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Entry version 154 (11 Dec 2019)
Sequence version 1 (01 Oct 1993)
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Protein

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Gene

DPH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.1 Publication

Miscellaneous

Present with 3486 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-15579
YEAST:MONOMER-15579

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.108 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2Curated (EC:2.5.1.1082 Publications)
Alternative name(s):
Diphthamide biosynthesis protein 2
Diphtheria toxin resistance protein 2
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPH2
Ordered Locus Names:YKL191W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YKL191W

Saccharomyces Genome Database

More...
SGDi
S000001674 DPH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833941 – 5342-(3-amino-3-carboxypropyl)histidine synthase subunit 2Add BLAST534

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32461

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32461

PRoteomics IDEntifications database

More...
PRIDEi
P32461

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32461

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the diphthamide biosynthesis proteins DPH1 and KTI11/DPH3.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P404873EBI-6090,EBI-25162

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33930, 122 interactors

Database of interacting proteins

More...
DIPi
DIP-5654N

Protein interaction database and analysis system

More...
IntActi
P32461, 2 interactors

Molecular INTeraction database

More...
MINTi
P32461

STRING: functional protein association networks

More...
STRINGi
4932.YKL191W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32461 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000182223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32461

KEGG Orthology (KO)

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KOi
K17866

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVTPFEM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010014 DHP2
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3

The PANTHER Classification System

More...
PANTHERi
PTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01866 Diphthamide_syn, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32461-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVAPALSTT QSDVAFQKVE THEIDRSSYL GPCYNSDELM QLISAYYNVE
60 70 80 90 100
PLVGYLEQHP EYQNVTLQFP DDLIKDSSLI VRLLQSKFPH GKIKFWVLAD
110 120 130 140 150
TAYSACCVDE VAAEHVHAEV VVHFGDACLN AIQNLPVVYS FGTPFLDLAL
160 170 180 190 200
VVENFQRAFP DLSSKICLMA NAPFSKHLSQ LYNILKGDLH YTNIIYSQVN
210 220 230 240 250
TSAVEEKFVT ILDTFHVPED VDQVGVFEKN SVLFGQHDKA DNISPEDYHL
260 270 280 290 300
FHLTTPQDPR LLYLSTVFQS VHIFDPALPG MVTGPFPSLM RRYKYMHVAR
310 320 330 340 350
TAGCIGILVN TLSLRNTRET INELVKLIKT REKKHYLFVV GKPNVAKLAN
360 370 380 390 400
FEDIDIWCIL GCSQSGIIVD QFNEFYKPII TPYELNLALS EEVTWTGKWV
410 420 430 440 450
VDFRDAIDEI EQNLGGQDTI SASTTSDEPE FDVVRGRYTS TSRPLRALTH
460 470 480 490 500
LELEAADDDD SKQLTTRHTA SGAVIKGTVS TSASALQNRS WKGLGSDFDS
510 520 530
TEVDNTGADI EEGISGVARG YGFDREDAMK KENK
Length:534
Mass (Da):59,775
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F2728DAE0A27431
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L01424 Genomic DNA Translation: AAA64990.1
X69765 Genomic DNA Translation: CAA49420.1
X74151 Genomic DNA Translation: CAA52247.1
Z28191 Genomic DNA Translation: CAA82035.1
Z26521 Genomic DNA Translation: CAA81289.1
BK006944 Genomic DNA Translation: DAA08975.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B59228 S34679

NCBI Reference Sequences

More...
RefSeqi
NP_012730.1, NM_001179757.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL191W_mRNA; YKL191W; YKL191W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL191W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01424 Genomic DNA Translation: AAA64990.1
X69765 Genomic DNA Translation: CAA49420.1
X74151 Genomic DNA Translation: CAA52247.1
Z28191 Genomic DNA Translation: CAA82035.1
Z26521 Genomic DNA Translation: CAA81289.1
BK006944 Genomic DNA Translation: DAA08975.1
PIRiB59228 S34679
RefSeqiNP_012730.1, NM_001179757.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi33930, 122 interactors
DIPiDIP-5654N
IntActiP32461, 2 interactors
MINTiP32461
STRINGi4932.YKL191W

PTM databases

iPTMnetiP32461

Proteomic databases

MaxQBiP32461
PaxDbiP32461
PRIDEiP32461

Genome annotation databases

EnsemblFungiiYKL191W_mRNA; YKL191W; YKL191W
GeneIDi853643
KEGGisce:YKL191W

Organism-specific databases

EuPathDBiFungiDB:YKL191W
SGDiS000001674 DPH2

Phylogenomic databases

HOGENOMiHOG000182223
InParanoidiP32461
KOiK17866
OMAiVVTPFEM

Enzyme and pathway databases

UniPathwayiUPA00559
BioCyciMetaCyc:MONOMER-15579
YEAST:MONOMER-15579
BRENDAi2.5.1.108 984
ReactomeiR-SCE-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32461
RNActiP32461 protein

Family and domain databases

Gene3Di3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit
InterProiView protein in InterPro
IPR010014 DHP2
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3
PANTHERiPTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit
PfamiView protein in Pfam
PF01866 Diphthamide_syn, 1 hit
SFLDiSFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32461
Secondary accession number(s): D6VX09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 11, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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