UniProtKB - P32487 (LYP1_YEAST)
Protein
Lysine-specific permease
Gene
LYP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
High-affinity permease for lysine.1 Publication
Miscellaneous
Present with 2580 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- basic amino acid transmembrane transporter activity Source: SGD
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- basic amino acid transport Source: SGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Protein family/group databases
TCDBi | 2.A.3.10.10, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine-specific permease |
Gene namesi | Name:LYP1 Ordered Locus Names:YNL268W ORF Names:N0790 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005212, LYP1 |
VEuPathDBi | FungiDB:YNL268W |
Subcellular locationi
Other locations
Mitochondrion
- mitochondrion Source: SGD
Other locations
- eisosome Source: SGD
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 115 | CytoplasmicSequence analysisAdd BLAST | 115 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 137 – 141 | ExtracellularSequence analysis | 5 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 185 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 186 – 205 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 206 – 223 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 224 – 243 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 244 – 256 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 257 – 274 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 275 – 303 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 304 – 321 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 322 – 344 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 366 – 398 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 399 – 418 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 419 – 445 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 446 – 464 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 465 – 473 | ExtracellularSequence analysis | 9 | |
Transmembranei | 474 – 494 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 495 – 513 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 514 – 532 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 533 – 547 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 548 – 566 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 567 – 611 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054156 | 1 – 611 | Lysine-specific permeaseAdd BLAST | 611 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 54 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 64 | PhosphoserineCombined sources | 1 | |
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 77 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 79 | PhosphoserineCombined sources | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P32487 |
PaxDbi | P32487 |
PRIDEi | P32487 |
PTM databases
iPTMneti | P32487 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35572, 39 interactors |
IntActi | P32487, 4 interactors |
MINTi | P32487 |
STRINGi | 4932.YNL268W |
Miscellaneous databases
RNActi | P32487, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P32487 |
OMAi | KRRWLNS |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P32487-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRFSNIITS NKWDEKQNNI GEQSMQELPE DQIEHEMEAI DPSNKTTPYS
60 70 80 90 100
IDEKQYNTKK KHGSLQGGAI ADVNSITNSL TRLQVVSHET DINEDEEEAH
110 120 130 140 150
YEDKHVKRAL KQRHIGMIAL GGTIGTGLFV GISTPLSNAG PVGSLIAYIF
160 170 180 190 200
MGTIVYFVTQ SLGEMATFIP VTSSITVFSK RFLSPAFGVS NGYMYWFNWA
210 220 230 240 250
ITYAVEVSVI GQVIEYWTDK VPLAAWIAIF WVIITLMNFF PVKVYGEFEF
260 270 280 290 300
WVASVKVLAI MGYLIYALII VCGGSHQGPI GFRYWRNPGA WGPGIISSDK
310 320 330 340 350
SEGRFLGWVS SLINAAFTYQ GTELVGITAG EAANPRKTVP RAINKVVFRI
360 370 380 390 400
VLFYIMSLFF IGLLVPYNDS RLSASSAVIA SSPFVISIQN AGTYALPDIF
410 420 430 440 450
NAVVLITVVS AANSNVYVGS RVLYSLARTG NAPKQFGYVT RQGVPYLGVV
460 470 480 490 500
CTAALGLLAF LVVNNNANTA FNWLINISTL AGLCAWLFIS LAHIRFMQAL
510 520 530 540 550
KHRGISRDDL PFKAKLMPYG AYYAAFFVTV IIFIQGFQAF CPFKVSEFFT
560 570 580 590 600
SYISLILLAV VFIGCQIYYK CRFIWKLEDI DIDSDRREIE AIIWEDDEPK
610
NLWEKFWAAV A
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | T → P in CAA47729 (PubMed:8368011).Curated | 1 | |
Sequence conflicti | 93 | N → D in CAA47729 (PubMed:8368011).Curated | 1 | |
Sequence conflicti | 561 | V → M in CAA47729 (PubMed:8368011).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X67315 Genomic DNA Translation: CAA47729.1 X92494 Genomic DNA Translation: CAA63230.1 Z71544 Genomic DNA Translation: CAA96175.1 BK006947 Genomic DNA Translation: DAA10292.1 |
PIRi | S60914 |
RefSeqi | NP_014131.1, NM_001183106.1 |
Genome annotation databases
EnsemblFungii | YNL268W_mRNA; YNL268W; YNL268W |
GeneIDi | 855453 |
KEGGi | sce:YNL268W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X67315 Genomic DNA Translation: CAA47729.1 X92494 Genomic DNA Translation: CAA63230.1 Z71544 Genomic DNA Translation: CAA96175.1 BK006947 Genomic DNA Translation: DAA10292.1 |
PIRi | S60914 |
RefSeqi | NP_014131.1, NM_001183106.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35572, 39 interactors |
IntActi | P32487, 4 interactors |
MINTi | P32487 |
STRINGi | 4932.YNL268W |
Protein family/group databases
TCDBi | 2.A.3.10.10, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | P32487 |
Proteomic databases
MaxQBi | P32487 |
PaxDbi | P32487 |
PRIDEi | P32487 |
Genome annotation databases
EnsemblFungii | YNL268W_mRNA; YNL268W; YNL268W |
GeneIDi | 855453 |
KEGGi | sce:YNL268W |
Organism-specific databases
SGDi | S000005212, LYP1 |
VEuPathDBi | FungiDB:YNL268W |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P32487 |
OMAi | KRRWLNS |
Miscellaneous databases
PROi | PR:P32487 |
RNActi | P32487, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYP1_YEAST | |
Accessioni | P32487Primary (citable) accession number: P32487 Secondary accession number(s): D6W0S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - SIMILARITY comments
Index of protein domains and families