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Protein

Homeobox protein MOX-2

Gene

Meox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 245HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • limb development Source: MGI
  • negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
  • neuron death Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • roof of mouth development Source: MGI
  • skeletal muscle tissue development Source: MGI
  • somite development Source: GO_Central
  • somite specification Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Mesenchyme homeobox 2
Gene namesi
Name:Meox2
Synonyms:Gax, Mox-2, Mox2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:103219 Meox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display defective differentiation and morphogenesis of the limb muscles (PubMed:12925591). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation. They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491981 – 303Homeobox protein MOX-2Add BLAST303

Proteomic databases

PaxDbiP32443
PRIDEiP32443

PTM databases

iPTMnetiP32443
PhosphoSitePlusiP32443

Expressioni

Developmental stagei

It is not expressed before 8-8.5 dpc. At 8-8.5 dpc it is found on the entire epithelium of the somite. At 9.5 dpc its expression is restricted to the sclerotome. At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors.1 Publication

Gene expression databases

BgeeiENSMUSG00000036144 Expressed in 197 organ(s), highest expression level in limb bud
CleanExiMM_MEOX2
GenevisibleiP32443 MM

Interactioni

Subunit structurei

Interacts with RNF10.By similarity

Protein-protein interaction databases

BioGridi201395, 4 interactors
STRINGi10090.ENSMUSP00000043587

Structurei

3D structure databases

ProteinModelPortaliP32443
SMRiP32443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 47Poly-Ser6
Compositional biasi63 – 85Gln/His-rich (OPA repeat)Add BLAST23
Compositional biasi68 – 79Poly-HisAdd BLAST12
Compositional biasi80 – 85Poly-Gln6

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.By similarity

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP32443
KOiK09322
OMAiSWHIPQM
OrthoDBiEOG091G0PFO
PhylomeDBiP32443
TreeFamiTF351603

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP
110 120 130 140 150
SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR
160 170 180 190 200
QALSPADVEK RSGSKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE
210 220 230 240 250
LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG
260 270 280 290 300
AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH

AHL
Length:303
Mass (Da):33,506
Last modified:October 1, 1993 - v1
Checksum:i41BD05FC39AA4427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16406 mRNA Translation: CAA78899.1
AK028352 mRNA Translation: BAC25898.1
AK031152 mRNA Translation: BAC27282.1
AK142690 mRNA Translation: BAE25163.1
S79168 Genomic DNA No translation available.
CCDSiCCDS25888.1
PIRiB49122
RefSeqiNP_032610.1, NM_008584.3
UniGeneiMm.341398

Genome annotation databases

EnsembliENSMUST00000041183; ENSMUSP00000043587; ENSMUSG00000036144
GeneIDi17286
KEGGimmu:17286
UCSCiuc007nkf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16406 mRNA Translation: CAA78899.1
AK028352 mRNA Translation: BAC25898.1
AK031152 mRNA Translation: BAC27282.1
AK142690 mRNA Translation: BAE25163.1
S79168 Genomic DNA No translation available.
CCDSiCCDS25888.1
PIRiB49122
RefSeqiNP_032610.1, NM_008584.3
UniGeneiMm.341398

3D structure databases

ProteinModelPortaliP32443
SMRiP32443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201395, 4 interactors
STRINGi10090.ENSMUSP00000043587

PTM databases

iPTMnetiP32443
PhosphoSitePlusiP32443

Proteomic databases

PaxDbiP32443
PRIDEiP32443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041183; ENSMUSP00000043587; ENSMUSG00000036144
GeneIDi17286
KEGGimmu:17286
UCSCiuc007nkf.1 mouse

Organism-specific databases

CTDi4223
MGIiMGI:103219 Meox2

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP32443
KOiK09322
OMAiSWHIPQM
OrthoDBiEOG091G0PFO
PhylomeDBiP32443
TreeFamiTF351603

Miscellaneous databases

PROiPR:P32443
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036144 Expressed in 197 organ(s), highest expression level in limb bud
CleanExiMM_MEOX2
GenevisibleiP32443 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEOX2_MOUSE
AccessioniPrimary (citable) accession number: P32443
Secondary accession number(s): Q544T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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