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UniProtKB - P32390 (ARP3_SCHPO)
Protein
Actin-related protein 3
Gene
act2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
May be involved in cytokinesis.
By similarityGO - Molecular functioni
- actin filament binding Source: PomBase
- ATP binding Source: PomBase
GO - Biological processi
- actin cortical patch organization Source: PomBase
- actin filament polymerization Source: PomBase
- Arp2/3 complex-mediated actin nucleation Source: PomBase
- endocytosis Source: PomBase
Keywordsi
Molecular function | Actin-binding |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-2029482, Regulation of actin dynamics for phagocytic cup formation R-SPO-5663213, RHO GTPases Activate WASPs and WAVEs R-SPO-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 3Alternative name(s): Actin-like protein 3 |
Gene namesi | Name:act2 ORF Names:SPAC630.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC630.03 |
VEuPathDBi | FungiDB:SPAC630.03 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin cortical patch Source: PomBase
- Arp2/3 protein complex Source: PomBase
Cytosol
- cytosol Source: PomBase
Other locations
- cell cortex of cell tip Source: PomBase
- cell division site Source: PomBase
- cytoplasm Source: PomBase
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089088 | 1 – 427 | Actin-related protein 3Add BLAST | 427 |
Proteomic databases
MaxQBi | P32390 |
PaxDbi | P32390 |
PTM databases
iPTMneti | P32390 |
Interactioni
Subunit structurei
Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.
1 PublicationGO - Molecular functioni
- actin filament binding Source: PomBase
Protein-protein interaction databases
BioGRIDi | 279661, 19 interactors |
IntActi | P32390, 3 interactors |
STRINGi | 4896.SPAC630.03.1 |
Structurei
3D structure databases
SMRi | P32390 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32390 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0678, Eukaryota |
HOGENOMi | CLU_027965_3_0_1 |
InParanoidi | P32390 |
OMAi | GIHYPIR |
PhylomeDBi | P32390 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR015623, Arp3 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF175, PTHR11937:SF175, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS01132, ACTINS_ACT_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
P32390-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASFNVPIIM DNGTGYSKLG YAGNDAPSYV FPTVIATRSA GASSGPAVSS
60 70 80 90 100
KPSYMASKGS GHLSSKRATE DLDFFIGNDA LKKASAGYSL DYPIRHGQIE
110 120 130 140 150
NWDHMERFWQ QSLFKYLRCE PEDHYFLLTE PPLNPPENRE NTAEIMFESF
160 170 180 190 200
NCAGLYIAVQ AVLALAASWT SSKVTDRSLT GTVVDSGDGV THIIPVAEGY
210 220 230 240 250
VIGSSIKTMP LAGRDVTYFV QSLLRDRNEP DSSLKTAERI KEECCYVCPD
260 270 280 290 300
IVKEFSRFDR EPDRYLKYAS ESITGHSTTI DVGFERFLAP EIFFNPEIAS
310 320 330 340 350
SDFLTPLPEL VDNVVQSSPI DVRKGLYKNI VLSGGSTLFK NFGNRLQRDL
360 370 380 390 400
KRIVDERIHR SEMLSGAKSG GVDVNVISHK RQRNAVWFGG SLLAQTPEFG
410 420
SYCHTKADYE EYGASIARRY QIFGNSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81068 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB52725.1 |
PIRi | A41790 |
RefSeqi | NP_592898.1, NM_001018298.2 |
Genome annotation databases
EnsemblFungii | SPAC630.03.1; SPAC630.03.1:pep; SPAC630.03 |
GeneIDi | 2543233 |
KEGGi | spo:SPAC630.03 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81068 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB52725.1 |
PIRi | A41790 |
RefSeqi | NP_592898.1, NM_001018298.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DWL | X-ray | 3.78 | A/B | 1-427 | [»] | |
6W17 | electron microscopy | 3.90 | A | 1-427 | [»] | |
6W18 | electron microscopy | 4.20 | A | 1-427 | [»] | |
SMRi | P32390 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 279661, 19 interactors |
IntActi | P32390, 3 interactors |
STRINGi | 4896.SPAC630.03.1 |
PTM databases
iPTMneti | P32390 |
Proteomic databases
MaxQBi | P32390 |
PaxDbi | P32390 |
Genome annotation databases
EnsemblFungii | SPAC630.03.1; SPAC630.03.1:pep; SPAC630.03 |
GeneIDi | 2543233 |
KEGGi | spo:SPAC630.03 |
Organism-specific databases
PomBasei | SPAC630.03 |
VEuPathDBi | FungiDB:SPAC630.03 |
Phylogenomic databases
eggNOGi | KOG0678, Eukaryota |
HOGENOMi | CLU_027965_3_0_1 |
InParanoidi | P32390 |
OMAi | GIHYPIR |
PhylomeDBi | P32390 |
Enzyme and pathway databases
Reactomei | R-SPO-2029482, Regulation of actin dynamics for phagocytic cup formation R-SPO-5663213, RHO GTPases Activate WASPs and WAVEs R-SPO-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
EvolutionaryTracei | P32390 |
PROi | PR:P32390 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR015623, Arp3 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF175, PTHR11937:SF175, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS01132, ACTINS_ACT_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARP3_SCHPO | |
Accessioni | P32390Primary (citable) accession number: P32390 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families