Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 192 (07 Oct 2020)
Sequence version 1 (01 Oct 1993)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

GCD6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a catalytic component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.2 Publications

Miscellaneous

Present with 33800 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.5.3, 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-72731, Recycling of eIF2:GDP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCD6
Synonyms:TIF225
Ordered Locus Names:YDR211W
ORF Names:YD8142.12, YD8142B.03
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR211W

Saccharomyces Genome Database

More...
SGDi
S000002619, GCD6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi552T → I: Reduced exchange activity. 1 Publication1
Mutagenesisi569E → A: Lethal. 1 Publication1
Mutagenesisi576S → N: Reduced exchange activity. 1 Publication1
Mutagenesisi655 – 677LFSAL…IYKWW → AFSAAVSAADNDAAEAAVAA KWA: Abolishes binding to SUI3. 1 PublicationAdd BLAST23
Mutagenesisi696 – 706WVEWLQNADEE → AAEAAQNAAAA: Abolishes binding to SUI3; probably impairs the conversion of eIF-2-GDP to eIF-2-GTP. 1 PublicationAdd BLAST11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001560781 – 712Translation initiation factor eIF-2B subunit epsilonAdd BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei478PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32501

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32501

PRoteomics IDEntifications database

More...
PRIDEi
P32501

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Translation initiation factor 2B (eIF2-B) is composed of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6). A catalytic subcomplex comprising GCD1 and GCD6 interacts with both, phosphorylated and non-phosphorylated eIF-2 and has exchange activity in vitro. GCD6 interacts with SUI3.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32265, 96 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-429, Eukaryotic translation initiation factor 2B complex

Database of interacting proteins

More...
DIPi
DIP-2328N

Protein interaction database and analysis system

More...
IntActi
P32501, 31 interactors

Molecular INTeraction database

More...
MINTi
P32501

STRING: functional protein association networks

More...
STRINGi
4932.YDR211W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32501, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1712
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32501

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P32501

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini539 – 710W2PROSITE-ProRule annotationAdd BLAST172

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1461, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012507_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32501

KEGG Orthology (KO)

More...
KOi
K03240

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRMSMNV

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04197, eIF-2B_epsilon_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR035543, eIF-2B_epsilon_N
IPR001451, Hexapep
IPR016021, MIF4-like_sf
IPR005835, NTP_transferase_dom
IPR029044, Nucleotide-diphossugar_trans
IPR011004, Trimer_LpxA-like_sf
IPR003307, W2_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00132, Hexapep, 2 hits
PF00483, NTP_transferase, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515, eIF5C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF51161, SSF51161, 1 hit
SSF53448, SSF53448, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32501-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKKGQKKS GLGNHGKNSD MDVEDRLQAV VLTDSYETRF MPLTAVKPRC
60 70 80 90 100
LLPLANVPLI EYTLEFLAKA GVHEVFLICS SHANQINDYI ENSKWNLPWS
110 120 130 140 150
PFKITTIMSP EARCTGDVMR DLDNRGIITG DFILVSGDVL TNIDFSKMLE
160 170 180 190 200
FHKKMHLQDK DHISTMCLSK ASTYPKTRTI EPAAFVLDKS TSRCIYYQDL
210 220 230 240 250
PLPSSREKTS IQIDPELLDN VDEFVIRNDL IDCRIDICTS HVPLIFQENF
260 270 280 290 300
DYQSLRTDFV KGVISSDILG KHIYAYLTDE YAVRVESWQT YDTISQDFLG
310 320 330 340 350
RWCYPLVLDS NIQDDQTYSY ESRHIYKEKD VVLAQSCKIG KCTAIGSGTK
360 370 380 390 400
IGEGTKIENS VIGRNCQIGE NIRIKNSFIW DDCIIGNNSI IDHSLIASNA
410 420 430 440 450
TLGSNVRLND GCIIGFNVKI DDNMDLDRNT KISASPLKNA GSRMYDNESN
460 470 480 490 500
EQFDQDLDDQ TLAVSIVGDK GVGYIYESEV SDDEDSSTEA CKEINTLSNQ
510 520 530 540 550
LDELYLSDDS ISSATKKTKK RRTMSVNSIY TDREEIDSEF EDEDFEKEGI
560 570 580 590 600
ATVERAMENN HDLDTALLEL NTLRMSMNVT YHEVRIATIT ALLRRVYHFI
610 620 630 640 650
ATQTLGPKDA VVKVFNQWGL LFKRQAFDEE EYIDLMNIIM EKIVEQSFDK
660 670 680 690 700
PDLILFSALV SLYDNDIIEE DVIYKWWDNV STDPRYDEVK KLTVKWVEWL
710
QNADEESSSE EE
Length:712
Mass (Da):81,161
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFE87F6AE2941619
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L07115 Genomic DNA Translation: AAA65498.1
Z68194 Genomic DNA Translation: CAA92354.1
Z68195 Genomic DNA Translation: CAA92362.1
BK006938 Genomic DNA Translation: DAA12055.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48156

NCBI Reference Sequences

More...
RefSeqi
NP_010497.3, NM_001180519.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR211W_mRNA; YDR211W; YDR211W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR211W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07115 Genomic DNA Translation: AAA65498.1
Z68194 Genomic DNA Translation: CAA92354.1
Z68195 Genomic DNA Translation: CAA92362.1
BK006938 Genomic DNA Translation: DAA12055.1
PIRiA48156
RefSeqiNP_010497.3, NM_001180519.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PAQX-ray2.30A524-712[»]
6I3Melectron microscopy3.93G/H1-712[»]
6I7Telectron microscopy4.61G/H1-712[»]
6QG0electron microscopy4.20I/J1-712[»]
6QG1electron microscopy4.20I/J1-712[»]
6QG2electron microscopy4.60I/J1-712[»]
6QG3electron microscopy9.40I/J1-712[»]
6QG5electron microscopy10.10I/J1-712[»]
6QG6electron microscopy4.65I/J1-712[»]
SMRiP32501
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32265, 96 interactors
ComplexPortaliCPX-429, Eukaryotic translation initiation factor 2B complex
DIPiDIP-2328N
IntActiP32501, 31 interactors
MINTiP32501
STRINGi4932.YDR211W

PTM databases

iPTMnetiP32501

Proteomic databases

MaxQBiP32501
PaxDbiP32501
PRIDEiP32501

Genome annotation databases

EnsemblFungiiYDR211W_mRNA; YDR211W; YDR211W
GeneIDi851797
KEGGisce:YDR211W

Organism-specific databases

EuPathDBiFungiDB:YDR211W
SGDiS000002619, GCD6

Phylogenomic databases

eggNOGiKOG1461, Eukaryota
GeneTreeiENSGT00510000047568
HOGENOMiCLU_012507_1_0_1
InParanoidiP32501
KOiK03240
OMAiLRMSMNV

Enzyme and pathway databases

BRENDAi3.6.5.3, 984
ReactomeiR-SCE-72731, Recycling of eIF2:GDP

Miscellaneous databases

EvolutionaryTraceiP32501

Protein Ontology

More...
PROi
PR:P32501
RNActiP32501, protein

Family and domain databases

CDDicd04197, eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035543, eIF-2B_epsilon_N
IPR001451, Hexapep
IPR016021, MIF4-like_sf
IPR005835, NTP_transferase_dom
IPR029044, Nucleotide-diphossugar_trans
IPR011004, Trimer_LpxA-like_sf
IPR003307, W2_domain
PfamiView protein in Pfam
PF00132, Hexapep, 2 hits
PF00483, NTP_transferase, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF51161, SSF51161, 1 hit
SSF53448, SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51363, W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEI2BE_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32501
Secondary accession number(s): D6VSJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 7, 2020
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again