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Entry version 144 (13 Feb 2019)
Sequence version 1 (01 Oct 1993)
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Protein

2-deoxy-glucose resistant protein 2

Gene

DGR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31904-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-deoxy-glucose resistant protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGR2
Ordered Locus Names:YKL121W
ORF Names:YKL525
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YKL121W

Saccharomyces Genome Database

More...
SGDi
S000001604 DGR2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increases cellular tolerance to 2-deoxy-glucose.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514791 – 8522-deoxy-glucose resistant protein 2Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei716PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P32330

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32330

PRoteomics IDEntifications database

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PRIDEi
P32330

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32330

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34014, 129 interactors

Protein interaction database and analysis system

More...
IntActi
P32330, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YKL121W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P32330

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32330

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati171 – 210WD 1Add BLAST40
Repeati278 – 316WD 2Add BLAST39
Repeati318 – 358WD 3Add BLAST41
Repeati426 – 471WD 4Add BLAST46
Repeati476 – 515WD 5Add BLAST40
Repeati651 – 689WD 6Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat DGR2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000157557

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P32330

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHEDFVT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2

The PANTHER Classification System

More...
PANTHERi
PTHR14221 PTHR14221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32330-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI
60 70 80 90 100
ADSKRSSSRY DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN
110 120 130 140 150
KLSENDRWYF DLFDRKYFEN YLEEPTYIKI FKKKEGLEQF DRMFLAQELK
160 170 180 190 200
IPDVYKSTTY QGEPAVANSE LFKNSICCCT FSHDGKYMVI GCKDGSLHLW
210 220 230 240 250
KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN GSISSNDLKP
260 270 280 290 300
SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD
310 320 330 340 350
KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI
360 370 380 390 400
LDNEVSYAFD CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS
410 420 430 440 450
FHVSDKSTQG TTKNSFHPSS EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT
460 470 480 490 500
TNDSKIQIFD LNEKKPLELF KGFQSGSSRH RGQFLMMKNE PVVFTGSDDH
510 520 530 540 550
WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV SNKSTNDECL
560 570 580 590 600
TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI
610 620 630 640 650
APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG
660 670 680 690 700
GFSSNLSNVV NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL
710 720 730 740 750
FHLEAAGKIN NHNNDSILEN RMDERSSTED NEFSTTPPSN THNSRPSHDF
760 770 780 790 800
CELHPNNSPV ISGMPSRASA IFKNSIFNKS NGSFISLKSR SESTSSTVFG
810 820 830 840 850
PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT CADCGTILNN

FR
Length:852
Mass (Da):96,022
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA673BAF9AF22B608
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S44213 Genomic DNA Translation: AAB23072.2
Z28121 Genomic DNA Translation: CAA81962.1
BK006944 Genomic DNA Translation: DAA09039.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25359

NCBI Reference Sequences

More...
RefSeqi
NP_012801.1, NM_001179687.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL121W_mRNA; YKL121W_mRNA; YKL121W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL121W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S44213 Genomic DNA Translation: AAB23072.2
Z28121 Genomic DNA Translation: CAA81962.1
BK006944 Genomic DNA Translation: DAA09039.1
PIRiS25359
RefSeqiNP_012801.1, NM_001179687.1

3D structure databases

ProteinModelPortaliP32330
SMRiP32330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34014, 129 interactors
IntActiP32330, 1 interactor
STRINGi4932.YKL121W

PTM databases

iPTMnetiP32330

Proteomic databases

MaxQBiP32330
PaxDbiP32330
PRIDEiP32330

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL121W_mRNA; YKL121W_mRNA; YKL121W
GeneIDi853738
KEGGisce:YKL121W

Organism-specific databases

EuPathDBiFungiDB:YKL121W
SGDiS000001604 DGR2

Phylogenomic databases

GeneTreeiENSGT00940000157557
InParanoidiP32330
OMAiQHEDFVT

Enzyme and pathway databases

BioCyciYEAST:G3O-31904-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32330

Family and domain databases

InterProiView protein in InterPro
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2
PANTHERiPTHR14221 PTHR14221, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGR2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32330
Secondary accession number(s): D6VXG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 13, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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