UniProtKB - P32325 (DBF4_YEAST)

BLAST

>sp|P32325|DBF4_YEAST DDK kinase regulatory subunit DBF4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DBF4 PE=1 SV=2
MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSL
ERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIM
KRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVE
NIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHN
EKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILK
IGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQ
TKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSIL
LNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDL
CTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQ
TNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPK
VATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGY
CENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI

Align
Format
Add to basket Added to basket
History
Entry version 161 (07 Nov 2018)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

DDK kinase regulatory subunit DBF4

Gene

DBF4

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.12 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	654 – 703	DBF4-typePROSITE-ProRule annotationAdd BLAST		50

GO - Molecular functionⁱ

DNA replication origin binding
Source: SGD
Inferred from direct assayⁱ
- 8066465
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activator activity
Source: SGD
Inferred from mutant phenotypeⁱ
- 8474449
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
chromosome segregation Source: UniProtKB-KW
DNA replication initiation
Source: SGD
Inferred from physical interactionⁱ
- 8474449
mitotic DNA replication checkpoint
Source: SGD
Inferred from genetic interactionⁱ
- 18372119
negative regulation of exit from mitosis
Source: SGD
Inferred from mutant phenotypeⁱ
- 19478884
positive regulation of DNA replication
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of DNA replication initiation
Source: SGD
Inferred from genetic interactionⁱ
- 9407029
positive regulation of meiosis I
Source: SGD
Inferred from mutant phenotypeⁱ
- 16319063
positive regulation of protein kinase activity
Source: SGD
Inferred from direct assayⁱ
- 19692334
positive regulation of protein serine/threonine kinase activity
Source: SGD
Inferred from mutant phenotypeⁱ
- 8474449
premeiotic DNA replication
Source: SGD
Inferred from mutant phenotypeⁱ
- 16319063

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Cell cycle, Cell division, Chromosome partition, DNA replication, Meiosis, Mitosis
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29662-MONOMER

BioCycⁱ

YEAST:G3O-29662-MONOMER

Protein family/group databases

MoonDBⁱ	P32325 Predicted

MoonDBⁱ

P32325 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DDK kinase regulatory subunit DBF4 Alternative name(s): Dumbbell forming protein 4
Gene namesⁱ	Name:DBF4 Synonyms:DNA52 Ordered Locus Names:YDR052C ORF Names:D4205, YD9609.07C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000002459 DBF4

SGDⁱ

S000002459 DBF4

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	83	R → A or E: Defective for interaction with CDC5. 1 Publication	1
Mutagenesisⁱ	84	S → A: No effect. 1 Publication	1
Mutagenesisⁱ	85	I → A: Defective for interaction with CDC5. 1 Publication	1
Mutagenesisⁱ	86	E → K: No effect. 1 Publication	1
Mutagenesisⁱ	87	G → A: Defective for interaction with CDC5. 1 Publication	1
Mutagenesisⁱ	88	A → V: Defective for interaction with CDC5. 1 Publication	1
Mutagenesisⁱ	661	C → A in DBF4-AAHH; weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands; when associated with A-664. 1 Publication	1
Mutagenesisⁱ	664	C → A in DBF4-AAHH; weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands; when associated with A-661. 1 Publication	1
Mutagenesisⁱ	674	H → A in DBF4-CCAA; weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands; when associated with A-680. 1 Publication	1
Mutagenesisⁱ	680	H → A: Weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands. In DBF4-CCAA; weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands; when associated with A-674. 1 Publication	1
Mutagenesisⁱ	680	H → C: Weakens interaction with ARS1 origin DNA and MCM2, but not other known ligands. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079791	1 – 704	DDK kinase regulatory subunit DBF4Add BLAST		704

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	59	PhosphoserineCombined sources	1
Modified residueⁱ	84	PhosphoserineCombined sources	1
Modified residueⁱ	235	PhosphoserineCombined sources	1
Modified residueⁱ	623	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CDC7 and by CDC5.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32325
PaxDbⁱ	P32325
PRIDEⁱ	P32325

PTM databases

iPTMnetⁱ	P32325

iPTMnetⁱ

P32325

Expressionⁱ

Inductionⁱ

Cell cycle-regulated. Protein levels increase as cells begin S phase and remain high through late mitosis.2 Publications

Interactionⁱ

Subunit structureⁱ

Heterodimer with CDC7 to form the DBF4-dependent kinase (DDK) complex. Interacts (via PBD-binding motif) with CDC5 (via POLO box domains). Interacts (via N-terminus) with ORC2, ORC3 and RAD53. Binds to ARS1 origin DNA.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDC7	P06243	8	EBI-5575,EBI-4451

With

Entry

#Exp.

IntAct

Notes

CDC7

P06243

EBI-5575,EBI-4451

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	32106, 818 interactors
ComplexPortalⁱ	CPX-867 DBF4-dependent CDC7 kinase complex
Database of interacting proteins More...DIPⁱ	DIP-2290N
IntActⁱ	P32325, 5 interactors
Molecular INTeraction database More...MINTⁱ	P32325
STRINGⁱ	4932.YDR052C

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	106 – 122	Combined sources	17
Beta strandⁱ	125 – 128	Combined sources	4
Helixⁱ	138 – 157	Combined sources	20
Beta strandⁱ	161 – 165	Combined sources	5
Beta strandⁱ	172 – 177	Combined sources	6
Helixⁱ	179 – 184	Combined sources	6
Helixⁱ	190 – 196	Combined sources	7
Beta strandⁱ	200 – 203	Combined sources	4
Helixⁱ	204 – 213	Combined sources	10
Helixⁱ	218 – 221	Combined sources	4
Helixⁱ	233 – 241	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P32325
SMRⁱ	P32325
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P32325

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	10 – 19	D box 1		10
Regionⁱ	62 – 70	D box 2		9

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	83 – 88	POLO box domain (PBD)-binding		6

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	654 – 703	DBF4-typePROSITE-ProRule annotationAdd BLAST		50

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

HOGENOMⁱ	HOG000112168
InParanoidⁱ	P32325
KEGG Orthology (KO) More...KOⁱ	K02309
OMAⁱ	PIITLEW
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4W9O

Family and domain databases

Gene3Dⁱ	3.30.160.680, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR036420 BRCT_dom_sf IPR013939 Regulatory_Dfp1/Him1 IPR006572 Znf_DBF IPR038545 Znf_DBF_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08630 Dfp1_Him1_M, 1 hit PF07535 zf-DBF, 1 hit
SMARTⁱ	View protein in SMART SM00586 ZnF_DBF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51265 ZF_DBF4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P32325-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVSPTKMIIR SPLKETDTNL KHNNGIAAST TAAGHLNVFS NDNNCNNNNT 
        60         70         80         90        100
TESFPKKRSL ERLELQQQQH LHEKKRARIE RARSIEGAVQ VSKGTGLKNV 
       110        120        130        140        150
EPRVTPKELL EWQTNWKKIM KRDSRIYFDI TDDVEMNTYN KSKMDKRRDL 
       160        170        180        190        200
LKRGFLTLGA QITQFFDTTV TIVITRRSVE NIYLLKDTDI LSRAKKNYMK 
       210        220        230        240        250
VWSYEKAARF LKNLDVDLDH LSKTKSASLA APTLSNLLHN EKLYGPTDRD 
       260        270        280        290        300
PRTKRDDIHY FKYPHVYLYD LWQTWAPIIT LEWKPQELTN LDELPYPILK 
       310        320        330        340        350
IGSFGRCPFI GDRNYDESSY KRVVKRYSRD KANKKYALQL RALFQYHADT 
       360        370        380        390        400
LLNTSSVNDQ TKNLIFIPHT CNDSTKSFKK WMQEKAKNFE KTELKKTDDS 
       410        420        430        440        450
AVQDVRNEHA DQTDEKNSIL LNETETKEPP LKEEKENKQS IAEESNKYPQ 
       460        470        480        490        500
RKELAATPKL NHPVLATFAR QETEEVPDDL CTLKTKSRQA FEIKASGAHQ 
       510        520        530        540        550
SNDVATSFGN GLGPTRASVM SKNMKSLSRL MVDRKLGVKQ TNGNNKNYTA 
       560        570        580        590        600
TIATTAETSK ENRHRLDFNA LKKDEAPSKE TGKDSAVHLE TNRKPQNFPK 
       610        620        630        640        650
VATKSVSADS KVHNDIKITT TESPTASKKS TSTNVTLHFN AQTAQTAQPV 
       660        670        680        690        700
KKETVKNSGY CENCRVKYES LEQHIVSEKH LSFAENDLNF EAIDSLIENL 

RFQI

Length:704

Mass (Da):80,690

Last modified:February 1, 1996 - v2

Checksum:ⁱBDB93E72EF2ABC0B

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	159 – 160	GA → NT in CAA42819 (PubMed:1592236).Curated	2
Sequence conflictⁱ	177	R → RR in CAA42819 (PubMed:1592236).Curated	1
Sequence conflictⁱ	197	N → K in CAA42819 (PubMed:1592236).Curated	1
Sequence conflictⁱ	256	D → G in CAA42819 (PubMed:1592236).Curated	1
Sequence conflictⁱ	416 – 425	Missing in CAA42819 (PubMed:1592236).Curated	10
Sequence conflictⁱ	439	Q → R in CAA42819 (PubMed:1592236).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60279 Genomic DNA Translation: CAA42819.1 M83539 Genomic DNA Translation: AAA34573.1 X84162 Genomic DNA Translation: CAA58969.1 Z49209 Genomic DNA Translation: CAA89082.1 Z74348 Genomic DNA Translation: CAA98869.1 BK006938 Genomic DNA Translation: DAA11899.1
PIRⁱ	S25371
NCBI Reference Sequences More...RefSeqⁱ	NP_010337.3, NM_001180360.3

Genome annotation databases

EnsemblFungiⁱ	YDR052C; YDR052C; YDR052C
GeneIDⁱ	851623
KEGGⁱ	sce:YDR052C

Protein	Similar proteins		Species	Score	Length	Source
P32325	K7_Dbf4p		YEASK		707	UniRef90_P32325
Cdc7p-Dbf4p kinase complex regulatory subunit		YEAS1		704
Dbf4p		YEAS8		704
Dbf4p		SACCK		704
DBF4p Regulatory subunit of Cdc7p-Dbf4p kinase complex		Saccharomyces sp. 'boulardii'		704
+5

Protein	Similar proteins		Species	Score	Length	Source
P32325	K7_Dbf4p		YEASK		707	UniRef50_P32325
Dbf4p		YEAS2		704
Cdc7p-Dbf4p kinase complex regulatory subunit		YEAS7		704
Cdc7p-Dbf4p kinase complex regulatory subunit		YEAS1		704
Dbf4p		YEAS8		704
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60279 Genomic DNA Translation: CAA42819.1 M83539 Genomic DNA Translation: AAA34573.1 X84162 Genomic DNA Translation: CAA58969.1 Z49209 Genomic DNA Translation: CAA89082.1 Z74348 Genomic DNA Translation: CAA98869.1 BK006938 Genomic DNA Translation: DAA11899.1
PIRⁱ	S25371
RefSeqⁱ	NP_010337.3, NM_001180360.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3OQ0	X-ray	2.70	A/B/C/D/E/F/G/H/I/J	120-250	[»]
	3OQ4	X-ray	2.40	A/B/C/D/E	120-250	[»]
	3QBZ	X-ray	2.69	A	66-221	[»]
	5T2F	X-ray	2.66	A/B/C/D	105-220	[»]
	5T2S	X-ray	2.40	A/C	105-220	[»]
ProteinModelPortalⁱ	P32325
SMRⁱ	P32325
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32106, 818 interactors
ComplexPortalⁱ	CPX-867 DBF4-dependent CDC7 kinase complex
DIPⁱ	DIP-2290N
IntActⁱ	P32325, 5 interactors
MINTⁱ	P32325
STRINGⁱ	4932.YDR052C

Protein family/group databases

MoonDBⁱ	P32325 Predicted

MoonDBⁱ

P32325 Predicted

PTM databases

iPTMnetⁱ	P32325

iPTMnetⁱ

P32325

Proteomic databases

MaxQBⁱ	P32325
PaxDbⁱ	P32325
PRIDEⁱ	P32325

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDR052C; YDR052C; YDR052C
GeneIDⁱ	851623
KEGGⁱ	sce:YDR052C

Organism-specific databases

SGDⁱ	S000002459 DBF4

Phylogenomic databases

HOGENOMⁱ	HOG000112168
InParanoidⁱ	P32325
KOⁱ	K02309
OMAⁱ	PIITLEW
OrthoDBⁱ	EOG092C4W9O

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29662-MONOMER

BioCycⁱ

YEAST:G3O-29662-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P32325
Protein Ontology More...PROⁱ	PR:P32325

Family and domain databases

Gene3Dⁱ	3.30.160.680, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR036420 BRCT_dom_sf IPR013939 Regulatory_Dfp1/Him1 IPR006572 Znf_DBF IPR038545 Znf_DBF_sf
Pfamⁱ	View protein in Pfam PF08630 Dfp1_Him1_M, 1 hit PF07535 zf-DBF, 1 hit
SMARTⁱ	View protein in SMART SM00586 ZnF_DBF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51265 ZF_DBF4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DBF4_YEAST
Accessionⁱ	P32325Primary (citable) accession number: P32325 Secondary accession number(s): D6VS39, P32355
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P32325 (DBF4_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

DDK kinase regulatory subunit DBF4

DBF4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ