BioMutaⁱ	ELF1
DMDMⁱ	212288097

Proteomic databases

EPDⁱ	P32519
MaxQBⁱ	P32519
PaxDbⁱ	P32519
PeptideAtlasⁱ	P32519
PRIDEⁱ	P32519
ProteomicsDBⁱ	54879

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1997
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1] ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]
GeneIDⁱ	1997
KEGGⁱ	hsa:1997
UCSCⁱ	uc001uxs.4 human [P32519-1]

Organism-specific databases

CTDⁱ	1997
DisGeNETⁱ	1997
EuPathDBⁱ	HostDB:ENSG00000120690.14
GeneCardsⁱ	ELF1
HGNCⁱ	HGNC:3316 ELF1
HPAⁱ	CAB005172 HPA001755
MIMⁱ	189973 gene
neXtProtⁱ	NX_P32519
OpenTargetsⁱ	ENSG00000120690
PharmGKBⁱ	PA27744
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3804 Eukaryota ENOG4111K4J LUCA
GeneTreeⁱ	ENSGT00760000118996
HOGENOMⁱ	HOG000049253
HOVERGENⁱ	HBG007183
InParanoidⁱ	P32519
KOⁱ	K09428
OMAⁱ	HLHTVTL
OrthoDBⁱ	EOG091G04RR
PhylomeDBⁱ	P32519
TreeFamⁱ	TF318679

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
SIGNORⁱ	P32519

Miscellaneous databases

ChiTaRSⁱ	ELF1 human
GenomeRNAiⁱ	1997
Protein Ontology More...PROⁱ	PR:P32519
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_ELF1
ExpressionAtlasⁱ	P32519 baseline and differential
Genevisibleⁱ	P32519 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR022084 TF_Elf_N IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF12310 Elf-1_N, 1 hit PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELF1_HUMAN
Accessionⁱ	P32519Primary (citable) accession number: P32519 Secondary accession number(s): B4E2I5 , E9PDQ9, Q8N6F6, Q9UDE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	July 22, 2008
	Last modified:	October 10, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

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UniRef

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Supporting data

UniProtKB - P32519 (ELF1_HUMAN)

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ETS-related transcription factor Elf-1

ELF1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ