UniProtKB - P32455 (GBP1_HUMAN)

BLAST

>sp|P32455|GBP1_HUMAN Guanylate-binding protein 1 OS=Homo sapiens OX=9606 GN=GBP1 PE=1 SV=2
MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDS
EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEE
EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS

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History
Entry version 171 (07 Nov 2018)
Sequence version 2 (02 Nov 2010)
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Protein

Guanylate-binding protein 1

Gene

GBP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.1 Publication

Catalytic activityⁱ

GTP + H₂O = GDP + phosphate.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	45 – 52	GTP	8
Nucleotide bindingⁱ	67 – 69	GTP	3
Nucleotide bindingⁱ	97 – 101	GTP	5

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24337748
cytokine binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
GDP binding
Source: CAFA
Inferred from direct assayⁱ
- 10676968
GTPase activity
Source: CAFA
Inferred from direct assayⁱ
- 10676968
GTP binding
Source: CAFA
Inferred from direct assayⁱ
- 10676968
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21151871
spectrin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interferon-gamma
Source: UniProtKB
Inferred from direct assayⁱ
- 17266443
- 21151871
cellular response to interleukin-1
Source: UniProtKB
Inferred from expression patternⁱ
- 17266443
cellular response to tumor necrosis factor
Source: UniProtKB
Inferred from expression patternⁱ
- 17266443
defense response to virus Source: UniProtKB-KW
interferon-gamma-mediated signaling pathway Source: Reactome
negative regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
negative regulation of interleukin-2 secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
negative regulation of protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
negative regulation of substrate adhesion-dependent cell spreading
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
negative regulation of T cell receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
protein homooligomerization
Source: CAFA
Inferred from direct assayⁱ
- 10676968
protein localization to vacuole
Source: UniProtKB
Inferred from direct assayⁱ
- 21151871
regulation of calcium-mediated signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24337748
regulation of protein localization to plasma membrane
Source: UniProtKB
Inferred from genetic interactionⁱ
- 24337748

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Antiviral defense, Immunity
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300 Interferon gamma signaling

Reactomeⁱ

R-HSA-877300 Interferon gamma signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanylate-binding protein 1 (EC:3.6.5.-2 Publications) Alternative name(s): GTP-binding protein 1 Short name: GBP-1 Short name: HuGBP-1 Guanine nucleotide-binding protein 1 Interferon-induced guanylate-binding protein 1
Gene namesⁱ	Name:GBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117228.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4182 GBP1
MIMⁱ	600411 gene
neXtProtⁱ	NX_P32455

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	51	K → A: Loss of GTPase activity. Constitutively monomeric. Expressed throughout the cytoplasm, loss of vesicular accumulation. 1 Publication	1
Mutagenesisⁱ	227 – 228	RK → EE: Constitutively dimeric. Localizes at vesicle-like structures at the plasma membrane. 1 Publication	2
Mutagenesisⁱ	589 – 592	Missing : Loss of association with membranes. 1 Publication	4

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2633
Open Targets More...OpenTargetsⁱ	ENSG00000117228
PharmGKBⁱ	PA28596

Polymorphism and mutation databases

BioMutaⁱ	GBP1
DMDMⁱ	311033383

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000190963	1 – 589	Guanylate-binding protein 1Add BLAST		589
PropeptideⁱPRO_0000396777	590 – 592	Removed in mature form		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	589	Cysteine methyl esterBy similarity		1
Lipidationⁱ	589	S-farnesyl cysteine1 Publication		1

Post-translational modificationⁱ

Isoprenylation is required for proper subcellular location.1 Publication

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P32455
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32455
PaxDbⁱ	P32455
PeptideAtlas More...PeptideAtlasⁱ	P32455
PRIDEⁱ	P32455
ProteomicsDBⁱ	54877

PTM databases

iPTMnetⁱ	P32455
PhosphoSitePlusⁱ	P32455
SwissPalmⁱ	P32455

Expressionⁱ

Inductionⁱ

By IFNG during macrophage activation, and by TNF and IL1B.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000117228 Expressed in 222 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_GBP1
Genevisibleⁱ	P32455 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015450

HPAⁱ

CAB015450

Interactionⁱ

Subunit structureⁱ

Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		9	EBI-2869161,EBI-2869161

With

Entry

#Exp.

IntAct

Notes

itself

EBI-2869161,EBI-2869161

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24337748
cytokine binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21151871
spectrin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24337748

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108903, 20 interactors
Database of interacting proteins More...DIPⁱ	DIP-60423N
IntActⁱ	P32455, 2 interactors
Molecular INTeraction database More...MINTⁱ	P32455
STRINGⁱ	9606.ENSP00000359504

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	11 – 17	Combined sources	7
Beta strandⁱ	20 – 23	Combined sources	4
Helixⁱ	25 – 32	Combined sources	8
Beta strandⁱ	36 – 46	Combined sources	11
Helixⁱ	47 – 49	Combined sources	3
Helixⁱ	51 – 58	Combined sources	8
Beta strandⁱ	62 – 65	Combined sources	4
Beta strandⁱ	70 – 72	Combined sources	3
Beta strandⁱ	77 – 84	Combined sources	8
Beta strandⁱ	86 – 88	Combined sources	3
Beta strandⁱ	92 – 98	Combined sources	7
Turnⁱ	101 – 103	Combined sources	3
Helixⁱ	104 – 106	Combined sources	3
Helixⁱ	112 – 122	Combined sources	11
Beta strandⁱ	124 – 132	Combined sources	9
Helixⁱ	136 – 140	Combined sources	5
Helixⁱ	143 – 146	Combined sources	4
Helixⁱ	148 – 151	Combined sources	4
Beta strandⁱ	156 – 158	Combined sources	3
Helixⁱ	167 – 170	Combined sources	4
Helixⁱ	171 – 174	Combined sources	4
Beta strandⁱ	177 – 183	Combined sources	7
Beta strandⁱ	192 – 194	Combined sources	3
Helixⁱ	198 – 205	Combined sources	8
Helixⁱ	214 – 229	Combined sources	16
Beta strandⁱ	233 – 237	Combined sources	5
Helixⁱ	244 – 252	Combined sources	9
Helixⁱ	255 – 257	Combined sources	3
Helixⁱ	260 – 276	Combined sources	17
Turnⁱ	283 – 285	Combined sources	3
Helixⁱ	290 – 306	Combined sources	17
Helixⁱ	312 – 342	Combined sources	31
Helixⁱ	350 – 371	Combined sources	22
Helixⁱ	376 – 378	Combined sources	3
Helixⁱ	379 – 423	Combined sources	45
Turnⁱ	424 – 427	Combined sources	4
Helixⁱ	432 – 449	Combined sources	18
Helixⁱ	457 – 467	Combined sources	11
Helixⁱ	469 – 478	Combined sources	10
Beta strandⁱ	480 – 482	Combined sources	3
Helixⁱ	484 – 563	Combined sources	80
Helixⁱ	566 – 582	Combined sources	17

Show more details

3D structure databases

ProteinModelPortalⁱ	P32455
SMRⁱ	P32455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P32455

EvolutionaryTraceⁱ

P32455

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 278	GB1/RHD3-type GAdd BLAST		244

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 311	GTPase domain (Globular)Add BLAST		311

Sequence similaritiesⁱ

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG2037 Eukaryota ENOG410XR6Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074475
HOGENOMⁱ	HOG000266974
HOVERGENⁱ	HBG001979
InParanoidⁱ	P32455
KEGG Orthology (KO) More...KOⁱ	K20899
OMAⁱ	MAGLYRT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03P3
PhylomeDBⁱ	P32455
TreeFamⁱ	TF331602

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16269 GBP_C, 1 hit
InterProⁱ	View protein in InterPro IPR030386 G_GB1_RHD3_dom IPR037684 GBP_C IPR003191 Guanylate-bd/ATL_C IPR036543 Guanylate-bd_C_sf IPR015894 Guanylate-bd_N IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02263 GBP, 1 hit PF02841 GBP_C, 1 hit
SUPFAMⁱ	SSF48340 SSF48340, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51715 G_GB1_RHD3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P32455-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASEIHMTGP MCLIENTNGR LMANPEALKI LSAITQPMVV VAIVGLYRTG 
        60         70         80         90        100
KSYLMNKLAG KKKGFSLGST VQSHTKGIWM WCVPHPKKPG HILVLLDTEG 
       110        120        130        140        150
LGDVEKGDNQ NDSWIFALAV LLSSTFVYNS IGTINQQAMD QLYYVTELTH 
       160        170        180        190        200
RIRSKSSPDE NENEVEDSAD FVSFFPDFVW TLRDFSLDLE ADGQPLTPDE 
       210        220        230        240        250
YLTYSLKLKK GTSQKDETFN LPRLCIRKFF PKKKCFVFDR PVHRRKLAQL 
       260        270        280        290        300
EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY 
       310        320        330        340        350
VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTETL 
       360        370        380        390        400
QELLDLHRDS EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ 
       410        420        430        440        450
EASSDRCSAL LQVIFSPLEE EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE 
       460        470        480        490        500
PRKGIQAEEI LQTYLKSKES MTDAILQTDQ TLTEKEKEIE VERVKAESAQ 
       510        520        530        540        550
ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV QLLKEQERTL 
       560        570        580        590 
ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS

Length:592

Mass (Da):67,931

Last modified:November 2, 2010 - v2

Checksum:ⁱ3A06741218360732

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033950	78	I → V. Corresponds to variant dbSNP:rs1048401Ensembl.	1
Natural variantⁱVAR_033951	166	E → D. Corresponds to variant dbSNP:rs17130717Ensembl.	1
Natural variantⁱVAR_014849	349	T → S3 PublicationsCorresponds to variant dbSNP:rs1048425Ensembl.	1
Natural variantⁱVAR_046550	409	A → G3 PublicationsCorresponds to variant dbSNP:rs1048443Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55542 mRNA Translation: AAA35871.1 BT006847 mRNA Translation: AAP35493.1 AK291783 mRNA Translation: BAF84472.1 AL160008 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73148.1 CH471097 Genomic DNA Translation: EAW73150.1 BC002666 mRNA Translation: AAH02666.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS718.1
PIRⁱ	A41268
NCBI Reference Sequences More...RefSeqⁱ	NP_002044.2, NM_002053.2
UniGeneⁱ	Hs.62661

Genome annotation databases

Ensemblⁱ	ENST00000370473; ENSP00000359504; ENSG00000117228
GeneIDⁱ	2633
KEGGⁱ	hsa:2633
UCSC genome browser More...UCSCⁱ	uc001dmx.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32455	Guanylate-binding protein 1 (Fragment)		HUMAN		227	UniRef100_P32455

Protein	Similar proteins		Species	Score	Length	Source
P32455	Guanylate-binding protein 1		PONAB		592	UniRef90_P32455
Guanylate-binding protein 1		CHLAE		590
Guanylate-binding protein 1 (Fragment)		HUMAN		227
Uncharacterized protein		PANPA		597
Guanylate binding protein 1		PANTR		594
+31

Protein	Similar proteins		Species	Score	Length	Source
P32455	Guanylate-binding protein 1		PONAB		592	UniRef50_P32455
Guanylate-binding protein 1		CHLAE		590
Guanylate-binding protein 2		HUMAN		591
Guanylate-binding protein 1		RAT		589
Guanylate-binding protein 5		MOUSE		590
+358

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55542 mRNA Translation: AAA35871.1 BT006847 mRNA Translation: AAP35493.1 AK291783 mRNA Translation: BAF84472.1 AL160008 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73148.1 CH471097 Genomic DNA Translation: EAW73150.1 BC002666 mRNA Translation: AAH02666.1
CCDSⁱ	CCDS718.1
PIRⁱ	A41268
RefSeqⁱ	NP_002044.2, NM_002053.2
UniGeneⁱ	Hs.62661

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DG3	X-ray	1.80	A	1-592	[»]
	1F5N	X-ray	1.70	A	1-592	[»]
	2B8W	X-ray	2.22	A/B	1-317	[»]
	2B92	X-ray	3.20	A/B	1-317	[»]
	2BC9	X-ray	2.80	A	1-317	[»]
	2D4H	X-ray	2.90	A/B	1-317	[»]
ProteinModelPortalⁱ	P32455
SMRⁱ	P32455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108903, 20 interactors
DIPⁱ	DIP-60423N
IntActⁱ	P32455, 2 interactors
MINTⁱ	P32455
STRINGⁱ	9606.ENSP00000359504

PTM databases

iPTMnetⁱ	P32455
PhosphoSitePlusⁱ	P32455
SwissPalmⁱ	P32455

Polymorphism and mutation databases

BioMutaⁱ	GBP1
DMDMⁱ	311033383

Proteomic databases

EPDⁱ	P32455
MaxQBⁱ	P32455
PaxDbⁱ	P32455
PeptideAtlasⁱ	P32455
PRIDEⁱ	P32455
ProteomicsDBⁱ	54877

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2633
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370473; ENSP00000359504; ENSG00000117228
GeneIDⁱ	2633
KEGGⁱ	hsa:2633
UCSCⁱ	uc001dmx.3 human

Organism-specific databases

CTDⁱ	2633
DisGeNETⁱ	2633
EuPathDBⁱ	HostDB:ENSG00000117228.9
GeneCardsⁱ	GBP1
H-InvDBⁱ	HIX0018119 HIX0200036
HGNCⁱ	HGNC:4182 GBP1
HPAⁱ	CAB015450
MIMⁱ	600411 gene
neXtProtⁱ	NX_P32455
OpenTargetsⁱ	ENSG00000117228
PharmGKBⁱ	PA28596
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2037 Eukaryota ENOG410XR6Z LUCA
GeneTreeⁱ	ENSGT00550000074475
HOGENOMⁱ	HOG000266974
HOVERGENⁱ	HBG001979
InParanoidⁱ	P32455
KOⁱ	K20899
OMAⁱ	MAGLYRT
OrthoDBⁱ	EOG091G03P3
PhylomeDBⁱ	P32455
TreeFamⁱ	TF331602

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300 Interferon gamma signaling

Reactomeⁱ

R-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSⁱ	GBP1 human
EvolutionaryTraceⁱ	P32455
GeneWikiⁱ	GBP1
GenomeRNAiⁱ	2633
Protein Ontology More...PROⁱ	PR:P32455
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117228 Expressed in 222 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_GBP1
Genevisibleⁱ	P32455 HS

Family and domain databases

CDDⁱ	cd16269 GBP_C, 1 hit
InterProⁱ	View protein in InterPro IPR030386 G_GB1_RHD3_dom IPR037684 GBP_C IPR003191 Guanylate-bd/ATL_C IPR036543 Guanylate-bd_C_sf IPR015894 Guanylate-bd_N IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF02263 GBP, 1 hit PF02841 GBP_C, 1 hit
SUPFAMⁱ	SSF48340 SSF48340, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51715 G_GB1_RHD3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GBP1_HUMAN
Accessionⁱ	P32455Primary (citable) accession number: P32455 Secondary accession number(s): D3DT26, Q5T8M1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P32455 (GBP1_HUMAN)

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Guanylate-binding protein 1

GBP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Golgi apparatus

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ