UniProtKB - P32320 (CDD_HUMAN)
Protein
Cytidine deaminase
Gene
CDA
Organism
Homo sapiens (Human)
Status
Functioni
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 65 | Zinc; catalytic | 1 | |
Active sitei | 67 | Proton donor | 1 | |
Metal bindingi | 99 | Zinc; catalytic | 1 | |
Metal bindingi | 102 | Zinc; catalytic | 1 |
GO - Molecular functioni
- cytidine deaminase activity Source: UniProtKB
- deoxycytidine deaminase activity Source: RHEA
- identical protein binding Source: UniProtKB
- nucleoside binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: UniProtKB
- cytidine deamination Source: UniProtKB
- cytosine metabolic process Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of nucleotide metabolic process Source: UniProtKB
- neutrophil degranulation Source: Reactome
- pyrimidine-containing compound salvage Source: UniProtKB
- pyrimidine nucleoside salvage Source: Reactome
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08334-MONOMER |
BRENDAi | 3.5.4.5, 2681 |
PathwayCommonsi | P32320 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-73614, Pyrimidine salvage |
SABIO-RKi | P32320 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDA Synonyms:CDD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1712, CDA |
MIMi | 123920, gene |
neXtProti | NX_P32320 |
VEuPathDBi | HostDB:ENSG00000158825.5 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- secretory granule lumen Source: Reactome
- tertiary granule lumen Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 978 |
OpenTargetsi | ENSG00000158825 |
PharmGKBi | PA98 |
Miscellaneous databases
Pharosi | P32320, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4502 |
DrugBanki | DB03185, 1-Beta-Ribofuranosyl-1,3-Diazepinone DB00928, Azacitidine DB01101, Capecitabine DB15694, Cedazuridine DB00987, Cytarabine DB01262, Decitabine DB00441, Gemcitabine |
GuidetoPHARMACOLOGYi | 3133 |
Genetic variation databases
BioMutai | CDA |
DMDMi | 1705718 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171682 | 1 – 146 | Cytidine deaminaseAdd BLAST | 146 |
Proteomic databases
EPDi | P32320 |
jPOSTi | P32320 |
MassIVEi | P32320 |
MaxQBi | P32320 |
PaxDbi | P32320 |
PeptideAtlasi | P32320 |
PRIDEi | P32320 |
ProteomicsDBi | 54869 |
TopDownProteomicsi | P32320 |
PTM databases
iPTMneti | P32320 |
PhosphoSitePlusi | P32320 |
Expressioni
Tissue specificityi
Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
Gene expression databases
Bgeei | ENSG00000158825, Expressed in blood and 138 other tissues |
Genevisiblei | P32320, HS |
Organism-specific databases
HPAi | ENSG00000158825, Tissue enhanced (blood, bone marrow) |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationBinary interactionsi
Hide detailsP32320
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107416, 47 interactors |
IntActi | P32320, 26 interactors |
STRINGi | 9606.ENSP00000364212 |
Chemistry databases
BindingDBi | P32320 |
Miscellaneous databases
RNActi | P32320, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P32320 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32320 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 140 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 128 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 60 | Substrate binding | 7 |
Sequence similaritiesi
Belongs to the cytidine and deoxycytidylate deaminase family.Curated
Phylogenomic databases
eggNOGi | KOG0833, Eukaryota |
GeneTreei | ENSGT00390000000911 |
HOGENOMi | CLU_097262_1_2_1 |
InParanoidi | P32320 |
OMAi | LTHFTCV |
OrthoDBi | 1400471at2759 |
PhylomeDBi | P32320 |
TreeFami | TF314486 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P32320-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQKRPACTL KPECVQQLLV CSQEAKKSAY CPYSHFPVGA ALLTQEGRIF
60 70 80 90 100
KGCNIENACY PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG
110 120 130 140
ACRQVMREFG TNWPVYMTKP DGTYIVMTVQ ELLPSSFGPE DLQKTQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021559 | 27 | K → Q2 PublicationsCorresponds to variant dbSNP:rs2072671Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27943 mRNA Translation: AAA57254.1 AF061658 , AF061655, AF061656, AF061657 Genomic DNA Translation: AAD15828.1 AJ000474 mRNA Translation: CAA04113.1 AL391357 Genomic DNA No translation available. BC054036 mRNA Translation: AAH54036.1 S52873 mRNA Translation: AAB24946.1 |
CCDSi | CCDS210.1 |
PIRi | I52710 |
RefSeqi | NP_001776.1, NM_001785.2 |
Genome annotation databases
Ensembli | ENST00000375071; ENSP00000364212; ENSG00000158825 |
GeneIDi | 978 |
KEGGi | hsa:978 |
UCSCi | uc001bdk.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27943 mRNA Translation: AAA57254.1 AF061658 , AF061655, AF061656, AF061657 Genomic DNA Translation: AAD15828.1 AJ000474 mRNA Translation: CAA04113.1 AL391357 Genomic DNA No translation available. BC054036 mRNA Translation: AAH54036.1 S52873 mRNA Translation: AAB24946.1 |
CCDSi | CCDS210.1 |
PIRi | I52710 |
RefSeqi | NP_001776.1, NM_001785.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MQ0 | X-ray | 2.40 | A/B | 11-146 | [»] | |
SMRi | P32320 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107416, 47 interactors |
IntActi | P32320, 26 interactors |
STRINGi | 9606.ENSP00000364212 |
Chemistry databases
BindingDBi | P32320 |
ChEMBLi | CHEMBL4502 |
DrugBanki | DB03185, 1-Beta-Ribofuranosyl-1,3-Diazepinone DB00928, Azacitidine DB01101, Capecitabine DB15694, Cedazuridine DB00987, Cytarabine DB01262, Decitabine DB00441, Gemcitabine |
GuidetoPHARMACOLOGYi | 3133 |
PTM databases
iPTMneti | P32320 |
PhosphoSitePlusi | P32320 |
Genetic variation databases
BioMutai | CDA |
DMDMi | 1705718 |
Proteomic databases
EPDi | P32320 |
jPOSTi | P32320 |
MassIVEi | P32320 |
MaxQBi | P32320 |
PaxDbi | P32320 |
PeptideAtlasi | P32320 |
PRIDEi | P32320 |
ProteomicsDBi | 54869 |
TopDownProteomicsi | P32320 |
Protocols and materials databases
Antibodypediai | 29806, 311 antibodies |
DNASUi | 978 |
Genome annotation databases
Ensembli | ENST00000375071; ENSP00000364212; ENSG00000158825 |
GeneIDi | 978 |
KEGGi | hsa:978 |
UCSCi | uc001bdk.4, human |
Organism-specific databases
CTDi | 978 |
DisGeNETi | 978 |
GeneCardsi | CDA |
HGNCi | HGNC:1712, CDA |
HPAi | ENSG00000158825, Tissue enhanced (blood, bone marrow) |
MIMi | 123920, gene |
neXtProti | NX_P32320 |
OpenTargetsi | ENSG00000158825 |
PharmGKBi | PA98 |
VEuPathDBi | HostDB:ENSG00000158825.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0833, Eukaryota |
GeneTreei | ENSGT00390000000911 |
HOGENOMi | CLU_097262_1_2_1 |
InParanoidi | P32320 |
OMAi | LTHFTCV |
OrthoDBi | 1400471at2759 |
PhylomeDBi | P32320 |
TreeFami | TF314486 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08334-MONOMER |
BRENDAi | 3.5.4.5, 2681 |
PathwayCommonsi | P32320 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-73614, Pyrimidine salvage |
SABIO-RKi | P32320 |
Miscellaneous databases
BioGRID-ORCSi | 978, 8 hits in 985 CRISPR screens |
ChiTaRSi | CDA, human |
EvolutionaryTracei | P32320 |
GeneWikii | Cytidine_deaminase |
GenomeRNAii | 978 |
Pharosi | P32320, Tchem |
PROi | PR:P32320 |
RNActi | P32320, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158825, Expressed in blood and 138 other tissues |
Genevisiblei | P32320, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDD_HUMAN | |
Accessioni | P32320Primary (citable) accession number: P32320 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families