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Protein

Homeobox protein MOX-1

Gene

Meox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity).By similarity7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 229HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-1
Alternative name(s):
Mesenchyme homeobox 1
Gene namesi
Name:Meox1
Synonyms:Mox-1, Mox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103220 Meox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display mild defects in sclerotome derived vertebral and rib bones (PubMed:12925591). Abnormalities are restricted to the sclerotome and its derivatives and are characterized by a remodeling of the cranio-cervical joints, leading to the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis (PubMed:19520072). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation. They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi219Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491961 – 253Homeobox protein MOX-1Add BLAST253

Proteomic databases

PaxDbiP32442
PRIDEiP32442

PTM databases

PhosphoSitePlusiP32442

Expressioni

Tissue specificityi

Heart, lateral plate derivatives, kidney, loose connective tissue at sites of bone formation and skeletal muscle-connective tissue apposition.1 Publication

Developmental stagei

After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme.1 Publication

Gene expression databases

BgeeiENSMUSG00000001493 Expressed in 148 organ(s), highest expression level in somite
CleanExiMM_MEOX1
GenevisibleiP32442 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201394, 3 interactors
STRINGi10090.ENSMUSP00000051158

Structurei

3D structure databases

ProteinModelPortaliP32442
SMRiP32442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP32442
KOiK09322
OMAiWHFPVSE
OrthoDBiEOG091G0PFO
TreeFamiTF351603

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPVANSCVR NPQPPAPVWG CLRNPHSEDS SASGLSHYPP TPFSFHQKSD
60 70 80 90 100
FPATAAYPDF SASCLAATPH SLPRTERIFN EQHPAFPQTP DWHFPISEAG
110 120 130 140 150
QRLNLGPAGS AREMGAGSPG LVDGTAGLGE DCMVLGTIAN ETEKKSSRRK
160 170 180 190 200
KERSDNQENG GGKPEGSSKA RKERTAFTKE QLRELEAEFA HHNYLTRLRR
210 220 230 240 250
YEIAVNLDLS ERQVKVWFQN RRMKWKRVKG GQPVSPQEQD REDGDSAASP

SSE
Length:253
Mass (Da):27,980
Last modified:October 1, 1993 - v1
Checksum:i5B8757EFE503EDDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15103 mRNA Translation: CAA78812.1
AK052370 mRNA Translation: BAC34961.1
CH466558 Genomic DNA Translation: EDL34069.1
BC011082 mRNA Translation: AAH11082.1
CCDSiCCDS25480.1
PIRiA49122
RefSeqiNP_034921.1, NM_010791.3
UniGeneiMm.3404

Genome annotation databases

EnsembliENSMUST00000057054; ENSMUSP00000051158; ENSMUSG00000001493
GeneIDi17285
KEGGimmu:17285
UCSCiuc007lpx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15103 mRNA Translation: CAA78812.1
AK052370 mRNA Translation: BAC34961.1
CH466558 Genomic DNA Translation: EDL34069.1
BC011082 mRNA Translation: AAH11082.1
CCDSiCCDS25480.1
PIRiA49122
RefSeqiNP_034921.1, NM_010791.3
UniGeneiMm.3404

3D structure databases

ProteinModelPortaliP32442
SMRiP32442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201394, 3 interactors
STRINGi10090.ENSMUSP00000051158

PTM databases

PhosphoSitePlusiP32442

Proteomic databases

PaxDbiP32442
PRIDEiP32442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057054; ENSMUSP00000051158; ENSMUSG00000001493
GeneIDi17285
KEGGimmu:17285
UCSCiuc007lpx.1 mouse

Organism-specific databases

CTDi4222
MGIiMGI:103220 Meox1

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP32442
KOiK09322
OMAiWHFPVSE
OrthoDBiEOG091G0PFO
TreeFamiTF351603

Miscellaneous databases

PROiPR:P32442
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001493 Expressed in 148 organ(s), highest expression level in somite
CleanExiMM_MEOX1
GenevisibleiP32442 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEOX1_MOUSE
AccessioniPrimary (citable) accession number: P32442
Secondary accession number(s): Q543E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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