Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 169 (05 Jun 2019)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Lysine-specific permease

Gene

LYP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity permease for lysine.1 Publication

Miscellaneous

Present with 2580 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33262-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.10.10 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYP1
Ordered Locus Names:YNL268W
ORF Names:N0790
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YNL268W

Saccharomyces Genome Database

More...
SGDi
S000005212 LYP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 115CytoplasmicSequence analysisAdd BLAST115
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 141ExtracellularSequence analysis5
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 185CytoplasmicSequence analysisAdd BLAST23
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 223ExtracellularSequence analysisAdd BLAST18
Transmembranei224 – 243HelicalSequence analysisAdd BLAST20
Topological domaini244 – 256CytoplasmicSequence analysisAdd BLAST13
Transmembranei257 – 274HelicalSequence analysisAdd BLAST18
Topological domaini275 – 303ExtracellularSequence analysisAdd BLAST29
Transmembranei304 – 321HelicalSequence analysisAdd BLAST18
Topological domaini322 – 344CytoplasmicSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 398ExtracellularSequence analysisAdd BLAST33
Transmembranei399 – 418HelicalSequence analysisAdd BLAST20
Topological domaini419 – 445CytoplasmicSequence analysisAdd BLAST27
Transmembranei446 – 464HelicalSequence analysisAdd BLAST19
Topological domaini465 – 473ExtracellularSequence analysis9
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 513CytoplasmicSequence analysisAdd BLAST19
Transmembranei514 – 532HelicalSequence analysisAdd BLAST19
Topological domaini533 – 547ExtracellularSequence analysisAdd BLAST15
Transmembranei548 – 566HelicalSequence analysisAdd BLAST19
Topological domaini567 – 611CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541561 – 611Lysine-specific permeaseAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei90PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32487

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32487

PRoteomics IDEntifications database

More...
PRIDEi
P32487

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32487

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35572, 38 interactors

Protein interaction database and analysis system

More...
IntActi
P32487, 4 interactors

Molecular INTeraction database

More...
MINTi
P32487

STRING: functional protein association networks

More...
STRINGi
4932.YNL268W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261850

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32487

KEGG Orthology (KO)

More...
KOi
K16261

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYWFNWA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00913 2A0310, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRFSNIITS NKWDEKQNNI GEQSMQELPE DQIEHEMEAI DPSNKTTPYS
60 70 80 90 100
IDEKQYNTKK KHGSLQGGAI ADVNSITNSL TRLQVVSHET DINEDEEEAH
110 120 130 140 150
YEDKHVKRAL KQRHIGMIAL GGTIGTGLFV GISTPLSNAG PVGSLIAYIF
160 170 180 190 200
MGTIVYFVTQ SLGEMATFIP VTSSITVFSK RFLSPAFGVS NGYMYWFNWA
210 220 230 240 250
ITYAVEVSVI GQVIEYWTDK VPLAAWIAIF WVIITLMNFF PVKVYGEFEF
260 270 280 290 300
WVASVKVLAI MGYLIYALII VCGGSHQGPI GFRYWRNPGA WGPGIISSDK
310 320 330 340 350
SEGRFLGWVS SLINAAFTYQ GTELVGITAG EAANPRKTVP RAINKVVFRI
360 370 380 390 400
VLFYIMSLFF IGLLVPYNDS RLSASSAVIA SSPFVISIQN AGTYALPDIF
410 420 430 440 450
NAVVLITVVS AANSNVYVGS RVLYSLARTG NAPKQFGYVT RQGVPYLGVV
460 470 480 490 500
CTAALGLLAF LVVNNNANTA FNWLINISTL AGLCAWLFIS LAHIRFMQAL
510 520 530 540 550
KHRGISRDDL PFKAKLMPYG AYYAAFFVTV IIFIQGFQAF CPFKVSEFFT
560 570 580 590 600
SYISLILLAV VFIGCQIYYK CRFIWKLEDI DIDSDRREIE AIIWEDDEPK
610
NLWEKFWAAV A
Length:611
Mass (Da):68,090
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E7AF6F7F5F1461B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90T → P in CAA47729 (PubMed:8368011).Curated1
Sequence conflicti93N → D in CAA47729 (PubMed:8368011).Curated1
Sequence conflicti561V → M in CAA47729 (PubMed:8368011).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67315 Genomic DNA Translation: CAA47729.1
X92494 Genomic DNA Translation: CAA63230.1
Z71544 Genomic DNA Translation: CAA96175.1
BK006947 Genomic DNA Translation: DAA10292.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S60914

NCBI Reference Sequences

More...
RefSeqi
NP_014131.1, NM_001183106.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL268W_mRNA; YNL268W_mRNA; YNL268W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL268W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67315 Genomic DNA Translation: CAA47729.1
X92494 Genomic DNA Translation: CAA63230.1
Z71544 Genomic DNA Translation: CAA96175.1
BK006947 Genomic DNA Translation: DAA10292.1
PIRiS60914
RefSeqiNP_014131.1, NM_001183106.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi35572, 38 interactors
IntActiP32487, 4 interactors
MINTiP32487
STRINGi4932.YNL268W

Protein family/group databases

TCDBi2.A.3.10.10 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiP32487

Proteomic databases

MaxQBiP32487
PaxDbiP32487
PRIDEiP32487

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL268W_mRNA; YNL268W_mRNA; YNL268W
GeneIDi855453
KEGGisce:YNL268W

Organism-specific databases

EuPathDBiFungiDB:YNL268W
SGDiS000005212 LYP1

Phylogenomic databases

HOGENOMiHOG000261850
InParanoidiP32487
KOiK16261
OMAiMYWFNWA

Enzyme and pathway databases

BioCyciYEAST:G3O-33262-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32487

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYP1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32487
Secondary accession number(s): D6W0S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: June 5, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again