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Protein

Cytidine deaminase

Gene

CDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Zinc; catalytic1
Active sitei67Proton donor1
Metal bindingi99Zinc; catalytic1
Metal bindingi102Zinc; catalytic1

GO - Molecular functioni

  • cytidine deaminase activity Source: UniProtKB
  • nucleoside binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: UniProtKB
  • cytidine deamination Source: UniProtKB
  • cytosine metabolic process Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of nucleotide metabolic process Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • protein homotetramerization Source: UniProtKB
  • pyrimidine-containing compound salvage Source: UniProtKB
  • pyrimidine nucleoside salvage Source: Reactome

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS08334-MONOMER
BRENDAi3.5.4.5 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-73614 Pyrimidine salvage
SABIO-RKiP32320

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:CDA
Synonyms:CDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158825.5
HGNCiHGNC:1712 CDA
MIMi123920 gene
neXtProtiNX_P32320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi978
OpenTargetsiENSG00000158825
PharmGKBiPA98

Chemistry databases

ChEMBLiCHEMBL4502
DrugBankiDB00928 Azacitidine
DB01101 Capecitabine
DB00987 Cytarabine
DB05314 DN-101
DB00441 Gemcitabine

Polymorphism and mutation databases

BioMutaiCDA
DMDMi1705718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716821 – 146Cytidine deaminaseAdd BLAST146

Proteomic databases

EPDiP32320
MaxQBiP32320
PaxDbiP32320
PeptideAtlasiP32320
PRIDEiP32320
ProteomicsDBi54869
TopDownProteomicsiP32320

PTM databases

iPTMnetiP32320
PhosphoSitePlusiP32320

Expressioni

Tissue specificityi

Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Gene expression databases

BgeeiENSG00000158825
CleanExiHS_CDA
GenevisibleiP32320 HS

Organism-specific databases

HPAiHPA064202

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107416, 36 interactors
IntActiP32320, 17 interactors
STRINGi9606.ENSP00000364212

Chemistry databases

BindingDBiP32320

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 25Combined sources11
Helixi26 – 28Combined sources3
Turni32 – 34Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi49 – 53Combined sources5
Helixi60 – 62Combined sources3
Helixi66 – 76Combined sources11
Beta strandi83 – 90Combined sources8
Helixi100 – 107Combined sources8
Beta strandi111 – 118Combined sources8
Beta strandi124 – 128Combined sources5
Helixi129 – 132Combined sources4
Helixi139 – 141Combined sources3

3D structure databases

ProteinModelPortaliP32320
SMRiP32320
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32320

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 140CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 60Substrate binding7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0833 Eukaryota
COG0295 LUCA
GeneTreeiENSGT00390000000911
HOGENOMiHOG000014707
HOVERGENiHBG005294
InParanoidiP32320
KOiK01489
OMAiAVYMTKP
OrthoDBiEOG091G09D3
PhylomeDBiP32320
TreeFamiTF314486

Family and domain databases

InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR006262 Cyt_deam_tetra
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR01354 cyt_deam_tetra, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKRPACTL KPECVQQLLV CSQEAKKSAY CPYSHFPVGA ALLTQEGRIF
60 70 80 90 100
KGCNIENACY PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG
110 120 130 140
ACRQVMREFG TNWPVYMTKP DGTYIVMTVQ ELLPSSFGPE DLQKTQ
Length:146
Mass (Da):16,185
Last modified:October 1, 1996 - v2
Checksum:iAF33D09EE4E176B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02155927K → Q2 PublicationsCorresponds to variant dbSNP:rs2072671Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27943 mRNA Translation: AAA57254.1
AF061658
, AF061655, AF061656, AF061657 Genomic DNA Translation: AAD15828.1
AJ000474 mRNA Translation: CAA04113.1
AL391357 Genomic DNA No translation available.
BC054036 mRNA Translation: AAH54036.1
S52873 mRNA Translation: AAB24946.1
CCDSiCCDS210.1
PIRiI52710
RefSeqiNP_001776.1, NM_001785.2
UniGeneiHs.466910

Genome annotation databases

EnsembliENST00000375071; ENSP00000364212; ENSG00000158825
GeneIDi978
KEGGihsa:978
UCSCiuc001bdk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDD_HUMAN
AccessioniPrimary (citable) accession number: P32320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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